IL314136A - Imidazole macrocycles for the treatment of autoimmune diseases - Google Patents

Imidazole macrocycles for the treatment of autoimmune diseases

Info

Publication number
IL314136A
IL314136A IL314136A IL31413624A IL314136A IL 314136 A IL314136 A IL 314136A IL 314136 A IL314136 A IL 314136A IL 31413624 A IL31413624 A IL 31413624A IL 314136 A IL314136 A IL 314136A
Authority
IL
Israel
Prior art keywords
macrocycles
imidazole
treatment
autoimmune diseases
autoimmune
Prior art date
Application number
IL314136A
Other languages
Hebrew (he)
Inventor
Shuai Chen
Wolfgang Guba
Xingchun Han
Min Jiang
Buyu Kou
Zhaohu Lin
Haixia Liu
Yafei Liu
Hong Shen
Yao Wu
Weixing Zhang
Wei Zhu
Zhiwei Zhang
Jiansheng Zhu
Zhang Zhenhong
Chen Jianguo
Original Assignee
Hoffmann La Roche
Shuai Chen
Wolfgang Guba
Xingchun Han
Min Jiang
Buyu Kou
Zhaohu Lin
Haixia Liu
Yafei Liu
Hong Shen
Yao Wu
Weixing Zhang
Wei Zhu
Zhiwei Zhang
Jiansheng Zhu
Zhang Zhenhong
Chen Jianguo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Shuai Chen, Wolfgang Guba, Xingchun Han, Min Jiang, Buyu Kou, Zhaohu Lin, Haixia Liu, Yafei Liu, Hong Shen, Yao Wu, Weixing Zhang, Wei Zhu, Zhiwei Zhang, Jiansheng Zhu, Zhang Zhenhong, Chen Jianguo filed Critical Hoffmann La Roche
Publication of IL314136A publication Critical patent/IL314136A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • C07D491/056Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL314136A 2022-02-02 2023-01-31 Imidazole macrocycles for the treatment of autoimmune diseases IL314136A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2022075304 2022-02-02
CN2022137604 2022-12-08
PCT/EP2023/052218 WO2023148129A1 (en) 2022-02-02 2023-01-31 Imidazole macrocycles for the treatment of autoimmune disease

Publications (1)

Publication Number Publication Date
IL314136A true IL314136A (en) 2024-09-01

Family

ID=85175764

Family Applications (1)

Application Number Title Priority Date Filing Date
IL314136A IL314136A (en) 2022-02-02 2023-01-31 Imidazole macrocycles for the treatment of autoimmune diseases

Country Status (15)

Country Link
EP (1) EP4472739A1 (en)
JP (1) JP2025506393A (en)
KR (1) KR20240145483A (en)
CN (1) CN120641428A (en)
AR (1) AR128413A1 (en)
AU (1) AU2023215702A1 (en)
CA (1) CA3250448A1 (en)
CL (1) CL2024002334A1 (en)
CO (1) CO2024011088A2 (en)
CR (1) CR20240312A (en)
IL (1) IL314136A (en)
MX (1) MX2024009404A (en)
PE (1) PE20241762A1 (en)
TW (1) TW202342483A (en)
WO (1) WO2023148129A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR133199A1 (en) * 2023-07-10 2025-09-03 Hoffmann La Roche BICYCLIC MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASES
AR133266A1 (en) * 2023-07-19 2025-09-10 Hoffmann La Roche Macrocycles for the treatment of autoimmune diseases
CN121532398A (en) * 2023-07-21 2026-02-13 豪夫迈·罗氏有限公司 Macrocyclic steroids used to treat autoimmune diseases
AR133915A1 (en) 2023-09-26 2025-11-12 Hoffmann La Roche MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASES
US20250333398A1 (en) 2024-04-30 2025-10-30 Boehringer Ingelheim International Gmbh Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament
WO2025228902A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Heterocyclic acids as sting antagonists and the use thereof as medicament
WO2025228899A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Further heterocyclic compounds as sting antagonists and the use thereof as medicament
WO2025228900A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Arylamide substituted indazoles and the use thereof as medicament
WO2025228895A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament
WO2025228889A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Monoarylic heterocyclic compounds as sting antagonists and the use thereof as medicament

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20220936T1 (en) * 2016-04-07 2022-10-28 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
WO2019053617A1 (en) * 2017-09-12 2019-03-21 Glaxosmithkline Intellectual Property Development Limited Chemical compounds

Also Published As

Publication number Publication date
EP4472739A1 (en) 2024-12-11
MX2024009404A (en) 2024-08-14
TW202342483A (en) 2023-11-01
PE20241762A1 (en) 2024-08-28
CN120641428A (en) 2025-09-12
CR20240312A (en) 2024-09-04
WO2023148129A1 (en) 2023-08-10
KR20240145483A (en) 2024-10-07
JP2025506393A (en) 2025-03-11
AU2023215702A1 (en) 2024-07-25
AR128413A1 (en) 2024-05-08
CL2024002334A1 (en) 2025-01-17
CA3250448A1 (en) 2023-08-10
CO2024011088A2 (en) 2024-08-30

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