IL204126A - נגזרות של 1, 3 – דיהידרואיזואינדול, תהליך להכנתן, שימושן, תרופות וערכה המכילות אותן וחומרי ביניים - Google Patents

נגזרות של 1, 3 – דיהידרואיזואינדול, תהליך להכנתן, שימושן, תרופות וערכה המכילות אותן וחומרי ביניים

Info

Publication number: IL204126A
Authority: IL; Israel
Prior art keywords: medicaments; intermediates; kit; preparation; dihydroisoindole
Prior art date: 2007-08-30

Application number

IL204126A

Other languages

English (en)

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-30

Filing date

2010-02-23

Publication date

2015-07-30

2010-02-23 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2015-07-30 Publication of IL204126A publication Critical patent/IL204126A/he

Links

239000003814 drug Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
GWVMLCQWXVFZCN-UHFFFAOYSA-N isoindoline Chemical class C1=CC=C2CNCC2=C1 GWVMLCQWXVFZCN-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)

IL204126A 2007-08-30 2010-02-23 נגזרות של 1, 3 – דיהידרואיזואינדול, תהליך להכנתן, שימושן, תרופות וערכה המכילות אותן וחומרי ביניים IL204126A (he)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102007041116A DE102007041116A1 (de)	2007-08-30	2007-08-30	1,3-Dihydro-isoindolderivate
PCT/EP2008/006198 WO2009030316A1 (de)	2007-08-30	2008-07-28	1,3-dihydro-isoindolderivate

Publications (1)

Publication Number	Publication Date
IL204126A true IL204126A (he)	2015-07-30

Family

ID=40029128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL204126A IL204126A (he)	2007-08-30	2010-02-23	נגזרות של 1, 3 – דיהידרואיזואינדול, תהליך להכנתן, שימושן, תרופות וערכה המכילות אותן וחומרי ביניים

Country Status (16)

Country	Link
US (1)	US8183279B2 (he)
EP (1)	EP2181092B1 (he)
JP (1)	JP5529739B2 (he)
KR (1)	KR20100061817A (he)
CN (1)	CN101790513A (he)
AR (1)	AR070649A1 (he)
AU (1)	AU2008295176B2 (he)
BR (1)	BRPI0815059A2 (he)
CA (1)	CA2697934C (he)
DE (1)	DE102007041116A1 (he)
EA (1)	EA201000362A1 (he)
ES (1)	ES2532853T3 (he)
IL (1)	IL204126A (he)
MX (1)	MX2010002042A (he)
WO (1)	WO2009030316A1 (he)
ZA (1)	ZA201002217B (he)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2949467B1 (fr)	2009-09-03	2011-11-25	Sanofi Aventis	Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
NZ702169A (en)	2012-05-25	2016-10-28	Berg Llc	The use of heat shock protein 90 (hsp90) modulators for the treatment of metabolic syndrome
CA2896554C (en) *	2012-12-27	2019-11-05	Drexel University	Novel antiviral agents against hbv infection
WO2015188198A2 (en)	2014-06-06	2015-12-10	Berg Llc	Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
LT3166925T (lt) *	2014-07-08	2018-06-11	Viiv Healthcare Uk Limited	Izoindolino dariniai, skirti panaudoti virusinės infekcijos gydymui
US10316167B2 (en)	2014-09-19	2019-06-11	Plastipak Packaging	Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions
WO2017131500A1 (ko) *	2016-01-29	2017-08-03	계명대학교 산학협력단	Hsp90 억제 활성을 갖는 신규 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도
WO2018001944A1 (en)	2016-06-29	2018-01-04	F. Hoffmann-La Roche Ag	Novel dihydropyrrolopyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN106366089B (zh) *	2016-08-19	2019-06-11	爱斯特（成都）生物制药股份有限公司	二氢异吲哚衍生物及其类似物的制备方法
US10927076B2 (en)	2017-01-12	2021-02-23	University Of Kansas	HSP90B N-terminal isoform-selective inhibitors
US20260055060A1 (en) *	2022-08-21	2026-02-26	University Of Notre Dame Du Lac	Use of (isoindolin-2-yl)(4-hydroxy-3-(isoindoline-2-carbonyl)phenyl)methanones in the treatment of tumor necrosis factor receptor-associated protein 1 dysfunction
CN117402075B (zh) *	2023-10-17	2026-01-09	厦门大学深圳研究院	一种具有特异性抗肿瘤活性的可见光响应的人工h+/ci-离子通道的制备

