IL323883A - Crystalline lysine acetyltransferase 6a (kat6a) inhibitor and uses thereof - Google Patents

Crystalline lysine acetyltransferase 6a (kat6a) inhibitor and uses thereof

Info

Publication number
IL323883A
IL323883A IL323883A IL32388325A IL323883A IL 323883 A IL323883 A IL 323883A IL 323883 A IL323883 A IL 323883A IL 32388325 A IL32388325 A IL 32388325A IL 323883 A IL323883 A IL 323883A
Authority
IL
Israel
Prior art keywords
compound
xrpd
crystalline form
pattern
radiation
Prior art date
Application number
IL323883A
Other languages
English (en)
Hebrew (he)
Inventor
Yushu Yin
Xing Liang
Xin Cheng
Luoheng Qin
Original Assignee
Insilico Medicine Ip Ltd
Yushu Yin
Xing Liang
Xin Cheng
Luoheng Qin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insilico Medicine Ip Ltd, Yushu Yin, Xing Liang, Xin Cheng, Luoheng Qin filed Critical Insilico Medicine Ip Ltd
Publication of IL323883A publication Critical patent/IL323883A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL323883A 2023-04-25 2025-10-12 Crystalline lysine acetyltransferase 6a (kat6a) inhibitor and uses thereof IL323883A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2023090649 2023-04-25
PCT/CN2024/089494 WO2024222725A1 (fr) 2023-04-25 2024-04-24 Inhibiteur de lysine acétyltransférase 6a (kat6a) cristallin et ses utilisations

Publications (1)

Publication Number Publication Date
IL323883A true IL323883A (en) 2025-12-01

Family

ID=93255616

Family Applications (1)

Application Number Title Priority Date Filing Date
IL323883A IL323883A (en) 2023-04-25 2025-10-12 Crystalline lysine acetyltransferase 6a (kat6a) inhibitor and uses thereof

Country Status (7)

Country Link
EP (1) EP4702019A1 (fr)
KR (1) KR20260016479A (fr)
CN (1) CN121358730A (fr)
AU (1) AU2024262206A1 (fr)
IL (1) IL323883A (fr)
MX (1) MX2025012350A (fr)
WO (1) WO2024222725A1 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201810092D0 (en) * 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
CN114072394A (zh) * 2019-04-25 2022-02-18 拜耳股份公司 用于治疗癌症的酰基磺酰胺
PH12021553107A1 (en) * 2019-06-18 2022-08-01 Ctxt Pty Ltd Benzisoxazole sulfonamide derivatives
AU2020295006B2 (en) * 2019-06-19 2023-11-09 Ctxt Pty Ltd Cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives
WO2023088233A1 (fr) * 2021-11-16 2023-05-25 Insilico Medicine Ip Limited Inhibiteurs de la lysine acétyltransférase 6a (kat6a) et leurs utilisations

Also Published As

Publication number Publication date
EP4702019A1 (fr) 2026-03-04
AU2024262206A1 (en) 2025-12-04
WO2024222725A1 (fr) 2024-10-31
CN121358730A (zh) 2026-01-16
KR20260016479A (ko) 2026-02-03
MX2025012350A (es) 2025-12-01

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