IL53692A - 17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation - Google Patents

17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation

Info

Publication number: IL53692A
Authority: IL; Israel
Prior art keywords: pregn; ene; hydroxy; preparation; carboxylic acids
Prior art date: 1976-12-27

Application number

IL53692A

Other languages

English (en)

Other versions

IL53692A0 (en

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-12-27

Filing date

1977-12-26

Publication date

1982-07-30

1977-12-26 Application filed by Searle & Co filed Critical Searle & Co

1978-03-10 Publication of IL53692A0 publication Critical patent/IL53692A0/xx

1982-07-30 Publication of IL53692A publication Critical patent/IL53692A/xx

Links

LFXXBOPPAILDMW-LHZXLZLDSA-N 3-[(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,3,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl]propanoic acid Chemical class O[C@]1(CCC(=O)O)CC[C@H]2[C@@H]3CCC4=CCCC[C@]4(C)[C@H]3CC[C@]12C LFXXBOPPAILDMW-LHZXLZLDSA-N 0.000 title 1
150000002596 lactones Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL53692A 1976-12-27 1977-12-26 17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation IL53692A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/754,136 US4069219A (en)	1976-12-27	1976-12-27	7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (2)

Publication Number	Publication Date
IL53692A0 IL53692A0 (en)	1978-03-10
IL53692A true IL53692A (en)	1982-07-30

Family

ID=25033598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL53692A IL53692A (en)	1976-12-27	1977-12-26	17-hydroxy-pregn-4-ene-21-carboxylic acids and the corresponding lactones and their preparation

Country Status (19)

Country	Link
US (1)	US4069219A (de)
JP (1)	JPS5382767A (de)
AU (1)	AU518862B2 (de)
BE (1)	BE862365A (de)
CA (1)	CA1099702A (de)
CH (6)	CH637403A5 (de)
DE (1)	DE2758279A1 (de)
DK (1)	DK577377A (de)
FI (1)	FI773936A7 (de)
FR (1)	FR2375253A1 (de)
GB (1)	GB1575986A (de)
IE (1)	IE46128B1 (de)
IL (1)	IL53692A (de)
NL (1)	NL7714428A (de)
NO (2)	NO774464L (de)
NZ (1)	NZ186119A (de)
PT (1)	PT67455B (de)
SE (1)	SE7714764L (de)
ZA (1)	ZA777684B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3111951A1 (de) *	1981-03-23	1982-09-30	Schering Ag, 1000 Berlin Und 4619 Bergkamen	7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) *	1982-07-22	1984-02-03	シエ−リング・アクチエンゲゼルシヤフト	１７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) *	1983-08-17	1985-03-07	Schering AG, 1000 Berlin und 4709 Bergkamen	7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
WO1997021720A2 (en) *	1995-12-11	1997-06-19	G.D. Searle And Co.	Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds
US8389687B2 (en) *	2000-10-23	2013-03-05	Shanbrom Technologies, Llc	Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7411006B2 (en) *	2000-10-23	2008-08-12	Shanbrom Technologies, Llc	Enhanced production of blood clotting factors and fibrin fabric
US7297716B2 (en) *	2000-10-23	2007-11-20	Shanbrom Technologies, Llc	Enhanced production of blood components, blood cells and plasma without freezing
EP1487859B1 (de) *	2002-03-22	2008-08-13	Pharmacia & Upjohn Company LLC	Verfahren zur herstellung von eplerenon
US7196208B2 (en) *	2002-11-06	2007-03-27	Peter Guillaume Marie Wuts	Processes for preparing 7-carboxy substituted steroids
RS20050339A (sr) *	2002-11-07	2007-08-03	Pharmacia & Upjohn Company Llc.,	Postupci za dobijanje c-7 supstituisanih 5-androstena
PT2527356T (pt)	2005-07-21	2018-03-26	Bayer Ip Gmbh	Processo para a produção de 3-oxo-pregn-4-eno-21,17-carbolactonas através da oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-diidroxiandrostanos
ES2311927T5 (es)	2005-07-21	2014-09-08	Bayer Pharma Aktiengesellschaft	Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE787940A (fr) *	1971-08-25	1973-02-26	Searle & Co	Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation
GB1368006A (en) *	1972-08-24	1974-09-25	Searle & Co	4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) *	1975-09-22	1976-08-03	G. D. Searle & Co.	6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

