IL60095A - Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophen - Google Patents

Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophen

Info

Publication number: IL60095A
Authority: IL; Israel
Prior art keywords: nalbuphine; acetaminophen; pharmaceutical compositions; analgesic pharmaceutical; synergistic analgesic
Prior art date: 1979-05-18

Application number

IL60095A

Other languages

English (en)

Other versions

IL60095A0 (en

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-05-18

Filing date

1980-05-16

Publication date

1982-12-31

1980-05-16 Application filed by Du Pont filed Critical Du Pont

1980-07-31 Publication of IL60095A0 publication Critical patent/IL60095A0/xx

1982-12-31 Publication of IL60095A publication Critical patent/IL60095A/xx

Links

RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title 2
230000000202 analgesic effect Effects 0.000 title 1
NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 title 1
229960000805 nalbuphine Drugs 0.000 title 1
229960005489 paracetamol Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
230000002195 synergetic effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL60095A 1979-05-18 1980-05-16 Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophen IL60095A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/040,281 US4237140A (en)	1979-05-18	1979-05-18	Analgesic mixture of nalbuphine and acetaminophen

Publications (2)

Publication Number	Publication Date
IL60095A0 IL60095A0 (en)	1980-07-31
IL60095A true IL60095A (en)	1982-12-31

Family

ID=21910135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL60095A IL60095A (en)	1979-05-18	1980-05-16	Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophen

Country Status (12)

