IL28977A - New vaccines for combating influenza and the preparation thereof - Google Patents

New vaccines for combating influenza and the preparation thereof

Info

Publication number: IL28977A
Authority: IL; Israel
Prior art keywords: suspension; vaccines; monovalent; suspensions; preparation
Prior art date: 1966-11-21

Application number

IL28977A

Other languages

English (en)

Original Assignee

Rhone Poulenc Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-11-21

Filing date

1967-11-20

Publication date

1972-05-30

1967-11-20 Application filed by Rhone Poulenc Sa filed Critical Rhone Poulenc Sa

1972-05-30 Publication of IL28977A publication Critical patent/IL28977A/en

Links

229960005486 vaccine Drugs 0.000 title claims description 25
238000002360 preparation method Methods 0.000 title claims description 17
206010022000 influenza Diseases 0.000 title description 8
239000000725 suspension Substances 0.000 claims description 46
230000003612 virological effect Effects 0.000 claims description 28
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 27
238000000034 method Methods 0.000 claims description 23
241000700605 Viruses Species 0.000 claims description 19
241000712461 unidentified influenza virus Species 0.000 claims description 19
241000282414 Homo sapiens Species 0.000 claims description 12
241000283073 Equus caballus Species 0.000 claims description 9
239000000203 mixture Substances 0.000 claims description 8
230000002779 inactivation Effects 0.000 claims description 6
239000000829 suppository Substances 0.000 claims description 6
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
229930195725 Mannitol Natural products 0.000 claims description 5
239000000594 mannitol Substances 0.000 claims description 5
235000010355 mannitol Nutrition 0.000 claims description 5
229940049964 oleate Drugs 0.000 claims description 5
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 5
239000008158 vegetable oil Substances 0.000 claims description 5
239000006172 buffering agent Substances 0.000 claims description 4
210000000991 chicken egg Anatomy 0.000 claims description 4
239000003995 emulsifying agent Substances 0.000 claims description 4
238000010908 decantation Methods 0.000 claims description 3
235000012424 soybean oil Nutrition 0.000 claims description 3
150000003626 triacylglycerols Chemical class 0.000 claims description 3
239000000443 aerosol Substances 0.000 claims description 2
230000015572 biosynthetic process Effects 0.000 claims description 2
239000002480 mineral oil Substances 0.000 claims description 2
238000002156 mixing Methods 0.000 claims description 2
235000013311 vegetables Nutrition 0.000 claims description 2
230000001804 emulsifying effect Effects 0.000 claims 1
238000010348 incorporation Methods 0.000 claims 1
PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 claims 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
230000001492 haemagglutinating effect Effects 0.000 description 11
239000002671 adjuvant Substances 0.000 description 8
208000015181 infectious disease Diseases 0.000 description 7
230000002458 infectious effect Effects 0.000 description 7
238000007918 intramuscular administration Methods 0.000 description 6
235000013601 eggs Nutrition 0.000 description 5
239000000839 emulsion Substances 0.000 description 5
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 5
229920000053 polysorbate 80 Polymers 0.000 description 5
230000000890 antigenic effect Effects 0.000 description 4
239000007900 aqueous suspension Substances 0.000 description 4
238000005119 centrifugation Methods 0.000 description 4
230000036512 infertility Effects 0.000 description 4
229960003971 influenza vaccine Drugs 0.000 description 4
239000002245 particle Substances 0.000 description 4
OIQOAYVCKAHSEJ-UHFFFAOYSA-N 2-[2,3-bis(2-hydroxyethoxy)propoxy]ethanol;hexadecanoic acid;octadecanoic acid Chemical compound OCCOCC(OCCO)COCCO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O OIQOAYVCKAHSEJ-UHFFFAOYSA-N 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
238000011534 incubation Methods 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000012528 membrane Substances 0.000 description 3
229940031348 multivalent vaccine Drugs 0.000 description 3
239000010452 phosphate Substances 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 3
239000002510 pyrogen Substances 0.000 description 3
238000007920 subcutaneous administration Methods 0.000 description 3
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 3
235000015112 vegetable and seed oil Nutrition 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
102000005348 Neuraminidase Human genes 0.000 description 2
108010006232 Neuraminidase Proteins 0.000 description 2
238000000889 atomisation Methods 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
238000001085 differential centrifugation Methods 0.000 description 2
238000010790 dilution Methods 0.000 description 2
239000012895 dilution Substances 0.000 description 2
239000006185 dispersion Substances 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000004945 emulsification Methods 0.000 description 2
238000001914 filtration Methods 0.000 description 2
238000002649 immunization Methods 0.000 description 2
239000002609 medium Substances 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
238000000746 purification Methods 0.000 description 2
230000001698 pyrogenic effect Effects 0.000 description 2
238000003756 stirring Methods 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
241000726306 Irus Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
102000001621 Mucoproteins Human genes 0.000 description 1
108010093825 Mucoproteins Proteins 0.000 description 1
241000204031 Mycoplasma Species 0.000 description 1
SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
241000286209 Phasianidae Species 0.000 description 1
108010001267 Protein Subunits Proteins 0.000 description 1
241000831652 Salinivibrio sharmensis Species 0.000 description 1
244000000231 Sesamum indicum Species 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
239000008272 agar Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
210000002257 embryonic structure Anatomy 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
230000035931 haemagglutination Effects 0.000 description 1
230000036039 immunity Effects 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229940031346 monovalent vaccine Drugs 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000006916 nutrient agar Substances 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
-1 oleic triglycerides Chemical class 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000008188 pellet Substances 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000011148 porous material Substances 0.000 description 1
AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
229940111695 potassium tartrate Drugs 0.000 description 1
239000001472 potassium tartrate Substances 0.000 description 1
235000011005 potassium tartrates Nutrition 0.000 description 1
239000000047 product Substances 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000005057 refrigeration Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000000243 solution Substances 0.000 description 1
241000894007 species Species 0.000 description 1
210000001913 submandibular gland Anatomy 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000001973 thioglycolate broth Substances 0.000 description 1
238000004448 titration Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL28977A 1966-11-21 1967-11-20 New vaccines for combating influenza and the preparation thereof IL28977A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR84337A FR1538322A (fr)	1966-11-21	1966-11-21	Procédé de préparation d'une suspension virale inactivée

