IL72018A - Biologically active heptapeptides structurally related to region within growth hormones and pharmaceutical compositions comprising them - Google Patents

Biologically active heptapeptides structurally related to region within growth hormones and pharmaceutical compositions comprising them

Info

Publication number: IL72018A
Authority: IL; Israel
Prior art keywords: sub; hgh; analogs; amino acid; acid residues
Prior art date: 1983-06-04

Application number

IL72018A

Other languages

English (en)

Other versions

IL72018A0 (en

Original Assignee

Amgen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-06-04

Filing date

1984-06-04

Publication date

1990-03-19

1984-06-04 Application filed by Amgen filed Critical Amgen

1984-10-31 Publication of IL72018A0 publication Critical patent/IL72018A0/xx

1990-03-19 Publication of IL72018A publication Critical patent/IL72018A/xx

Links

239000000122 growth hormone Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
125000000539 amino acid group Chemical group 0.000 abstract 3
239000012634 fragment Substances 0.000 abstract 3
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
102000002265 Human Growth Hormone Human genes 0.000 abstract 1
108010000521 Human Growth Hormone Proteins 0.000 abstract 1
239000000854 Human Growth Hormone Substances 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
241000894007 species Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL72018A 1983-06-04 1984-06-04 Biologically active heptapeptides structurally related to region within growth hormones and pharmaceutical compositions comprising them IL72018A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/501,024 US4699897A (en)	1983-06-04	1983-06-04	Biologically active peptides structurally related to regions within growth hormones

Publications (2)

Publication Number	Publication Date
IL72018A0 IL72018A0 (en)	1984-10-31
IL72018A true IL72018A (en)	1990-03-19

Family

ID=23991846

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL72018A IL72018A (en)	1983-06-04	1984-06-04	Biologically active heptapeptides structurally related to region within growth hormones and pharmaceutical compositions comprising them

Country Status (8)

Country	Link
US (1)	US4699897A (de)
EP (1)	EP0137904B1 (de)
JP (1)	JPH07116229B2 (de)
AT (1)	ATE50266T1 (de)
CA (1)	CA1267995A (de)
DE (1)	DE3481306D1 (de)
IL (1)	IL72018A (de)
WO (1)	WO1984004915A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0238473A3 (de) *	1986-03-18	1989-06-07	Monsanto Company	Serinprotease-Hemmungsstoffe
US5104806A (en) *	1987-03-12	1992-04-14	Amgen, Inc.	Porcine growth hormone analogs encoding dna
US5244882A (en) *	1987-03-12	1993-09-14	Amgen, Inc.	Porcine growth hormone analogs, and compositions
GB8707398D0 (en) *	1987-03-27	1987-04-29	Coopers Animal Health	Biologically active molecules
GB8718937D0 (en) *	1987-08-11	1987-09-16	Coopers Animal Health	Biologically active molecules
US5864008A (en) *	1988-03-25	1999-01-26	James; Stephen	Peptides derived from foot-and-mouth disease virus, pharmaceutical compositions, and methods for using the peptides
HU210966B (en) *	1988-03-25	1995-09-28	Mallinckrodt Veterinary Inc	Method for the preparation of peptides and veterinary compositions containing them
US5534617A (en) *	1988-10-28	1996-07-09	Genentech, Inc.	Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
EP0397834B1 (de) *	1988-10-28	2000-02-02	Genentech, Inc.	Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten
US5688666A (en) *	1988-10-28	1997-11-18	Genentech, Inc.	Growth hormone variants with altered binding properties
US6780613B1 (en)	1988-10-28	2004-08-24	Genentech, Inc.	Growth hormone variants
US5179080A (en) *	1989-08-31	1993-01-12	Clinical Homecare, Corp.	Formulations containing growth hormone and nutritional supplements, and methods of treating malnutrition in chronic lung disease
ES2113940T3 (es) *	1990-12-03	1998-05-16	Genentech Inc	Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
AU4238493A (en) *	1992-05-08	1993-12-13	Thomas Jefferson University	IGF-1 analogs
SE9203496D0 (sv) *	1992-11-20	1992-11-20	Kabi Pharmacia Ab	New oligopeptides
US5952465A (en) *	1993-04-23	1999-09-14	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
AU6770794A (en) *	1993-04-23	1994-11-21	Herbert J. Evans	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) *	1993-04-23	1999-07-27	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5965698A (en) *	1993-04-23	1999-10-12	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6258550B1 (en)	1993-04-23	2001-07-10	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US6084066A (en) *	1993-10-29	2000-07-04	Virginia Commonwealth University	Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
US6184208B1 (en)	1994-06-29	2001-02-06	Immunotech Developments Inc.	Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
RU2107691C1 (ru) *	1995-03-02	1998-03-27	Дейгин Владислав Исакович	Пептид и способ его получения
AU718439B2 (en) *	1995-09-21	2000-04-13	Genentech Inc.	Human growth hormone variants
US6159940A (en) *	1996-02-28	2000-12-12	Immunotech Developments Inc.	Method for modulating hemopoiesis
CA2534364A1 (en)	2003-08-07	2005-02-17	Alveolus Inc.	Therapeutic medical appliance, delivery and method of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2843525A (en) *	1953-01-23	1958-07-15	Allen & Hanburys Ltd	Insulin synthetic poly-amino acid complexes
US3326763A (en) *	1962-01-08	1967-06-20	Protein Foundation Inc	Reagent for increasing activity of insulin
US3698912A (en) *	1969-07-01	1972-10-17	Morton Norwich Products Inc	Process for making nutrient composition
US3868358A (en) *	1971-04-30	1975-02-25	Lilly Co Eli	Protamine-insulin product
US3912807A (en) *	1974-04-18	1975-10-14	American Home Prod	Treatment of diabetes using somatostatin and insulin
FR2296427A1 (fr) *	1974-12-31	1976-07-30	Choay Sa	Agent peptidique de regulation de la glycemie
US3941763A (en) *	1975-03-28	1976-03-02	American Home Products Corporation	PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
DE2658984C2 (de) *	1976-12-27	1983-08-18	Thera Gesellschaft für Patentverwertung mbH, 8036 Herrsching	Injizierbare Insulinpräparate
US4407948A (en) *	1977-09-23	1983-10-04	The Regents Of The University Of California	Purification of nucleotide sequences suitable for expression in bacteria
EP0053029A1 (de) *	1980-11-24	1982-06-02	Peninsula Laboratories Incorporated	Nicht-enkephalinartige Peptide, ihre Herstellung, sie enthaltende Zusammensetzungen und ihre medizinische und tierärztliche Verwendung
US4438032A (en) *	1981-01-30	1984-03-20	The Regents Of The University Of California	Unique T-lymphocyte line and products derived therefrom
US4558033A (en) *	1983-06-06	1985-12-10	Amgen	Potentiation of the effects of insulin by peptides

