IL300830B2 - An implantable object and a method of preparing it - Google Patents

An implantable object and a method of preparing it

Info

Publication number
IL300830B2
IL300830B2 IL300830A IL30083023A IL300830B2 IL 300830 B2 IL300830 B2 IL 300830B2 IL 300830 A IL300830 A IL 300830A IL 30083023 A IL30083023 A IL 30083023A IL 300830 B2 IL300830 B2 IL 300830B2
Authority
IL
Israel
Prior art keywords
whole blood
mixture
implantable
coagulation
implantable object
Prior art date
Application number
IL300830A
Other languages
Hebrew (he)
Other versions
IL300830A (en
IL300830B1 (en
Original Assignee
Reddress Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddress Ltd filed Critical Reddress Ltd
Priority to IL300830A priority Critical patent/IL300830B2/en
Publication of IL300830A publication Critical patent/IL300830A/en
Priority to PCT/IL2023/050931 priority patent/WO2024176214A1/en
Priority to EP23768373.5A priority patent/EP4669373A1/en
Publication of IL300830B1 publication Critical patent/IL300830B1/en
Publication of IL300830B2 publication Critical patent/IL300830B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/884—Constructional details other than related to driving of implantable pumps or pumping devices being associated to additional implantable blood treating devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Prostheses (AREA)
  • Manipulator (AREA)
  • Materials For Medical Uses (AREA)

