IL162616A0 - Tetrahydroquinoline analogues as muscarinic agonists - Google Patents

Tetrahydroquinoline analogues as muscarinic agonists

Info

Publication number: IL162616A0
Authority: IL; Israel
Prior art keywords: compounds; muscarinic agonists; tetrahydroquinoline; methods; muscarinic receptor
Prior art date: 2001-12-28

Application number

IL16261602A

Other languages

English (en)

Original Assignee

Acadia Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-28

Filing date

2002-12-23

Publication date

2005-11-20

2002-12-23 Application filed by Acadia Pharm Inc filed Critical Acadia Pharm Inc

2005-11-20 Publication of IL162616A0 publication Critical patent/IL162616A0/xx

Links

125000000147 tetrahydroquinolinyl group Chemical class N1(CCCC2=CC=CC=C12)* 0.000 title abstract 2
239000000472 muscarinic agonist Substances 0.000 title 1
102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 3
108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000018 receptor agonist Substances 0.000 abstract 1
229940044601 receptor agonist Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL16261602A 2001-12-28 2002-12-23 Tetrahydroquinoline analogues as muscarinic agonists IL162616A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US34472201P	2001-12-28	2001-12-28
PCT/US2002/041617 WO2003057672A2 (en)	2001-12-28	2002-12-23	Tetrahydroquinoline analogues as muscarinic agonists

Publications (1)

Publication Number	Publication Date
IL162616A0 true IL162616A0 (en)	2005-11-20

Family

ID=23351729

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL16261602A IL162616A0 (en)	2001-12-28	2002-12-23	Tetrahydroquinoline analogues as muscarinic agonists
IL162616A IL162616A (en)	2001-12-28	2004-06-17	Benzooxazine, benzothiazine and quinoline analogues as cholinergic receptor agonists and use thereof in the preparation of medicaments for treating diseases

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL162616A IL162616A (en)	2001-12-28	2004-06-17	Benzooxazine, benzothiazine and quinoline analogues as cholinergic receptor agonists and use thereof in the preparation of medicaments for treating diseases

Country Status (19)

Country	Link
US (3)	US7307075B2 (de)
EP (1)	EP1461318B9 (de)
JP (1)	JP4509565B2 (de)
KR (1)	KR100972614B1 (de)
CN (1)	CN100402032C (de)
AT (1)	ATE304533T1 (de)
AU (1)	AU2002359875B2 (de)
BR (1)	BR0215430A (de)
CA (1)	CA2470578C (de)
DE (1)	DE60206198T2 (de)
DK (1)	DK1461318T3 (de)
ES (1)	ES2251624T3 (de)
IL (2)	IL162616A0 (de)
MX (1)	MXPA04006281A (de)
NO (1)	NO327522B1 (de)
NZ (1)	NZ533566A (de)
RU (1)	RU2292346C2 (de)
WO (1)	WO2003057672A2 (de)
ZA (1)	ZA200405024B (de)

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US7550459B2 (en) *	2001-12-28	2009-06-23	Acadia Pharmaceuticals, Inc.	Tetrahydroquinoline analogues as muscarinic agonists
NZ533566A (en)	2001-12-28	2007-03-30	Acadia Pharm Inc	Tetrahydroquinoline analogues as muscarinic agonists
AU2004226430A1 (en) *	2003-03-28	2004-10-14	Acadia Pharmaceuticals Inc.	Muscarinic M1 receptor agonists for pain management
WO2006137485A1 (ja) *	2005-06-24	2006-12-28	Toyama Chemical Co., Ltd.	新規な含窒素複素環化合物およびその塩
EP2258358A3 (de)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenese mit Acetylcholinesterasehemmer
EP1928437A2 (de) *	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenese mittels muscarinrezeptormodulation
EP1940389A2 (de)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation von neurogenese durch pde-hemmung
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
GB0607952D0 (en) *	2006-04-21	2006-05-31	Minster Res Ltd	Novel treatment
GB0607949D0 (en) *	2006-04-21	2006-05-31	Minster Res The Ltd	Mono and combination therapy
WO2007134077A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
EP2049120A4 (de) *	2006-07-31	2011-09-07	Janssen Pharmaceutica Nv	Urotensin-ii-rezeptorantagonisten
EP2068872A1 (de)	2006-09-08	2009-06-17	Braincells, Inc.	Kombinationen mit einem 4-acylaminopyridin-derivat
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
ATE546448T1 (de)	2008-08-02	2012-03-15	Janssen Pharmaceutica Nv	Urotensin-ii-rezeptorantagonisten
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
AU2012338581B2 (en)	2011-11-18	2016-12-08	Nxera Pharma Uk Limited	Muscarinic M1 receptor agonists
GB201404922D0 (en)	2014-03-19	2014-04-30	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB201513743D0 (en)	2015-08-03	2015-09-16	Heptares Therapeutics Ltd	Muscarinic agonists
GB201519352D0 (en)	2015-11-02	2015-12-16	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB201617454D0 (en)	2016-10-14	2016-11-30	Heptares Therapeutics Limited	Pharmaceutical compounds
GB201810239D0 (en)	2018-06-22	2018-08-08	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB201819960D0 (en)	2018-12-07	2019-01-23	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB201819961D0 (en)	2018-12-07	2019-01-23	Heptares Therapeutics Ltd	Pharmaceutical compounds
GB202020191D0 (en)	2020-12-18	2021-02-03	Heptares Therapeutics Ltd	Pharmaceutical compounds
WO2023114224A1 (en)	2021-12-13	2023-06-22	Sage Therapeutics, Inc.	Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators

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NZ533566A (en)	2001-12-28	2007-03-30	Acadia Pharm Inc	Tetrahydroquinoline analogues as muscarinic agonists
AU2004226430A1 (en)	2003-03-28	2004-10-14	Acadia Pharmaceuticals Inc.	Muscarinic M1 receptor agonists for pain management

