IL35736A - Arthritis mixtures containing lead-gold phosphine or phosphite complexes and method of preparation - Google Patents

Arthritis mixtures containing lead-gold phosphine or phosphite complexes and method of preparation

Info

Publication number: IL35736A
Authority: IL; Israel
Prior art keywords: phosphine; lower alkyl; pharmaceutical composition; gold; solution
Prior art date: 1969-12-12

Application number

IL35736A

Other languages

English (en)

Hebrew (he)

Other versions

IL35736A0 (en

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-12-12

Filing date

1970-11-26

Publication date

1973-06-29

1970-11-26 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1971-01-28 Publication of IL35736A0 publication Critical patent/IL35736A0/xx

1973-06-29 Publication of IL35736A publication Critical patent/IL35736A/en

Links

XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical class P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 title claims description 18
238000000034 method Methods 0.000 title claims description 14
239000000203 mixture Substances 0.000 title claims description 13
230000002456 anti-arthritic effect Effects 0.000 title claims description 11
229910000073 phosphorus hydride Inorganic materials 0.000 title claims description 9
-1 phosphite gold halide Chemical class 0.000 title claims description 8
239000008194 pharmaceutical composition Substances 0.000 claims description 10
125000000217 alkyl group Chemical group 0.000 claims description 8
239000003814 drug Substances 0.000 claims description 7
239000003937 drug carrier Substances 0.000 claims description 7
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 7
239000010931 gold Substances 0.000 claims description 7
229910052737 gold Inorganic materials 0.000 claims description 7
125000003545 alkoxy group Chemical group 0.000 claims description 6
125000001309 chloro group Chemical group Cl* 0.000 claims description 6
238000002360 preparation method Methods 0.000 claims description 5
ZAYPNIAMEDVXRI-UHFFFAOYSA-K trichlorogold;triethylphosphane Chemical compound Cl[Au](Cl)Cl.CCP(CC)CC ZAYPNIAMEDVXRI-UHFFFAOYSA-K 0.000 claims description 4
125000001246 bromo group Chemical group Br* 0.000 claims description 3
125000004432 carbon atom Chemical group C* 0.000 claims description 3
125000002346 iodo group Chemical group I* 0.000 claims description 3
231100000252 nontoxic Toxicity 0.000 claims description 3
230000003000 nontoxic effect Effects 0.000 claims description 3
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
239000002775 capsule Substances 0.000 claims description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
239000000243 solution Substances 0.000 description 25
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 19
239000007787 solid Substances 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
YODZTKMDCQEPHD-UHFFFAOYSA-N thiodiglycol Chemical compound OCCSCCO YODZTKMDCQEPHD-UHFFFAOYSA-N 0.000 description 7
229950006389 thiodiglycol Drugs 0.000 description 7
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
239000000047 product Substances 0.000 description 6
230000000694 effects Effects 0.000 description 5
208000009386 Experimental Arthritis Diseases 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
239000000706 filtrate Substances 0.000 description 4
239000007788 liquid Substances 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000011541 reaction mixture Substances 0.000 description 4
238000003756 stirring Methods 0.000 description 4
XYYVDQWGDNRQDA-UHFFFAOYSA-K trichlorogold;trihydrate;hydrochloride Chemical compound O.O.O.Cl.Cl[Au](Cl)Cl XYYVDQWGDNRQDA-UHFFFAOYSA-K 0.000 description 4
229910003771 Gold(I) chloride Inorganic materials 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
241000700159 Rattus Species 0.000 description 3
235000021355 Stearic acid Nutrition 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
230000037396 body weight Effects 0.000 description 3
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 3
239000007903 gelatin capsule Substances 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
239000008117 stearic acid Substances 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