Description

AN IMPLANTABLE OBJECT AND A METHOD OF PREPARING IT TECHNOLOGICAL FIELD The present disclosure is in the medical field, in particular in the field of implantable objects intended to implanted in a patient by a medical procedure.
BACKGROUND ART References considered to be relevant as background to the presently disclosed subject matter are listed below: - US 9,180,1 Acknowledgement of the above references herein is not to be inferred as meaning that these are in any way relevant to the patentability of the presently disclosed subject matter.
GENERAL DESCRIPTION The present disclosure provides an implantable object and a method of preparing it. The implantable object may be any object or device that is intended to be implanted in a medical procedure to a patient. The implantable device is coated, at least partially, with coagulated whole blood, typically autologous whole blood that is withdrawn from the subject prior to the procedure. The coating of coagulated whole blood aims to improve the reception of the implantable object in the body of the patient, induce recovery in the area of the implantation and prevent infection reaction. Therefore, an aspect of the present disclosure provides a method for preparing an implantable object intended to be implanted in a subject. The method comprising contacting at least a portion of said implantable object with a mixture of whole blood and at least one coagulation initiator, prior to complete coagulation of said mixture. Namely, a portion of the implantable object contacts the whole blood when it is still in a flowable non-coagulated state to allow the blood to adhere to the portion of the implantable object. Then, the method further comprises allowing said mixture to coagulate on said portion.
It is to be noted that any combination of the described embodiments with respect to any aspect of this present disclosure is applicable. In other words, any aspect of the present disclosure can be defined by any combination of the described embodiments. In some embodiments of the method, said whole blood is autologous blood of the subject. In some embodiments, the method further comprising impregnating or immersing the implantable object within said mixture. In some embodiments the implantable object is fully immersed in the whole blood, and in other embodiments the implantable object is only partially immersed in the whole blood such that only a portion thereof contact the whole blood. In some embodiments of the method, said implantable object comprises pores and said contacting comprises introducing said mixture into said pores. In some embodiments of the method, the implantable object comprises a fabric portion, and said contacting comprises contacting the mixture with said fabric portion. In some embodiments of the method, said implantable object is a surgical mesh. The surgical mesh may be any kind known in the art that may be made of organic materials, biological material, inorganic materials, or any combination thereof. In some embodiments of the method, said implantable object is a cardiac implantable device. In some embodiments of the method, said cardiac implantable device is a pacemaker. In some embodiments, the method further comprising, prior to said contacting, adding one or more antibiotic agents with said mixture. In some embodiments of the method, said contacting comprises introducing said implantable object into a receiving space of a receptacle device and filling said coagulation mold with said mixture. It is to be noted that the introduction of the implantable object and the filling of the mixture can be in any order, namely the steps order is interchangeable. In some embodiments of the method, said receiving volume is defined by a contour of the receptacle device conforming with a contour, typically the external contour, of said implantable object. Typically, the implantable object is fitted into the receiving volume leaving a small gap between its external contour and the walls of the coagulation mold for allowing the filling of the mixture in said gap.
In some embodiments of the method, said at least one coagulation initiator is selected from any one of: Kaolin, Ca2+, Mg2+, negatively charged phospholipid (PL) and protamine sulfate, or any combination thereof. In some embodiments, the method further comprising, prior to said contacting, withdrawing whole blood from the subject and mixing it with at least one coagulation initiator. In some embodiments of the method, following said withdrawing, the method further comprising mixing the whole blood with one or more anti-coagulation agents. In some embodiments of the method, said one or more anti-coagulation agents are selected from a group consisting of: ACD-A (Anticoagulant Citrate Dextrose, Solution A), EDTA (ethylenediaminetetraacetic Acid), EGTA (ethylene glycol tetraacetic acid), a citrate, Heparin and oxalate. In some embodiments, the method further comprises roughening said portion of the implantable device to increase a surface roughness index of said portion to improve the adherence of the whole blood to said portion. In some embodiments, the method further comprises perforating said portion of the implantable device to increase a surface roughness index of said portion to improve the adherence of the whole blood to said portion. Yet another aspect of the present disclosure provides a method for implanting an implantable object in a subject. The method comprising (i) performing the method of any one of the above-described embodiments, or any combination thereof; and (ii) implanting said object in the subject. Yet another aspect of the present disclosure provides a kit for preparing an implantable object prior to implantation in a subject. The kit comprising: (i) one or more blood withdrawal devices for allowing withdrawal of blood from the subject; (ii) at least one coagulation initiator for mixing with the withdrawn whole blood for obtaining a mixture of whole blood and at least one coagulation initiator; and (iii) a receptacle device comprises a receiving volume for receiving said object and permitting a contact of said object with said mixture. In some embodiments of the kit, the receiving volume is defined by a contour of the receptacle device conforming with a contour of said implantable object. Typically, the implantable object is fitted into the receiving volume leaving a small gap between its external contour and the walls of the coagulation mold for allowing the filling of the mixture in said gap. In some embodiments, the kit further comprises one or more anti-coagulation agents. In some embodiments of the kit, said more anti-coagulation agents are selected from a group consisting of: ACD-A (Anticoagulant Citrate Dextrose, Solution A), EDTA (ethylenediaminetetraacetic Acid), EGTA (ethylene glycol tetraacetic acid), a citrate, Heparin and oxalate. In some embodiments, the kit is intended for use in a method according to any one of the above-described embodiments, or any combination thereof. Yet another aspect of the present disclosure provides an implantable object intended to be implanted in a subject, wherein said implantable object comprises at least a portion coated with coagulated whole blood. In some embodiments of the implantable object, said whole blood is autologous blood of the subject. In some embodiments of the implantable object, a vast majority or the entire external surface of the implantable object is coated with said whole blood. In some embodiments of the implantable object, said whole blood comprises antibiotic agents. In some embodiments, the implantable object is being prepared for implantation according to the method of any one of the above-described embodiments, or any combination thereof.
BRIEF DESCRIPTION OF THE DRAWINGS In order to better understand the subject matter that is disclosed herein and to exemplify how it may be carried out in practice, embodiments will now be described, by way of non-limiting example only, with reference to the accompanying drawings, in which: Figs. 1A-1B are flow diagrams exemplifying different embodiments of the method for preparing an implantable device according to an aspect of the present disclosure.
DETAILED DESCRIPTION The following figures are provided to exemplify embodiments and realization of the invention of the present disclosure. Figs. 1A-1B are non-limiting examples of flow diagrams of different embodiments of a method for preparing an implantable device according to an aspect of the present disclosure. Fig. 1Aexemplifies a method that comprises withdrawing whole blood form the subject 100and contacting an implantable object with the whole blood 102 . Following the contact of the implantable object and the whole blood, the whole blood is allowed to be coagulated on the implantable object 104 . The coagulation of the blood can be initiated, e.g. by mixing the whole blood with one or more coagulation initiators, prior to the contact of the implantable object with the whole blood, requiring that the contact is made not long after the coagulation initiation. Alternatively, the initiation of the coagulation can be made while the implantable object contact the whole blood. Fig. 1Bexemplifies a method that comprises withdrawing whole blood form the subject 110 . The method further comprises placing an implantable object in a receptacle device 112that is shaped and sized to receive the implantable object while leaving space for filling blood such that it contacts all the portions that are desired to be coated with coagulated whole blood. The whole blood is mixed with one or more coagulation initiators 114and optionally with one or more antibiotic agents (namely, the antibiotic agents are not mandatory) to obtain a coagulation mixture. The method further comprises filling the receptacle device with the coagulation mixture 116 to allow contact of the mixture with portions or the entire external surface of the implantable device 116 and allowing the whole blood to coagulate on the implantable object 118 . It is to be noted that the method steps 110 , 112 , 114 , 116 , are interchangeable, namely the order of their appearance in the description is not binding and they can be performed in various different orders.