Country	Link
US (1)	US4237140A (da)
EP (1)	EP0019282B1 (da)
JP (1)	JPS55154917A (da)
AU (1)	AU529764B2 (da)
CA (1)	CA1139671A (da)
DE (1)	DE3061597D1 (da)
HU (1)	HU178867B (da)
IE (1)	IE49988B1 (da)
IL (1)	IL60095A (da)
NZ (1)	NZ193695A (da)
PH (1)	PH15265A (da)
ZA (1)	ZA802916B (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322427A (en) *	1981-04-16	1982-03-30	Bristol-Myers Company	Analgetic compositions and methods of use
US4366159A (en) *	1981-09-08	1982-12-28	Michael Richard Magruder	Nalbuphine-narcotic analgesic composition and method of producing analgesia
US4404211A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and flurbiprofen
US4407805A (en) *	1982-06-30	1983-10-04	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and zomepirac
US4404208A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and tiflamizole
US4404210A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and ibuprofen
US4404209A (en) *	1982-06-30	1983-09-13	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and sulindac
US4407804A (en) *	1982-06-30	1983-10-04	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and indomethacin
US4402962A (en) *	1982-06-30	1983-09-06	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole
AU565634B2 (en) *	1982-06-30	1987-09-24	E.I. Du Pont De Nemours And Company	Synergistic compositions of nalbuphine and non-narcotic analgesic compounds
AU558485B2 (en) *	1982-07-22	1987-01-29	Richardson-Vicks Inc.	Improved analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4777174A (en) *	1982-07-22	1988-10-11	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4656177A (en) *	1982-07-22	1987-04-07	Analgesic Associates	Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4600579A (en) *	1983-06-07	1986-07-15	Mallinckrodt, Inc.	N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4722928A (en) *	1985-12-02	1988-02-02	E. I. Du Pont De Nemours And Company	N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes
DE122004000032I2 (de)	1991-09-06	2006-02-09	Mcneilab Inc	Zusammensetzung die eine Tramadol-Verbindung und Acetaminophen enth{lt, und ihre Verwendung
US5558876A (en) *	1995-03-29	1996-09-24	Alcon Laboratories, Inc.	Topical ophthalmic acidic drug formulations
US6348216B1 (en) *	1996-06-10	2002-02-19	Knoll Pharmaceutical Company	Ibuprofen and narcotic analgesic compositions
US6361794B1 (en)	1996-06-12	2002-03-26	Basf Corporation	Method of making ibuprofen and narcotic analgesic composition
TR200001942T2 (tr)	1997-12-22	2000-11-21	Euro-Celtique, S.A.	Opioid agonist/antagonist kombinasyonlar
US6375957B1 (en)	1997-12-22	2002-04-23	Euro-Celtique, S.A.	Opioid agonist/opioid antagonist/acetaminophen combinations
SI2283842T1 (sl)	2000-02-08	2015-07-31	Euro-Celtique S.A.	Oralne formulacije opioidnih agonistov, varne pred zlorabo
EP1387673B1 (en)	2001-05-11	2010-12-29	Endo Pharmaceuticals Inc.	Abuse-resistant controlled-release opioid dosage form
DK1416842T3 (da)	2001-07-18	2009-03-16	Euro Celtique Sa	Farmaceutiske kombinationer af oxycodon og naloxon
US20030044458A1 (en)	2001-08-06	2003-03-06	Curtis Wright	Oral dosage form comprising a therapeutic agent and an adverse-effect agent
ES2326794T3 (es)	2001-08-06	2009-10-20	Euro-Celtique S.A.	Formulaciones de agonistas opioides con antagonista liberable y secuestrado.
US20030157168A1 (en)	2001-08-06	2003-08-21	Christopher Breder	Sequestered antagonist formulations
LT2425821T (lt)	2002-04-05	2017-07-25	Euro-Celtique S.A.	Farmacinis preparatas, turintis oksikodono ir naloksono
SI1551372T1 (en)	2002-09-20	2018-08-31	Alpharma Pharmaceuticals Llc	SUBVENCATION DATA AND RELATED CONSTRUCTIONS AND PROCEDURES
US20040202717A1 (en)	2003-04-08	2004-10-14	Mehta Atul M.	Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en)	2003-04-21	2011-08-21	Euro Celtique Sa	Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en)	2004-06-08	2005-12-14	Euro-Celtique S.A.	Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1702558A1 (en)	2005-02-28	2006-09-20	Euro-Celtique S.A.	Method and device for the assessment of bowel function
CA2620224C (en)	2005-08-24	2015-11-24	Penwest Pharmaceuticals Company	Sustained release formulations of nalbuphine
US8394812B2 (en)	2005-08-24	2013-03-12	Penwest Pharmaceuticals Co.	Sustained release formulations of nalbuphine
SI2484346T1 (sl)	2006-06-19	2017-05-31	Alpharma Pharmaceuticals Llc	Farmacevtski sestavki
US8623418B2 (en)	2007-12-17	2014-01-07	Alpharma Pharmaceuticals Llc	Pharmaceutical composition
PL2405915T3 (pl)	2009-03-10	2019-05-31	Euro Celtique Sa	Kompozycje farmaceutyczne o natychmiastowym uwalnianiu zawierające oksykodon i nalokson
KR20160034352A (ko)	2013-07-23	2016-03-29	유로-셀티큐 에스.에이.	장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
EA201990684A1 (ru)	2013-12-24	2020-12-30	Вирджиния Коммонвелт Юниверсити	Способы применения оксигенированных холестеролсульфатов (ocs)
JOP20190094A1 (ar) *	2016-10-27	2019-04-25	Broad Inst Inc	مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh)
US11260048B2 (en)	2017-10-03	2022-03-01	The Schepens Eye Research Institute, Inc.	Compounds and compositions for inhibiting retinal pigment epithelium degeneration and methods using the same
JP7318987B2 (ja) *	2018-09-03	2023-08-01	ジェイコブバイオテックリミテッド	セバコイルジナルブフィンとアセトアミノフェンの医薬品製剤及び疼痛を治療する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL26896A (en) *	1966-01-19	1970-11-30	Endo Lab	14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US4029798A (en) *	1975-06-02	1977-06-14	Sumitomo Chemical Company, Limited	Analgetic composition
JPS5946205B2 (ja) *	1976-01-01	1984-11-10	科研製薬株式会社	ベンゾイル誘導体を有効成分とする消炎鎮痛剤

