IL28401A - Arylsulfonyl ureas,their manufacture and pharmaceutical compositions containing them - Google Patents

Arylsulfonyl ureas,their manufacture and pharmaceutical compositions containing them

Info

Publication number: IL28401A
Authority: IL; Israel
Prior art keywords: general formula; manufacture; same meaning; process according; acid
Prior art date: 1966-08-08

Application number

IL28401A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Sparamedica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-08-08

Filing date

1967-07-26

Publication date

1971-04-28

1966-08-08 Priority claimed from CH1136566A external-priority patent/CH500176A/de

1967-07-26 Application filed by Hoffmann La Roche, Sparamedica Ag filed Critical Hoffmann La Roche

1971-04-28 Publication of IL28401A publication Critical patent/IL28401A/en

Links

238000004519 manufacturing process Methods 0.000 title claims description 4
239000008194 pharmaceutical composition Substances 0.000 title description 2
-1 Arylsulfonyl ureas Chemical class 0.000 title 1
235000013877 carbamide Nutrition 0.000 title 1
238000000034 method Methods 0.000 claims description 11
239000002253 acid Substances 0.000 claims description 7
229940124530 sulfonamide Drugs 0.000 claims description 6
150000003456 sulfonamides Chemical class 0.000 claims description 6
150000001875 compounds Chemical class 0.000 claims description 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 3
BUXTXUBQAKIQKS-UHFFFAOYSA-N sulfuryl diisocyanate Chemical compound O=C=NS(=O)(=O)N=C=O BUXTXUBQAKIQKS-UHFFFAOYSA-N 0.000 claims description 3
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 claims description 2
125000000623 heterocyclic group Chemical group 0.000 claims description 2
JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 claims 2
238000002360 preparation method Methods 0.000 claims 2
XIWRCSVXKPGGAJ-UHFFFAOYSA-N 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-(4-chlorophenyl)urea Chemical compound C=1C=CC=CC=1N1N=C(C(C)(C)C)C=C1NC(=O)NC1=CC=C(Cl)C=C1 XIWRCSVXKPGGAJ-UHFFFAOYSA-N 0.000 claims 1
241000282320 Panthera leo Species 0.000 claims 1
125000002015 acyclic group Chemical group 0.000 claims 1
125000004414 alkyl thio group Chemical group 0.000 claims 1
150000001408 amides Chemical class 0.000 claims 1
239000008280 blood Substances 0.000 claims 1
210000004369 blood Anatomy 0.000 claims 1
230000000881 depressing effect Effects 0.000 claims 1
230000000994 depressogenic effect Effects 0.000 claims 1
239000007788 liquid Substances 0.000 claims 1
239000000126 substance Substances 0.000 claims 1
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
239000000243 solution Substances 0.000 description 9
238000002844 melting Methods 0.000 description 5
230000008018 melting Effects 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
235000011121 sodium hydroxide Nutrition 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
239000007795 chemical reaction product Substances 0.000 description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000011065 in-situ storage Methods 0.000 description 2
125000000468 ketone group Chemical group 0.000 description 2
239000000203 mixture Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 description 1
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
239000003513 alkali Substances 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
125000004391 aryl sulfonyl group Chemical group 0.000 description 1
KRVSOGSZCMJSLX-UHFFFAOYSA-L chromic acid Substances O[Cr](O)(=O)=O KRVSOGSZCMJSLX-UHFFFAOYSA-L 0.000 description 1
150000001844 chromium Chemical class 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
235000019439 ethyl acetate Nutrition 0.000 description 1
AWJWCTOOIBYHON-UHFFFAOYSA-N furo[3,4-b]pyrazine-5,7-dione Chemical compound C1=CN=C2C(=O)OC(=O)C2=N1 AWJWCTOOIBYHON-UHFFFAOYSA-N 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 description 1
229910052738 indium Inorganic materials 0.000 description 1
229910052987 metal hydride Inorganic materials 0.000 description 1
150000004681 metal hydrides Chemical class 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000010992 reflux Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
150000003385 sodium Chemical class 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL28401A 1966-08-08 1967-07-26 Arylsulfonyl ureas,their manufacture and pharmaceutical compositions containing them IL28401A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH787569A CH509992A (de)	1966-08-08	1966-08-08	Verfahren zur Herstellung von Sulfonamiden
CH1136566A CH500176A (de)	1966-08-08	1966-08-08	Verfahren zur Herstellung von Sulfonamiden
CH787469A CH509991A (de)	1966-08-08	1966-08-08	Verfahren zur Herstellung von Sulfonamiden

Publications (1)

Publication Number	Publication Date
IL28401A true IL28401A (en)	1971-04-28

Family

ID=27175874

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL28401A IL28401A (en)	1966-08-08	1967-07-26	Arylsulfonyl ureas,their manufacture and pharmaceutical compositions containing them

Country Status (11)