239000000454 talc Substances 0.000 description 3
229910052623 talc Inorganic materials 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
239000002253 acid Substances 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
206010003246 arthritis Diseases 0.000 description 2
239000000969 carrier Substances 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
RJHLTVSLYWWTEF-UHFFFAOYSA-K gold trichloride Chemical compound Cl[Au](Cl)Cl RJHLTVSLYWWTEF-UHFFFAOYSA-K 0.000 description 2
239000005457 ice water Substances 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000008101 lactose Substances 0.000 description 2
230000003902 lesion Effects 0.000 description 2
210000003141 lower extremity Anatomy 0.000 description 2
239000011777 magnesium Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000006188 syrup Substances 0.000 description 2
235000020357 syrup Nutrition 0.000 description 2
239000003826 tablet Substances 0.000 description 2
235000012222 talc Nutrition 0.000 description 2
YWWDBCBWQNCYNR-UHFFFAOYSA-N trimethylphosphine Chemical compound CP(C)C YWWDBCBWQNCYNR-UHFFFAOYSA-N 0.000 description 2
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 2
235000019786 weight gain Nutrition 0.000 description 2
229920001817 Agar Polymers 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
241000186359 Mycobacterium Species 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
206010036030 Polyarthritis Diseases 0.000 description 1
XDGCJGXFGCYHEK-UHFFFAOYSA-N [Au+3].[O-]P([O-])[O-] Chemical compound [Au+3].[O-]P([O-])[O-] XDGCJGXFGCYHEK-UHFFFAOYSA-N 0.000 description 1
239000008272 agar Substances 0.000 description 1
235000010419 agar Nutrition 0.000 description 1
239000003708 ampul Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
AUJRCFUBUPVWSZ-XTZHGVARSA-M auranofin Chemical compound CCP(CC)(CC)=[Au]S[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O AUJRCFUBUPVWSZ-XTZHGVARSA-M 0.000 description 1
150000001649 bromium compounds Chemical class 0.000 description 1
229940095672 calcium sulfate Drugs 0.000 description 1
PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000012043 crude product Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
229940057307 dihydrate calcium sulfate Drugs 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
210000002683 foot Anatomy 0.000 description 1
229940074045 glyceryl distearate Drugs 0.000 description 1
229940075507 glyceryl monostearate Drugs 0.000 description 1
150000002343 gold Chemical class 0.000 description 1
IFPWCRBNZXUWGC-UHFFFAOYSA-M gold(1+);triphenylphosphane;chloride Chemical compound [Cl-].[Au+].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 IFPWCRBNZXUWGC-UHFFFAOYSA-M 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
210000000548 hind-foot Anatomy 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
150000004694 iodide salts Chemical class 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000008188 pellet Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
208000030428 polyarticular arthritis Diseases 0.000 description 1
239000000843 powder Substances 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
JELHWNHHIOMFRD-UHFFFAOYSA-K tribromogold;triethylphosphane Chemical compound [Br-].[Br-].[Br-].[Au+3].CCP(CC)CC JELHWNHHIOMFRD-UHFFFAOYSA-K 0.000 description 1
BDZBKCUKTQZUTL-UHFFFAOYSA-N triethyl phosphite Chemical compound CCOP(OCC)OCC BDZBKCUKTQZUTL-UHFFFAOYSA-N 0.000 description 1
RXJKFRMDXUJTEX-UHFFFAOYSA-N triethylphosphine Chemical compound CCP(CC)CC RXJKFRMDXUJTEX-UHFFFAOYSA-N 0.000 description 1
IGNTWNVBGLNYDV-UHFFFAOYSA-N triisopropylphosphine Chemical compound CC(C)P(C(C)C)C(C)C IGNTWNVBGLNYDV-UHFFFAOYSA-N 0.000 description 1
CYTQBVOFDCPGCX-UHFFFAOYSA-N trimethyl phosphite Chemical compound COP(OC)OC CYTQBVOFDCPGCX-UHFFFAOYSA-N 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5045—Complexes or chelates of phosphines with metallic compounds or metals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL35736A 1969-12-12 1970-11-26 Arthritis mixtures containing lead-gold phosphine or phosphite complexes and method of preparation IL35736A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US88470969A	1969-12-12	1969-12-12