1979
- 1979-05-18 US US06/040,281 patent/US4237140A/en not_active Expired - Lifetime
1980
- 1980-05-13 NZ NZ193695A patent/NZ193695A/en unknown
- 1980-05-13 AU AU58351/80A patent/AU529764B2/en not_active Ceased
- 1980-05-15 EP EP80102696A patent/EP0019282B1/en not_active Expired
- 1980-05-15 CA CA000352011A patent/CA1139671A/en not_active Expired
- 1980-05-15 DE DE8080102696T patent/DE3061597D1/de not_active Expired
- 1980-05-16 PH PH24035A patent/PH15265A/en unknown
- 1980-05-16 HU HU80801223A patent/HU178867B/hu not_active IP Right Cessation
- 1980-05-16 IL IL60095A patent/IL60095A/xx unknown
- 1980-05-16 IE IE1019/80A patent/IE49988B1/en not_active IP Right Cessation
- 1980-05-16 ZA ZA00802916A patent/ZA802916B/xx unknown
- 1980-05-17 JP JP6469980A patent/JPS55154917A/ja active Granted

Also Published As

Publication number	Publication date
NZ193695A (en)	1984-05-31
AU5835180A (en)	1980-11-20
EP0019282A1 (en)	1980-11-26
IE49988B1 (en)	1986-01-22
PH15265A (en)	1982-11-02
JPH0144684B2 (da)	1989-09-29
IE801019L (en)	1980-11-18
DE3061597D1 (en)	1983-02-17
AU529764B2 (en)	1983-06-16
EP0019282B1 (en)	1983-01-12
JPS55154917A (en)	1980-12-02
CA1139671A (en)	1983-01-18
US4237140A (en)	1980-12-02
ZA802916B (en)	1981-12-30
HU178867B (en)	1982-07-28
IL60095A0 (en)	1980-07-31

Publication	Publication Date	Title
IL60095A0 (en)	1980-07-31	Pharmaceutical compositions comprising nalbuphine and acetaminophen
GB2103591B (en)	1985-03-06	Pharmaceutical compositions and process
DE3372705D1 (en)	1987-09-03	Pharmaceutical composition and its use
NZ194432A (en)	1983-09-02	Lipophilic muramyl-peptides and pharmaceutical compositions
PT76147A (en)	1983-02-01	Process for the preparation of pyrazolooxazines pyrazolothiazines and pyrazoloquinolines with a lipoxygenase inhibiting effect and their use for the preparation of pharmaceutical compositions having a lipoxygenase inhibiting effect
NZ194961A (en)	1983-09-30	Enkephalin analogues and pharmaceutical compositions
NZ194584A (en)	1983-05-31	-lactam antibiotics and pharmaceutical compositions
NZ210105A (en)	1988-10-28	Oxazolidine derivatives and pharmaceutical compositions
IL60550A (en)	1984-12-31	Pharmaceutical compositions comprising aryl-pyrazolineamine derivatives and certain novel such compounds
PH16443A (en)	1983-10-12	Substituted tetraazetricyclic compounds and their pharmaceutical compositions
DE2964696D1 (en)	1983-03-17	N-(benzothienopyrazol)-amides and pharmaceutical compositions containing them
IL61700A (en)	1984-04-30	Analgesic tetrapeptides,their preparation and pharmaceutical compositions comprising them
IL61703A (en)	1984-05-31	Analgesic pentapeptides,their preparation and pharmaceutical compositions comprising them
IL61117A (en)	1983-10-31	2beta-acetoxymethyl-penam compounds and pharmaceutical compositions containing them
GB2047534B (en)	1983-04-20	Analgesic and myotonolytic compositions
IL60376A (en)	1983-07-31	3-diphenylmethyleneazetidines and pharmaceutical compositions containing them
NZ194784A (en)	1982-12-21	7 -aminothiadizolylacetylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions
IL61701A (en)	1984-05-31	Analgesic pentapeptides,their preparation and pharmaceutical compositions comprising them
GB2050833B (en)	1983-03-30	Pharmaceutical compositions and process for the preparation thereof
IL69058A0 (en)	1983-10-31	Synergistic pharmaceutical analgesic compositions
PH16220A (en)	1983-08-09	Pyrro-lidine derivatives and pharmaceutical compositions thereof
IL59177A0 (en)	1980-05-30	Spiro-quinolylhydantoins and pharmaceutical compositions containing them
NZ203649A (en)	1985-02-28	2-beta-d-ribofuranosylselenazole-4-carboxamide derivatives and pharmaceutical compositions
NZ205732A (en)	1986-10-08	Thiatriazine derivatives and pharmaceutical compositions
PH19604A (en)	1986-05-27	Isoquinoline derivatives and pharmaceutical compositions containing the same