IL45672A - Anti-microbial compositions containing 1-(1,2,4-triazol-1-yl)-2-phenoxy-4,4-dimethyl-pentan-3-one derivatives - Google Patents

Anti-microbial compositions containing 1-(1,2,4-triazol-1-yl)-2-phenoxy-4,4-dimethyl-pentan-3-one derivatives

Info

Publication number: IL45672A
Authority: IL; Israel
Prior art keywords: compound; active ingredient; active; composition according; admixture
Prior art date: 1973-09-19

Application number

IL45672A

Other languages

English (en)

Other versions

IL45672A0 (en

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-09-19

Filing date

1974-09-16

Publication date

1977-06-30

1974-09-16 Application filed by Bayer Ag filed Critical Bayer Ag

1974-11-29 Publication of IL45672A0 publication Critical patent/IL45672A0/xx

1977-06-30 Publication of IL45672A publication Critical patent/IL45672A/en

Links

239000000203 mixture Substances 0.000 title claims description 18
230000000845 anti-microbial effect Effects 0.000 title description 4
239000004599 antimicrobial Substances 0.000 title description 2
GLQWJGFEJAFCHQ-UHFFFAOYSA-N 4,4-dimethyl-2-phenoxy-1-(1,2,4-triazol-1-yl)pentan-3-one Chemical class C=1C=CC=CC=1OC(C(=O)C(C)(C)C)CN1C=NC=N1 GLQWJGFEJAFCHQ-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 46
239000003814 drug Substances 0.000 claims description 28
239000008194 pharmaceutical composition Substances 0.000 claims description 23
239000003085 diluting agent Substances 0.000 claims description 21
239000004480 active ingredient Substances 0.000 claims description 15
150000003839 salts Chemical class 0.000 claims description 13
239000002904 solvent Substances 0.000 claims description 13
238000000034 method Methods 0.000 claims description 12
ALNWCYLRUYXLCD-UHFFFAOYSA-N 1-ethyltriazole Chemical compound CCN1C=CN=N1 ALNWCYLRUYXLCD-UHFFFAOYSA-N 0.000 claims description 9
125000000468 ketone group Chemical group 0.000 claims description 9
241001465754 Metazoa Species 0.000 claims description 8
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208000015181 infectious disease Diseases 0.000 claims description 7
239000002775 capsule Substances 0.000 claims description 6
239000006187 pill Substances 0.000 claims description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
239000008298 dragée Substances 0.000 claims description 5
230000037396 body weight Effects 0.000 claims description 4
239000000460 chlorine Substances 0.000 claims description 4
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125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
239000000829 suppository Substances 0.000 claims description 4
239000004094 surface-active agent Substances 0.000 claims description 4
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
229910052731 fluorine Inorganic materials 0.000 claims description 3
239000011737 fluorine Substances 0.000 claims description 3
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125000005843 halogen group Chemical group 0.000 claims description 3
239000007787 solid Substances 0.000 claims description 3
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125000000217 alkyl group Chemical group 0.000 claims description 2
239000007864 aqueous solution Substances 0.000 claims description 2
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239000007788 liquid Substances 0.000 claims description 2
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
230000000813 microbial effect Effects 0.000 claims 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
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RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 3
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239000000454 talc Substances 0.000 description 3
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VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 description 2
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FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
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GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
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SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
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BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
239000003495 polar organic solvent Substances 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
150000003852 triazoles Chemical class 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
235000014692 zinc oxide Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL45672A 1973-09-19 1974-09-16 Anti-microbial compositions containing 1-(1,2,4-triazol-1-yl)-2-phenoxy-4,4-dimethyl-pentan-3-one derivatives IL45672A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19732347057 DE2347057A1 (de)	1973-09-19	1973-09-19	Antimikrobielle mittel

Publications (2)

Publication Number	Publication Date
IL45672A0 IL45672A0 (en)	1974-11-29
IL45672A true IL45672A (en)	1977-06-30

Family

ID=5893019

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL45672A IL45672A (en)	1973-09-19	1974-09-16	Anti-microbial compositions containing 1-(1,2,4-triazol-1-yl)-2-phenoxy-4,4-dimethyl-pentan-3-one derivatives

Country Status (10)

Country	Link
US (1)	US3983240A (fr)
AU (1)	AU497850B2 (fr)
BE (1)	BE820057A (fr)
CA (1)	CA1029304A (fr)
DE (1)	DE2347057A1 (fr)
FR (1)	FR2243692B1 (fr)
GB (1)	GB1438440A (fr)
IL (1)	IL45672A (fr)
LU (1)	LU70939A1 (fr)
NL (1)	NL7412263A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2552967A1 (de) *	1975-11-26	1977-06-08	Bayer Ag	Fungizide mittel
US4156001A (en) *	1975-11-26	1979-05-22	Bayer Aktiengesellschaft	Synergistic fungicidal compositions containing 1,2,4-trizole derivatives and 2,4-dichloro-6-(o-chloroanilino)-1,3,5-triazine
DE2645496A1 (de) *	1976-10-08	1978-04-13	Bayer Ag	(1-phenyl-2-triazolyl-aethyl)-thioaether-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide und wachstumsregulatoren
US4584307A (en) *	1983-08-10	1986-04-22	Pfizer Inc.	Antifungal 2-aryl-2-hydroxy perfluoro-1-(1H-1,2,4-triazol-1-yl) alkanones and alkanols
DE3436452A1 (de) *	1984-10-05	1986-04-10	Bayer Ag, 5090 Leverkusen	Antimykotisches mittel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2105490C3 (de) *	1971-02-05	1979-06-13	Bayer Ag, 5090 Leverkusen	1 -Imidazolylketonderivate

