IL289109B2 - Isoxazoline formulations against parasites and methods for treating blepharitis - Google Patents

Isoxazoline formulations against parasites and methods for treating blepharitis

Info

Publication number
IL289109B2
IL289109B2 IL289109A IL28910921A IL289109B2 IL 289109 B2 IL289109 B2 IL 289109B2 IL 289109 A IL289109 A IL 289109A IL 28910921 A IL28910921 A IL 28910921A IL 289109 B2 IL289109 B2 IL 289109B2
Authority
IL
Israel
Prior art keywords
composition
blepharitis
formulation
treating
configurations
Prior art date
Application number
IL289109A
Other languages
English (en)
Hebrew (he)
Other versions
IL289109A (en
IL289109B1 (en
Inventor
Bobak Robert Azamian
Douglas Michael Ackermann
Shawn Hickok
Joseph Vehige
Original Assignee
Tarsus Pharmaceuticals Inc
Bobak Robert Azamian
Douglas Michael Ackermann
Shawn Hickok
Joseph Vehige
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tarsus Pharmaceuticals Inc, Bobak Robert Azamian, Douglas Michael Ackermann, Shawn Hickok, Joseph Vehige filed Critical Tarsus Pharmaceuticals Inc
Publication of IL289109A publication Critical patent/IL289109A/en
Publication of IL289109B1 publication Critical patent/IL289109B1/en
Publication of IL289109B2 publication Critical patent/IL289109B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/105Aliphatic or alicyclic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/40Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dentistry (AREA)
  • Birds (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL289109A 2019-06-19 2020-06-19 Isoxazoline formulations against parasites and methods for treating blepharitis IL289109B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962863822P 2019-06-19 2019-06-19
US202063029689P 2020-05-25 2020-05-25
PCT/US2020/038758 WO2020257663A1 (fr) 2019-06-19 2020-06-19 Formulations parasiticides à base d'isoxazoline et procédés de traitement de blépharite

Publications (3)

Publication Number Publication Date
IL289109A IL289109A (en) 2022-02-01
IL289109B1 IL289109B1 (en) 2025-06-01
IL289109B2 true IL289109B2 (en) 2025-10-01

Family

ID=74040459

Family Applications (2)

Application Number Title Priority Date Filing Date
IL289109A IL289109B2 (en) 2019-06-19 2020-06-19 Isoxazoline formulations against parasites and methods for treating blepharitis
IL321061A IL321061A (en) 2019-06-19 2020-06-19 Isoxazoline parasiticide formulations and methodsfor treating blepharitis

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL321061A IL321061A (en) 2019-06-19 2020-06-19 Isoxazoline parasiticide formulations and methodsfor treating blepharitis

Country Status (10)

Country Link
EP (1) EP3986377A4 (fr)
JP (2) JP2022537389A (fr)
KR (1) KR20220053550A (fr)
CN (1) CN114269324A (fr)
AU (1) AU2020295570A1 (fr)
BR (1) BR112021025701A2 (fr)
CA (1) CA3144264A1 (fr)
IL (2) IL289109B2 (fr)
MX (1) MX2021016055A (fr)
WO (1) WO2020257663A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016022066A1 (fr) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Compositions pharmaceutiques pour blépharite et encroûtement des paupières liés à demodex
AU2018385766B2 (en) 2017-12-15 2022-12-01 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and methods for treating blepharitis
WO2022156371A1 (fr) * 2021-01-22 2022-07-28 成都瑞沐生物医药科技有限公司 Support ou substance auxiliaire de préparation ophtalmique, son procédé de préparation et son application
US20220323472A1 (en) * 2021-03-30 2022-10-13 Frank Anthony SPALLITTA Anti-parasitic compounds for the treatment and prevention of viral diseases
PL4312986T3 (pl) * 2021-04-01 2025-02-17 Active Biotech Ab Preparat lakwinimodu do stosowania do oczu
WO2024168149A1 (fr) * 2023-02-10 2024-08-15 Tarsus Pharmaceuticals, Inc. Formulations parasiticides à base d'isoxazoline et méthodes de traitement de la blépharite

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090317503A1 (en) * 2008-06-20 2009-12-24 Ocusoft, Inc. Eyelid Preparation and Method of Use
US20120053140A1 (en) * 2005-09-30 2012-03-01 Galderma S.A. Administration of avermectin/milbemycin compounds for the treatment of ophthalmic pathologies
US20130324538A1 (en) * 2011-02-10 2013-12-05 Noëlle Gauvry Isoxazoline derivatives for controlling invertebrate pests
US20160317439A1 (en) * 2013-12-20 2016-11-03 Intervet Inc. Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090214676A1 (en) * 2005-04-30 2009-08-27 Tissuetech, Inc. Method for treating ocular demodex
JP5246182B2 (ja) * 2010-02-24 2013-07-24 ライオン株式会社 点眼剤、防腐剤及び防腐力向上剤
BR112012026364B1 (pt) * 2010-04-12 2018-04-10 Exosect Limited Controle de artrópodes em ambientes de animais
WO2016022066A1 (fr) * 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Compositions pharmaceutiques pour blépharite et encroûtement des paupières liés à demodex
AU2018385766B2 (en) * 2017-12-15 2022-12-01 Tarsus Pharmaceuticals, Inc. Isoxazoline parasiticide formulations and methods for treating blepharitis
JP7569781B2 (ja) * 2018-07-27 2024-10-18 アペルタ バイオサイエンシズ,エルエルシー デモデックスにより誘発される眼の異常および顔面の異常を治療するためのスピノシン配合

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120053140A1 (en) * 2005-09-30 2012-03-01 Galderma S.A. Administration of avermectin/milbemycin compounds for the treatment of ophthalmic pathologies
US20090317503A1 (en) * 2008-06-20 2009-12-24 Ocusoft, Inc. Eyelid Preparation and Method of Use
US20130324538A1 (en) * 2011-02-10 2013-12-05 Noëlle Gauvry Isoxazoline derivatives for controlling invertebrate pests
US20160317439A1 (en) * 2013-12-20 2016-11-03 Intervet Inc. Isoxazoline compositions and use thereof in the prevention or treatment of parasite infestations in animals

Also Published As

Publication number Publication date
CA3144264A1 (fr) 2020-12-24
CN114269324A (zh) 2022-04-01
IL289109A (en) 2022-02-01
EP3986377A1 (fr) 2022-04-27
WO2020257663A1 (fr) 2020-12-24
EP3986377A4 (fr) 2023-07-19
IL321061A (en) 2025-07-01
JP2025137609A (ja) 2025-09-19
KR20220053550A (ko) 2022-04-29
BR112021025701A2 (pt) 2022-03-03
JP2022537389A (ja) 2022-08-25
IL289109B1 (en) 2025-06-01
MX2021016055A (es) 2022-04-20
AU2020295570A1 (en) 2022-02-10

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