IL286914A - Systemic isoxazoline parasiticides for vector-borne and viral disease treatment or prophylaxis - Google Patents

Systemic isoxazoline parasiticides for vector-borne and viral disease treatment or prophylaxis

Info

Publication number
IL286914A
IL286914A IL286914A IL28691421A IL286914A IL 286914 A IL286914 A IL 286914A IL 286914 A IL286914 A IL 286914A IL 28691421 A IL28691421 A IL 28691421A IL 286914 A IL286914 A IL 286914A
Authority
IL
Israel
Prior art keywords
isoxazoline
systemic
viral
vector
prevention
Prior art date
Application number
IL286914A
Other languages
English (en)
Hebrew (he)
Inventor
Bobak Robert Azamian
Douglas Michael Ackermann
Christopher Stivers
Shawn D Hickok
Original Assignee
Tarsus Pharmaceuticals Inc
Bobak Robert Azamian
Douglas Michael Ackermann
Christopher Stivers
Shawn D Hickok
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tarsus Pharmaceuticals Inc, Bobak Robert Azamian, Douglas Michael Ackermann, Christopher Stivers, Shawn D Hickok filed Critical Tarsus Pharmaceuticals Inc
Publication of IL286914A publication Critical patent/IL286914A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL286914A 2019-04-04 2021-10-03 Systemic isoxazoline parasiticides for vector-borne and viral disease treatment or prophylaxis IL286914A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962829573P 2019-04-04 2019-04-04
PCT/IB2020/053229 WO2020202111A1 (fr) 2019-04-04 2020-04-03 Parasiticides systémiques à base d'isoxazoline pour le traitement ou la prophylaxie d'une maladie virale et à vecteur

Publications (1)

Publication Number Publication Date
IL286914A true IL286914A (en) 2021-10-31

Family

ID=72667108

Family Applications (1)

Application Number Title Priority Date Filing Date
IL286914A IL286914A (en) 2019-04-04 2021-10-03 Systemic isoxazoline parasiticides for vector-borne and viral disease treatment or prophylaxis

Country Status (11)

Country Link
US (2) US20220160682A1 (fr)
EP (1) EP3946325A4 (fr)
JP (2) JP2022527359A (fr)
KR (1) KR20220054241A (fr)
CN (1) CN113993518A (fr)
AU (2) AU2020251960A1 (fr)
BR (1) BR112021019931A2 (fr)
CA (1) CA3136042A1 (fr)
IL (1) IL286914A (fr)
MX (1) MX2021012188A (fr)
WO (1) WO2020202111A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170232024A1 (en) 2014-08-04 2017-08-17 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
CN119157876A (zh) 2017-12-15 2024-12-20 塔苏斯制药有限公司 用于治疗睑炎的异恶唑啉驱虫剂制剂和方法
US12502377B2 (en) * 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
CN111265528A (zh) 2020-01-21 2020-06-12 中国人民解放军军事科学院军事医学研究院 法匹拉韦在治疗冠状病毒感染方面的应用
WO2022079496A1 (fr) * 2020-10-13 2022-04-21 Menschlich Healthcare Opc Private Limited Composition pharmaceutique à base de nitazoxanide, d'albendazole et de pyrantel et procédé associé
CN112294793B (zh) * 2020-10-21 2022-03-22 青岛海洋生物医药研究院股份有限公司 氯生太尔或其药学上可接受的盐在制备用于预防和/或治疗冠状病毒感染的药物中的应用
WO2022130031A1 (fr) * 2020-12-17 2022-06-23 Chander Mohan Negi Composition pharmaceutique de nitazoxanide et de méfloquine et son procédé de fabrication
CN118420621A (zh) * 2021-02-07 2024-08-02 南京知和医药科技有限公司 一种磺酰胺类多环化合物及其制备方法与用途
US20250318529A1 (en) * 2022-05-16 2025-10-16 Syngenta Crop Protection Ag Method for mosquito control
WO2024168149A1 (fr) * 2023-02-10 2024-08-15 Tarsus Pharmaceuticals, Inc. Formulations parasiticides à base d'isoxazoline et méthodes de traitement de la blépharite
US20240366572A1 (en) * 2023-05-07 2024-11-07 Michael Farber Isoxazoline complexes and compositions thereof
US11903962B1 (en) * 2023-05-07 2024-02-20 Michael Farber Isoxazoline complexes and compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI556741B (zh) * 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
US8313752B2 (en) * 2009-04-14 2012-11-20 Merial Limited Macrocyclic lactone combination compositions, vaccines and methods for producing same
CN110167540A (zh) * 2016-10-31 2019-08-23 斯克利普斯研究所 用于预防媒介传播疾病的传播的方法和组合物
WO2020051106A1 (fr) * 2018-09-05 2020-03-12 Zoetis Services Llc Formulations antiparasitaires de goût agréable
BR112022000982A2 (pt) * 2019-07-22 2022-03-08 Intervet Int Bv Forma de dosagem veterinária mastigável macia

Also Published As

Publication number Publication date
US20220160682A1 (en) 2022-05-26
JP2022527359A (ja) 2022-06-01
AU2020251960A1 (en) 2021-11-11
WO2020202111A1 (fr) 2020-10-08
CN113993518A (zh) 2022-01-28
AU2026205483A1 (en) 2026-07-30
MX2021012188A (es) 2022-02-11
CA3136042A1 (fr) 2020-10-08
EP3946325A1 (fr) 2022-02-09
KR20220054241A (ko) 2022-05-02
US20230218584A1 (en) 2023-07-13
JP2026083151A (ja) 2026-05-19
BR112021019931A2 (pt) 2021-12-07
EP3946325A4 (fr) 2022-12-21

Similar Documents

Publication Publication Date Title
EP3946325A4 (fr) Parasiticides systémiques à base d'isoxazoline pour le traitement ou la prophylaxie d'une maladie virale et à vecteur
IL281277A (en) Preparations and methods for treating viral infections
IL281093A (en) Combinations for treatment of nash/nafld and related diseases
ZA202002069B (en) Novel mek-inhibitor for the treatment of viral and bacterial infections
IL290792B1 (en) Preparations and methods for treating viral infections
IL263972A (en) Dihydropyranopyrimidines for the treatment of viral infections
SG11202000939PA (en) Cytokine conjugates for the treatment of proliferative and infectious diseases
PL4157272T3 (pl) Remdesiwir do leczenia zakażeń wirusowych
HUE056471T2 (hu) Dalargin akut légzõszervi vírusos fertõzések kezelésében történõ alkalmazásra
SG11202104663PA (en) Treatment of nsclc patients refractory for anti-pd-1 antibody
IL283938A (en) Compounds and their use in the treatment of a1-antitrypsin deficiency
IL289109A (en) Isoxazoline formulations against parasites and methods for treating blepharitis
ZA202202370B (en) Compositions and methods for treating viral infections
GB202317063D0 (en) Microfluidic proximal tubile kidney-on-chip
PT3669791T (pt) Fórceps médico
IL284099A (en) Adeno-associated viruses and their uses for inner ear therapy
EP4007581A4 (fr) Protocoles et schémas posologiques pour traitement à l'aminostérol
GB201803197D0 (en) Viral treatment
GB201910645D0 (en) Treatment for dry eye disease
PT3863580T (pt) Fralda descartável
GB201916279D0 (en) Tobacco treatment
EP3634583A4 (fr) Implant à action prolongée pour le traitement de maladies infectieuses
GB201907493D0 (en) Agents and methods for treating viral infections
IL289692A (en) A device for treating vaginal atrophy
HUE065591T2 (hu) Gyógyszer fertõzõ betegségek kezelésére