Publications (1)

Publication Number	Publication Date
IL28977A true IL28977A (en)	1972-05-30

Family

ID=8621311

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL28977A IL28977A (en)	1966-11-21	1967-11-20	New vaccines for combating influenza and the preparation thereof

Country Status (15)

Country	Link
US (1)	US3655871A (de)
AT (1)	AT275733B (de)
BE (1)	BE706781A (de)
CH (1)	CH477552A (de)
DE (1)	DE1617779A1 (de)
DK (1)	DK117316B (de)
ES (1)	ES347412A1 (de)
FI (1)	FI43766B (de)
FR (1)	FR1538322A (de)
GB (1)	GB1183506A (de)
GR (1)	GR33293B (de)
IL (1)	IL28977A (de)
NL (1)	NL6715369A (de)
SE (1)	SE365542B (de)
YU (1)	YU31920B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4158054A (en)	1973-10-18	1979-06-12	Duncan Flockhart & Co. Ltd.	Preparation of virus sub-unit vaccines
US4000257A (en) *	1975-12-22	1976-12-28	American Cyanamid Company	Process for the purification of influenza virus vaccine
US4500513A (en) *	1979-05-15	1985-02-19	Miles Laboratories, Inc.	Influenza vaccine production in liquid cell culture
USRE33164E (en) *	1979-05-15	1990-02-13	Mobay Corporation	Influenza vaccine production in liquid cell culture
JPS59163313A (ja) *	1983-03-09	1984-09-14	Teijin Ltd	経鼻投与用ペプチドホルモン類組成物
US4764369A (en) *	1983-07-14	1988-08-16	New York Blood Center Inc.	Undenatured virus-free biologically active protein derivatives
US4820805A (en) *	1983-07-14	1989-04-11	New York Blood Center, Inc.	Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4841023A (en) *	1986-06-25	1989-06-20	New York Blood Center, Inc.	Inactivation of viruses in labile protein-containing compositions using fatty acids
US5639461A (en) *	1994-09-30	1997-06-17	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Influenza machine
ATE213646T1 (de) *	1995-10-20	2002-03-15	Yissum Res Dev Co	Grippe-impfstoff
AUPQ486699A0 (en) *	1999-12-23	2000-02-03	Aruba International Pty Ltd	A method of treating infectious diseases
US20090017069A1 (en)	2000-06-29	2009-01-15	Lipid Sciences, Inc.	SARS Vaccine Compositions and Methods of Making and Using Them
US6991727B2 (en)	2001-06-25	2006-01-31	Lipid Sciences, Inc.	Hollow fiber contactor systems for removal of lipids from fluids
US20060060520A1 (en)	2001-06-25	2006-03-23	Bomberger David C	Systems and methods using a solvent for the removal of lipids from fluids
US7033500B2 (en)	2001-06-25	2006-04-25	Lipid Sciences, Inc.	Systems and methods using multiple solvents for the removal of lipids from fluids
US20030133829A1 (en) *	2001-12-21	2003-07-17	Baxter Healthcare Corporation	Process for inactivating pathogens in a biological material
US7959929B2 (en)	2005-04-21	2011-06-14	University Of Florida Research Foundation, Inc.	Materials and methods for respiratory disease control in canines
US11865172B2 (en)	2005-04-21	2024-01-09	University Of Florida Research Foundation, Inc.	Materials and methods for respiratory disease control in canines
JP5130598B2 (ja) *	2005-09-02	2013-01-30	静岡県公立大学法人	ウイルスレセプター糖鎖認識特異性の判別方法
WO2013106548A1 (en)	2012-01-10	2013-07-18	The Broad Institute, Inc.	Methods and cells for the production of viral vaccines

