IL29814A - History of benzophenone oaks and process for their production - Google Patents

History of benzophenone oaks and process for their production

Info

Publication number: IL29814A
Authority: IL; Israel
Prior art keywords: oxime; general formula; treated; prepared according; manufacture
Prior art date: 1963-11-27

Application number

IL29814A

Other languages

English (en)

Hebrew (he)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1963-11-27

Filing date

1964-11-13

Publication date

1968-12-26

1964-11-13 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1968-12-26 Publication of IL29814A publication Critical patent/IL29814A/en

Links

238000000034 method Methods 0.000 title claims description 12
238000004519 manufacturing process Methods 0.000 title description 2
DNYZBFWKVMKMRM-UHFFFAOYSA-N n-benzhydrylidenehydroxylamine Chemical class C=1C=CC=CC=1C(=NO)C1=CC=CC=C1 DNYZBFWKVMKMRM-UHFFFAOYSA-N 0.000 title 1
150000002923 oximes Chemical class 0.000 claims description 11
FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 claims description 8
229960001413 acetanilide Drugs 0.000 claims description 4
229910052739 hydrogen Inorganic materials 0.000 claims description 4
239000001257 hydrogen Substances 0.000 claims description 4
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims description 2
239000000126 substance Substances 0.000 claims 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
150000001266 acyl halides Chemical class 0.000 claims 1
239000000460 chlorine Substances 0.000 claims 1
229910052801 chlorine Inorganic materials 0.000 claims 1
150000004820 halides Chemical class 0.000 claims 1
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 8
229910052708 sodium Inorganic materials 0.000 description 8
239000011734 sodium Substances 0.000 description 8
239000002904 solvent Substances 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
238000002844 melting Methods 0.000 description 5
230000008018 melting Effects 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000000203 mixture Substances 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
VGCXGMAHQTYDJK-UHFFFAOYSA-N Chloroacetyl chloride Chemical compound ClCC(Cl)=O VGCXGMAHQTYDJK-UHFFFAOYSA-N 0.000 description 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 2
FBCCMZVIWNDFMO-UHFFFAOYSA-N dichloroacetyl chloride Chemical compound ClC(Cl)C(Cl)=O FBCCMZVIWNDFMO-UHFFFAOYSA-N 0.000 description 2
229910052731 fluorine Inorganic materials 0.000 description 2
239000011737 fluorine Substances 0.000 description 2
239000010410 layer Substances 0.000 description 2
VZGCWPMHKLHOAG-UHFFFAOYSA-N n-[(2-chlorophenyl)-phenylmethylidene]hydroxylamine Chemical compound C=1C=CC=C(Cl)C=1C(=NO)C1=CC=CC=C1 VZGCWPMHKLHOAG-UHFFFAOYSA-N 0.000 description 2
239000012044 organic layer Substances 0.000 description 2
239000012258 stirred mixture Substances 0.000 description 2
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
239000012346 acetyl chloride Substances 0.000 description 1
125000002252 acyl group Chemical group 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
-1 dichloroacetyl Chemical group 0.000 description 1
238000001035 drying Methods 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical group 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
- C07D239/76—N-oxides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL29814A 1963-11-27 1964-11-13 History of benzophenone oaks and process for their production IL29814A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US326372A US3321467A (en)	1963-11-27	1963-11-27	3-halo-1, 4-benzodiazepin-2-ones
US369020A US3297698A (en)	1963-11-27	1964-05-20	Process for the preparation of quinazoline 3-oxides

Publications (1)

Publication Number	Publication Date
IL29814A true IL29814A (en)	1968-12-26

Family

ID=26985379

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
IL29814A IL29814A (en)	1963-11-27	1964-11-13	History of benzophenone oaks and process for their production
IL29815A IL29815A (en)	1963-11-27	1964-11-13	Quinazoline derivatives and process for the manufacture thereof
IL22440A IL22440A (en)	1963-11-27	1964-11-13	Benzodiazepine derivatives and process for the manufacture thereof
IL22464A IL22464A (en)	1963-11-27	1964-11-17	Manufacture of quinazoline derivatives
IL29815A IL29815A0 (en)	1963-11-27	1968-04-12	Quinazoline derivatives and process for the manufacture thereof
IL29814A IL29814A0 (en)	1963-11-27	1968-04-12	Benzophenone derivatives and process for the manufacture thereof

Family Applications After (5)