2002
- 2002-12-23 NZ NZ533566A patent/NZ533566A/en not_active IP Right Cessation
- 2002-12-23 AT AT02794441T patent/ATE304533T1/de active
- 2002-12-23 RU RU2004123203/04A patent/RU2292346C2/ru not_active IP Right Cessation
- 2002-12-23 BR BR0215430-7A patent/BR0215430A/pt not_active Application Discontinuation
- 2002-12-23 MX MXPA04006281A patent/MXPA04006281A/es active IP Right Grant
- 2002-12-23 KR KR1020047010190A patent/KR100972614B1/ko not_active Expired - Fee Related
- 2002-12-23 ES ES02794441T patent/ES2251624T3/es not_active Expired - Lifetime
- 2002-12-23 EP EP02794441A patent/EP1461318B9/de not_active Expired - Lifetime
- 2002-12-23 DE DE60206198T patent/DE60206198T2/de not_active Expired - Lifetime
- 2002-12-23 CN CNB028270495A patent/CN100402032C/zh not_active Expired - Fee Related
- 2002-12-23 AU AU2002359875A patent/AU2002359875B2/en not_active Ceased
- 2002-12-23 US US10/329,455 patent/US7307075B2/en not_active Expired - Fee Related
- 2002-12-23 JP JP2003557989A patent/JP4509565B2/ja not_active Expired - Fee Related
- 2002-12-23 CA CA2470578A patent/CA2470578C/en not_active Expired - Fee Related
- 2002-12-23 DK DK02794441T patent/DK1461318T3/da active
- 2002-12-23 WO PCT/US2002/041617 patent/WO2003057672A2/en not_active Ceased
- 2002-12-23 IL IL16261602A patent/IL162616A0/xx unknown
2004
- 2004-06-17 IL IL162616A patent/IL162616A/en not_active IP Right Cessation
- 2004-06-24 ZA ZA2004/05024A patent/ZA200405024B/en unknown
- 2004-07-15 NO NO20043013A patent/NO327522B1/no not_active IP Right Cessation
2006
- 2006-05-03 US US11/417,867 patent/US7576100B2/en not_active Expired - Fee Related
- 2006-05-03 US US11/417,865 patent/US7576078B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL162616A (en)	2011-06-30
ES2251624T3 (es)	2006-05-01
ZA200405024B (en)	2005-07-27
HK1074573A1 (zh)	2005-11-18
RU2292346C2 (ru)	2007-01-27
NO20043013L (no)	2004-07-28
MXPA04006281A (es)	2004-09-27
WO2003057672A2 (en)	2003-07-17
BR0215430A (pt)	2004-12-14
EP1461318B1 (de)	2005-09-14
AU2002359875B2 (en)	2009-01-08
KR20040070287A (ko)	2004-08-06
DK1461318T3 (da)	2006-01-09
DE60206198D1 (de)	2005-10-20
CA2470578C (en)	2010-10-12
ATE304533T1 (de)	2005-09-15
CN100402032C (zh)	2008-07-16
US20030176418A1 (en)	2003-09-18
DE60206198T2 (de)	2006-06-14
JP2005519060A (ja)	2005-06-30
CN1635891A (zh)	2005-07-06
WO2003057672A3 (en)	2003-11-13
AU2002359875A1 (en)	2003-07-24
RU2004123203A (ru)	2006-01-20
EP1461318B9 (de)	2005-12-28
CA2470578A1 (en)	2003-07-17
US7576078B2 (en)	2009-08-18
US7307075B2 (en)	2007-12-11
JP4509565B2 (ja)	2010-07-21
US7576100B2 (en)	2009-08-18
US20060199813A1 (en)	2006-09-07
NO327522B1 (no)	2009-08-03
NZ533566A (en)	2007-03-30
EP1461318A2 (de)	2004-09-29
US20060199810A1 (en)	2006-09-07
KR100972614B1 (ko)	2010-07-27

Publication	Publication Date	Title
IL162616A0 (en)	2005-11-20	Tetrahydroquinoline analogues as muscarinic agonists
TW200634006A (en)	2006-10-01	Tetrahydroquinoline analogues as muscarinic agonists
MXPA04006280A (es)	2004-09-27	Compuestos espiroazaciclicos como moduladores de receptor de monoamina.
NO20022655D0 (no)	2002-06-05	<Beta>-2-adrenerge reseptoragonister
AP1498A (en)	2005-11-21	Inhibitors of impdh enzyme.
WO2004052348A3 (en)	2004-10-21	Treatment of diseases with combinations of alpha 7 nicotinic acetylcholine receptor agonists and other compounds
NO20013443D0 (no)	2001-07-11	Triazolforbindelser med dopamin-D3-reseptoraktivitet
MXPA02012712A (es)	2003-04-25	N-ureidoheterocicloalquil-piperidinas como moduladores de la actividad del receptor de quimiocinas.
TR200101859T2 (tr)	2001-12-21	Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler
IL195256A0 (en)	2009-08-03	Compositions of r(+)and s(-)pramipexole and methods of using the same
WO2003105840A3 (en)	2004-03-25	Sphingosine kinase inhibitors
NO20035025L (no)	2003-11-12	Anvendelse av osteopontin for behandling og/eller for a hindre nevrologiske sykdommer, samt farmasoytisk sammensetning omfattende osteopontin eller en antagonist med osteopontinaktivitet.
IL175762A0 (en)	2008-04-13	Use of substituted 2-aminotetralines for the preventative treatment of parkinson's disease
DE60019586D1 (de)	2005-05-25	Myostatin genpromoter und inhibierung dessen aktivierung
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