IL29066A - Pharmaceutical preparations containing multi-chain poly-nucleotides to encourage interferon production in humans, animals or cell cultures - Google Patents
Pharmaceutical preparations containing multi-chain poly-nucleotides to encourage interferon production in humans, animals or cell culturesInfo
- Publication number
- IL29066A IL29066A IL2906667A IL2906667A IL29066A IL 29066 A IL29066 A IL 29066A IL 2906667 A IL2906667 A IL 2906667A IL 2906667 A IL2906667 A IL 2906667A IL 29066 A IL29066 A IL 29066A
- Authority
- IL
- Israel
- Prior art keywords
- interferon
- rna
- acid
- compositions according
- animals
- Prior art date
Links
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- 206010024264 Lethargy Diseases 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
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- 239000003513 alkali Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
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- 239000006286 aqueous extract Substances 0.000 description 1
- 238000013096 assay test Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- NKQIMNKPSDEDMO-UHFFFAOYSA-L barium bromide Chemical compound [Br-].[Br-].[Ba+2] NKQIMNKPSDEDMO-UHFFFAOYSA-L 0.000 description 1
- 229910001620 barium bromide Inorganic materials 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
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- 239000007975 buffered saline Substances 0.000 description 1
- 244000309466 calf Species 0.000 description 1
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- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
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- 239000003599 detergent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
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- 229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
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- 208000028331 flaccid paralysis Diseases 0.000 description 1
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- 239000012362 glacial acetic acid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002402 hexoses Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000000215 hyperchromic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
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- 238000012423 maintenance Methods 0.000 description 1
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- 239000000178 monomer Substances 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 238000000424 optical density measurement Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
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- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000008196 pharmacological composition Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000002962 plaque-reduction assay Methods 0.000 description 1
- 238000012809 post-inoculation Methods 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- LJCNRYVRMXRIQR-OLXYHTOASA-L potassium sodium L-tartrate Chemical class [Na+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O LJCNRYVRMXRIQR-OLXYHTOASA-L 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- OABGXCSOGYJCPE-UHFFFAOYSA-N propan-2-ol;hydrate;hydrochloride Chemical compound O.Cl.CC(C)O OABGXCSOGYJCPE-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 229940121649 protein inhibitor Drugs 0.000 description 1
- 239000012268 protein inhibitor Substances 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000004153 renaturation Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000012465 retentate Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 231100000161 signs of toxicity Toxicity 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 235000011006 sodium potassium tartrate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
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- 230000007704 transition Effects 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 230000024275 uncoating of virus Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
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- 230000036642 wellbeing Effects 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60413766A | 1966-12-23 | 1966-12-23 | |
| US64111967A | 1967-05-25 | 1967-05-25 | |
| US65930867A | 1967-08-09 | 1967-08-09 | |
| US68493667A | 1967-11-22 | 1967-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL29066A true IL29066A (en) | 1972-11-28 |
Family
ID=27505067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL2906667A IL29066A (en) | 1966-12-23 | 1967-12-05 | Pharmaceutical preparations containing multi-chain poly-nucleotides to encourage interferon production in humans, animals or cell cultures |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE708470A (de) |
| DE (1) | DE1617659C3 (de) |
| FR (2) | FR1605535A (de) |
| GB (1) | GB1187830A (de) |
| IE (1) | IE31924B1 (de) |
| IL (1) | IL29066A (de) |
| NL (1) | NL159282B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2092875A1 (en) * | 1970-06-26 | 1972-01-28 | Maes Roland | Interferon stimulants - dialkylaminoalkyl dextran-nucleic acid comple |
| EP0063657A1 (de) * | 1981-04-29 | 1982-11-03 | Merck & Co. Inc. | Topische Anwendung von Interferon-Induktoren |
| GB2216416B (en) * | 1988-03-11 | 1992-06-24 | Sandoz Ltd | Nucleobase source for the stimulation of the immune system |
| US5624912A (en) * | 1991-08-21 | 1997-04-29 | Burcoglu; Arsinur | Method of treating HIV infection and related secondary infections with defibrotide |
| AU692433B2 (en) * | 1993-01-13 | 1998-06-11 | Arsinur Burcoglu | Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1046770A (en) * | 1963-05-14 | 1966-10-26 | James Harrison Stanton | Therapeutic composition containing mycelial matter |
-
1967
- 1967-12-05 IL IL2906667A patent/IL29066A/en unknown
- 1967-12-05 IE IE147367A patent/IE31924B1/xx unknown
- 1967-12-15 GB GB5707967A patent/GB1187830A/en not_active Expired
- 1967-12-21 DE DE19671617659 patent/DE1617659C3/de not_active Expired
- 1967-12-22 NL NL6717585A patent/NL159282B/xx not_active IP Right Cessation
- 1967-12-22 FR FR133660A patent/FR1605535A/fr not_active Expired
- 1967-12-22 BE BE708470D patent/BE708470A/xx unknown
-
1968
- 1968-03-22 FR FR144921A patent/FR8373M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE31924B1 (en) | 1973-02-21 |
| FR8373M (de) | 1971-02-22 |
| NL6717585A (de) | 1968-06-24 |
| DE1617659A1 (de) | 1971-04-01 |
| NL159282B (nl) | 1979-02-15 |
| IE31924L (en) | 1968-06-23 |
| FR1605535A (en) | 1979-02-23 |
| BE708470A (de) | 1968-06-24 |
| GB1187830A (en) | 1970-04-15 |
| DE1617659B2 (de) | 1981-05-21 |
| DE1617659C3 (de) | 1982-01-21 |
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