IL25649A - Estra-5(10),7-diene-3,17-dione and its preparation - Google Patents

Estra-5(10),7-diene-3,17-dione and its preparation

Info

Publication number: IL25649A
Authority: IL; Israel
Prior art keywords: dione; preparing; preparation; estra; diene
Prior art date: 1965-05-03

Application number

IL25649A

Other languages

English (en)

Original Assignee

Ayerst Mckenna & Harrison

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1965-05-03

Filing date

1966-04-28

Publication date

1970-02-19

1966-04-28 Application filed by Ayerst Mckenna & Harrison filed Critical Ayerst Mckenna & Harrison

1970-02-19 Publication of IL25649A publication Critical patent/IL25649A/en

Links

238000002360 preparation method Methods 0.000 title description 3
OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 title 1
238000000034 method Methods 0.000 claims description 8
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 3
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
239000011701 zinc Substances 0.000 claims description 2
229910052725 zinc Inorganic materials 0.000 claims description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
229910052757 nitrogen Inorganic materials 0.000 claims 1
238000000197 pyrolysis Methods 0.000 claims 1
150000001875 compounds Chemical class 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
239000005977 Ethylene Substances 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
239000000725 suspension Substances 0.000 description 2
HWCYISVQOIISSU-HULBTWJISA-N (8R,9R,10S,13R)-13-methyl-1,2,3,4,5,6,7,8,9,10,11,12-dodecahydrocyclopenta[a]phenanthrene Chemical compound C([C@@H]12)CCCC1CC[C@@H]1[C@@H]2CC[C@@]2(C)C1=CC=C2 HWCYISVQOIISSU-HULBTWJISA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000012280 lithium aluminium hydride Substances 0.000 description 1
-1 lithium aluminum hydride Chemical compound 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
230000009466 transformation Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL25649A 1965-05-03 1966-04-28 Estra-5(10),7-diene-3,17-dione and its preparation IL25649A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US452886A US3340278A (en)	1965-05-03	1965-05-03	5(10), 7-estradiene-3, 17-dione and the process for the production thereof

Publications (1)

Publication Number	Publication Date
IL25649A true IL25649A (en)	1970-02-19

Family

ID=23798354

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL25649A IL25649A (en)	1965-05-03	1966-04-28	Estra-5(10),7-diene-3,17-dione and its preparation

Country Status (6)

Country	Link
US (1)	US3340278A (fr)
CH (1)	CH454846A (fr)
DE (1)	DE1568006A1 (fr)
GB (1)	GB1127128A (fr)
IL (1)	IL25649A (fr)
NL (1)	NL6605955A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3445487A (en) *	1965-06-22	1969-05-20	Glaxo Lab Ltd	Process for the preparation of 3-oxo-4,6-dehydro-19-nor-steroids
GB1151865A (en) *	1965-06-22	1969-05-14	Glaxo Lab Ltd	Process for the production of 5(10), 7-Dehydrosteroids
US3472883A (en) *	1967-07-05	1969-10-14	American Home Prod	Process for preparing estren-3-ones
NZ500217A (en) *	1997-04-07	2001-11-30	American Home Prod	Estra-5(10), 7-dienes for treating estrogen deficiency, osteoporosis and free radical induced disease states
US6458778B1 (en)	1997-04-07	2002-10-01	Wyeth	Estradienes

1965
- 1965-05-03 US US452886A patent/US3340278A/en not_active Expired - Lifetime
1966
- 1966-04-27 GB GB18496/66A patent/GB1127128A/en not_active Expired
- 1966-04-28 IL IL25649A patent/IL25649A/en unknown
- 1966-05-03 DE DE19661568006 patent/DE1568006A1/de active Pending
- 1966-05-03 NL NL6605955A patent/NL6605955A/xx unknown
- 1966-05-03 CH CH637566A patent/CH454846A/fr unknown

Also Published As

Publication number	Publication date
CH454846A (fr)	1968-04-30
NL6605955A (fr)	1966-11-04
US3340278A (en)	1967-09-05
DE1568006A1 (de)	1970-02-12
GB1127128A (en)	1968-09-11

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