IL160694A0 - Intermediate compounds for the preparation of mirtazapine and the production methods thereof - Google Patents
Intermediate compounds for the preparation of mirtazapine and the production methods thereofInfo
- Publication number
- IL160694A0 IL160694A0 IL16069401A IL16069401A IL160694A0 IL 160694 A0 IL160694 A0 IL 160694A0 IL 16069401 A IL16069401 A IL 16069401A IL 16069401 A IL16069401 A IL 16069401A IL 160694 A0 IL160694 A0 IL 160694A0
- Authority
- IL
- Israel
- Prior art keywords
- mirtazapine
- preparation
- intermediate compounds
- obtaining
- production methods
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001785 mirtazapine Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- IRMBVBDXXYXPEW-UHFFFAOYSA-N 1-methyl-3-phenylpiperazine Chemical compound C1N(C)CCNC1C1=CC=CC=C1 IRMBVBDXXYXPEW-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000006073 displacement reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/ES2001/000347 WO2003024918A1 (es) | 2001-09-14 | 2001-09-14 | Compuestos intermedios para la preparación de mirtazapina y sus procedimientos de obtención |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL160694A0 true IL160694A0 (en) | 2004-08-31 |
Family
ID=8244377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16069401A IL160694A0 (en) | 2001-09-14 | 2001-09-14 | Intermediate compounds for the preparation of mirtazapine and the production methods thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7265223B2 (de) |
| EP (1) | EP1426356B1 (de) |
| AT (1) | ATE392410T1 (de) |
| CA (1) | CA2460571A1 (de) |
| DE (1) | DE60133674D1 (de) |
| HU (1) | HUP0401921A3 (de) |
| IL (1) | IL160694A0 (de) |
| WO (1) | WO2003024918A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041826B2 (en) * | 2003-06-02 | 2006-05-09 | Aurobindo Pharma Ltd. | Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate |
| TW200815370A (en) * | 2006-06-16 | 2008-04-01 | Organon Nv | Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine |
| CN101679431B (zh) | 2007-04-11 | 2013-08-14 | Msd欧斯股份有限公司 | 制备四环苯并氮杂卓的对映异构体的方法 |
| CN112094241B (zh) * | 2020-09-19 | 2023-04-18 | 浙江凯普化工有限公司 | 一种1,4-二氮杂螺[5,5]十一烷-3-酮的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3102068A (en) * | 1961-10-10 | 1963-08-27 | Michigan State University Of A | Method of controlling bacterial diseases of fruit trees |
| US5378729A (en) * | 1985-02-15 | 1995-01-03 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
| FR2585702B1 (fr) * | 1985-07-31 | 1989-03-03 | Lafon Labor | Derives de phenyl-piperazine, procede de preparation et utilisation en therapeutique |
| GB9305175D0 (en) * | 1993-03-13 | 1993-04-28 | Smithkline Beecham Plc | Novel process |
| TR200103035T2 (tr) * | 1999-04-19 | 2002-01-21 | Teva Pharmaceutical Industries Ltd. | Yeni piperazin halkası sentezi. |
-
2001
- 2001-09-14 AT AT01969812T patent/ATE392410T1/de not_active IP Right Cessation
- 2001-09-14 US US10/488,909 patent/US7265223B2/en not_active Expired - Fee Related
- 2001-09-14 IL IL16069401A patent/IL160694A0/xx unknown
- 2001-09-14 EP EP01969812A patent/EP1426356B1/de not_active Expired - Lifetime
- 2001-09-14 HU HU0401921A patent/HUP0401921A3/hu unknown
- 2001-09-14 WO PCT/ES2001/000347 patent/WO2003024918A1/es not_active Ceased
- 2001-09-14 DE DE60133674T patent/DE60133674D1/de not_active Expired - Lifetime
- 2001-09-14 CA CA002460571A patent/CA2460571A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60133674D1 (de) | 2008-05-29 |
| US7265223B2 (en) | 2007-09-04 |
| ATE392410T1 (de) | 2008-05-15 |
| EP1426356A1 (de) | 2004-06-09 |
| CA2460571A1 (en) | 2003-03-27 |
| HUP0401921A3 (en) | 2008-03-28 |
| EP1426356B1 (de) | 2008-04-16 |
| WO2003024918A1 (es) | 2003-03-27 |
| US20040236107A1 (en) | 2004-11-25 |
| HUP0401921A2 (hu) | 2005-01-28 |
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