IL247663A0 - Reverse strand nucleic acids - Google Patents

Reverse strand nucleic acids

Info

Publication number
IL247663A0
IL247663A0 IL247663A IL24766316A IL247663A0 IL 247663 A0 IL247663 A0 IL 247663A0 IL 247663 A IL247663 A IL 247663A IL 24766316 A IL24766316 A IL 24766316A IL 247663 A0 IL247663 A0 IL 247663A0
Authority
IL
Israel
Prior art keywords
nucleic acids
reverse strand
strand nucleic
reverse
acids
Prior art date
Application number
IL247663A
Other languages
Hebrew (he)
Other versions
IL247663B (en
Inventor
Wakayama Tatsushi
Seo Haruna
Satou Youhei
Takeda Shin'ichi
Nagata Tetsuya
Original Assignee
Nippon Shinyaku Co Ltd
Nat Center Neurology & Psychiatry
Wakayama Tatsushi
Seo Haruna
Satou Youhei
Shinichi Takeda
Nagata Tetsuya
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd, Nat Center Neurology & Psychiatry, Wakayama Tatsushi, Seo Haruna, Satou Youhei, Shinichi Takeda, Nagata Tetsuya filed Critical Nippon Shinyaku Co Ltd
Publication of IL247663A0 publication Critical patent/IL247663A0/en
Publication of IL247663B publication Critical patent/IL247663B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3233—Morpholino-type ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3535—Nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL247663A 2014-03-12 2016-09-06 Antisense oligomers for skipping exon 51 in the human dystrophin gene IL247663B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014048897 2014-03-12
PCT/JP2015/057180 WO2015137409A1 (en) 2014-03-12 2015-03-11 Antisense nucleic acid

Publications (2)

Publication Number Publication Date
IL247663A0 true IL247663A0 (en) 2016-11-30
IL247663B IL247663B (en) 2020-06-30

Family

ID=54071850

Family Applications (1)

Application Number Title Priority Date Filing Date
IL247663A IL247663B (en) 2014-03-12 2016-09-06 Antisense oligomers for skipping exon 51 in the human dystrophin gene

Country Status (31)

