IL324885A - Heterobicyclic amides as inhibitors of cd38 - Google Patents

Heterobicyclic amides as inhibitors of cd38

Info

Publication number
IL324885A
IL324885A IL324885A IL32488525A IL324885A IL 324885 A IL324885 A IL 324885A IL 324885 A IL324885 A IL 324885A IL 32488525 A IL32488525 A IL 32488525A IL 324885 A IL324885 A IL 324885A
Authority
IL
Israel
Prior art keywords
alkyl
carboxamide
imidazol
pyrimidine
cyclohexyl
Prior art date
Application number
IL324885A
Other languages
English (en)
Hebrew (he)
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IL324885A publication Critical patent/IL324885A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL324885A 2019-07-31 2020-07-30 Heterobicyclic amides as inhibitors of cd38 IL324885A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962880923P 2019-07-31 2019-07-31
US201962951604P 2019-12-20 2019-12-20
US202063034750P 2020-06-04 2020-06-04
PCT/US2020/044156 WO2021021986A1 (fr) 2019-07-31 2020-07-30 Amides hétérobicycliques servant d'inhibiteurs de cd38

Publications (1)

Publication Number Publication Date
IL324885A true IL324885A (en) 2026-01-01

Family

ID=72139677

Family Applications (2)

Application Number Title Priority Date Filing Date
IL324885A IL324885A (en) 2019-07-31 2020-07-30 Heterobicyclic amides as inhibitors of cd38
IL289878A IL289878B2 (en) 2019-07-31 2020-07-30 Heterobicyclic amides as inhibitors of CD38

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL289878A IL289878B2 (en) 2019-07-31 2020-07-30 Heterobicyclic amides as inhibitors of CD38

Country Status (12)

Country Link
US (4) US11535621B2 (fr)
EP (1) EP4003980A1 (fr)
JP (2) JP7721501B2 (fr)
KR (1) KR20220061958A (fr)
CN (2) CN119431323A (fr)
AU (1) AU2020321956A1 (fr)
BR (1) BR112022001291A2 (fr)
CA (1) CA3147902A1 (fr)
IL (2) IL324885A (fr)
MX (3) MX2022001019A (fr)
TW (2) TW202615430A (fr)
WO (1) WO2021021986A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11535621B2 (en) 2019-07-31 2022-12-27 Ribon Therapeutics, Inc. Heterobicyclic amides as inhibitors of CD38
US20230025807A1 (en) * 2019-10-30 2023-01-26 Mitobridge Inc. Cd38 inhibitors
IL301991A (en) * 2020-10-09 2023-06-01 Napa Therapeutics Ltd Heteroaryl amide inhibitors for CD38
AR124718A1 (es) 2021-01-29 2023-04-26 Ribon Therapeutics Inc Quinolinas y azaquinolinas como inhibidores de cd38
CN117715897A (zh) * 2021-04-30 2024-03-15 南京艾美斐生物医药科技有限公司 化合物及其作为cd38抑制剂的用途
US20230116972A1 (en) * 2021-07-12 2023-04-20 Cytokinetics, Inc. Cd38 modulators and methods of use thereof
CN116041344B (zh) * 2021-10-28 2026-07-24 北京望实智慧科技有限公司 双环杂芳基甲酰胺化合物作为sos1抑制剂
WO2023084206A1 (fr) 2021-11-09 2023-05-19 Cerevance Ltd Dérivés de n-(4-aminocyclohexyl)pyrimidine-4-carboxamide en tant qu'inhibiteurs de cd38
CN114306366B (zh) * 2021-11-30 2023-01-06 合肥康诺生物制药有限公司 含nad和cd38抑制剂的药物组合物及其用途
WO2023098699A1 (fr) * 2021-12-01 2023-06-08 Nanjing Immunophage Biotech Co., Ltd Composés et leurs utilisations en tant qu'inhibiteurs de cd38
GB202207721D0 (en) * 2022-05-25 2022-07-06 Cerevance Ltd Novel Compounds
EP4567035A4 (fr) * 2022-08-05 2026-07-08 Nextgen Bioscience Co Ltd Nouveau composé utilisé en tant qu'inhibiteur du facteur 1 inductible par l'hypoxie (hif-1) ou inhibiteur du facteur de croissance endothéliale vasculaire (vegf) et composition pharmaceutique le comprenant
CN115825297B (zh) * 2022-11-11 2025-03-28 武汉海特生物创新医药研究有限公司 一种(s)-3-氨基哌啶-2,6-二酮盐酸盐对映异构体的检测方法
EP4713323A1 (fr) * 2023-05-18 2026-03-25 Cerevance, Inc. Dérivés de 3-carbonyl imidazo[1,5-a]pyridine destinés à être utilisés en tant qu'inhibiteurs de cd38 pour le traitement de troubles du snc
GB202307426D0 (en) * 2023-05-18 2023-07-05 Cerevance Inc Novel compounds
EP4724430A1 (fr) * 2023-06-07 2026-04-15 Flagship Pioneering Innovations VI, LLC Azines condensées utilisées en tant qu'inhibiteurs de l'adp ribose hydrolase cyclique
WO2026000074A1 (fr) * 2024-06-25 2026-01-02 Welnx Company Inc. Utilisation d'inhibiteurs de cd38 pour réduire l'inflammation th2
WO2026075971A1 (fr) 2024-10-01 2026-04-09 Neolaia Inc. Polythérapie pour le traitement de troubles métaboliques et de troubles liés à l'inflammation au moyen de composés d'incrétine et d'inhibiteurs de cd38
WO2026090857A1 (fr) * 2024-10-29 2026-05-07 甫康（上海）健康科技有限责任公司 Composé d'aminoquinoline polysubstitué et son utilisation

