IL295626A - A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor - Google Patents

A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor

Info

Publication number: IL295626A
Authority: IL; Israel
Prior art keywords: braf; dabrafenib; compound; seq; pharmaceutic
Prior art date: 2020-02-28

Application number

IL295626A

Other languages

English (en)

Hebrew (he)

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-02-28

Filing date

2021-02-26

Publication date

2022-10-01

2021-02-26 Application filed by Novartis Ag filed Critical Novartis Ag

2022-10-01 Publication of IL295626A publication Critical patent/IL295626A/en

Links

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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL295626A 2020-02-28 2021-02-26 A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor IL295626A (en)

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US202062983020P	2020-02-28	2020-02-28
PCT/IB2021/051641 WO2021171260A2 (en)	2020-02-28	2021-02-26	A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor or a pd-1 inhibitor

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IL295626A true IL295626A (en)	2022-10-01

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EP (1)	EP4110341A2 (de)
JP (1)	JP2023516155A (de)
KR (1)	KR20220148846A (de)
CN (1)	CN115279374A (de)
AU (1)	AU2021225491A1 (de)
CA (1)	CA3173356A1 (de)
IL (1)	IL295626A (de)
TW (1)	TW202146024A (de)
WO (1)	WO2021171260A2 (de)

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2021
- 2021-02-26 EP EP21739775.1A patent/EP4110341A2/de not_active Withdrawn
- 2021-02-26 WO PCT/IB2021/051641 patent/WO2021171260A2/en not_active Ceased
- 2021-02-26 JP JP2022551299A patent/JP2023516155A/ja active Pending
- 2021-02-26 CN CN202180017128.7A patent/CN115279374A/zh active Pending
- 2021-02-26 IL IL295626A patent/IL295626A/en unknown
- 2021-02-26 KR KR1020227032733A patent/KR20220148846A/ko not_active Withdrawn
- 2021-02-26 CA CA3173356A patent/CA3173356A1/en active Pending
- 2021-02-26 TW TW110107183A patent/TW202146024A/zh unknown
- 2021-02-26 AU AU2021225491A patent/AU2021225491A1/en not_active Abandoned

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Publication number	Publication date
CA3173356A1 (en)	2021-09-02
KR20220148846A (ko)	2022-11-07
JP2023516155A (ja)	2023-04-18
WO2021171260A3 (en)	2021-10-07
CN115279374A (zh)	2022-11-01
WO2021171260A2 (en)	2021-09-02
EP4110341A2 (de)	2023-01-04
AU2021225491A1 (en)	2022-10-20
TW202146024A (zh)	2021-12-16

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