IL37889A - Indulamin inhibitors - N - methyl transferase - Google Patents

Indulamin inhibitors - N - methyl transferase

Info

Publication number: IL37889A
Authority: IL; Israel
Prior art keywords: agents; parts; compositions; compound; methyl transferase
Prior art date: 1970-10-12

Application number

IL37889A

Other languages

English (en)

Hebrew (he)

Other versions

IL37889A0 (en

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-10-12

Filing date

1971-10-08

Publication date

1974-10-22

1971-10-08 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1971-12-29 Publication of IL37889A0 publication Critical patent/IL37889A0/xx

1974-10-22 Publication of IL37889A publication Critical patent/IL37889A/en

Links

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239000000203 mixture Substances 0.000 title description 17
108010003546 indoleamine-N-methyltransferase Proteins 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims description 14
239000008194 pharmaceutical composition Substances 0.000 claims description 12
108090000992 Transferases Proteins 0.000 claims description 4
102000004357 Transferases Human genes 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 2
239000008187 granular material Substances 0.000 description 8
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
-1 quinuclidine 1-Pyrrolidinecarboxamidine 3 ,4 ,6 ,7 , 8 , 9-hexahydro-2H-pyrido [1 ,2-a] pyrimidine Chemical compound 0.000 description 8
239000004480 active ingredient Substances 0.000 description 7
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239000003765 sweetening agent Substances 0.000 description 6
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235000019359 magnesium stearate Nutrition 0.000 description 4
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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PIGIRWPZTWLVLB-UHFFFAOYSA-N pyrrolidine-1-carboximidamide Chemical compound NC(=N)N1CCCC1 PIGIRWPZTWLVLB-UHFFFAOYSA-N 0.000 description 2
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
SGUVLZREKBPKCE-UHFFFAOYSA-N 1,5-diazabicyclo[4.3.0]-non-5-ene Chemical compound C1CCN=C2CCCN21 SGUVLZREKBPKCE-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
XQLATFZKFMFMAB-UHFFFAOYSA-N 2-bromo-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione Chemical compound COC1=C(OC)C(=O)C(Br)=C(C)C1=O XQLATFZKFMFMAB-UHFFFAOYSA-N 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
QJVBBTQJGKITKK-UHFFFAOYSA-N 5-[(2,4-dioxo-1h-pyrimidin-5-yl)disulfanyl]-1h-pyrimidine-2,4-dione Chemical compound O=C1NC(=O)NC=C1SSC1=CNC(=O)NC1=O QJVBBTQJGKITKK-UHFFFAOYSA-N 0.000 description 1
CEXKXUHVXAGOLB-UHFFFAOYSA-N 5-[[2-(3-bromoanilino)pyrimidin-4-yl]amino]-2-methylphenol Chemical group C1=C(O)C(C)=CC=C1NC1=CC=NC(NC=2C=C(Br)C=CC=2)=N1 CEXKXUHVXAGOLB-UHFFFAOYSA-N 0.000 description 1
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DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
DMULVCHRPCFFGV-UHFFFAOYSA-N N,N-dimethyltryptamine Chemical compound C1=CC=C2C(CCN(C)C)=CNC2=C1 DMULVCHRPCFFGV-UHFFFAOYSA-N 0.000 description 1
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235000021355 Stearic acid Nutrition 0.000 description 1
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WERKSKAQRVDLDW-ANOHMWSOSA-N [(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO WERKSKAQRVDLDW-ANOHMWSOSA-N 0.000 description 1
125000002947 alkylene group Chemical group 0.000 description 1
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125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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239000003814 drug Substances 0.000 description 1
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239000003995 emulsifying agent Substances 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
KCXODFMHDFXFSV-UHFFFAOYSA-N ethylsulfinylmethylbenzene Chemical compound CCS(=O)CC1=CC=CC=C1 KCXODFMHDFXFSV-UHFFFAOYSA-N 0.000 description 1
LFVPBERIVUNMGV-UHFFFAOYSA-N fasudil hydrochloride Chemical compound Cl.C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 LFVPBERIVUNMGV-UHFFFAOYSA-N 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
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FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
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239000007924 injection Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
229920005610 lignin Polymers 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
230000011987 methylation Effects 0.000 description 1
238000007069 methylation reaction Methods 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
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231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000012053 oil suspension Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
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239000003196 psychodysleptic agent Substances 0.000 description 1
230000004044 response Effects 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
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239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229910001467 sodium calcium phosphate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
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239000000600 sorbitol Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL37889A 1970-10-12 1971-10-08 Indulamin inhibitors - N - methyl transferase IL37889A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US8017670A	1970-10-12	1970-10-12