Publications (2)

Publication Number	Publication Date
IL35736A0 IL35736A0 (en)	1971-01-28
IL35736A true IL35736A (en)	1973-06-29

Family

ID=25385205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL35736A IL35736A (en)	1969-12-12	1970-11-26	Arthritis mixtures containing lead-gold phosphine or phosphite complexes and method of preparation

Country Status (9)

Country	Link
BE (1)	BE760073A (fr)
CA (1)	CA974881A (fr)
DE (1)	DE2061181C3 (fr)
FR (1)	FR2081345B1 (fr)
GB (1)	GB1271906A (fr)
IE (1)	IE34764B1 (fr)
IL (1)	IL35736A (fr)
NL (1)	NL160165C (fr)
ZA (1)	ZA707816B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4171360A (en) *	1978-02-21	1979-10-16	Smithkline Corporation	Phosphinegold (I) salts having antiarthritic activity
CZ303649B6 (cs) *	2011-07-11	2013-01-23	Univerzita Palackého	Komplexy zlata s deriváty N6-benzyladeninu a deriváty fosfanu, zpusob jejich prípravy a pouzití techto komplexu jako léciv v protizánetlivé terapii

1970
- 1970-11-18 CA CA098,455A patent/CA974881A/en not_active Expired
- 1970-11-19 ZA ZA707816A patent/ZA707816B/xx unknown
- 1970-11-26 IL IL35736A patent/IL35736A/en unknown
- 1970-11-26 IE IE1517/70A patent/IE34764B1/xx unknown
- 1970-12-09 BE BE760073D patent/BE760073A/fr not_active IP Right Cessation
- 1970-12-10 FR FR7044555A patent/FR2081345B1/fr not_active Expired
- 1970-12-11 DE DE2061181A patent/DE2061181C3/de not_active Expired
- 1970-12-11 NL NL7018126.A patent/NL160165C/xx not_active IP Right Cessation
- 1970-12-11 GB GB58979/70A patent/GB1271906A/en not_active Expired

Also Published As

Publication number	Publication date
DE2061181B2 (de)	1980-10-23
FR2081345A1 (fr)	1971-12-03
FR2081345B1 (fr)	1975-01-10
IL35736A0 (en)	1971-01-28
IE34764B1 (en)	1975-08-06
DE2061181C3 (de)	1981-05-27
CA974881A (en)	1975-09-23
NL160165C (nl)	1979-10-15
NL7018126A (fr)	1971-06-15
GB1271906A (en)	1972-04-26
DE2061181A1 (de)	1971-06-16
BE760073A (fr)	1971-06-09
IE34764L (en)	1971-06-12
NL160165B (nl)	1979-05-15
ZA707816B (en)	1971-08-25

Publication	Publication Date	Title
US3676554A (en)	1972-07-11	Anti-arthritic compositions comprising phosphine or phosphite gold halide complexes and methods of producing anti-arthritic activity
US3718680A (en)	1973-02-27	Phosphine or phosphite gold complexes of thioethanol and derivatives thereof
US3718679A (en)	1973-02-27	Phosphine or phosphite gold complexes of thiomalic acid
US3842107A (en)	1974-10-15	Phosphine or phosphite gold complexes of thiobenzoic acid and substituted thiophenols
US3923994A (en)	1975-12-02	Anti-arthritic compositions comprising a 3-aryl 2-thiohydantoin and methods of producing anti-arthritic acitvity
IL35736A (en)	1973-06-29	Arthritis mixtures containing lead-gold phosphine or phosphite complexes and method of preparation
CA1054609A (fr)	1979-05-15	Derives heterocycliques (s) des mercaptides d'or combine a un groupe phosphine ou phosphite
US3792165A (en)	1974-02-12	Phosphine or phosphite gold complexes of thiomalic acid in treating arthritis
US4096250A (en)	1978-06-20	Tri-substituted phosphinegold(I) 1-thio-β-D-glucopyranosides
US4165380A (en)	1979-08-21	Bis(sulfide)gold(1+) salts
US3784687A (en)	1974-01-08	Phosphine or phosphite gold complexes of thioethanol and derivatives thereof to treat arthritis
US3887707A (en)	1975-06-03	Anti-arthritic compositions comprising an S-phosphine or phosphite gold thio-cyanate and methods of producing anti-arthritic activity
EP0003897B1 (fr)	1983-05-25	Sels de phosphine-or(I), leur procédé de préparation et compositions les contenant
US3787568A (en)	1974-01-22	Arthritic compositions comprising an s-(phosphino-or phosphitoaurous)-thiouronium halide and method of producing anti-arthritic activity
US3377241A (en)	1968-04-09	Certain diacyl derivatives of phloroglucinol as anthelmintics
GB2093027A (en)	1982-08-25	2-amino-3-(halobenzoyl)-methylphenylacetic acids, esters and salts thereof
US3143469A (en)	1964-08-04	Anti-cholesterol nicotinic acid nu-oxide
DE2437146C2 (de)	1983-02-10	Phosphin-Gold-Chelate und ihre Verwendung
US3903274A (en)	1975-09-02	Anti-arthritic compositions comprising phosphine or phosphite gold complexes of thiobenzoic acid and substituted thiophenols and methods of producing anti-arthritic activity
US4201775A (en)	1980-05-06	Bis[triethylphosphine)aurio]sulfonium sugars
US4057630A (en)	1977-11-08	Antiarthritic compositions comprising bis-coordinated gold(1+) salts and methods of producing antiarthritic activity
EP0107188A1 (fr)	1984-05-02	Composition pharmaceutique et son utilisation pour le traitement de l'inflammation
US4098887A (en)	1978-07-04	Pharmaceutical compositions and methods of producing antiarthritic activity with bis(pyridine)gold(1+) salts
US3947565A (en)	1976-03-30	Anti-arthritic compositions comprising s-heterocyclic derivatives of phosphine or phosphite gold mercaptides and methods of producing anti-arthritic activity
US4093719A (en)	1978-06-06	Antiarthritic compositions comprising bis[(trialkyl-phosphine)gold(I)]sulfides and methods of producing antiarthritic activity