IL324885A - Heterobicyclic amides as inhibitors of cd38 - Google Patents

Heterobicyclic amides as inhibitors of cd38

Info

Publication number
IL324885A
IL324885A IL324885A IL32488525A IL324885A IL 324885 A IL324885 A IL 324885A IL 324885 A IL324885 A IL 324885A IL 32488525 A IL32488525 A IL 32488525A IL 324885 A IL324885 A IL 324885A
Authority
IL
Israel
Prior art keywords
alkyl
carboxamide
imidazol
pyrimidine
cyclohexyl
Prior art date
Application number
IL324885A
Other languages
English (en)
Hebrew (he)
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IL324885A publication Critical patent/IL324885A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL324885A 2019-07-31 2020-07-30 Heterobicyclic amides as inhibitors of cd38 IL324885A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962880923P 2019-07-31 2019-07-31
US201962951604P 2019-12-20 2019-12-20
US202063034750P 2020-06-04 2020-06-04
PCT/US2020/044156 WO2021021986A1 (fr) 2019-07-31 2020-07-30 Amides hétérobicycliques servant d'inhibiteurs de cd38

Publications (1)

Publication Number Publication Date
IL324885A true IL324885A (en) 2026-01-01

Family

ID=72139677

Family Applications (2)

Application Number Title Priority Date Filing Date
IL324885A IL324885A (en) 2019-07-31 2020-07-30 Heterobicyclic amides as inhibitors of cd38
IL289878A IL289878B1 (en) 2019-07-31 2022-01-16 Heterobicyclic amides as inhibitors of CD38

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL289878A IL289878B1 (en) 2019-07-31 2022-01-16 Heterobicyclic amides as inhibitors of CD38

Country Status (12)

Country Link
US (4) US11535621B2 (fr)
EP (1) EP4003980A1 (fr)
JP (2) JP7721501B2 (fr)
KR (1) KR20220061958A (fr)
CN (2) CN114423753B (fr)
AU (1) AU2020321956A1 (fr)
BR (1) BR112022001291A2 (fr)
CA (1) CA3147902A1 (fr)
IL (2) IL324885A (fr)
MX (3) MX2022001019A (fr)
TW (1) TWI891649B (fr)
WO (1) WO2021021986A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2020321956A1 (en) 2019-07-31 2022-03-10 Boehringer Ingelheim International Gmbh Heterobicyclic amides as inhibitors of CD38
WO2021087087A1 (fr) * 2019-10-30 2021-05-06 Mitobridge Inc. Dérivés de n-cyclohexyle-5-(thiazol-5-yl)-1 h-indole-7-carboxamide et composés apparentés en tant qu'inhibiteurs de cd38 pour augmenter la nad+ et pour le traitement de troubles musculaires, par exemple
CA3195121A1 (fr) * 2020-10-09 2022-04-14 Robert A. Volkmann Inhibiteurs amides heteroaryles de cd38
WO2022165114A1 (fr) 2021-01-29 2022-08-04 Ribon Therapeutics, Inc. Quinoléines et azaquinolines en tant qu'inhibiteurs de cd38
EP4330247A4 (fr) * 2021-04-30 2025-05-28 Nanjing Immunophage Biotech Co., Ltd Composés et leurs utilisations en tant qu'inhibiteurs de cd38
CA3225785A1 (fr) * 2021-07-12 2023-01-19 Cytokinetics, Inc. Modulateurs de cd38 et leurs procedes d'utilisation
CN116041344A (zh) * 2021-10-28 2023-05-02 北京望实智慧科技有限公司 双环杂芳基甲酰胺化合物作为sos1抑制剂
CA3236793A1 (fr) 2021-11-09 2023-05-19 Roland Burli Derives de n-(4-aminocyclohexyl)pyrimidine-4-carboxamide en tant qu'inhibiteurs de cd38
CN114306366B (zh) * 2021-11-30 2023-01-06 合肥康诺生物制药有限公司 含nad和cd38抑制剂的药物组合物及其用途
WO2023098699A1 (fr) * 2021-12-01 2023-06-08 Nanjing Immunophage Biotech Co., Ltd Composés et leurs utilisations en tant qu'inhibiteurs de cd38
GB202207721D0 (en) * 2022-05-25 2022-07-06 Cerevance Ltd Novel Compounds
AU2023318665A1 (en) * 2022-08-05 2025-01-23 Nextgen Bioscience Co., Ltd. Novel compound as hypoxia-inducible factor 1(hif-1) inhibitor or vascular endothelial growth factor (vegf) inhibitor, and pharmaceutical composition comprising same
CN115825297B (zh) * 2022-11-11 2025-03-28 武汉海特生物创新医药研究有限公司 一种(s)-3-氨基哌啶-2,6-二酮盐酸盐对映异构体的检测方法
GB202307426D0 (en) * 2023-05-18 2023-07-05 Cerevance Inc Novel compounds
EP4713323A1 (fr) * 2023-05-18 2026-03-25 Cerevance, Inc. Dérivés de 3-carbonyl imidazo[1,5-a]pyridine destinés à être utilisés en tant qu'inhibiteurs de cd38 pour le traitement de troubles du snc
AU2024285368A1 (en) * 2023-06-07 2025-12-18 Flagship Pioneering Innovations Vi, Llc Condensed azines as inhibitors of cyclic adp ribose hydrolase

