IL24076A - Salts of phenyltoloxamine - Google Patents

Salts of phenyltoloxamine

Info

Publication number: IL24076A
Authority: IL; Israel
Prior art keywords: phenyltoloxamine; pamoate; aluminum; phenyltoloxamlne; salt
Prior art date: 1964-08-17

Application number

IL24076A

Other languages

English (en)

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1964-08-17

Filing date

1965-07-02

Publication date

1969-02-27

1965-07-02 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1969-02-27 Publication of IL24076A publication Critical patent/IL24076A/en

Links

IZRPKIZLIFYYKR-UHFFFAOYSA-N phenyltoloxamine Chemical class CN(C)CCOC1=CC=CC=C1CC1=CC=CC=C1 IZRPKIZLIFYYKR-UHFFFAOYSA-N 0.000 title claims description 27
229960001526 phenyltoloxamine Drugs 0.000 title claims description 27
150000003839 salts Chemical class 0.000 title claims description 15
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 14
229910052782 aluminium Inorganic materials 0.000 claims description 14
238000000034 method Methods 0.000 claims description 6
239000003960 organic solvent Substances 0.000 claims description 6
SMZOGRDCAXLAAR-UHFFFAOYSA-N aluminium isopropoxide Chemical compound [Al+3].CC(C)[O-].CC(C)[O-].CC(C)[O-] SMZOGRDCAXLAAR-UHFFFAOYSA-N 0.000 claims description 3
150000001412 amines Chemical class 0.000 claims description 3
WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
239000002904 solvent Substances 0.000 claims description 3
-1 amine salt Chemical class 0.000 claims description 2
239000011541 reaction mixture Substances 0.000 claims 1
239000000725 suspension Substances 0.000 description 5
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
239000007787 solid Substances 0.000 description 3
238000003756 stirring Methods 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
238000010992 reflux Methods 0.000 description 2
239000002002 slurry Substances 0.000 description 2
ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
230000003444 anaesthetic effect Effects 0.000 description 1
230000001387 anti-histamine Effects 0.000 description 1
239000000043 antiallergic agent Substances 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000007910 chewable tablet Substances 0.000 description 1
238000002690 local anesthesia Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000000126 substance Substances 0.000 description 1
OBROYCQXICMORW-UHFFFAOYSA-N tripropoxyalumane Chemical compound [Al+3].CCC[O-].CCC[O-].CCC[O-] OBROYCQXICMORW-UHFFFAOYSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
- C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Emergency Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL24076A 1964-08-17 1965-07-02 Salts of phenyltoloxamine IL24076A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US390204A US3372177A (en)	1964-08-17	1964-08-17	Phenyltoloxamine aluminum pamoate

Publications (1)

Publication Number	Publication Date
IL24076A true IL24076A (en)	1969-02-27

Family

ID=23541541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL24076A IL24076A (en)	1964-08-17	1965-07-02	Salts of phenyltoloxamine

Country Status (13)

Country	Link
US (1)	US3372177A (de)
BE (1)	BE668227A (de)
BR (1)	BR6572186D0 (de)
CH (1)	CH464232A (de)
DE (1)	DE1493489A1 (de)
DK (1)	DK120957B (de)
ES (1)	ES316439A1 (de)
FI (1)	FI44623C (de)
FR (2)	FR4762M (de)
GB (1)	GB1046167A (de)
IL (1)	IL24076A (de)
NL (1)	NL6510752A (de)
SE (1)	SE334161B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3491135A (en) *	1969-03-03	1970-01-20	American Cyanamid Co	Pamoates of (3-cyclohexyl-3-hydroxy-3-phenylpropyl) triethylammonium having unobjectionable flavors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2731470A (en) *		1956-01-17		N-pyrtoylmethyl
US2578537A (en) *	1949-12-08	1951-12-11	Bristol Lab Inc	Amine salt of penicillin
US2703324A (en) *	1950-08-30	1955-03-01	Bristol Lab Inc	Basic ethers of aralkyl phenols and salts thereof
US2641610A (en) *	1950-10-27	1953-06-09	May & Baker Ltd	Quaternary ammonium salts
NL83750C (de) *	1951-02-05
US3225091A (en) *	1962-02-01	1965-12-21	Lilly Co Eli	Anticholinergic substituted butyramides
BE633486A (de) *	1962-06-18
US3261868A (en) *	1963-03-14	1966-07-19	Upjohn Co	Aminoalkoxy-hydroxyacetophenones
US3173835A (en) *	1963-03-19	1965-03-16	Endo Lab	Composition of n-acetyl-p-aminophenol and phenyltoloxamine for analgesia