Country Link
US (5) US9988629B2 (en)
EP (2) EP3514234A1 (en)
JP (1) JP6606488B2 (en)
KR (1) KR102335801B1 (en)
CN (2) CN106459955B (en)
AU (2) AU2015227733B2 (en)
BR (1) BR112016020618B1 (en)
CA (1) CA2939948A1 (en)
CY (1) CY1121322T1 (en)
DK (1) DK3118311T3 (en)
ES (1) ES2710802T3 (en)
HR (1) HRP20190235T1 (en)
HU (1) HUE042283T2 (en)
IL (1) IL247663B (en)
LT (1) LT3118311T (en)
MX (1) MX2016011538A (en)
MY (1) MY193708A (en)
NZ (1) NZ724836A (en)
PH (1) PH12016501761B1 (en)
PL (1) PL3118311T3 (en)
PT (1) PT3118311T (en)
RS (1) RS58573B1 (en)
RU (2) RU2730681C2 (en)
SG (1) SG11201607095RA (en)
SI (1) SI3118311T1 (en)
SM (1) SMT201900169T1 (en)
TR (1) TR201901939T4 (en)
TW (2) TW201945383A (en)
UA (1) UA120849C2 (en)
WO (1) WO2015137409A1 (en)
ZA (1) ZA201605864B (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2730681C2 (en) * 2014-03-12 2020-08-24 Ниппон Синяку Ко., Лтд. Antisense nucleic acids
AU2015277924B2 (en) 2014-06-17 2021-02-25 National Center Of Neurology And Psychiatry Antisense nucleic acids
HRP20201125T1 (en) 2015-09-15 2020-10-30 Nippon Shinyaku Co., Ltd. ANTISENS NUCLEIC ACID
EP3359523A4 (en) 2015-10-09 2019-07-24 Wave Life Sciences Ltd. OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS
KR102775461B1 (en) 2016-04-01 2025-02-28 어비디티 바이오사이언시스 인크. Nucleic acid-polypeptide compositions and uses thereof
AU2017290231A1 (en) 2016-06-30 2019-02-07 Sarepta Therapeutics, Inc. Exon skipping oligomers for muscular dystrophy
US20190330626A1 (en) * 2016-07-15 2019-10-31 Ionis Pharmaceuticals, Inc. Compounds and methods for use in dystrophin transcript
CA3037663A1 (en) * 2016-09-23 2018-03-29 Synthena Ag Mixed tricyclo-dna, 2'-modified-rna oligonucleotide compositions and uses thereof
LT3554553T (en) 2016-12-19 2022-08-25 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
CN117298290A (en) 2016-12-19 2023-12-29 萨勒普塔医疗公司 Exon-skipping oligomer conjugates for muscular dystrophy
EP3554552B1 (en) 2016-12-19 2022-08-17 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
CN110381980A (en) * 2017-01-06 2019-10-25 艾维迪提生物科学有限责任公司 The method that nucleic acid-peptide composition and inducing exon are skipped
GB201711809D0 (en) 2017-07-21 2017-09-06 Governors Of The Univ Of Alberta Antisense oligonucleotide
EA201991450A1 (en) 2017-09-22 2019-12-30 Сарепта Терапьютикс, Инк. OLIGOMER CONJUGATES FOR EXONISM SKIP IN MUSCULAR DYSTROPHY
MA49986A (en) 2017-09-25 2020-07-01 Massachusetts Inst Technology PROCESSES FOR PREPARING MORPHOLINO PHOSPHORODIAMIDATE OLIGOMERS VIA RAPID FLOW SYNTHESIS
JP2020536060A (en) 2017-09-28 2020-12-10 サレプタ セラピューティクス， インコーポレイテッド Combination therapy to treat muscular dystrophy
IL277889B2 (en) 2018-04-12 2025-01-01 Wave Life Sciences Ltd Oligonucleotide compositions and methods of use thereof
SG11202010131QA (en) 2018-05-11 2020-11-27 Wave Life Sciences Ltd Oligonucleotide compositions and methods of use thereof
US10758629B2 (en) 2018-05-29 2020-09-01 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
US20210346290A1 (en) * 2018-06-13 2021-11-11 Kawasaki Institute Of Industrial Promotion POLYION COMPLEX MICELLE THAT INCLUDES ANTISENSE OLIGONUCLEOTIDE AND BLOCK COPOLYMER OF PEG BLOCK AND CATIONIC POLYMER, SAID BLOCK COPOLYMER HAVING NUMBER-AVERAGE MOLECULAR WEIGHT OF 3-10 kDa
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US20220193250A1 (en) 2018-08-02 2022-06-23 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
JP7611825B2 (en) 2018-08-02 2025-01-10 ダイン セラピューティクス，インコーポレーテッド Muscle-targeting complexes and their uses for treating dystrophinopathies
IL326747A (en) 2018-11-02 2026-04-01 Biomarin Tech Bv Bispecific antisense oligonucleotides for dystrophin exon skipping
CN113383078A (en) * 2018-12-06 2021-09-10 波涛生命科学有限公司 Oligonucleotide compositions and methods thereof
CN113660938A (en) * 2019-01-30 2021-11-16 国立研究开发法人国立精神·神经医疗研究中心 Nucleic acid delivery complexes
CA3137715A1 (en) 2019-04-25 2020-10-29 Avidity Biosciences, Inc. Nucleic acid compositions and methods of multi-exon skipping
EP4079329A4 (en) * 2019-12-19 2024-04-17 Nippon Shinyaku Co., Ltd. Antisense nucleic acid enabling exon skipping
AU2021226089A1 (en) * 2020-02-28 2022-09-15 National Center Of Neurology And Psychiatry Antisense nucleic acid inducing skipping of exon 51
