IL36801A - Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation - Google Patents

Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation

Info

Publication number: IL36801A
Authority: IL; Israel
Prior art keywords: compound; hydrogen; novel; preparation; benzoylhexahydro
Prior art date: 1966-05-10

Application number

IL3680167A

Other languages

English (en)

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-05-10

Filing date

1967-04-11

Publication date

1971-11-29

1967-04-11 Application filed by Upjohn Co filed Critical Upjohn Co

1971-11-29 Publication of IL36801A publication Critical patent/IL36801A/en

Links

238000000034 method Methods 0.000 title description 6
238000002360 preparation method Methods 0.000 title description 3
CFZRTDHGRHTNHP-UHFFFAOYSA-N 1-benzoylazepan-4-one Chemical compound C=1C=CC=CC=1C(=O)N1CCCC(=O)CC1 CFZRTDHGRHTNHP-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 17
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
125000003545 alkoxy group Chemical group 0.000 claims description 3
229910052799 carbon Inorganic materials 0.000 claims description 3
229910052739 hydrogen Inorganic materials 0.000 claims 6
239000001257 hydrogen Substances 0.000 claims 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
125000001475 halogen functional group Chemical group 0.000 claims 1
-1 hydro compound Chemical class 0.000 claims 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
HKOOXMFOFWEVGF-UHFFFAOYSA-N phenylhydrazine Chemical compound NNC1=CC=CC=C1 HKOOXMFOFWEVGF-UHFFFAOYSA-N 0.000 description 2
229940067157 phenylhydrazine Drugs 0.000 description 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
239000003377 acid catalyst Substances 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 description 1
150000002475 indoles Chemical class 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

IL3680167A 1966-05-10 1967-04-11 Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation IL36801A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US54888066A	1966-05-10	1966-05-10

Publications (1)

Publication Number	Publication Date
IL36801A true IL36801A (en)	1971-11-29

Family

ID=24190763

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL3680167A IL36801A (en)	1966-05-10	1967-04-11	Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation
IL2777667A IL27776A (en)	1966-05-10	1967-04-11	1,2,3,4,5,6-hexahydroazepino(4,5-b)-indoles and process for their preparation

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL2777667A IL27776A (en)	1966-05-10	1967-04-11	1,2,3,4,5,6-hexahydroazepino(4,5-b)-indoles and process for their preparation

Country Status (9)

Country	Link
BE (1)	BE698268A (de)
CH (1)	CH506543A (de)
DE (1)	DE1695943A1 (de)
ES (1)	ES340258A1 (de)
FR (1)	FR6699M (de)
GB (2)	GB1180616A (de)
GR (1)	GR35044B (de)
IL (2)	IL36801A (de)
NL (1)	NL6706513A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2434166A2 (fr) *	1978-08-24	1980-03-21	Omnium Chimique Sa	Procede de preparation de vincadifformine et derives similaires
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
MY122278A (en)	1999-07-19	2006-04-29	Upjohn Co	1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
US7030109B2 (en)	1999-07-19	2006-04-18	Pharmacia & Upjohn Company	1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position
WO2002004456A1 (en) *	2000-07-06	2002-01-17	Pharmacia & Upjohn Company	SUBSTITUTED 2,3,7,8,9,10,11,12-OCTAHYDROAZEPINO[4,5-b]PYRANO[3,2-e]INDOLES
WO2002024700A2 (en) *	2000-09-20	2002-03-28	Pharmacia & Upjohn Company	SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES
US7595311B2 (en)	2002-05-24	2009-09-29	Exelixis, Inc.	Azepinoindole derivatives as pharmaceutical agents
TWI329111B (en)	2002-05-24	2010-08-21	X Ceptor Therapeutics Inc	Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US8466143B2 (en) *	2003-07-23	2013-06-18	Exelixis, Inc.	Azepine derivatives as pharmaceutical agents
WO2023092045A1 (en)	2021-11-17	2023-05-25	Terran Biosciences, Inc.	Salt and solid forms of tabernanthalog