Publications (2)

Publication Number	Publication Date
IL37889A0 IL37889A0 (en)	1971-12-29
IL37889A true IL37889A (en)	1974-10-22

Family

ID=22155742

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL37889A IL37889A (en)	1970-10-12	1971-10-08	Indulamin inhibitors - N - methyl transferase

Country Status (8)

Country	Link
AU (1)	AU462834B2 (fr)
BE (1)	BE773761A (fr)
CA (1)	CA966421A (fr)
FR (1)	FR2110357B1 (fr)
GB (6)	GB1327467A (fr)
IE (1)	IE35711B1 (fr)
IL (1)	IL37889A (fr)
ZA (1)	ZA716308B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4451576A (en) *	1981-05-11	1984-05-29	The Firestone Tire & Rubber Company	Molecular weight distribution and microstructure modifiers for elastomers
DE3508666A1 (de) *	1985-03-12	1986-09-18	Hoechst Ag, 6230 Frankfurt	Heterocyclische disulfide und ihre anwendung als immunmodulatoren
CA2134009C (fr) *	1993-11-11	2005-03-08	Oleg Werbitzky	Amidines bicycliques, methode pour leur obtention et leur utilisation comme catalyseur

1971
- 1971-02-18 GB GB4904272A patent/GB1327467A/en not_active Expired
- 1971-09-21 ZA ZA716308A patent/ZA716308B/xx unknown
- 1971-09-22 AU AU33750/71A patent/AU462834B2/en not_active Expired
- 1971-10-04 GB GB4608871A patent/GB1327464A/en not_active Expired
- 1971-10-04 CA CA124,372A patent/CA966421A/en not_active Expired
- 1971-10-08 IE IE1266/71A patent/IE35711B1/xx unknown
- 1971-10-08 IL IL37889A patent/IL37889A/en unknown
- 1971-10-11 FR FR7136445A patent/FR2110357B1/fr not_active Expired
- 1971-10-11 BE BE773761A patent/BE773761A/fr unknown
- 1971-10-21 GB GB4904372A patent/GB1327468A/en not_active Expired
- 1971-10-21 GB GB4904472A patent/GB1327469A/en not_active Expired
- 1971-10-21 GB GB4904172A patent/GB1327466A/en not_active Expired
1972
- 1972-10-04 GB GB4904072A patent/GB1327465A/en not_active Expired

Also Published As

Publication number	Publication date
FR2110357A1 (fr)	1972-06-02
BE773761A (fr)	1972-04-11
AU3375071A (en)	1973-03-29
GB1327469A (en)	1973-08-22
IE35711L (en)	1972-04-12
IL37889A0 (en)	1971-12-29
FR2110357B1 (fr)	1975-08-01
GB1327464A (en)	1973-08-22
GB1327466A (en)	1973-08-22
IE35711B1 (en)	1976-04-28
GB1327468A (en)	1973-08-22
CA966421A (en)	1975-04-22
GB1327467A (en)	1973-08-22
AU462834B2 (en)	1975-07-10
ZA716308B (en)	1973-04-25
GB1327465A (en)	1973-08-22

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