CA3216839A1 (en) 2021-04-30 2022-11-03 Sarepta Therapeutics, Inc. Treatment methods for muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN117980006A (en) 2021-07-09 2024-05-03 达因疗法公司 Muscle-targeted compounds and formulations for the treatment of dystrophinopathy
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
KR20240129006A (en) 2021-12-27 2024-08-27 니뽄 신야쿠 가부시키가이샤 Method for preparing oligonucleic acid compounds
CN120129745A (en) 2022-03-10 2025-06-10 日本新药株式会社 Antiviral antisense oligomers
JP2025509438A (en) 2022-03-17 2025-04-11 サレプタ セラピューティクス， インコーポレイテッド Phosphorodiamidate morpholino oligomer conjugates
US12071621B2 (en) 2022-04-05 2024-08-27 Avidity Biosciences, Inc. Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
EP0962463B1 (en) 1989-12-20 2002-07-10 Antivirals Inc. Uncharged morpholino-based polymers having phosphorus-containing chiral intersubunit linkages
JP2924179B2 (en) 1993-02-19 1999-07-26 日本新薬株式会社 Glycerol derivatives, devices and pharmaceutical compositions
IL115849A0 (en) 1994-11-03 1996-01-31 Merz & Co Gmbh & Co Tangential filtration preparation of liposomal drugs and liposome product thereof
EP1191097A1 (en) 2000-09-21 2002-03-27 Leids Universitair Medisch Centrum Induction of exon skipping in eukaryotic cells
US7902160B2 (en) 2002-11-25 2011-03-08 Masafumi Matsuo ENA nucleic acid drugs modifying splicing in mRNA precursor
PL1766010T3 (en) * 2004-06-28 2011-07-29 Univ Western Australia Antisense oligonucleotides for inducing exon skipping and methods of use thereof
JPWO2006038608A1 (en) 2004-10-05 2008-05-15 日本新薬株式会社 Oligo double-stranded RNA and pharmaceutical composition
US20090312532A1 (en) * 2005-04-22 2009-12-17 Van Deutekom Judith Christina Modulation of exon recognition in pre-mrna by interfering with the binding of sr proteins and by interfering with secodary rna structure
JP5056413B2 (en) 2005-05-30 2012-10-24 日本新薬株式会社 Method for producing nucleic acid-containing complex preparation
US8067571B2 (en) * 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
RU2418068C2 (en) * 2005-08-17 2011-05-10 Сирна Терапьютикс, Инк. Chemically modified short interfering nucleic acid molecules that mediate rna interference
EP1963538A2 (en) * 2005-11-30 2008-09-03 Guild Associates, Inc. Differentially fluorescent yeast biosensors for the detection and biodegradation of chemical agents
WO2008096690A1 (en) 2007-02-05 2008-08-14 Nippon Shinyaku Co., Ltd. Polyethylene glycol derivative
EP2203173B1 (en) 2007-10-26 2015-12-23 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
DK2207779T3 (en) 2007-11-15 2014-07-14 Sarepta Therapeutics Inc Process for the Synthesis of Morpholine Oligomers
US8084601B2 (en) 2008-09-11 2011-12-27 Royal Holloway And Bedford New College Royal Holloway, University Of London Oligomers
CN105779453A (en) 2008-10-24 2016-07-20 萨雷普塔治疗公司 Multiple exon skipping compositions for DMD
PT2344637E (en) 2008-10-27 2015-03-23 Academisch Ziekenhuis Leiden METHODS AND MEANS FOR EFFICIENT EXHAUSTION 45 JUMP IN DUCHENNE MUSCULAR DYSTROPHY PRE-MRNA
US20110269665A1 (en) 2009-06-26 2011-11-03 Avi Biopharma, Inc. Compound and method for treating myotonic dystrophy
BR122023023194A2 (en) * 2009-11-12 2023-12-26 The University Of Western Australia ANTISENSE OLIGONUCLEOTIDE, COMPOSITION AND RESPECTIVE USE
KR102182663B1 (en) 2010-05-28 2020-11-25 사렙타 쎄러퓨틱스, 인코퍼레이티드 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
IT1400425B1 (en) * 2010-06-08 2013-05-31 Amsterdam Molecular Therapeutics Bv MODIFIED SNRNAS FOR USE IN THERAPY.
TWI541024B (en) * 2010-09-01 2016-07-11 日本新藥股份有限公司 Antisense nucleic acid
CA2826836A1 (en) * 2011-02-08 2012-08-16 The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Medical Center Antisense oligonucleotides
IL273838B (en) * 2011-05-05 2022-09-01 Sarepta Therapeutics Inc Peptide oligonucleotide conjugates ,compositions comprising the same and uses thereof
CA3132111A1 (en) * 2011-12-28 2013-07-04 Nippon Shinyaku Co., Ltd. Antisense nucleic acids for skipping of exon 55 of human dystrophin gene
RU2730681C2 (en) * 2014-03-12 2020-08-24 Ниппон Синяку Ко., Лтд. Antisense nucleic acids