Country	Link
JP (1)	JPS5516575B1 (fr)
BE (1)	BE702280A (fr)
CH (2)	CH509992A (fr)
DE (1)	DE1668199B2 (fr)
DK (1)	DK122761B (fr)
ES (1)	ES343910A1 (fr)
FR (1)	FR7148M (fr)
GB (3)	GB1147403A (fr)
IL (1)	IL28401A (fr)
NL (1)	NL6710676A (fr)
SE (1)	SE334354B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6929792B2 (ja)	2015-02-16	2021-09-01	ザユニバーシティオブクィーンズランド	スルホニル尿素及び関連化合物並びにその使用
US11840543B2 (en)	2017-05-24	2023-12-12	The University Of Queensland	Compounds and uses
CN110914256A (zh)	2017-07-07	2020-03-24	英夫拉索姆有限公司	新颖磺酰胺羧酰胺化合物

1966
- 1966-08-08 CH CH787569A patent/CH509992A/de not_active IP Right Cessation
- 1966-08-08 CH CH787469A patent/CH509991A/de not_active IP Right Cessation
1967
- 1967-07-12 SE SE10481/67A patent/SE334354B/xx unknown
- 1967-07-26 IL IL28401A patent/IL28401A/en unknown
- 1967-07-29 DE DE1967H0063446 patent/DE1668199B2/de active Granted
- 1967-08-02 NL NL6710676A patent/NL6710676A/xx unknown
- 1967-08-04 GB GB35845/67A patent/GB1147403A/en not_active Expired
- 1967-08-04 GB GB50520/68A patent/GB1147404A/en not_active Expired
- 1967-08-04 GB GB50521/68A patent/GB1147405A/en not_active Expired
- 1967-08-04 BE BE702280D patent/BE702280A/xx unknown
- 1967-08-07 ES ES343910A patent/ES343910A1/es not_active Expired
- 1967-08-07 DK DK401867AA patent/DK122761B/da unknown
- 1967-08-08 JP JP5054967A patent/JPS5516575B1/ja active Pending
- 1967-08-08 FR FR117192A patent/FR7148M/fr not_active Expired

Also Published As

Publication number	Publication date
CH509991A (de)	1971-07-15
SE334354B (fr)	1971-04-26
BE702280A (fr)	1968-02-05
GB1147403A (en)	1969-04-02
GB1147405A (en)	1969-04-02
DE1668199A1 (de)	1971-09-02
GB1147404A (en)	1969-04-02
CH509992A (de)	1971-07-15
ES343910A1 (es)	1968-10-01
JPS5516575B1 (fr)	1980-05-02
NL6710676A (fr)	1968-02-09
DK122761B (da)	1972-04-10
FR7148M (fr)	1969-08-04
DE1668199B2 (de)	1976-06-24

Publication	Publication Date	Title
US2554816A (en)	1951-05-29	Heterocyclic sulfonamides and methods of preparation thereof
US2595334A (en)	1952-05-06	Benzothiazolesulfonamides and method of preparing the same
US2455894A (en)	1948-12-07	Production of 1-mono-and 1, 2-disubstituted-3-cyanoguanidines
US2072348A (en)	1937-03-02	Chlorinated trialkyl amines and method of producing
DE949742C (de)	1956-09-27	Verfahren zur Herstellung von N-Allylnormorphin aus Normorphin und Allylhalogenid
US2603649A (en)	1952-07-15	Heterocyclic sulfonamides and method of preparing the same
US2740781A (en)	1956-04-03	3, 26-dihydroxy-16, 22-imino-5-cholestenes, 3, 26-dihydroxy-16, 22-imino-5, 16, 20(22)-cholestatrienes and derivatives thereof
US2664428A (en)	1953-12-29	delta-17 alpha-hydroxy-3,20-diketo-pregnen-21-als
NO122920B (fr)	1971-09-06
US2863873A (en)	1958-12-09	Esters of nicotinic acid
IL22148A (en)	1968-04-25	Benzenesulfonyl ureas
NO133892B (fr)	1976-04-05
US3350407A (en)	1967-10-31	Sulfur containing pyrazole derivatives
US3234210A (en)	1966-02-08	New ureas and process for preparing same
US3444167A (en)	1969-05-13	Process for the production of thiamine derivatives
US3068238A (en)	1962-12-11	3-cyano, 4-hydroxy-1, 2, 5-thiadiazole, derivatives and process
US2697095A (en)	1954-12-14	Penicillin salts of glycine-diphenylamides
US3183232A (en)	1965-05-11	O, s-disubstituted thiol-type thiamines
US2673873A (en)	1954-03-30	Basic esters of 9, 10-dihalogenated 9, 10-dihydro-9, 10-ethanoanthracene-11-carboxylic acids and their derivatives
US3468889A (en)	1969-09-23	O-and/or s-nicotinoyl diacylthiamines and acylation process for preparing the same
US2674614A (en)	1954-04-06	Thiocarbhydrazine compounds
SU436492A3 (ru)	1974-07-15	Способ получения производных пиколиновойкислоты
US3152123A (en)	1964-10-06	Process for the preparation of benzo-
AT277277B (de)	1969-12-29	Verfahren zur herstellung von neuen sulfonylharnstoffderivaten
US3322760A (en)	1967-05-30	6-(substituted-amino)-1-tetralones