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2474582C2 (ru) * 2006-10-19 2013-02-10 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Гетероарильные соединения, их композиции и их применение в качестве ингибиторов протеинкиназы
JP5794922B2 (ja) 2009-12-28 2015-10-14 一般社団法人ファルマバレープロジェクト支援機構 １，３，４−オキサジアゾール−２−カルボキサミド化合物
WO2012005805A1 (fr) 2010-05-07 2012-01-12 Glaxosmithkline Llc Aza-indazoles
EP2646020B1 (fr) * 2010-12-01 2016-09-21 Glaxosmithkline LLC Indoles
EP2651405A2 (fr) 2010-12-14 2013-10-23 Electrophoretics Limited Inhibiteurs de caséine kinase 1 (ck1 )
WO2012118812A2 (fr) 2011-02-28 2012-09-07 Epizyme, Inc. Composés hétéroaryles bicycliques substitués condensés en 6,5
US9073924B2 (en) 2011-09-13 2015-07-07 Glaxosmithkline Llc Azaindazoles
CN103998036B (zh) * 2011-10-19 2017-05-31 西格诺药品有限公司 利用tor激酶抑制剂治疗癌症
AU2012332297B2 (en) * 2011-11-04 2016-01-07 Glaxosmithkline Intellectual Property (No.2) Limited Method of treatment
WO2013067302A1 (fr) 2011-11-04 2013-05-10 Glaxosmithkline Intellectual Property (No. 2) Limited Méthode de traitement
CN104271159B (zh) * 2012-02-24 2017-11-28 西格诺药品有限公司 利用tor激酶抑制剂联合治疗来治疗非小细胞肺癌的方法
US20150164910A1 (en) 2012-06-15 2015-06-18 The Regents Of The University Of Califonia Antiviral compounds and methods of use
WO2014037340A1 (fr) 2012-09-05 2014-03-13 Bayer Cropscience Ag Utilisation de 2-amidobenzimidazoles, de 2-amidobenzoxazoles et de 2-amidobenzothiazoles substitués ou de leurs sels comme principes actifs contre le stress abiotique des plantes
EA201591746A1 (ru) 2013-03-14 2016-08-31 КОНВЕРДЖЕН ЭлЭлСи Способы и композиции для ингибирования бромодомен-содержащих белков
CN105017221B (zh) 2014-04-30 2019-05-28 中国医学科学院药物研究所 苯并咪唑衍生物及其制法和药物组合物与用途
CN107428733A (zh) * 2014-12-03 2017-12-01 葛兰素史克知识产权第二有限公司 Cd38抑制剂和治疗方法
WO2017053604A1 (fr) 2015-09-23 2017-03-30 The Regents Of The University Of California Composés pyrazolopyridines antiviraux puissants
WO2018151830A1 (fr) 2017-02-17 2018-08-23 Fronthera U.S. Pharmaceuticals Llc Inhibiteurs de kinase de régulation du signal apoptotique à base de pyridinyle
EP3434692A1 (fr) 2017-07-24 2019-01-30 Encefa Composes se liant specifiquement a cd38 pour leur utilisation dans le traitement de maladies neurodegeneratives
US11180498B2 (en) * 2017-09-27 2021-11-23 The Regents Of The University Of California Substituted pyrrolo[2,3-b]pyridines, pyrazolo[3,4-d]pyrimidines and [1,2,3]triazolo[4,5-b]pyridines as potent antivirals
US11535621B2 (en) 2019-07-31 2022-12-27 Ribon Therapeutics, Inc. Heterobicyclic amides as inhibitors of CD38
US20230025807A1 (en) 2019-10-30 2023-01-26 Mitobridge Inc. Cd38 inhibitors
KR20230051425A (ko) 2020-04-07 2023-04-18 미토브리지, 인크. Cd38 억제제
AR124718A1 (es) 2021-01-29 2023-04-26 Ribon Therapeutics Inc Quinolinas y azaquinolinas como inhibidores de cd38