Application Number	Title	Priority Date	Filing Date
IL29815A IL29815A (en)	1963-11-27	1964-11-13	Quinazoline derivatives and process for the manufacture thereof
IL22440A IL22440A (en)	1963-11-27	1964-11-13	Benzodiazepine derivatives and process for the manufacture thereof
IL22464A IL22464A (en)	1963-11-27	1964-11-17	Manufacture of quinazoline derivatives
IL29815A IL29815A0 (en)	1963-11-27	1968-04-12	Quinazoline derivatives and process for the manufacture thereof
IL29814A IL29814A0 (en)	1963-11-27	1968-04-12	Benzophenone derivatives and process for the manufacture thereof

Country Status (12)

Country	Link
US (2)	US3321467A (de)
BE (2)	BE656226A (de)
BR (2)	BR6464383D0 (de)
CH (2)	CH443318A (de)
DE (2)	DE1445913A1 (de)
DK (3)	DK107031C (de)
ES (1)	ES306429A1 (de)
FR (2)	FR1453248A (de)
GB (4)	GB1081948A (de)
IL (6)	IL29814A (de)
NL (2)	NL6413591A (de)
SE (4)	SE316778B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL23270A (en) *	1964-04-10	1969-02-27	Hoffmann La Roche	Quinazoline derivatives and process for the manufacture and conversion thereof
NL131198C (de) *	1966-01-19
US4182760A (en) *	1977-06-16	1980-01-08	E. I. Du Pont De Nemours And Company	Benzophenone anti-oximes, diazepin-N-oxides, and their use as pharmaceutical agents and as intermediates for pharmaceutical agents
US4244730A (en) *	1979-07-02	1981-01-13	Chevron Research Company	Herbicidal N-haloacetyl-2-alkyl-6-acylanilines
US4753943A (en) *	1981-09-29	1988-06-28	Chevron Research Company	Algicidal and fungicidal 2-haloalkyl-3-oxo-4-substituted quinazoline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3179656A (en) *		1965-04-20		Azepine x-oxidss
NL131733C (de) *	1961-06-20

1963
- 1963-11-27 US US326372A patent/US3321467A/en not_active Expired - Lifetime
1964
- 1964-05-20 US US369020A patent/US3297698A/en not_active Expired - Lifetime
- 1964-11-09 CH CH1445364A patent/CH443318A/de unknown
- 1964-11-12 DE DE19641445913 patent/DE1445913A1/de active Pending
- 1964-11-12 DE DE19641795469 patent/DE1795469A1/de active Pending
- 1964-11-13 IL IL29814A patent/IL29814A/en unknown
- 1964-11-13 CH CH1471864A patent/CH441335A/de unknown
- 1964-11-13 IL IL29815A patent/IL29815A/xx unknown
- 1964-11-13 IL IL22440A patent/IL22440A/xx unknown
- 1964-11-17 BR BR164383/64A patent/BR6464383D0/pt unknown
- 1964-11-17 IL IL22464A patent/IL22464A/xx unknown
- 1964-11-18 SE SE13907/64A patent/SE316778B/xx unknown
- 1964-11-18 SE SE03339/69A patent/SE352634B/xx unknown
- 1964-11-23 NL NL6413591A patent/NL6413591A/xx unknown
- 1964-11-23 SE SE14111/64A patent/SE308317B/xx unknown
- 1964-11-24 FR FR996031A patent/FR1453248A/fr not_active Expired
- 1964-11-25 BR BR164771/64A patent/BR6464771D0/pt unknown
- 1964-11-25 GB GB26008/66A patent/GB1081948A/en not_active Expired
- 1964-11-25 GB GB47914/64A patent/GB1081945A/en not_active Expired
- 1964-11-25 GB GB47913/64A patent/GB1081944A/en not_active Expired
- 1964-11-25 FR FR996172A patent/FR1415205A/fr not_active Expired
- 1964-11-25 BE BE656226D patent/BE656226A/xx unknown
- 1964-11-25 GB GB26007/66A patent/GB1081947A/en not_active Expired
- 1964-11-26 DK DK583464AA patent/DK107031C/da active
- 1964-11-26 BE BE656251D patent/BE656251A/xx unknown
- 1964-11-26 ES ES0306429A patent/ES306429A1/es not_active Expired
- 1964-11-26 NL NL6413744A patent/NL6413744A/xx unknown
- 1964-11-26 DK DK583364AA patent/DK119010B/da unknown
1967
- 1967-06-29 SE SE9683/67A patent/SE322783B/xx unknown
1968
- 1968-04-12 IL IL29815A patent/IL29815A0/xx unknown
- 1968-04-12 IL IL29814A patent/IL29814A0/xx unknown
1969
- 1969-02-14 DK DK81369AA patent/DK122960B/da unknown