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5968921A (en)	1997-10-24	1999-10-19	Orgegon Health Sciences University	Compositions and methods for promoting nerve regeneration
AU3378599A (en)	1998-04-03	1999-10-25	University Of Pittsburgh	Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
JP2003523313A (ja)	1999-03-12	2003-08-05	アメリカ合衆国	シャペロン蛋白質の阻害方法
AU2001247759A1 (en)	2000-03-24	2001-10-08	Duke University	Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto
WO2002002123A1 (en)	2000-06-29	2002-01-10	Trustees Of Boston University	Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders
EP1322325A4 (en)	2000-07-20	2004-09-15	Merck & Co Inc	INHIBITION OF PROCESSING AND REPLICATION OF HEPATITIS C VIRUS
ATE526019T1 (de)	2000-07-28	2011-10-15	Sloan Kettering Inst Cancer	Verfahren zur behandlung von zellproliferationen störungen und virusinfektionen
WO2002083648A1 (fr)	2001-04-16	2002-10-24	Eisai Co., Ltd.	Nouveau compose a base de 1h-indazole
US7553979B2 (en)	2001-11-09	2009-06-30	Conforma Therapeutics Corporation	HSP90-inhibiting zearalanol compounds and methods of producing and using same
US20090039811A1 (en)	2004-07-27	2009-02-12	Patrick Chene	Inhibitors of HSP90
US20080306054A1 (en)	2005-04-13	2008-12-11	Astex Therapeutics Limited	Pharmaceutical Compounds
US20090215742A1 (en)	2005-05-03	2009-08-27	Pfizer, Inc.	Amide resorcinol compounds

2007
- 2007-08-30 DE DE102007041116A patent/DE102007041116A1/de not_active Withdrawn
2008
- 2008-07-28 CN CN200880104684A patent/CN101790513A/zh active Pending
- 2008-07-28 CA CA2697934A patent/CA2697934C/en not_active Expired - Fee Related
- 2008-07-28 EP EP08785148.1A patent/EP2181092B1/de not_active Not-in-force
- 2008-07-28 BR BRPI0815059-1A2A patent/BRPI0815059A2/pt not_active Application Discontinuation
- 2008-07-28 WO PCT/EP2008/006198 patent/WO2009030316A1/de not_active Ceased
- 2008-07-28 MX MX2010002042A patent/MX2010002042A/es not_active Application Discontinuation
- 2008-07-28 EA EA201000362A patent/EA201000362A1/ru unknown
- 2008-07-28 JP JP2010522201A patent/JP5529739B2/ja not_active Expired - Fee Related
- 2008-07-28 US US12/675,410 patent/US8183279B2/en not_active Expired - Fee Related
- 2008-07-28 AU AU2008295176A patent/AU2008295176B2/en not_active Ceased
- 2008-07-28 ES ES08785148.1T patent/ES2532853T3/es active Active
- 2008-07-28 KR KR1020107006638A patent/KR20100061817A/ko not_active Withdrawn
- 2008-08-29 AR ARP080103758A patent/AR070649A1/es unknown
2010
- 2010-02-23 IL IL204126A patent/IL204126A/he not_active IP Right Cessation
- 2010-03-29 ZA ZA2010/02217A patent/ZA201002217B/en unknown

Also Published As

Publication number	Publication date
EP2181092A1 (de)	2010-05-05
ES2532853T3 (es)	2015-04-01
DE102007041116A1 (de)	2009-03-05
CN101790513A (zh)	2010-07-28
EA201000362A1 (ru)	2010-08-30
KR20100061817A (ko)	2010-06-09
AU2008295176A1 (en)	2009-03-12
JP5529739B2 (ja)	2014-06-25
US20100311745A1 (en)	2010-12-09
ZA201002217B (en)	2017-11-29
BRPI0815059A2 (pt)	2015-02-10
JP2010536893A (ja)	2010-12-02
CA2697934A1 (en)	2009-03-12
CA2697934C (en)	2016-02-16
EP2181092B1 (de)	2015-01-14
AU2008295176B2 (en)	2013-05-02
US8183279B2 (en)	2012-05-22
WO2009030316A1 (de)	2009-03-12
MX2010002042A (es)	2010-03-15
AR070649A1 (es)	2010-04-28

Legal Events

Date	Code	Title
2015-11-30	FF	Patent granted
2015-12-31	KB	Patent renewed
2019-03-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
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