1967
- 1967-04-10 GR GR670135044A patent/GR35044B/el unknown
- 1967-04-11 IL IL3680167A patent/IL36801A/en unknown
- 1967-04-11 IL IL2777667A patent/IL27776A/en unknown
- 1967-04-17 GB GB4488369A patent/GB1180616A/en not_active Expired
- 1967-04-17 GB GB1757867A patent/GB1180615A/en not_active Expired
- 1967-05-05 CH CH637567A patent/CH506543A/de not_active IP Right Cessation
- 1967-05-08 ES ES340258A patent/ES340258A1/es not_active Expired
- 1967-05-09 DE DE19671695943 patent/DE1695943A1/de active Pending
- 1967-05-10 BE BE698268D patent/BE698268A/xx unknown
- 1967-05-10 NL NL6706513A patent/NL6706513A/xx unknown
- 1967-08-08 FR FR117261A patent/FR6699M/fr not_active Expired

Also Published As

Publication number	Publication date
NL6706513A (de)	1967-11-13
GB1180616A (en)	1970-02-04
GR35044B (el)	1968-07-31
CH506543A (de)	1971-04-30
IL27776A (en)	1971-11-29
FR6699M (de)	1969-02-10
GB1180615A (en)	1970-02-04
BE698268A (de)	1967-11-10
ES340258A1 (es)	1968-06-01
DE1695943A1 (de)	1971-05-13

Publication	Publication Date	Title
IL36801A (en)	1971-11-29	Novel phenylhydrazones of 1-benzoylhexahydro-4h-azepin-4-one and process for their preparation
Ykman et al.	1971	Reactions of carbonyl azides with α-keto phosphorus ylides: Synthesis of N-2 acyl and N-2 carbethoxy-1, 2, 3-triazoles
JPH01160957A (ja)	1989-06-23	ビス（インドリル）エチレン
GB939675A (en)	1963-10-16	New dyes and the production thereof
Mao et al.	1980	Syntheses of dihydropyrenes with functionality in the cavity of the. pi.-electron cloud
Buzykin et al.	1971	Reaction of azines with 5-pyrazolones
ES403209A1 (es)	1976-01-16	Un metodo para la produccion de nuevos derivados de aceto- fenon-oxima.
Shvo et al.	1981	Stereoselectivity in the formation of heterocyclic amine oxides
Tsunashima et al.	1981	The chemistry of carbazole. VI. On the formation of N‐ethylcarbazoles in the cadogan reaction
GB1398375A (en)	1975-06-18	1,1,3,3-substituted hydroxyindanes
Akiba et al.	1981	Wittig-horner reaction of a phosphonate of reissert analogue a new method for introduction of alkyl groups into isoquinoline
ES406031A1 (es)	1975-09-16	Un procedimiento para preparar derivados de acidos indol-2-ilfenilaceticos.
US3349091A (en)	1967-10-24	1-aminoalkyl-5-[(halo/alkoxy) phenyl]-2-pyrrolepropionic acids
Carroll et al.	1965	Benzylation and Benzoylation of Methyl Phenacyl Sulfone
IE42933B1 (en)	1980-11-19	Glyoxylic acid derivatives
US3598844A (en)	1971-08-10	Azidocinnamic aldehydes
US3274246A (en)	1966-09-20	Phosphorinanone-phenylhydrazones
US3346588A (en)	1967-10-10	Silicon-substituted pyrroles
GB1346126A (en)	1974-02-06	Process for the manufacture of 1,1-dianthraquinonyls
Padwa et al.	1987	Reaction of hydrazonyl chlorides and carboalkoxymethylene triphenylphosphoranes to give 5‐alkoxy substituted pyrazoles
IL39209A (en)	1973-08-29	3,5-dihydrophenazine derivatives
US2478661A (en)	1949-08-09	Oxazolone derivative and process for preparing same
GB1346378A (en)	1974-02-06	2-stilbenyl-4-styryl-v-triazoles their use for the optical brightening of organic materials and processes for their manufacture
Gabitov et al.	1972	Synthesis and tranformations of trinitroethyl esters of pyrazoline-carboxylic acids
GB599891A (en)	1948-03-23	1-substituted-2,5-diketo-7-methyl-pyrimido-pyrazoles and process of preparing the same