1964
- 1964-08-17 US US390204A patent/US3372177A/en not_active Expired - Lifetime
1965
- 1965-07-02 IL IL24076A patent/IL24076A/en unknown
- 1965-07-31 DK DK395765AA patent/DK120957B/da unknown
- 1965-08-10 GB GB34212/65A patent/GB1046167A/en not_active Expired
- 1965-08-12 ES ES0316439A patent/ES316439A1/es not_active Expired
- 1965-08-12 FI FI651950A patent/FI44623C/fi active
- 1965-08-12 BE BE668227A patent/BE668227A/xx unknown
- 1965-08-12 DE DE19651493489 patent/DE1493489A1/de active Pending
- 1965-08-16 CH CH1147565A patent/CH464232A/de unknown
- 1965-08-16 SE SE10668/65A patent/SE334161B/xx unknown
- 1965-08-17 FR FR28513A patent/FR4762M/fr not_active Expired
- 1965-08-17 BR BR172186/65A patent/BR6572186D0/pt unknown
- 1965-08-17 FR FR28515A patent/FR1449108A/fr not_active Expired
- 1965-08-17 NL NL6510752A patent/NL6510752A/xx unknown

Also Published As

Publication number	Publication date
FI44623B (de)	1971-08-31
FI44623C (fi)	1971-12-10
FR1449108A (fr)	1966-03-18
SE334161B (de)	1971-04-19
FR4762M (de)	1967-01-16
CH464232A (de)	1968-10-31
BR6572186D0 (pt)	1973-08-14
US3372177A (en)	1968-03-05
ES316439A1 (es)	1966-04-01
NL6510752A (de)	1966-02-18
GB1046167A (en)	1966-10-19
DE1493489A1 (de)	1969-04-24
DK120957B (da)	1971-08-09
BE668227A (de)	1966-02-14

Publication	Publication Date	Title
EP0008645B1 (de)	1984-09-05	Alkoxyphenylpyrrolidone, Verfahren zu ihrer Herstellung und Arzneimittel auf Basis dieser Verbindungen
JPS60258183A (ja)	1985-12-20	１４‐ヒドロキシ‐モルフイナンアルカロイドの脱アルキル化方法
US2645594A (en)	1953-07-14	Antiseptic acridane compounds
IL24076A (en)	1969-02-27	Salts of phenyltoloxamine
Gilman et al.	1935	Dibenzofuran. V. dimetalation
Martin	1952	Hydroxymethylphenols
US3325515A (en)	1967-06-13	Coumarin derivatives and their preparation
Dutcher et al.	1944	Gliotoxin, the antibiotic principle of Gliocladium fimbriatum. IV. The structure of gliotoxin: The action of selenium
US2857401A (en)	1958-10-21	Acetylated coumarin derivatives
US2625566A (en)	1953-01-13	Beta-(ortho-methoxy) phenyl-isopropyl benzyl alkyl amines and salts thereof
JPS6411015B2 (de)	1989-02-23
DE1122070C2 (de)	1973-05-30	Verfahren zur Herstellung von diuretisch wirksamen Disulfamylanilinverbindungen
Moersch et al.	1947	Heterocyclic Basic Compounds. XI. 1, 1a Derivatives of 8-(3-Aminopropylamino)-6-methoxyquinoline
DE1695580C (de)	1972-09-07	Quaternare Verbindungen des Benzil saure beta piperidino athylesters und ein Verfahren zu ihrer Herstellung
US5011974A (en)	1991-04-30	Process for the preparation of derivative of 2-diethylamino-1-methylethyl-1-hydroxy-(bicyclohexyl)-2-carboxylate
US2856405A (en)	1958-10-14	Mecuration products of 1-(2-pyrimidyl)-3-allylurea
US2085064A (en)	1937-06-29	Aromatic mercury cyclic alkaloid compounds and method of making them
KR790001538B1 (ko)	1979-10-27	이소퀴놀린 유도체의 제조방법
DE1906551C3 (de)	1976-02-26	2-Alkoxy-3,5-dihalogenphenyldialkylamlnoalkyläther
US3239501A (en)	1966-03-08	Antibiotic amine addition compounds
US2390593A (en)	1945-12-11	Dicarboxylic acid derivatives of lower alkyl ethers of vitamin b6, and a process of peparing the same
AT218527B (de)	1961-12-11	Verfahren zur Herstellung neuer Hydrazone
US2969357A (en)	1961-01-24	Penicillin salts of amino salicylates
AT334333B (de)	1976-01-10	Verfahren zur herstellung von neuen 3-n-butylamino- 4-phenoxy-5 -alkoxymethyl-sulfamoylbenzoesauren
GB1365097A (en)	1974-08-29	Substituted phenoxyalkyamines process for their preparation and applications thereof