Claims (18)

- 6 - CLAIMS:
1. A method for preparing an implantable object intended to be implanted in a subject, comprising: contacting at least a portion of said implantable object with a mixture of whole blood and at least one coagulation initiator, prior to complete coagulation of said mixture, said contacting being carried out in a receiving volume of a receptacle device; and allowing said mixture to coagulate on said portion; wherein said whole blood is autologous blood of the subject.
2. The method of claim 1, wherein said contacting comprises impregnating or immersing the implantable object within said mixture.
3. The method of claim 1 or 2, wherein said implantable object comprises pores and said contacting comprises introducing said mixture into said pores.
4. The method of any one of claims 1-3, wherein the implantable object comprises a fabric portion, and said contacting comprises contacting the mixture with said fabric portion.
5. The method of any one of claims 1-4, wherein said implantable object is a surgical mesh.
6. The method of any one of claims 1-4, wherein said implantable object is a cardiac implantable device.
7. The method of claim 6, wherein said cardiac implantable device is a pacemaker.
8. The method of any one of claims 1-7, comprising, prior to said contacting, adding one or more antibiotic agents with said mixture.
9. The method of any one of claims 1-8, wherein said receiving volume is defined by a contour of the receptacle device conforming with a contour of said portion.
10. The method of any one of claims 1-9, wherein said at least one coagulation initiator is selected from any one of: Kaolin, Ca2+, Mg2+, negatively charged phospholipid (PL) and protamine sulfate, or any combination thereof.
11. The method of any one of claims 1-10, wherein the whole blood is autologous whole blood withdrawn from the subject.
12. The method of claim 11, wherein the withdrawn whole blood is mixed with one or more anti-coagulation agents. - 7 -
13. The method of claim 12, wherein said one or more anti-coagulation agents are selected from a group consisting of: ACD-A (Anticoagulant Citrate Dextrose, Solution A), EDTA (ethylenediaminetetraacetic Acid), EGTA (ethylene glycol tetraacetic acid), a citrate, Heparin and oxalate.
14. A kit for preparing an implantable object prior to implantation in a subject, comprising: one or more blood withdrawal devices for withdrawal of whole blood from the subject; at least one coagulation initiator for mixing with the withdrawn whole blood for obtaining a mixture of whole blood and at least one coagulation initiator; and a receptacle device comprises a receiving volume for receiving said object and permitting contact of said object with said mixture.
15. The kit of claim 14, wherein said receiving volume is defined by a contour of the receptacle device conforming with a contour of said implantable object.
16. The kit of claim 14 or 15, comprising one or more anti-coagulation agents.
17. The kit of claim 16, wherein said more anti-coagulation agents are selected from a group consisting of: ACD-A (Anticoagulant Citrate Dextrose, Solution A), EDTA (ethylenediaminetetraacetic Acid), EGTA (ethylene glycol tetraacetic acid), a citrate, Heparin and oxalate.
18. The kit of any one of claims 15-18, for use in a method of any one of claims 1-14.
IL300830A 2023-02-21 2023-02-21 An implantable object and a method of preparing it IL300830B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL300830A IL300830B2 (en) 2023-02-21 2023-02-21 An implantable object and a method of preparing it
PCT/IL2023/050931 WO2024176214A1 (en) 2023-02-21 2023-08-31 An implantable object and a method of preparing it
EP23768373.5A EP4669373A1 (en) 2023-02-21 2023-08-31 IMPLANTABLE OBJECT AND METHOD FOR ITS MANUFACTURE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL300830A IL300830B2 (en) 2023-02-21 2023-02-21 An implantable object and a method of preparing it