1983
- 1983-06-04 US US06/501,024 patent/US4699897A/en not_active Expired - Fee Related
1984
- 1984-06-01 JP JP59502360A patent/JPH07116229B2/ja not_active Expired - Lifetime
- 1984-06-01 WO PCT/US1984/000834 patent/WO1984004915A1/en not_active Ceased
- 1984-06-01 CA CA000455648A patent/CA1267995A/en not_active Expired - Lifetime
- 1984-06-04 EP EP84106337A patent/EP0137904B1/de not_active Expired - Lifetime
- 1984-06-04 DE DE8484106337T patent/DE3481306D1/de not_active Expired - Fee Related
- 1984-06-04 AT AT84106337T patent/ATE50266T1/de not_active IP Right Cessation
- 1984-06-04 IL IL72018A patent/IL72018A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3481306D1 (de)	1990-03-15
CA1267995A (en)	1990-04-17
EP0137904B1 (de)	1990-02-07
JPS60501504A (ja)	1985-09-12
US4699897A (en)	1987-10-13
JPH07116229B2 (ja)	1995-12-13
EP0137904A3 (en)	1987-01-07
IL72018A0 (en)	1984-10-31
ATE50266T1 (de)	1990-02-15
WO1984004915A1 (en)	1984-12-20
EP0137904A2 (de)	1985-04-24

Legal Events

Date	Code	Title	Description
1998-11-26	KB	Patent renewed
2003-03-12	MM9K	Patent not in force due to non-payment of renewal fees
2018-08-30	ERR	Corrigendum	Free format text: CORRECT DATE OF PRIORITY NUMBER 29.04.2016

Publication	Publication Date	Title
IL72018A0 (en)	1984-10-31	Biologically active peptides structurally related to regions within growth hormones
DE69630133T2 (de)	2004-06-09	Analoga des parathyroid-hormons
KR100699422B1 (ko)	2007-03-28	부갑상선 호르몬의 동족체
US5137872A (en)	1992-08-11	Growth hormone-releasing factor analogs
FI950169A0 (fi)	1995-01-13	PTH:n ja PTHRP:n analogit, niiden synteesi ja käyttö osteoporoosin hoitoon
ES2070322T3 (es)	1995-06-01	Polipeptidos biologicamente activos basados en las secuencias del factor de crecimiento de transformacion beta.
DK413986D0 (da)	1986-08-29	Syntetisk peptid og farmaceutisk middel indeholdende peptidet
DE69525544D1 (de)	2002-03-28	Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
IL72630A (en)	1988-11-30	Growth hormone-releasing peptides,their preparation and pharmaceutical preparations therefrom
RU97105374A (ru)	1999-04-20	Модифицированные белки
US4801456A (en)	1989-01-31	Growth hormone-releasing factor analogs
USRE33699E (en)	1991-09-24	Growth hormone-releasing factor analogs
IL102346A0 (en)	1993-01-14	Cysteine depleted il-6 muteins
NZ508816A (en)	2003-03-28	Bactericidal/permeability-increasing protein (BPI) deletion analogs
MY103251A (en)	1993-05-29	Biologically active molecules
HU884790D0 (en)	1990-07-28	Process for producing biologically active peptides and antigenous medicinal preparatives containing these peptides as active substance
TW360661B (en)	1999-06-11	Superactive GRF analogs
Li et al.	1978	Human somatotropin: semisynthesis of the hormone by noncovalent interaction of the NH2-terminal fragment with synthetic analogs of the COOH-terminal fragment
RU2119800C1 (ru)	1998-10-10	Аналог пептида фактора гормона роста (фгр), способ стимулирования секреции гормона роста и композиция для стимулирования секреции
YU64192A (sh)	1994-06-10	Analozi insulina
NO955059L (no)	1995-12-13	Peptider som utviser oksytocin antagonistisk aktivitet
HUT54388A (en)	1991-02-28	Process for producing new analogues of stimulator hormone for growth hormone secretion (grf)
Potts Jr et al.	1972	Comparative biochemistry of parathyroid hormone and calcitonin