Also Published As

Publication number	Publication date
DK122960B (da)	1972-05-01
SE352634B (de)	1973-01-08
IL22464A (en)	1968-04-25
IL29815A (en)	1969-06-25
US3297698A (en)	1967-01-10
ES306429A1 (es)	1965-05-01
CH441335A (de)	1967-08-15
IL29815A0 (en)	1968-06-20
BE656251A (de)	1965-05-26
SE316778B (de)	1969-11-03
SE308317B (de)	1969-02-10
DK119010B (da)	1970-11-02
FR1453248A (fr)	1966-06-03
IL22440A (en)	1968-12-26
IL29814A0 (en)	1968-06-20
BR6464771D0 (pt)	1973-08-02
GB1081947A (en)	1967-09-06
SE322783B (de)	1970-04-20
CH443318A (de)	1967-09-15
DK107031C (da)	1967-04-17
GB1081948A (en)	1967-09-06
BE656226A (de)	1965-05-25
NL6413591A (de)	1965-05-28
GB1081945A (en)	1967-09-06
BR6464383D0 (pt)	1973-07-26
NL6413744A (de)	1965-05-28
FR1415205A (fr)	1965-10-22
DE1445913A1 (de)	1969-01-30
GB1081944A (en)	1967-09-06
DE1795469A1 (de)	1972-01-20
US3321467A (en)	1967-05-23

Publication	Publication Date	Title
US3577441A (en)	1971-05-04	Nitro substituted benzofurans
US3168532A (en)	1965-02-02	1, 5-diarylpyrrole-2-propionic acid compounds
US2816125A (en)	1957-12-10	Esters of methane sulfonic acid
US3038930A (en)	1962-06-12	1, 2, 3, 4, 4a, 9, 10, 10a-octahydro-7-hydroxy-6-methoxy-1, 4a-dimethyl-phenanthrene-1-(carboxylic acid/methanol)and corresponding esters
US3539550A (en)	1970-11-10	Process for the preparation of 2'-halo-2'-deoxy pyrimidine nucleosides
US2852531A (en)	1958-09-16	Tris-(2-tetrahydropyranyl) esters of 6, 8-bis (hydrocarbonmercapto)-4, 4-dicarboxy-5-ocaprylic acid and preparation thereof
US2394583A (en)	1946-02-12	Thiocyano aliphatic acid esters of endoethylene-hydroxycyclopentanoindane
US2646434A (en)	1953-07-21	Method of preparing delta4-pregnenes
Shapira et al.	1953	Sodium Hydride as a Condensing Agent with Acylaminomalonates in the Synthesis of Amino Acids1, 2
US3382251A (en)	1968-05-07	Benzylidenic derivatives of substituted gamma-lactones and their process of preparation
US2944071A (en)	1960-07-05	Acyl hydrazines
US2534112A (en)	1950-12-12	Certain thio derivatives of alpha alkylidene cyanoacetic esters
US2596631A (en)	1952-05-13	Acylated amino acid silver salts
US2721200A (en)	1955-10-18	Sulfisoxazole compounds
US2759976A (en)	1956-08-21	Aminoaceto-mercaptophenones
US2678321A (en)	1954-05-11	Dialkylaminoalkyl amides of alpha, alpha-diaryltoluic acids and their salts
US3102133A (en)	1963-08-27	1-[5-(6-methoxy-2-naphthyl)-2-oxycyclopentyl]-2-propanone derivatives
US2806028A (en)	1957-09-10	3, 12-dioxygenated 12a-aza-c-homospirostans
US4038284A (en)	1977-07-26	N-acylation of oxazolidines
US2153591A (en)	1939-04-11	Process for the production of salts of beta-methylcholine and acyl derivatives thereof
US3092657A (en)	1963-06-04	Vitamin a ester
US2744912A (en)	1956-05-08	4-o. o-diphenylphosphonylamino-antipyrin and process for its production
US2821540A (en)	1958-01-28	Preparation of hindered 4-acylamido-benzoates
US3145229A (en)	1964-08-18	Process for the production of nu-substituted-1-phenylcyclohexylamines
US3153062A (en)	1964-10-13	13alpha-androst-5-ene-3beta, 17alpha-diol and esters thereof