IL287962A - טיפולים משולבים עם נוגדנים אנטי- egfr/c-met ביספציפיים ומעכבי egfr טירוסין קינאז דור שלישי - Google Patents
טיפולים משולבים עם נוגדנים אנטי- egfr/c-met ביספציפיים ומעכבי egfr טירוסין קינאז דור שלישיInfo
- Publication number
- IL287962A IL287962A IL287962A IL28796221A IL287962A IL 287962 A IL287962 A IL 287962A IL 287962 A IL287962 A IL 287962A IL 28796221 A IL28796221 A IL 28796221A IL 287962 A IL287962 A IL 287962A
- Authority
- IL
- Israel
- Prior art keywords
- egfr
- tyrosine kinase
- kinase inhibitors
- combination therapies
- bispecific anti
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962847605P | 2019-05-14 | 2019-05-14 | |
| PCT/IB2020/054594 WO2020230091A1 (en) | 2019-05-14 | 2020-05-14 | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL287962A true IL287962A (he) | 2022-01-01 |
Family
ID=78716450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL287962A IL287962A (he) | 2019-05-14 | 2021-11-09 | טיפולים משולבים עם נוגדנים אנטי- egfr/c-met ביספציפיים ומעכבי egfr טירוסין קינאז דור שלישי |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP3968985A4 (he) |
| JP (2) | JP2022531980A (he) |
| KR (1) | KR20220010731A (he) |
| CN (1) | CN113840601A (he) |
| AU (1) | AU2020275272A1 (he) |
| BR (1) | BR112021022828A2 (he) |
| CA (1) | CA3140360A1 (he) |
| EA (1) | EA202193117A1 (he) |
| IL (1) | IL287962A (he) |
| MA (1) | MA55978A (he) |
| MX (1) | MX2021013955A (he) |
| SG (1) | SG11202112412QA (he) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025060962A1 (en) * | 2023-09-21 | 2025-03-27 | Beijing Neox Biotech Limited | Multi-specific antibodies and uses thereof |
| CN122028932A (zh) * | 2023-09-28 | 2026-05-12 | 上海翰森生物医药科技有限公司 | 一种双特异性抗体在制备治疗癌症的药物中的用途 |
| CN120271706A (zh) * | 2023-12-29 | 2025-07-08 | 上海安领科生物医药有限公司 | 抗egfr单抗、其双特异性抗体、药物组合物和用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7595378B2 (en) * | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| MX2010009669A (es) * | 2008-03-06 | 2010-09-22 | Genentech Inc | Terapia de combinacion con antagonistas de c-met y egfr. |
| JP6040148B2 (ja) * | 2010-04-20 | 2016-12-07 | ゲンマブ エー/エス | ヘテロ二量体抗体Fc含有タンパク質およびその産生方法 |
| US9695228B2 (en) * | 2012-11-21 | 2017-07-04 | Janssen Biotech, Inc. | EGFR and c-Met fibronectin type III domain binding molecules |
| ES2831374T3 (es) * | 2012-11-21 | 2021-06-08 | Janssen Biotech Inc | Anticuerpos de EGFR/c-Met biespecíficos |
| NZ730012A (en) * | 2014-10-13 | 2019-06-28 | Yuhan Corp | Compounds and compositions for modulating egfr mutant kinase activities |
| AR111469A1 (es) * | 2017-04-21 | 2019-07-17 | Yuhan Corp | Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma |
| SG11202108311RA (en) * | 2019-02-26 | 2021-09-29 | Janssen Biotech Inc | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies |
-
2020
- 2020-05-14 KR KR1020217040739A patent/KR20220010731A/ko active Pending
- 2020-05-14 SG SG11202112412QA patent/SG11202112412QA/en unknown
- 2020-05-14 CN CN202080035662.6A patent/CN113840601A/zh active Pending
- 2020-05-14 EA EA202193117A patent/EA202193117A1/ru unknown
- 2020-05-14 AU AU2020275272A patent/AU2020275272A1/en active Pending
- 2020-05-14 EP EP20806609.2A patent/EP3968985A4/en active Pending
