IL40628A - Alpha-(substituted ureido)derivatives of benzyl-,hydroxybenzyl-and cyclohexadienylmethyl penicillins,their preparation and pharmaceutical compositions or feed additives containing them - Google Patents
Alpha-(substituted ureido)derivatives of benzyl-,hydroxybenzyl-and cyclohexadienylmethyl penicillins,their preparation and pharmaceutical compositions or feed additives containing themInfo
- Publication number
- IL40628A IL40628A IL7240628A IL4062872A IL40628A IL 40628 A IL40628 A IL 40628A IL 7240628 A IL7240628 A IL 7240628A IL 4062872 A IL4062872 A IL 4062872A IL 40628 A IL40628 A IL 40628A
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- IL
- Israel
- Prior art keywords
- compound
- radical
- general formula
- compounds
- general
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Abstract
1392849 Penicillins BAYER AG 23 Oct 1972 [23 Oct 1971 22 Nov 1971 25 March 1972 25 July 1972] 48699/72 Heading C2C [Also in Division C3] Penicillins of the general formula or their salts in which C* is a carbon atom constituting a centre of chirality; A is a radical of one of the general formulµ (in which general formulµ X is Y is Q 1 is or a radical of formula and Q 2 is or a radical of formula wherein R is a straight-chain or branched alkyl radical with up to 5 carbon atoms; R 1 is a hydrogen atom or an alkyl, cycloalkyl, alkenyl or cycloalkenyl radical with up to 10 carbon atoms, or a vinyl, arylvinyl, mono-, di- or trihalo C 1-6 alkyl radical, or an H 2 N-, R-NH-, (R) 2 =N-, aryl -NH-, or aryl C 1-6 alkylamino radical or an alkoxy*, or aralkoxy* radical with up to 8 carbon atoms, or a cycloalkoxy* radical with up to 7 carbon atoms, or an aryloxy*, R-O-V-, R-S-V-, (R) 2 =N-CO-V- or a radical of formulµ V is a divalent organic radical with 1 to 3 carbon atoms; n is 0, 1, or 2; R 2 and R 3 which may be the same or different are each a hydrogen atom or an alkyl or alkenyl radical having up to 8 carbon atoms or a vinyl, allyl or propenyl radical, or a cycloalkyl or cycloalkenyl radical having up to 6 carbon atoms; or a mono di-, or tri-halogeno C 1-6 alkyl or aryl radical; R 4 , R 5 and R 6 which may be the same or different are each a hydrogen, nitro, nitrile, (R) 2 =N-, (R) 2 = N-CO-, R-CO-NH-, R-O-CO-, R-CO-O-, R, R-O, H 2 N-SO 2 -, chlorine, bromine, iodine, fluorine or trifluoromethyl radical; and G is a hydrogen atom or a radical R; with the proviso that the meanings marked* are only available if X is not an -SO 2 - radical); Z is a -CO- or -SO- radical; and B is a radical of the general formula in which R 7 , R 8 and R 9 are identical or different radicals selected from hydrogen, halogen, R-, R-O-, R-S-, R-SO-, R-SO 2 -, nitro(R 2 )=N-, R-CO-NH-, OH, and radicals and R is as above defined; and in which above general formulµ the arrow in the divalent linkage member ##Q 2 means that the linkage of two atoms by the two free valencies of this linking member is not free to take place in either direction but only in the manner indicated by the arrow are prepared by reacting a 6-amino-penicillanic acid derivative of the general formula or a product of the condensation of such a derivative with a carbonyl compound 'of formula or a silyl or disilyl derivative of the derivative of the general formulµ respectively is reacted with a compound of the general formula A-Z-W, in an anhydrous or aqueous solvent in the presence of a base, when a compound of general Formulae XIV and XV is reacted, and in an anhydrous solvent free of hydroxyl groups, with or without a base, when a compound of the general Formulµ XVI and XVII is reacted, at a temperature of - 50‹ to + 50‹ C. (wherein A, C*, G, Q 1 , Q 2 , R 1 , R 2 , X, Y, Z and B are as above defined and R 10 , R 11 and R 12 , which can be the same or different are C 1-6 alkyl and W is halogen, azide or Compounds of the above general formula wherein B is phenyl, cyclohexadienyl or hydroxyphenyl are stated to be novel. Compounds of the formula A-Z-W, and Formulµ XVIII and XIX are prepared by conventional methods. Pharmaceutical compositions having antibacterial activity useful in human and veterinary medicine comprise the above penicillins and a carrier. The compositions may be administered orally, parenterally, rectally or topically in conventional pharmaceutical forms. The following starting materials are also prepared: 3 - acetyl - 3 - (N - methylaminocarbonyl}-, 3 - methoxy - carbonyl, 3 - methylsulphonyl-, 3 - aminocarbonyl-, 3 - dimethylaminocarbonyl-, 3 - isopropoxycarbonyl-, 3 - pyrrolidyl - N- carbonyl-, 3 - piperidyl - N - carbonyl-, 3- phenylaminocarbonyl-, 3 - phenoxycarbonyl-, 3- benzoyl-, 3-furoyl-, 3-butyryl-, -, 3-formyl- 3 - pivaloyl-, 3 - cyclohexyloxycarbonyl-, 3- ethane - sulphonyl-, 3 - propionyl-, 3 - benzenesulphonyl-, 3 - methane - sulphonyl - aminocarbonyl- and 3 - thienyl - 2 - sulphonyl - imidazolidine - 1 - carbonyl chloride and the corresponding N - substituted - imidazolidin - 2- ones; 2 - chlorosulphonylthiophene; 1 - methanesulphonyl - 3 - chlorocarbonyl - 4 or -5 - methylimidazolidine - 2 - one and 1 - methanesulphonyl- 4- or 5 - methylimidazolid - 2 - one; 4 - methylimidazolidin - 2 - one; 1 - chlorocarbonyl - 2- methylsulphonylamino- and 2 - tosylamino - 4,5- dihydroimidazoles; 1 - (methylaminocarbonyl)- 3 - ethoxycarbonyl - guanidine and its N- nitroso derivative, N (1,1 -dioxo-isothiazolidin-2- yl] - carbonyl] - N - methyl - carbamic acid chloride; N - mesyl - N<SP>1</SP> - chlorocarbonylurea; 3- acetyl-, 3 - formyl-, 3 - mesyl-, and 3 - phenyl sulphonyl-, 1 - chlorocarbonyl - 2 - oxo - 1,3- diazacyclohexanes and their 1 -unsubstituted derivatives.
[GB1392849A]
Claims (1)
1. CLAIMS i Compounds which are penicillins of the general formula their in which is a carbon atom constituting a centre of and is one of the following a radical of the general formula x V in which is hydrogen if X is lower lower lower alkoxy X is lower cycloalkoxy X is X is C lower alkyl thiazolyl lower alkyl lowe carbonylamino CO or and is and which are optionall substituted by lower or a radical of the general formula in which is lower alkyl or lower or 124 a radical of the general formula in which is lower a radical of the general formula in which is lower alkyl lower is X is GO or and Y is or B is hydroxyphenyl or 1 The compounds according to claim in which A is 0 The compounds according to claim in which A is The compounds according to claim in which A is 125 The compounds according to claim 1 in which A is 0 The compounds according to claim in which A is The compounds according to claim in which A is The compounds according to claim in which A is 0 The compounds according to claim in which A is 1 in which A is The compounds according to any of claims 1 to in which is a phenyl 12 The according to any of claims 1 to in which B is 13 The compounds according to any of claims 1 to in which B is The compounds according to any of claims 1 to which is in the 16 0 1 130 39 or ylami Compounds according to Claim 1 which are hereinbefore specifically mentioned in the other than those according to any of claims 17 to 133 A process for the production of a compound according to any of Claims 1 to 51 and also of similar compounds claimed in copending Application in which a acid derivative of the general formula or a product of the condensation of such a derivative with a carbonyl the said product having the general 0 or a silyl or disilyl derivative of the said the general respectively is reacted with a compound of the general formula in an anhydrous or aqueous in the presence of a when a compound of the general formula II III is and in an anhydrous solvent free of hydro yl with or without a when a compound of the general formula IV or V is at a temperature in the range of to which general formulae Y and Z are as defined in any of claims 1 to G is hydrogen or a straight or branched group or are each an alkyl group with up to 6 Carbon is a or NO A process according to claim which the reaction is carried out at a pH in the range to I A process accordin to claim in which the said pH is between nd A process according to claim in which the s id d A process according to any of Claims 52 to 55 in which the reaction is carried out at a temperature between 0 and A process according to any of Claims 52 to 56 in which is a chlorine A process according to any of Claims 52 to 57 in which a compound formula II or III is reacted in the presence of a the said base being triethylamine or A process according to any of Claims 52 to 57 in which a compound of the general formula IV or V is reacted in the presence of a the said base being a secondary or tertiary A process according to Claim substantially as hereinbefore described in any of the Compounds according to Claim 1 whenever produced by the process of any of Claims 52 to A composition containing as an active ingredient a compound according to any of Claims 1 to 51 or in admixture with a solid or liquified gaseous diluent or in admixture with a liquid diluent other than a solvent o molecular weight less than 200 except in the presence of a A pharmaceutical composition containing as an active ingredient a compound according to any of Claims 1 to 51 or in the form of a sterile or isotonic aqueous A according to Claim 62 or 63 containing from to 95 of active by A composition according to Claim 63 or 64 in which the said compound a compound according to Claim 10 or 38 to A compsition according to Claim 63 or 64 in which the said compound is a compound according to Claim to A pharmaceutical composition according to Claim 62 or substantially as hereinbefore described or specifically A medicament in dosage unit form comprising a compound according to an of Claims 1 to 51 or 61 either alone or in admixture with a A medicament in the form of ampoules or suppositories comprising a compound according to any of Claims 1 to 51 or either alone or in admixture with a A medicament according to Claim 68 or in which the said compound is a compound according to Claim 10 or 38 to A medicament according to Claim 68 or in which the said compound is a compound according Claim 46 to A medicament according to any of Claims 68 or substantially as hereinbefore described or specifically A method of combatting bacterial infections in animals which comprises administering to the animals an active compound according to any of Claims 1 to 51 or either alone or in admixture with a diluent or in the form of a medicament according to Claim 68 or method according to Claim in which the active compound is administered in an amount of 25000 to of body A method according to Claim 73 or 74 in which the active compound is a compound aceording to Claim 10 or 38 to A method according to Claim 73 or 74 in which the is a compound aceording to Claim 46 to according to Claim 73 substantially as hereinbefore specifically described or An animal comprising a nutritious material and a compound according to any of Claims 1 to 51 or An animal feedstuff comprising a nutritious material and a compound according to Claim 10 or 38 to An animal feedstuff comprising a nutritious material and a compound according to 46 to insufficientOCRQuality
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2152967A DE2152967C3 (en) | 1971-10-23 | 1971-10-23 | Acylureidopenicillins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL40628A0 IL40628A0 (en) | 1972-12-29 |
| IL40628A true IL40628A (en) | 1976-08-31 |
Family
ID=5823251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL7240628A IL40628A (en) | 1971-10-23 | 1972-10-20 | Alpha-(substituted ureido)derivatives of benzyl-,hydroxybenzyl-and cyclohexadienylmethyl penicillins,their preparation and pharmaceutical compositions or feed additives containing them |
Country Status (31)
| Country | Link |
|---|---|
| JP (2) | JPS57843B2 (en) |
| AR (1) | AR195805A1 (en) |
| AT (1) | AT320152B (en) |
| BE (1) | BE790440A (en) |
| BG (2) | BG21609A3 (en) |
| CA (1) | CA1019323A (en) |
| CH (1) | CH579089A5 (en) |
| CS (1) | CS188883B2 (en) |
| CY (1) | CY947A (en) |
| DD (1) | DD106044B3 (en) |
| DE (1) | DE2152967C3 (en) |
| DK (1) | DK134992C (en) |
| EG (1) | EG10826A (en) |
| ES (1) | ES407851A1 (en) |
| FI (1) | FI56839C (en) |
| FR (1) | FR2157908B1 (en) |
| GB (1) | GB1392849A (en) |
| HK (1) | HK18578A (en) |
| HU (1) | HU167986B (en) |
| IE (1) | IE37123B1 (en) |
| IL (1) | IL40628A (en) |
| KE (1) | KE2824A (en) |
| LU (1) | LU66332A1 (en) |
| NO (1) | NO143909C (en) |
| PH (1) | PH9893A (en) |
| PL (2) | PL89056B1 (en) |
| RO (2) | RO60670A (en) |
| SE (1) | SE412236B (en) |
| SU (1) | SU527139A3 (en) |
| YU (1) | YU264072A (en) |
| ZA (1) | ZA727473B (en) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4009272A (en) * | 1971-10-23 | 1977-02-22 | Bayer Aktiengesellschaft | Penicillins |
| US3974142A (en) * | 1971-10-23 | 1976-08-10 | Bayer Aktiengesellschaft | Penicillins |
| US3974141A (en) * | 1971-10-23 | 1976-08-10 | Bayer Aktiengesellschaft | Penicillins |
| US3983105A (en) * | 1971-10-23 | 1976-09-28 | Bayer Aktiengesellschaft | Penicillins |
| US3972869A (en) * | 1971-10-23 | 1976-08-03 | Bayer Aktiengesellschaft | Penicillins |
| US3978056A (en) * | 1971-10-23 | 1976-08-31 | Bayer Aktiengesellschaft | Penicillins |
| NL175419C (en) * | 1971-10-23 | 1984-11-01 | Bayer Ag | METHOD FOR PREPARING OR MANUFACTURING ANTIBIOTIC ACTIVE PHARMACEUTICAL PREPARATIONS AND METHOD FOR PREPARING ANTIBIOTIC ACTIVE ALPHA-SUBSTITUTED 6- (ALFA- (3-ACYLUREIDO) -PETYL-ACIDYL-ACIDYL-ACIDYL) |
| US3972870A (en) * | 1971-10-23 | 1976-08-03 | Bayer Aktiengesellschaft | Penicillins |
| DE2258973A1 (en) * | 1972-12-01 | 1974-06-06 | Bayer Ag | PENICILLIN, THE METHOD FOR MANUFACTURING IT AND THEIR USE AS A MEDICINAL PRODUCT |
| JPS587637B2 (en) * | 1973-12-27 | 1983-02-10 | 住友化学工業株式会社 | Shinkipenicillin no Seihou |
| DE2407715C2 (en) * | 1974-02-18 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | Cephalosporins, processes for their production, as well as pharmaceuticals |
| IL47168A (en) * | 1974-05-09 | 1979-07-25 | Toyama Chemical Co Ltd | Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same |
| DE2525541C2 (en) * | 1975-06-07 | 1984-01-12 | Bayer Ag, 5090 Leverkusen | β-lactam antibiotics, processes for their preparation and pharmaceuticals containing them |
| DE2810083A1 (en) | 1978-03-08 | 1979-09-20 | Bayer Ag | BETA-LACTAM COMPOUNDS |
| GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| EP1780213A1 (en) * | 2005-10-27 | 2007-05-02 | 3M Innovative Properties Company | Silicon-urea-azolides, their preparation and use in the preparation of silicones with isocyanate terminal groups |
| TWI417095B (en) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of mglur2-receptors |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| CA2696948C (en) | 2007-09-14 | 2013-04-30 | Jose Maria Cid-Nunez | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones |
| KR20100065191A (en) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
| KR20100080597A (en) | 2007-09-14 | 2010-07-09 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 1,3-disubstituted-4-phenyl-1h-pyridin-2-ones |
| EP2220083B1 (en) | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CA2735764C (en) | 2008-09-02 | 2016-06-14 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| BRPI0921333A2 (en) | 2008-11-28 | 2015-12-29 | Addex Pharmaceuticals Sa | indole and benzoxazine derivatives as metabotropic glutamate receptor modulators |
| NZ596078A (en) | 2009-05-12 | 2013-06-28 | Janssen Pharmaceuticals Inc | 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| EA020671B1 (en) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS |
| KR102102972B1 (en) * | 2009-06-10 | 2020-04-22 | 테크필즈 바이오켐 코., 엘티디. | High penetration compositions or prodrugs of antimicrobials and antimicrobial-related compounds |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN103298810B (en) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | The purposes of 1,2,4-triazolo [4,3-a] pyridine derivate and the positive allosteric modulators as MGLUR2 acceptor thereof |
| EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| JO3368B1 (en) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6, 7- dihydropyrazolu [5,1-a] pyrazine-4 (5 hands) -on compounds and their use as negative excretory regulators of Miglore 2 receptors. |
| JO3367B1 (en) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| KR102414246B1 (en) | 2014-01-21 | 2022-06-27 | 얀센 파마슈티카 엔.브이. | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| LT3431106T (en) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1770620A1 (en) * | 1968-06-12 | 1971-11-11 | Bayer Ag | New penicillins |
-
0
- BE BE790440D patent/BE790440A/xx not_active IP Right Cessation
-
1971
- 1971-10-23 DE DE2152967A patent/DE2152967C3/en not_active Expired
-
1972
- 1972-10-12 SU SU1839113A patent/SU527139A3/en active
- 1972-10-17 RO RO197272544A patent/RO60670A/ro unknown
- 1972-10-17 PH PH14018A patent/PH9893A/en unknown
- 1972-10-17 RO RO197285500A patent/RO63066A/en unknown
- 1972-10-19 FI FI2897/72A patent/FI56839C/en active
- 1972-10-19 HU HUBA2815A patent/HU167986B/hu not_active IP Right Cessation
- 1972-10-19 CS CS727048A patent/CS188883B2/en unknown
- 1972-10-19 BG BG021665A patent/BG21609A3/en unknown
- 1972-10-19 BG BG024757A patent/BG20813A3/en unknown
- 1972-10-19 DD DD72166352A patent/DD106044B3/en unknown
- 1972-10-20 SE SE7213592A patent/SE412236B/en unknown
- 1972-10-20 IL IL7240628A patent/IL40628A/en unknown
- 1972-10-20 CA CA154,338A patent/CA1019323A/en not_active Expired
- 1972-10-20 IE IE1422/72A patent/IE37123B1/en unknown
- 1972-10-20 AT AT901072A patent/AT320152B/en not_active IP Right Cessation
- 1972-10-20 LU LU66332A patent/LU66332A1/xx unknown
- 1972-10-20 DK DK522172A patent/DK134992C/en active
- 1972-10-20 CH CH1531272A patent/CH579089A5/xx not_active IP Right Cessation
- 1972-10-20 ZA ZA727473A patent/ZA727473B/en unknown
- 1972-10-21 PL PL1972158392A patent/PL89056B1/pl unknown
- 1972-10-21 JP JP10490272A patent/JPS57843B2/ja not_active Expired
- 1972-10-21 EG EG437/72A patent/EG10826A/en active
- 1972-10-21 PL PL1972183057A patent/PL93574B1/pl unknown
- 1972-10-21 JP JP10490172A patent/JPS55391B2/ja not_active Expired
- 1972-10-21 ES ES407851A patent/ES407851A1/en not_active Expired
- 1972-10-23 NO NO723810A patent/NO143909C/en unknown
- 1972-10-23 FR FR7237482A patent/FR2157908B1/fr not_active Expired
- 1972-10-23 YU YU02640/72A patent/YU264072A/en unknown
- 1972-10-23 CY CY947A patent/CY947A/en unknown
- 1972-10-23 AR AR244770A patent/AR195805A1/en active
- 1972-10-23 GB GB4869972A patent/GB1392849A/en not_active Expired
-
1978
- 1978-03-14 KE KE2824A patent/KE2824A/en unknown
- 1978-04-04 HK HK185/78A patent/HK18578A/en unknown
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