1976
- 1976-12-27 US US05/754,136 patent/US4069219A/en not_active Expired - Lifetime
1977
- 1977-12-22 NZ NZ186119A patent/NZ186119A/xx unknown
- 1977-12-23 AU AU32012/77A patent/AU518862B2/en not_active Expired
- 1977-12-23 DK DK577377A patent/DK577377A/da unknown
- 1977-12-23 GB GB53717/77A patent/GB1575986A/en not_active Expired
- 1977-12-23 CA CA293,844A patent/CA1099702A/en not_active Expired
- 1977-12-26 FR FR7739218A patent/FR2375253A1/fr active Granted
- 1977-12-26 IL IL53692A patent/IL53692A/xx unknown
- 1977-12-26 PT PT67455A patent/PT67455B/pt unknown
- 1977-12-27 FI FI773936A patent/FI773936A7/fi not_active Application Discontinuation
- 1977-12-27 DE DE19772758279 patent/DE2758279A1/de not_active Withdrawn
- 1977-12-27 CH CH1607777A patent/CH637403A5/de not_active IP Right Cessation
- 1977-12-27 NO NO774464A patent/NO774464L/no unknown
- 1977-12-27 JP JP15852277A patent/JPS5382767A/ja active Pending
- 1977-12-27 NL NL7714428A patent/NL7714428A/xx not_active Application Discontinuation
- 1977-12-27 BE BE183884A patent/BE862365A/xx not_active IP Right Cessation
- 1977-12-27 SE SE7714764A patent/SE7714764L/xx unknown
- 1977-12-28 ZA ZA00777684A patent/ZA777684B/xx unknown
- 1977-12-29 IE IE2635/77A patent/IE46128B1/en unknown
1982
- 1982-01-11 NO NO820059A patent/NO820059L/no unknown
- 1982-05-18 CH CH310682A patent/CH637404A5/de not_active IP Right Cessation
- 1982-06-03 CH CH343482A patent/CH637405A5/de not_active IP Right Cessation
- 1982-06-03 CH CH343682A patent/CH637408A5/de not_active IP Right Cessation
- 1982-06-03 CH CH343582A patent/CH635595A5/de not_active IP Right Cessation
- 1982-11-15 CH CH665682A patent/CH638536A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE46128B1 (en)	1983-02-23
PT67455A (en)	1978-01-01
NZ186119A (en)	1979-08-31
CH637403A5 (de)	1983-07-29
CH635595A5 (de)	1983-04-15
FR2375253B1 (de)	1981-04-30
GB1575986A (en)	1980-10-01
US4069219A (en)	1978-01-17
IL53692A0 (en)	1978-03-10
PT67455B (en)	1979-05-25
NO774464L (no)	1978-06-28
CH638536A5 (de)	1983-09-30
AU3201277A (en)	1979-06-28
CH637405A5 (de)	1983-07-29
NL7714428A (nl)	1978-06-29
BE862365A (fr)	1978-06-27
IE46128L (en)	1978-06-27
SE7714764L (sv)	1978-06-28
CH637408A5 (de)	1983-07-29
NO820059L (no)	1978-06-28
JPS5382767A (en)	1978-07-21
ZA777684B (en)	1979-08-29
FI773936A7 (fi)	1978-06-28
FR2375253A1 (fr)	1978-07-21
CH637404A5 (de)	1983-07-29
AU518862B2 (en)	1981-10-22
DK577377A (da)	1978-06-28
DE2758279A1 (de)	1978-06-29
CA1099702A (en)	1981-04-21

Publication	Publication Date	Title
ZA77564B (en)	1977-12-28	Carboxyalkylacylamino acids
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IL51705A (en)	1982-09-30	Acetohydroxamic acids and their preparation
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AU514389B2 (en)	1981-02-05	Polyvinylbenzenesulphonic acids
ZA777629B (en)	1978-10-25	Sulphamoylbenzoic acids
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AU2266077A (en)	1978-08-31	15, 16-dioxy prostenoic acids and esters
ZA775350B (en)	1978-07-26	Substituted 5-amino-2-pyridinecarboxylic acids
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JPS5346960A (en)	1978-04-27	Biss22furanizylether and its preparation
AU514082B2 (en)	1978-08-10	Carboxyalkylacylamino acids
IL52123A (en)	1980-11-30	7-acylamino-3-pyrazinylthiomethyl-3-cephem-4-carboxylic acids and preparation thereof
IL50155A (en)	1979-12-30	6,11 dihydro-11-oxodibenz oxepinalkynoic acids and esters thereof