IL37638A - Process for separating citric acid - Google Patents

Process for separating citric acid

Info

Publication number: IL37638A
Authority: IL; Israel
Prior art keywords: acid; citric acid; isocitric; citric; sulfuric acid
Prior art date: 1970-09-11

Application number

IL37638A

Other languages

English (en)

Other versions

IL37638A0 (en

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-09-11

Filing date

1971-09-02

Publication date

1974-07-31

1971-09-02 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1971-11-29 Publication of IL37638A0 publication Critical patent/IL37638A0/xx

1974-07-31 Publication of IL37638A publication Critical patent/IL37638A/en

Links

KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 title description 241
238000000034 method Methods 0.000 title description 10
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 84
229960004106 citric acid Drugs 0.000 description 79
ODBLHEXUDAPZAU-UHFFFAOYSA-N threo-D-isocitric acid Natural products OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 61
239000013078 crystal Substances 0.000 description 24
239000007864 aqueous solution Substances 0.000 description 20
238000002425 crystallisation Methods 0.000 description 16
230000008025 crystallization Effects 0.000 description 16
239000000706 filtrate Substances 0.000 description 15
239000012452 mother liquor Substances 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
239000000243 solution Substances 0.000 description 12
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
239000002253 acid Substances 0.000 description 8
ODBLHEXUDAPZAU-ZAFYKAAXSA-N D-threo-isocitric acid Chemical compound OC(=O)[C@H](O)[C@@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-ZAFYKAAXSA-N 0.000 description 6
ODBLHEXUDAPZAU-FONMRSAGSA-N Isocitric acid Natural products OC(=O)[C@@H](O)[C@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-FONMRSAGSA-N 0.000 description 6
238000000354 decomposition reaction Methods 0.000 description 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 5
238000001914 filtration Methods 0.000 description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
240000004808 Saccharomyces cerevisiae Species 0.000 description 4
238000005119 centrifugation Methods 0.000 description 4
UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 3
229910001861 calcium hydroxide Inorganic materials 0.000 description 3
159000000007 calcium salts Chemical class 0.000 description 3
229910002091 carbon monoxide Inorganic materials 0.000 description 3
239000012141 concentrate Substances 0.000 description 3
239000000203 mixture Substances 0.000 description 3
150000004682 monohydrates Chemical class 0.000 description 3
239000000725 suspension Substances 0.000 description 3
239000012085 test solution Substances 0.000 description 3
210000005253 yeast cell Anatomy 0.000 description 3
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
241000222120 Candida <Saccharomycetales> Species 0.000 description 2
241000222173 Candida parapsilosis Species 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical class [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
229910021529 ammonia Inorganic materials 0.000 description 2
229910001424 calcium ion Inorganic materials 0.000 description 2
229920001429 chelating resin Polymers 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
239000002002 slurry Substances 0.000 description 2
241000894007 species Species 0.000 description 2
229940088594 vitamin Drugs 0.000 description 2
229930003231 vitamin Natural products 0.000 description 2
235000013343 vitamin Nutrition 0.000 description 2
239000011782 vitamin Substances 0.000 description 2
150000003722 vitamin derivatives Chemical class 0.000 description 2
238000005406 washing Methods 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
-1 Candida lipolytica Natural products 0.000 description 1
241000222178 Candida tropicalis Species 0.000 description 1
YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
241000235035 Debaryomyces Species 0.000 description 1
241000235048 Meyerozyma guilliermondii Species 0.000 description 1
241001193070 Wickerhamomyces subpelliculosus Species 0.000 description 1
241000235015 Yarrowia lipolytica Species 0.000 description 1
241000191335 [Candida] intermedia Species 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000003466 anti-cipated effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
239000000920 calcium hydroxide Substances 0.000 description 1
229940055022 candida parapsilosis Drugs 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
239000003729 cation exchange resin Substances 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
229960002303 citric acid monohydrate Drugs 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000012364 cultivation method Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
239000000463 material Substances 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
APVPOHHVBBYQAV-UHFFFAOYSA-N n-(4-aminophenyl)sulfonyloctadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 APVPOHHVBBYQAV-UHFFFAOYSA-N 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
230000006911 nucleation Effects 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000013049 sediment Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
230000007704 transition Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/48—Tricarboxylic acids, e.g. citric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL37638A 1970-09-11 1971-09-02 Process for separating citric acid IL37638A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP8024670		1970-09-11

Publications (2)

Publication Number	Publication Date
IL37638A0 IL37638A0 (en)	1971-11-29
IL37638A true IL37638A (en)	1974-07-31

Family

ID=13712949

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL37638A IL37638A (en)	1970-09-11	1971-09-02	Process for separating citric acid

Country Status (12)