- 2020-05-14 MX MX2021013955A patent/MX2021013955A/es unknown
- 2020-05-14 MA MA055978A patent/MA55978A/fr unknown
- 2020-05-14 BR BR112021022828A patent/BR112021022828A2/pt unknown
- 2020-05-14 JP JP2021567974A patent/JP2022531980A/ja active Pending
- 2020-05-14 CA CA3140360A patent/CA3140360A1/en active Pending
-
2021
- 2021-11-09 IL IL287962A patent/IL287962A/he unknown
-
2025
- 2025-04-01 JP JP2025060710A patent/JP2025118606A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2021013955A (es) | 2022-03-11 |
| JP2022531980A (ja) | 2022-07-12 |
| EP3968985A1 (en) | 2022-03-23 |
| SG11202112412QA (en) | 2021-12-30 |
| MA55978A (fr) | 2022-03-23 |
| BR112021022828A2 (pt) | 2022-04-12 |
| EP3968985A4 (en) | 2023-07-26 |
| JP2025118606A (ja) | 2025-08-13 |
| CN113840601A (zh) | 2021-12-24 |
| AU2020275272A1 (en) | 2021-12-02 |
| KR20220010731A (ko) | 2022-01-26 |
| EA202193117A1 (ru) | 2022-02-11 |
| CA3140360A1 (en) | 2020-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JOP20210304A1 (ar) | علاجات مركبة باستخدام الأجسام المضادة ثنائية النوعية المضادة لمستقبل عامل نمو البشرة (EGFR)/ مستقبل عامل نمو خلايا الكبد (c-Met) ومثبطات كيناز التيروسين الخاصة بمستقبل عامل نمو البشرة (EGFR) من الجيل الثالث | |
| IL285718A (he) | טיפולים משולבים וריבוד מטופלים עם נוגדנים אנטי- egfr/c-met ביספציפיים | |
| IL278920A (he) | נוגדני entpd2, טיפולים שילוביים, ושיטות לשימוש בנוגדנים וטיפולים משולבים | |
| EP3889174A4 (en) | BISPECIFIC HOMODIMER-TYPE ANTIBODY AGAINST HER2 AND CD3 AND USE THEREOF | |
| IL279251A (he) | שיטות לטיפול בסרטן עם נוגדנים דו-ספציפיים נגד cd3xmuc16 ונוגדנים נגד pd-1 | |
| MY192668A (en) | Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use | |
| MX2022014762A (es) | Anticuerpos biespecificos contra beta amiloide humana/receptor de transferrina humano y metodos de uso. | |
| HK1202431A1 (en) | Humanized pan-her antibody compositions | |
| MX2020001432A (es) | Anticuerpos que se unen al receptor del factor de crecimiento epidermico (egfr) y tirosina-proteina cinasa met (cmet). | |
| MY172867A (en) | Bispecific egfr/c-met antibodies | |
| MX2017004311A (es) | Anticuerpos del receptor del factor de necrosis tumoral inducido por glucocorticoide (gitr) y metodos de uso de los mismos. | |
| SG11202112412QA (en) | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors | |
| TN2017000470A1 (en) | Heterodimeric antibodies that bind cd3 and tumor antigens. | |
| HK1247577A1 (zh) | Egfr突变阳性的非小细胞肺癌的联合疗法 | |
| SG10201912545PA (en) | T cell redirecting bispecific antibodies for the treatment of egfr positive cancers | |
| TN2019000161A1 (en) | Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody of heterodimeric form and preparation thereof | |
| IL279325A (en) | Poziotinib combinations with an anti-her1, her2 or her4 antibody and methods of use thereof | |
| HK40066572A (en) | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies | |
| IL308225A (he) | טיפולים משולבים הכוללים מעכבי shp2 ומעכבי egfr טירוסין קינאז | |
| HK40028770A (en) | Compositions and methods for treating cancer with anti-egfr antibodies | |
| EA201792249A1 (ru) | Комбинированная терапия злокачественной опухоли |