IL192593A0 - Combination of triazine derivatives and ppar?? agonists - Google Patents

Combination of triazine derivatives and ppar?? agonists

Info

Publication number
IL192593A0
IL192593A0 IL192593A IL19259308A IL192593A0 IL 192593 A0 IL192593 A0 IL 192593A0 IL 192593 A IL192593 A IL 192593A IL 19259308 A IL19259308 A IL 19259308A IL 192593 A0 IL192593 A0 IL 192593A0
Authority
IL
Israel
Prior art keywords
ppar
agonists
combination
triazine derivatives
triazine
Prior art date
Application number
IL192593A
Original Assignee
Poxel Sas
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poxel Sas, Merck Patent Gmbh filed Critical Poxel Sas
Publication of IL192593A0 publication Critical patent/IL192593A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL192593A 2006-01-13 2008-07-02 Combination of triazine derivatives and ppar?? agonists IL192593A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0600345A FR2896160B1 (en) 2006-01-13 2006-01-13 COMBINATION OF TRIAZINE DERIVATIVES AND AGONISTS OF PPAR ALPHA.
PCT/EP2006/012186 WO2007079918A1 (en) 2006-01-13 2006-12-18 COMBINATION OF TRIAZINE DERIVATIVES AND PPARα AGONISTS

Publications (1)

Publication Number Publication Date
IL192593A0 true IL192593A0 (en) 2009-09-22

Family

ID=36649543

Family Applications (1)

Application Number Title Priority Date Filing Date
IL192593A IL192593A0 (en) 2006-01-13 2008-07-02 Combination of triazine derivatives and ppar?? agonists

Country Status (14)

Country Link
US (1) US20100159005A1 (en)
EP (1) EP1976500A1 (en)
JP (1) JP2009523143A (en)
KR (1) KR20080088631A (en)
CN (1) CN101355932A (en)
AR (1) AR059033A1 (en)
AU (1) AU2006334735A1 (en)
BR (1) BRPI0620992A2 (en)
CA (1) CA2636841A1 (en)
EA (1) EA016869B1 (en)
FR (1) FR2896160B1 (en)
IL (1) IL192593A0 (en)
WO (1) WO2007079918A1 (en)
ZA (1) ZA200806936B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2948028B1 (en) * 2009-07-17 2011-12-02 Merck Sante Sas ASSOCIATION OF A SODIUM-PROTON EXCHANGER INHIBITOR AND A DIHYDRO-1,3,5-TRIAZINE AMINOUS DERIVATIVE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020382A (en) * 1996-02-02 2000-02-01 Merck & Co., Inc. Method of treating diabetes and related disease states
FR2804113B1 (en) * 2000-01-26 2004-06-18 Lipha ANIMATED DIHYDRO-1,3,5-TRIAZINE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
KR20050067419A (en) * 2002-10-21 2005-07-01 얀센 파마슈티카 엔.브이. Treating syndrome x with substituted tetralins and indanes
EP1424070A1 (en) * 2002-11-28 2004-06-02 Fournier Laboratories Ireland Limited Combination of a PPAR alpha agonist and metformin for decreasing the serum triglycerides
FR2853650B1 (en) * 2003-04-10 2006-07-07 Merck Sante Sas AMINE DEDOUBLING PROCESS USEFUL FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INSULINO-RESISTANCE SYNDROME

Also Published As

Publication number Publication date
EP1976500A1 (en) 2008-10-08
AU2006334735A1 (en) 2007-07-19
EA200801677A1 (en) 2008-12-30
KR20080088631A (en) 2008-10-02
US20100159005A1 (en) 2010-06-24
FR2896160A1 (en) 2007-07-20
EA016869B1 (en) 2012-08-30
WO2007079918A1 (en) 2007-07-19
FR2896160B1 (en) 2008-04-25
CN101355932A (en) 2009-01-28
BRPI0620992A2 (en) 2011-11-29
CA2636841A1 (en) 2007-07-19
AR059033A1 (en) 2008-03-12
ZA200806936B (en) 2009-07-29
JP2009523143A (en) 2009-06-18

Similar Documents

Publication Publication Date Title
ZA200900662B (en) Fused heterocyclic derivatives and methods of use
IL198397A0 (en) Anilinopiperazine derivatives and methods of use thereof
IL196799A0 (en) Fused heterocyclic derivative and use thereof
ZA201001051B (en) Benzylbenzene derivatives and methods of use
IL193042A0 (en) Phenyl-cycloalkyl and phenyl-heterocyclic derivatives as sip receptor agonists
CR10815A (en) NEW DERIVATIVES OF ISOQUINOLIN AND ISOQUINOLINONA REPLACED
IL200639A0 (en) Benzimidazole derivatives and methods of use thereof
IL220270A0 (en) Polymyxin derivatives and uses thereof
IL197693A0 (en) Phenyl derivatives and their use as immunomodulators
ZA201001860B (en) Pyridazinone derivatives and use thereof as p2z7 receptor inhibitors
IL198046A0 (en) Metastin derivatives and use thereof
PL2057153T3 (en) (3-aryl-piperazin-1-yl) derivatives of 6,7-dialkoxyquinazoline, 6,7- dialkoxyphtalazine and 6,7-dialkoxyisoquinoline
IL206146A0 (en) Dibenzoazepine and dibenzooxazepine trpa1 agonists
ZA201001261B (en) 1-amino-alklcyclohexane derivatives for the treatmrnt and prevention of hearing loss
IL205207A0 (en) Benzimidazole derivatives and their use as fxr agonists
IL196594A0 (en) Derivatives of 4-trimethylammonium-3-aminobutyrate and 4-trimethylphosphonium-3-aminobutyrate as cpt-inhibitors
IL193475A0 (en) Benzimidazole derivatives
EP2099299A4 (en) Oxazolidinone derivatives and methods of use
IL196469A0 (en) New medical use of triazine derivatives
IL197301A0 (en) Quinoline derivatives with 5-ht-binding properties
GB0622472D0 (en) Novel heterocyclic derivatives
TWI372762B (en) Amino derivatives of b-homoandrostanes and b-heteroandrostanes
GB0708326D0 (en) Triazine derivatives
ZA200809112B (en) N-oxides of pyridylmethylpiperazine and -piperidine derivatives
ZA200902452B (en) Metastin derivatives and use thereof