IL319424A - Compounds containing radionucleotides and their use for detecting cancer cells - Google Patents

Compounds containing radionucleotides and their use for detecting cancer cells

Info

Publication number
IL319424A
IL319424A IL319424A IL31942425A IL319424A IL 319424 A IL319424 A IL 319424A IL 319424 A IL319424 A IL 319424A IL 31942425 A IL31942425 A IL 31942425A IL 319424 A IL319424 A IL 319424A
Authority
IL
Israel
Prior art keywords
alkyl
independently
alkylaryl
alkylheteroaryl
aryl
Prior art date
Application number
IL319424A
Other languages
English (en)
Hebrew (he)
Inventor
Jacob Houghton
Vilma Jallinoja
Original Assignee
Univ New York State Res Found
Jacob Houghton
Vilma Jallinoja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Jacob Houghton, Vilma Jallinoja filed Critical Univ New York State Res Found
Publication of IL319424A publication Critical patent/IL319424A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0495—Pretargeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1268—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules host-guest, closed hollow molecules, inclusion complexes, e.g. with cyclodextrins, clathrates, cavitates, fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL319424A 2022-09-09 2023-09-08 Compounds containing radionucleotides and their use for detecting cancer cells IL319424A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263375159P 2022-09-09 2022-09-09
US202363481517P 2023-01-25 2023-01-25
PCT/US2023/073725 WO2024054972A2 (fr) 2022-09-09 2023-09-08 Composition radionucléidique et procédé d'utilisation associée pour la détection de cellules tumorales

Publications (1)

Publication Number Publication Date
IL319424A true IL319424A (en) 2025-05-01

Family

ID=90191967

Family Applications (1)

Application Number Title Priority Date Filing Date
IL319424A IL319424A (en) 2022-09-09 2023-09-08 Compounds containing radionucleotides and their use for detecting cancer cells

Country Status (8)

Country Link
EP (1) EP4583928A2 (fr)
JP (1) JP2025530298A (fr)
KR (1) KR20250065366A (fr)
CN (1) CN120129539A (fr)
AU (1) AU2023338487A1 (fr)
CA (1) CA3266257A1 (fr)
IL (1) IL319424A (fr)
WO (1) WO2024054972A2 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160331852A1 (en) * 2015-05-11 2016-11-17 Memorial Sloan Kettering Cancer Center Radioligands for pretargeted pet imaging and methods of their therapeutic use
WO2019195890A1 (fr) * 2018-04-11 2019-10-17 Clarity Pharmaceuticals Pty Ltd Formulations et kits pour radiothérapie et imagerie diagnostique

Also Published As

Publication number Publication date
WO2024054972A3 (fr) 2024-04-18
JP2025530298A (ja) 2025-09-11
WO2024054972A2 (fr) 2024-03-14
CN120129539A (zh) 2025-06-10
CA3266257A1 (fr) 2024-03-14
AU2023338487A1 (en) 2025-03-20
EP4583928A2 (fr) 2025-07-16
KR20250065366A (ko) 2025-05-12

Similar Documents

Publication Publication Date Title
CN111991570B (zh) 一种FAP-α特异性肿瘤诊断SPECT显像剂
CN111511408A (zh) 靶向成纤维细胞活化蛋白-α(FAP-α)的成像剂及放射治疗剂
IL227003A (en) 2her-binding peptides are radioactively labeled
JP7324763B2 (ja) 分子イメージングのための二重標識プローブ及びその使用
Boss et al. Comparative studies of three pairs of α-and γ-conjugated folic acid derivatives labeled with fluorine-18
US20250025582A1 (en) Ligands and their use
Zhou et al. Synthesis and preclinical evaluation of novel 18F-labeled fibroblast activation protein tracers for positron emission tomography imaging of cancer-associated fibroblasts
JP2020512348A (ja) 放射標識生体分子およびその使用
US9422286B2 (en) Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's disease
Wang et al. Synthesis of a new bifunctional NODA for bioconjugation with PSMA ligand and one-step Al18F labeling
Chaudhary et al. Design, development and bio-evaluation of a novel radio-ligand 99mTc-THQ-DTPA as a sigma 2 receptor specific breast tumor imaging agent
CN110172084A (zh) 68Ga标记NODAGA修饰c-Met分子探针及制备与应用
Yao et al. Synthesis, preclinical evaluation and pilot clinical study of a P2Y12 receptor targeting radiotracer [18F] QTFT for imaging brain disorders by visualizing anti-inflammatory microglia
IL319424A (en) Compounds containing radionucleotides and their use for detecting cancer cells
US20240285808A1 (en) Molecular probes for in vivo detection of aldehydes
Feng et al. Development of a novel 99mTc-labeled folate derivative containing phenyl isonitrile to target folate receptor with reduced renal uptake
IL280308B1 (en) Imaging agents for radiolabeling exogenous and endogenous albumin
Qiu et al. Rational modifications on N-(4-quinolinoyl)-Gly-2-cyanopyrrolidine to develop fibroblast activation protein-targeted radioligands with improved affinity and tumor uptake
JP2024519603A (ja) 神経内分泌セラノスティクスのための前駆体および放射性トレーサー
Zhang et al. Development of galectin-3 targeted radioimmunoligands for cancer theranostics
EP4667019A1 (fr) Produit radiopharmaceutique ciblant le psma, sa synthèse et son utilisation
WO2020045638A1 (fr) Composé dérivé d'imidazothiadiazole radioactif
WO2026055371A2 (fr) Composition à teneur en radionucléides et son procédé d'utilisation pour la détection de cellules tumorales
Deri Zirconium-89: Radiochemistry and ligand development toward improved PET applications
HK40094491A (zh) 靶向成纤维细胞活化蛋白α的化合物、药物组合物及用途