Country	Link
US (1)	US3799980A (fr)
AU (1)	AU458747B2 (fr)
BE (1)	BE772474A (fr)
CA (1)	CA960691A (fr)
DE (1)	DE2145084C3 (fr)
FR (1)	FR2107571A5 (fr)
GB (1)	GB1365362A (fr)
IE (1)	IE35629B1 (fr)
IL (1)	IL37638A (fr)
IT (1)	IT945760B (fr)
NL (1)	NL173284C (fr)
ZA (1)	ZA716088B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4139556A (en) *	1976-04-29	1979-02-13	Chevron Research Company	Mono-ol from diol and improved citric acid process
WO2009153886A1 (fr) *	2008-06-20	2009-12-23	旭化成ケミカルズ株式会社	PROCESSUS DESTINÉ À PRODUIRE DE L’ACIDE α-HYDROXY

1971
- 1971-09-02 IL IL37638A patent/IL37638A/en unknown
- 1971-09-08 IE IE1145/71A patent/IE35629B1/xx unknown
- 1971-09-09 AU AU33306/71A patent/AU458747B2/en not_active Expired
- 1971-09-09 GB GB4204671A patent/GB1365362A/en not_active Expired
- 1971-09-09 DE DE2145084A patent/DE2145084C3/de not_active Expired
- 1971-09-10 BE BE772474A patent/BE772474A/fr not_active IP Right Cessation
- 1971-09-10 FR FR7132831A patent/FR2107571A5/fr not_active Expired
- 1971-09-10 ZA ZA716088A patent/ZA716088B/xx unknown
- 1971-09-10 CA CA122,531A patent/CA960691A/en not_active Expired
- 1971-09-10 IT IT70005/71A patent/IT945760B/it active
- 1971-09-10 NL NLAANVRAGE7112484,A patent/NL173284C/xx not_active IP Right Cessation
- 1971-09-10 US US00179412A patent/US3799980A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE35629B1 (en)	1976-04-14
IT945760B (it)	1973-05-10
BE772474A (fr)	1972-01-17
ZA716088B (en)	1972-05-31
FR2107571A5 (fr)	1972-05-05
IL37638A0 (en)	1971-11-29
AU458747B2 (en)	1975-03-06
IE35629L (en)	1972-03-11
US3799980A (en)	1974-03-26
AU3330671A (en)	1973-03-15
NL173284C (nl)	1984-01-02
NL7112484A (fr)	1972-03-14
DE2145084A1 (de)	1972-03-16
GB1365362A (en)	1974-09-04
DE2145084B2 (de)	1980-11-20
CA960691A (en)	1975-01-07
DE2145084C3 (de)	1981-07-02
NL173284B (nl)	1983-08-01

Publication	Publication Date	Title
WO1995003268A1 (fr)	1995-02-02	Procede de recuperation d'acides organiques
US3086928A (en)	1963-04-23	Process of producing citric acid
US3904684A (en)	1975-09-09	Method for producing sodium citrate dihydrate
US3253023A (en)	1966-05-24	Recovery of 3-(3, 4-dihydroxyphenyl)-l-alanine from velvet beans
IL37638A (en)	1974-07-31	Process for separating citric acid
US3391187A (en)	1968-07-02	Purification of malic acid
US5202476A (en)	1993-04-13	Purification of 2-keto-L-gulonic acid
DE3400574A1 (de)	1985-07-18	Verfahren zur isolierung von l-aminosaeuren
EP0373583B1 (fr)	1995-02-15	Isolation de la L-phénylalanine de ses mélanges racémiques
US2918492A (en)	1959-12-22	Method of preparing methyl 2-ketogluconate
JPS6338B2 (fr)	1988-01-05
US2929839A (en)	1960-03-22	Process for recovering glutamic acid
US3037973A (en)	1962-06-05	Tetracycline recovery process
US3366681A (en)	1968-01-30	Process for the recovery of methionine
US3360554A (en)	1967-12-26	Process for crystallizing out l-glutamic acid
US3205261A (en)	1965-09-07	Method for separation of glutamic acid
US3381027A (en)	1968-04-30	Preparation and recovery of methyl 2-ketogluconate
US3925465A (en)	1975-12-09	Crystallization of alpha monosodium citrate monohydrate
JPH034532B2 (fr)	1991-01-23
US3172830A (en)	1965-03-09	Koh ore
USRE28203E (en)	1974-10-15	Process of producing citric acid
US3817718A (en)	1974-06-18	Process for the recovery of ammonium sulphate from an aqueous ammonium sulphate solution containing methionine
US2796434A (en)	1957-06-18	Recovery of glutamic acid values
US3206506A (en)	1965-09-14	Separation of acetylglutamine
EP0174142A2 (fr)	1986-03-12	Récupération de l'acide squarique