Also Published As

Publication number Publication date
US20180179538A1 (en) 2018-06-28
BR112016020618B1 (en) 2023-04-04
KR102335801B1 (en) 2021-12-03
US20170067048A1 (en) 2017-03-09
US11053497B2 (en) 2021-07-06
WO2015137409A1 (en) 2015-09-17
CN106459955B (en) 2019-12-20
SI3118311T1 (en) 2019-05-31
TW201540724A (en) 2015-11-01
AU2020200679A1 (en) 2020-02-20
RU2016139108A3 (en) 2018-08-06
SG11201607095RA (en) 2016-10-28
US20200149040A1 (en) 2020-05-14
EP3514234A1 (en) 2019-07-24
TWI672314B (en) 2019-09-21
JPWO2015137409A1 (en) 2017-04-06
PH12016501761A1 (en) 2016-11-07
JP6606488B2 (en) 2019-11-13
PT3118311T (en) 2019-02-15
DK3118311T3 (en) 2019-03-11
SMT201900169T1 (en) 2019-05-10
MX2016011538A (en) 2017-04-13
AU2015227733B2 (en) 2019-10-31
LT3118311T (en) 2019-04-10
TW201945383A (en) 2019-12-01
CN106459955A (en) 2017-02-22
CY1121322T1 (en) 2020-05-29
RS58573B1 (en) 2019-05-31
RU2016139108A (en) 2018-04-13
RU2730681C2 (en) 2020-08-24
US9988629B2 (en) 2018-06-05
AU2015227733A1 (en) 2016-10-20
RU2019130513A3 (en) 2020-03-13
UA120849C2 (en) 2020-02-25
CN110951732A (en) 2020-04-03
EP3118311B1 (en) 2018-12-26
KR20160132056A (en) 2016-11-16
TR201901939T4 (en) 2019-03-21
PH12016501761B1 (en) 2016-11-07
RU2702424C2 (en) 2019-10-08
HUE042283T2 (en) 2019-06-28
PL3118311T3 (en) 2019-09-30
HRP20190235T1 (en) 2019-05-03
BR112016020618A2 (en) 2017-08-15
MY193708A (en) 2022-10-26
BR112016020618A8 (en) 2021-07-13
RU2019130513A (en) 2019-10-10
NZ724836A (en) 2022-07-01
ZA201605864B (en) 2018-12-19
AU2020200679B2 (en) 2022-03-10
EP3118311A4 (en) 2017-10-11
EP3118311A1 (en) 2017-01-18
US20250145997A1 (en) 2025-05-08
US20220162604A1 (en) 2022-05-26
IL247663B (en) 2020-06-30
ES2710802T3 (en) 2019-04-26
CA2939948A1 (en) 2015-09-17

Similar Documents

Publication Publication Date Title
IL249574B (en) Reverse strand nucleic acids
PL3118311T3 (en) ANTISENSIVE NUCLEIC ACID
DK3234132T3 (en) LIGAND-MODIFIED DOUBLE-STRUCTED NUCLEIC ACIDS
IL246703A0 (en) chiral structure
IL249981A0 (en) method
EP3152371C0 (en) STRUCTURAL ELEMENT
DK3167044T3 (en) microfluidic
EP3286549A4 (en) BIOSENSOR
DK3174483T3 (en) HYPORUBE CONSTRUCTION
MA55696A (en) COMBINATIONS
EP3156789C0 (en) BIOSENSOR
DK3245331T3 (en) Mooring element
DK3026813T3 (en) DRIVE
FI20155008A7 (en) Vehicle-assisted implement
DK3152465T3 (en) Drive
EP4546794C0 (en) AUDIOSPLEISS CONCEPT
EP3387414A4 (en) BIOSENSOR
EP3371575A4 (en) BIOSENSOR
DK3371293T3 (en) FERMENTATION
DE112015006486A5 (en) Inkubationsrinne
DE112015002916A5 (en) drive system
DE102015206660A8 (en) Beamsaw
DE112015005904A5 (en) Gurtschlossbringer
FI20146118L (en) Catamaran
DK3390621T3 (en) IMPROVED FERMENTATION

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed