IL40640A - Compounds derived from tetrahydro-isoquinoline and gamma-benzopyrone,their preparation and pharmaceutical compositions containing them - Google Patents

Compounds derived from tetrahydro-isoquinoline and gamma-benzopyrone,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL40640A
Authority: IL; Israel
Prior art keywords: compound; formula; solvent; set forth; isoquinoline
Prior art date: 1971-10-21

Application number

IL40640A

Other languages

English (en)

Other versions

IL40640A0 (en

Original Assignee

Blaise R

I Ind Chimi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-10-21

Filing date

1972-10-22

Publication date

1976-06-30

1971-10-21 Priority claimed from FR7137850A external-priority patent/FR2156469A1/fr

1972-07-13 Priority claimed from FR7225542A external-priority patent/FR2191892A1/fr

1972-10-22 Application filed by Blaise R, I Ind Chimi Sa filed Critical Blaise R

1972-12-29 Publication of IL40640A0 publication Critical patent/IL40640A0/xx

1976-06-30 Publication of IL40640A publication Critical patent/IL40640A/en

Links

150000001875 compounds Chemical class 0.000 title claims 9
UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 title claims 4
239000008194 pharmaceutical composition Substances 0.000 title 1
239000002904 solvent Substances 0.000 claims 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
239000002253 acid Substances 0.000 claims 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
239000003795 chemical substances by application Substances 0.000 claims 3
229910052739 hydrogen Inorganic materials 0.000 claims 3
239000001257 hydrogen Substances 0.000 claims 3
238000000034 method Methods 0.000 claims 3
229910052760 oxygen Inorganic materials 0.000 claims 3
239000001301 oxygen Substances 0.000 claims 3
239000004480 active ingredient Substances 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
229940079593 drug Drugs 0.000 claims 2
229910052736 halogen Inorganic materials 0.000 claims 2
150000002367 halogens Chemical class 0.000 claims 2
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 2
230000002048 spasmolytic effect Effects 0.000 claims 2
LIPRKYKMVQPYPG-UHFFFAOYSA-N 3-Hydroxy-2H-pyran-2-one Chemical compound OC1=CC=COC1=O LIPRKYKMVQPYPG-UHFFFAOYSA-N 0.000 claims 1
FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 claims 1
125000001931 aliphatic group Chemical group 0.000 claims 1
239000008280 blood Substances 0.000 claims 1
210000004369 blood Anatomy 0.000 claims 1
OTAFHZMPRISVEM-UHFFFAOYSA-N chromone Chemical compound C1=CC=C2C(=O)C=COC2=C1 OTAFHZMPRISVEM-UHFFFAOYSA-N 0.000 claims 1
238000001816 cooling Methods 0.000 claims 1
150000002148 esters Chemical class 0.000 claims 1
150000004820 halides Chemical class 0.000 claims 1
125000005843 halogen group Chemical group 0.000 claims 1
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
230000003301 hydrolyzing effect Effects 0.000 claims 1
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
229910052500 inorganic mineral Inorganic materials 0.000 claims 1
239000011707 mineral Substances 0.000 claims 1
230000003472 neutralizing effect Effects 0.000 claims 1
150000007530 organic bases Chemical class 0.000 claims 1
150000003839 salts Chemical class 0.000 claims 1
239000000725 suspension Substances 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)

IL40640A 1971-10-21 1972-10-22 Compounds derived from tetrahydro-isoquinoline and gamma-benzopyrone,their preparation and pharmaceutical compositions containing them IL40640A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR7137850A FR2156469A1 (en)	1971-10-21	1971-10-21	Tetrahydroisoquinolinoylalkoxy-7-(2-phenyl)-gamma - -benzopyrones - as spasmolytics and vascular protecting agents
FR7225542A FR2191892A1 (en)	1972-07-13	1972-07-13	Tetrahydroisoquinolinoylalkoxy-7-(2-phenyl)-gamma - -benzopyrones - as spasmolytics and vascular protecting agents