1973
- 1973-09-19 DE DE19732347057 patent/DE2347057A1/de not_active Withdrawn
1974
- 1974-09-09 US US05/504,429 patent/US3983240A/en not_active Expired - Lifetime
- 1974-09-10 CA CA208,817A patent/CA1029304A/fr not_active Expired
- 1974-09-16 IL IL45672A patent/IL45672A/en unknown
- 1974-09-16 NL NL7412263A patent/NL7412263A/xx not_active Application Discontinuation
- 1974-09-17 LU LU70939A patent/LU70939A1/xx unknown
- 1974-09-18 BE BE148651A patent/BE820057A/fr unknown
- 1974-09-18 GB GB4069174A patent/GB1438440A/en not_active Expired
- 1974-09-19 AU AU73382/74A patent/AU497850B2/en not_active Expired
- 1974-09-19 FR FR7431675A patent/FR2243692B1/fr not_active Expired

Also Published As

Publication number	Publication date
US3983240A (en)	1976-09-28
BE820057A (fr)	1975-03-18
FR2243692A1 (fr)	1975-04-11
GB1438440A (en)	1976-06-09
AU7338274A (en)	1976-03-25
LU70939A1 (fr)	1975-05-28
AU497850B2 (en)	1979-01-18
CA1029304A (fr)	1978-04-11
NL7412263A (nl)	1975-03-21
DE2347057A1 (de)	1975-04-03
IL45672A0 (en)	1974-11-29
FR2243692B1 (fr)	1978-07-28

Publication	Publication Date	Title
US3812142A (en)	1974-05-21	Imidazolyl ketones
JPH0222731B2 (fr)	1990-05-21
FI71134B (fi)	1986-08-14	Foerfarande foer framstaellning av antifungicid 2-(2,4-difluorfenyl)-1,3-bis-(1h-1,2,4-triatsol-1-yl)-propan-2-ol
IE48881B1 (en)	1985-06-12	New hydroxyethyl-azole compounds,their production and their medicinal use
US4233311A (en)	1980-11-11	Antimicrobial agents and their use
JPS6258355B2 (fr)	1987-12-05
US4910213A (en)	1990-03-20	Antimycotic agents
US3903287A (en)	1975-09-02	Imidazolyl ketones for treating mycotic infections
EP0132508A2 (fr)	1985-02-13	Dérivés hydroxyéthyl-azolyliques, leur utilisation et agents antiviraux les contenant
US4894382A (en)	1990-01-16	Substituted 1,3-diazolyl-2-propanols and their use as antimycotic agents
US4215131A (en)	1980-07-29	Antimicrobial agents
IL44794A (en)	1977-08-31	Antimicrobial compositions containing certain 1,2,4-or 1,2,3-triazolyl o,n-acetal derivatives
IL45672A (en)	1977-06-30	Anti-microbial compositions containing 1-(1,2,4-triazol-1-yl)-2-phenoxy-4,4-dimethyl-pentan-3-one derivatives
CA1160237A (fr)	1984-01-10	Composes de biphenylyl-azolylethane, production et application medicale
GB1564371A (en)	1980-04-10	Antimicrobial agents containing imidazole derivatives
IL45771A (en)	1977-11-30	Pharmaceutical compositions containing 1-(2-phenoxy-3-hydroxy-alkyl)-1,2,4-triazole derivatives
US5126359A (en)	1992-06-30	Substituted bisazoles and their use as medicaments
CA1198117A (fr)	1985-12-17	Diazolylalkanols, procede de preparation et utilisation comme agents antifongiques
US4239765A (en)	1980-12-16	Fluorenyl-azolylmethyl-carbinol compounds and their medicinal use
US4904682A (en)	1990-02-27	Treating mycoses with triazolylalkanols
IL43298A (en)	1977-02-28	Omega,omega-diphenyl-omega-imidazolyl-1-acetic acid amides,their production and pharmaceutical compositions containing them
US4418072A (en)	1983-11-29	Diastereomeric 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol compounds and their antimycotic use
IE42187B1 (en)	1980-06-18	Diaryloxy-imidazolyl-o,n-acetals,process for their preparation and their use as medicaments
HU186677B (en)	1985-09-30	Process for preparing substituted hydroxy-alkyl-imidazole and -triazole derivatives
CA1146950A (fr)	1983-05-24	Nouveaux derives de l'hydroxybutyl-imidazole