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EP2520575B1 (fr) 2009-12-28 2016-11-30 General Incorporated Association Pharma Valley Project Supporting Organisation Composé 1,3,4-oxadiazole-2-carboxamide
JP5889875B2 (ja) 2010-05-07 2016-03-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ アザインダゾール
WO2012075080A1 (fr) 2010-12-01 2012-06-07 Glaxosmithkline Llc Indoles
CN105920010A (zh) 2010-12-14 2016-09-07 电泳有限公司 酪蛋白激酶1δ(CK1δ)抑制剂
EP2681216B1 (fr) 2011-02-28 2017-09-27 Epizyme, Inc. Composés hétéroaryles bicycliques substitués condensés en 6,5
ES2624986T3 (es) 2011-09-13 2017-07-18 Glaxosmithkline Llc Azaindazoles
TWI629983B (zh) * 2011-10-19 2018-07-21 標誌製藥公司 以ｔｏｒ激酶抑制劑治療癌症
BR112014010803A2 (pt) 2011-11-04 2017-04-25 Glaxosmithkline Intellectual Property (No 2) Ltd método de tratamento
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WO2017053604A1 (fr) 2015-09-23 2017-03-30 The Regents Of The University Of California Composés pyrazolopyridines antiviraux puissants
WO2018151830A1 (fr) * 2017-02-17 2018-08-23 Fronthera U.S. Pharmaceuticals Llc Inhibiteurs de kinase de régulation du signal apoptotique à base de pyridinyle
EP3434692A1 (fr) 2017-07-24 2019-01-30 Encefa Composes se liant specifiquement a cd38 pour leur utilisation dans le traitement de maladies neurodegeneratives
EP3687529B1 (fr) 2017-09-27 2023-07-12 The Regents of the University of California Composés antiviraux puissants contenant de la pyridine
AU2020321956A1 (en) 2019-07-31 2022-03-10 Boehringer Ingelheim International Gmbh Heterobicyclic amides as inhibitors of CD38
WO2021087087A1 (fr) 2019-10-30 2021-05-06 Mitobridge Inc. Dérivés de n-cyclohexyle-5-(thiazol-5-yl)-1 h-indole-7-carboxamide et composés apparentés en tant qu'inhibiteurs de cd38 pour augmenter la nad+ et pour le traitement de troubles musculaires, par exemple
WO2021207186A1 (fr) 2020-04-07 2021-10-14 Mitobridge Inc. Inhibiteurs de cd38
WO2022165114A1 (fr) 2021-01-29 2022-08-04 Ribon Therapeutics, Inc. Quinoléines et azaquinolines en tant qu'inhibiteurs de cd38

Also Published As

Publication number Publication date
JP7721501B2 (ja) 2025-08-12
AU2020321956A1 (en) 2022-03-10
TWI891649B (zh) 2025-08-01
CA3147902A1 (fr) 2021-02-04
US11987584B2 (en) 2024-05-21
US11535621B2 (en) 2022-12-27
CN114423753B (zh) 2024-09-17
US20240368167A1 (en) 2024-11-07
WO2021021986A1 (fr) 2021-02-04
IL289878A (en) 2022-03-01
JP2022542396A (ja) 2022-10-03
KR20220061958A (ko) 2022-05-13
MX2022001019A (es) 2022-02-22
MX2025003444A (es) 2025-05-02
US20260078127A1 (en) 2026-03-19
JP2025160384A (ja) 2025-10-22
US20230312586A1 (en) 2023-10-05
BR112022001291A2 (pt) 2022-06-21
US20210032251A1 (en) 2021-02-04
MX2025003445A (es) 2025-05-02
CN119431323A (zh) 2025-02-14
US12398146B2 (en) 2025-08-26
CN114423753A (zh) 2022-04-29
TW202120496A (zh) 2021-06-01
IL289878B1 (en) 2026-01-01
EP4003980A1 (fr) 2022-06-01

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