Publications (2)

Publication Number	Publication Date
IL40640A0 IL40640A0 (en)	1972-12-29
IL40640A true IL40640A (en)	1976-06-30

Family

ID=26216670

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL40640A IL40640A (en)	1971-10-21	1972-10-22	Compounds derived from tetrahydro-isoquinoline and gamma-benzopyrone,their preparation and pharmaceutical compositions containing them

Country Status (11)

Country	Link
US (1)	US3891651A (fr)
JP (1)	JPS4935630B2 (fr)
BE (1)	BE790074A (fr)
CA (1)	CA982571A (fr)
CH (1)	CH557376A (fr)
DE (1)	DE2251872C3 (fr)
ES (1)	ES408114A1 (fr)
GB (1)	GB1378397A (fr)
IL (1)	IL40640A (fr)
LU (1)	LU66322A1 (fr)
NL (1)	NL7214168A (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU8045382A (en) *	1981-12-14	1983-06-23	Pennwalt Corp.	Chromones
IT1258315B (it) *	1992-04-10	1996-02-22	Recordati Chem Pharm	Derivati del flavone
CN108239029B (zh) *	2016-12-23	2021-04-13	中国医学科学院药物研究所	一类四氢异喹啉化合物及其盐的制备和医药用途
CN118684643B (zh) *	2024-05-31	2025-10-17	贵州医科大学	钩苞大丁草内分离出的化合物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1216878B (de) *	1963-04-02	1966-05-18	Cassella Farbwerke Mainkur Ag	Verfahren zur Herstellung von coronargefaesserweiternden Derivaten des 7-Hydroxy-2-oxo-1, 2-dihydrochinolins
GB1178400A (en) *	1966-12-13	1970-01-21	Delalande Sa	Nitrogen Substituted Amines and their process of Preparation.
GB1223690A (en) *	1967-10-17	1971-03-03	Fisons Pharmaceuticals Ltd	Substituted chromon-2-carboxylic acids
US3652557A (en) *	1968-01-19	1972-03-28	Cassella Farbwerke Mainkur Ag	3-(gamma-tertiary amino-beta-alkoxy benzoyloxy-propyl) - 4 -hydrocarbon - 5 8 - alkoxy coumarins

0
- BE BE790074D patent/BE790074A/fr unknown
1972
- 1972-10-12 CH CH1492172A patent/CH557376A/fr not_active IP Right Cessation
- 1972-10-19 LU LU66322A patent/LU66322A1/xx unknown
- 1972-10-19 NL NL7214168A patent/NL7214168A/xx not_active Application Discontinuation
- 1972-10-20 CA CA154,645A patent/CA982571A/en not_active Expired
- 1972-10-20 JP JP47104548A patent/JPS4935630B2/ja not_active Expired
- 1972-10-20 GB GB4846672A patent/GB1378397A/en not_active Expired
- 1972-10-21 ES ES408114A patent/ES408114A1/es not_active Expired
- 1972-10-22 IL IL40640A patent/IL40640A/en unknown
- 1972-10-23 DE DE2251872A patent/DE2251872C3/de not_active Expired
- 1972-10-24 US US299895A patent/US3891651A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL40640A0 (en)	1972-12-29
JPS4856688A (fr)	1973-08-09
CA982571A (en)	1976-01-27
DE2251872C3 (de)	1978-05-03
ES408114A1 (es)	1976-02-16
DE2251872A1 (de)	1973-04-26
LU66322A1 (fr)	1973-01-23
BE790074A (fr)	1973-02-01
GB1378397A (en)	1974-12-27
JPS4935630B2 (fr)	1974-09-25
DE2251872B2 (de)	1977-08-25
CH557376A (fr)	1974-12-31
US3891651A (en)	1975-06-24
NL7214168A (fr)	1973-04-25

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