Publications (3)

Publication Number Publication Date
IL300830A IL300830A (en) 2023-03-01
IL300830B1 IL300830B1 (en) 2024-04-01
IL300830B2 true IL300830B2 (en) 2024-08-01

Family

ID=88016211

Family Applications (1)

Application Number Title Priority Date Filing Date
IL300830A IL300830B2 (en) 2023-02-21 2023-02-21 An implantable object and a method of preparing it

Country Status (3)

Country Link
EP (1) EP4669373A1 (en)
IL (1) IL300830B2 (en)
WO (1) WO2024176214A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330891A (en) * 1979-03-07 1982-05-25 Branemark Per Ingvar Element for implantation in body tissue, particularly bone tissue
US20070037737A1 (en) * 2000-06-29 2007-02-15 Hoemann Caroline D Composition and method for the repair and regeneration of cartilage and other tissues
US8980302B2 (en) * 2010-03-24 2015-03-17 Covidien Lp Therapeutic implant
CN108478864A (en) * 2017-08-07 2018-09-04 上海交通大学医学院附属第九人民医院 Composite fibrous scaffold
WO2022168099A1 (en) * 2021-02-08 2022-08-11 Reddress Ltd. Method and kit for treating abnormal hollowed space

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5480416A (en) * 1994-09-22 1996-01-02 Intermedics, Inc. Cardiac pacemaker with universal coating
EP2331158B1 (en) * 2008-09-22 2013-09-11 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
DK2381969T3 (en) 2009-01-27 2016-09-05 Reddress Ltd METHODS OF MAKING wound dressings AND A BANK wound dressings
IL281044B (en) 2021-02-23 2022-04-01 Reddress Ltd Method and kit for treating an injured nerve
IL286333B2 (en) 2021-09-13 2023-04-01 Reddress Ltd Device and method for vaginal tissue treatment
IL289281B2 (en) 2021-12-22 2023-06-01 Reddress Ltd Method and kit for treating a damaged connective tissue

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330891A (en) * 1979-03-07 1982-05-25 Branemark Per Ingvar Element for implantation in body tissue, particularly bone tissue
US20070037737A1 (en) * 2000-06-29 2007-02-15 Hoemann Caroline D Composition and method for the repair and regeneration of cartilage and other tissues
US8980302B2 (en) * 2010-03-24 2015-03-17 Covidien Lp Therapeutic implant
CN108478864A (en) * 2017-08-07 2018-09-04 上海交通大学医学院附属第九人民医院 Composite fibrous scaffold
WO2022168099A1 (en) * 2021-02-08 2022-08-11 Reddress Ltd. Method and kit for treating abnormal hollowed space

Also Published As

Publication number Publication date
WO2024176214A1 (en) 2024-08-29
IL300830A (en) 2023-03-01
EP4669373A1 (en) 2025-12-31
IL300830B1 (en) 2024-04-01

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