Also Published As

Publication number Publication date
EP4003980A1 (fr) 2022-06-01
KR20220061958A (ko) 2022-05-13
JP2025160384A (ja) 2025-10-22
MX2025003445A (es) 2025-05-02
US12398146B2 (en) 2025-08-26
BR112022001291A2 (pt) 2022-06-21
CN114423753A (zh) 2022-04-29
US11535621B2 (en) 2022-12-27
US20240368167A1 (en) 2024-11-07
IL289878A (en) 2022-03-01
US20210032251A1 (en) 2021-02-04
US11987584B2 (en) 2024-05-21
MX2022001019A (es) 2022-02-22
JP7721501B2 (ja) 2025-08-12
CA3147902A1 (fr) 2021-02-04
CN114423753B (zh) 2024-09-17
IL289878B2 (en) 2026-05-01
US20230312586A1 (en) 2023-10-05
CN119431323A (zh) 2025-02-14
MX2025003444A (es) 2025-05-02
TW202120496A (zh) 2021-06-01
WO2021021986A1 (fr) 2021-02-04
AU2020321956A1 (en) 2022-03-10
IL289878B1 (en) 2026-01-01
TWI891649B (zh) 2025-08-01
TW202615430A (zh) 2026-04-16
US20260078127A1 (en) 2026-03-19
JP2022542396A (ja) 2022-10-03

Similar Documents

Publication Publication Date Title
JP7721501B2 (ja) Ｃｄ３８の阻害剤としてのヘテロ二環式アミド
JP7700196B2 (ja) Ａ２ａ／ａ２ｂ阻害剤としての縮合ピラジン誘導体
WO2023287896A1 (fr) Composés tricycliques utiles en tant qu'inhibiteurs de kras
US11952377B2 (en) Quinolines and azaquinolines as inhibitors of CD38
CA3078942A1 (fr) Composes de pyrrolotriazine et procedes d'inhibition de kinases tam
CA3259052A1 (fr) Composés hétérocycliques utilisés comme inhibiteurs de pi3k.alpha.
EA048196B1 (ru) Гетеробициклические амиды как ингибиторы cd38
HK40129150A (en) Azaquinolines as inhibitors of cd38
EA051811B1 (ru) Гетеробициклические амиды как ингибиторы cd38
EA049932B1 (ru) Хинолины и азахинолины в качестве ингибиторов cd38