IL251336B - תכשירי פרופאן–1–חומצה סולפונית {3–[5–(4–כלורו–פניל)–h1–פירולו[b–3,2] פירידין–3–קרבוניל]–4,2–דיפלואורו–פניל}–אמיד ושימושים בהם - Google Patents

תכשירי פרופאן–1–חומצה סולפונית {3–[5–(4–כלורו–פניל)–h1–פירולו[b–3,2] פירידין–3–קרבוניל]–4,2–דיפלואורו–פניל}–אמיד ושימושים בהם

Info

Publication number
IL251336B
IL251336B IL251336A IL25133617A IL251336B IL 251336 B IL251336 B IL 251336B IL 251336 A IL251336 A IL 251336A IL 25133617 A IL25133617 A IL 25133617A IL 251336 B IL251336 B IL 251336B
Authority
IL
Israel
Prior art keywords
phenyl
pyrrolo
difluoro
propane
carbonyl
Prior art date
Application number
IL251336A
Other languages
English (en)
Other versions
IL251336A0 (he
Original Assignee
Hoffmann La Roche
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2010/029489 external-priority patent/WO2010114928A2/en
Application filed by Hoffmann La Roche, Plexxikon Inc filed Critical Hoffmann La Roche
Publication of IL251336A0 publication Critical patent/IL251336A0/he
Publication of IL251336B publication Critical patent/IL251336B/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL251336A 2009-04-03 2017-03-22 תכשירי פרופאן–1–חומצה סולפונית {3–[5–(4–כלורו–פניל)–h1–פירולו[b–3,2] פירידין–3–קרבוניל]–4,2–דיפלואורו–פניל}–אמיד ושימושים בהם IL251336B (he)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16667709P 2009-04-03 2009-04-03
US17605109P 2009-05-06 2009-05-06
EP09175665 2009-11-11
PCT/US2010/029489 WO2010114928A2 (en) 2009-04-03 2010-03-31 Compositions and uses thereof

Publications (2)

Publication Number Publication Date
IL251336A0 IL251336A0 (he) 2017-05-29
IL251336B true IL251336B (he) 2020-04-30

Family

ID=54978682

Family Applications (1)

Application Number Title Priority Date Filing Date
IL251336A IL251336B (he) 2009-04-03 2017-03-22 תכשירי פרופאן–1–חומצה סולפונית {3–[5–(4–כלורו–פניל)–h1–פירולו[b–3,2] פירידין–3–קרבוניל]–4,2–דיפלואורו–פניל}–אמיד ושימושים בהם

Country Status (3)

Country Link
HR (1) HRP20151156T1 (he)
IL (1) IL251336B (he)
JO (1) JO3056B1 (he)

Also Published As

Publication number Publication date
JO3056B1 (ar) 2017-03-15
HRP20151156T1 (hr) 2016-01-01
HK1168590A1 (zh) 2013-01-04
HK1217195A1 (en) 2016-12-30
IL251336A0 (he) 2017-05-29

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