1966
- 1966-11-21 FR FR84337A patent/FR1538322A/fr not_active Expired
1967
- 1967-11-13 NL NL6715369A patent/NL6715369A/xx unknown
- 1967-11-18 GR GR670133293A patent/GR33293B/el unknown
- 1967-11-20 YU YU2268/67A patent/YU31920B/xx unknown
- 1967-11-20 US US684540A patent/US3655871A/en not_active Expired - Lifetime
- 1967-11-20 BE BE706781D patent/BE706781A/xx unknown
- 1967-11-20 FI FI3119/67A patent/FI43766B/fi active
- 1967-11-20 IL IL28977A patent/IL28977A/en unknown
- 1967-11-20 DK DK579067AA patent/DK117316B/da unknown
- 1967-11-20 GB GB52684/67A patent/GB1183506A/en not_active Expired
- 1967-11-20 SE SE15924/67A patent/SE365542B/xx unknown
- 1967-11-21 CH CH1626667A patent/CH477552A/fr not_active IP Right Cessation
- 1967-11-21 DE DE19671617779 patent/DE1617779A1/de active Pending
- 1967-11-21 ES ES347412A patent/ES347412A1/es not_active Expired
- 1967-11-21 AT AT1049667A patent/AT275733B/de active

Also Published As

Publication number	Publication date
SE365542B (de)	1974-03-25
FR1538322A (fr)	1968-09-06
GR33293B (el)	1967-11-21
AT275733B (de)	1969-11-10
FI43766B (de)	1971-03-01
YU31920B (en)	1974-02-28
CH477552A (fr)	1969-08-31
YU226867A (en)	1973-08-31
DK117316B (da)	1970-04-13
BE706781A (de)	1968-05-20
NL6715369A (de)	1968-05-22
GB1183506A (en)	1970-03-11
DE1617779A1 (de)	1972-03-23
ES347412A1 (es)	1969-01-16
US3655871A (en)	1972-04-11

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Hotchin et al.	1958	Lymphocytic choriomeningitis infection of mice as a model for the study of latent virus infection
US3962421A (en)	1976-06-08	Method for the disruption of lipid-containing viruses
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Sikes et al.	1967	Purified rabies vaccine: development and comparison of potency and safety with two human rabies vaccines
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EP0013449A1 (de)	1980-07-23	Impfstoff gegen durch Reoviren verursachte Krankheiten, kombinierter Impfstoff mit dem Newcastle-Disease-Virus, Verfahren zu ihrer Herstellung und der zu ihrer Herstellung benötigte Reovirus-Stamm
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