IL77978A0 - Racemization of tomoxetine - Google Patents
Racemization of tomoxetineInfo
- Publication number
- IL77978A0 IL77978A0 IL77978A IL7797886A IL77978A0 IL 77978 A0 IL77978 A0 IL 77978A0 IL 77978 A IL77978 A IL 77978A IL 7797886 A IL7797886 A IL 7797886A IL 77978 A0 IL77978 A0 IL 77978A0
- Authority
- IL
- Israel
- Prior art keywords
- tomoxetine
- racemization
- alkali metal
- phenylpropylamine
- epimerization
- Prior art date
Links
- VHGCDTVCOLNTBX-QGZVFWFLSA-N atomoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=CC=C1C VHGCDTVCOLNTBX-QGZVFWFLSA-N 0.000 title 1
- 229960002430 atomoxetine Drugs 0.000 title 1
- 230000006340 racemization Effects 0.000 title 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- -1 C1-C6 alkyl alkali metal Chemical class 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006345 epimerization reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- VHGCDTVCOLNTBX-UHFFFAOYSA-N n-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine Chemical compound C=1C=CC=CC=1C(CCNC)OC1=CC=CC=C1C VHGCDTVCOLNTBX-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/706,373 US4777291A (en) | 1985-02-27 | 1985-02-27 | Racemization process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL77978A0 true IL77978A0 (en) | 1986-08-31 |
Family
ID=24837278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL77978A IL77978A0 (en) | 1985-02-27 | 1986-02-25 | Racemization of tomoxetine |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4777291A (de) |
| EP (1) | EP0193405B1 (de) |
| JP (1) | JPS61210059A (de) |
| KR (1) | KR870002180B1 (de) |
| AT (1) | ATE41144T1 (de) |
| CA (1) | CA1269997A (de) |
| DE (1) | DE3662262D1 (de) |
| HU (1) | HU196586B (de) |
| IL (1) | IL77978A0 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8419683D0 (en) * | 1984-08-02 | 1984-09-05 | Erba Farmitalia | 3-substituted derivatives of 1-amino-2-hydroxy-propane |
| US5320825A (en) * | 1991-05-01 | 1994-06-14 | Trustees Of The University Of Pennsylvania | Serotonin reuptake inhibitors for S.P.E.C.T. imaging |
| WO2000058262A1 (en) * | 1999-03-29 | 2000-10-05 | Eli Lilly And Company | Stereospecific method for preparing tomoxetine and intermediates thereof |
| GB0229583D0 (en) * | 2002-12-19 | 2003-01-22 | Cipla Ltd | A process for preparing duloxetine and intermediates for use therein |
| ATE526954T1 (de) * | 2003-07-28 | 2011-10-15 | Leslie Joe Dunaway | Atomoxetin zur behandlung von allergischer rhinitis und asthma |
| AU2004312059A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Atomoxetine formulations |
| US7317127B2 (en) * | 2004-06-28 | 2008-01-08 | Teva Pharmaceutical Fine Chemicals S.R.L | Process for the optical resolution and recycling of tomoxetine |
| US7439399B2 (en) * | 2004-06-28 | 2008-10-21 | Teva Pharmaceutical Fine Chemicals | Processes for the preparation of atomoxetine hydrochloride |
| CA2568629A1 (en) * | 2004-07-22 | 2006-02-23 | Teva Pharmaceutical Fine Chemicals S.R.L. | Polymorphs of atomoxetine hydrochloride |
| WO2006037055A1 (en) * | 2004-09-27 | 2006-04-06 | Dr. Reddy's Laboratories Ltd. | Synthesis of atomoxetine hydrochloride |
| MX2007010268A (es) * | 2005-04-05 | 2008-02-19 | Teva Pharm Fine Chemicals Srl | Clorhidrato de atomoxetina estable, un proceso para la preparacion del mismo, y un control analitico de su estabilidad. |
| US7485754B2 (en) * | 2005-07-08 | 2009-02-03 | Apotex Pharmachem Inc. | Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers |
| US20080146675A1 (en) * | 2006-04-05 | 2008-06-19 | Eugenio Castelli | Stable Atomoxetine Hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
| EP2364977A1 (de) | 2010-01-26 | 2011-09-14 | Reuter Chemische Apparatebau KG | Verfahren zur Enantiomerenanreicherung von 3-Methyl-1-(2-Piperidinphenyl)-1-Butylamin |
| CN113336654B (zh) * | 2020-02-18 | 2022-12-09 | 上海医药工业研究院 | 一种n-甲基-3-(2-甲基苯氧基)苯丙胺的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3168566A (en) * | 1961-09-01 | 1965-02-02 | Nopco Chem Co | Process for racemizing alpha-phenyl and alpha-naphthyl ethylamines |
| GB1471389A (en) * | 1973-08-31 | 1977-04-27 | Sumitomo Chemical Co | Method for racemization of optically active amines |
| US4158016A (en) * | 1973-08-31 | 1979-06-12 | Sumitomo Chemical Company, Limited | Method for racemization of optically active amines |
| DE2348801A1 (de) * | 1973-09-28 | 1975-04-10 | Dynamit Nobel Ag | Verfahren zur racemisierung von optisch aktivem 1-phenylaethylamin |
| US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
| PL233786A1 (de) * | 1980-11-14 | 1982-05-24 | Lilly Co Eli |
-
1985
- 1985-02-27 US US06/706,373 patent/US4777291A/en not_active Expired - Lifetime
-
1986
- 1986-02-25 IL IL77978A patent/IL77978A0/xx unknown
- 1986-02-25 KR KR1019860001309A patent/KR870002180B1/ko not_active Expired
- 1986-02-25 CA CA000502597A patent/CA1269997A/en not_active Expired - Lifetime
- 1986-02-26 HU HU86815A patent/HU196586B/hu not_active IP Right Cessation
- 1986-02-26 JP JP61042792A patent/JPS61210059A/ja active Pending
- 1986-02-27 EP EP86301417A patent/EP0193405B1/de not_active Expired
- 1986-02-27 DE DE8686301417T patent/DE3662262D1/de not_active Expired
- 1986-02-27 AT AT86301417T patent/ATE41144T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3662262D1 (en) | 1989-04-13 |
| CA1269997A (en) | 1990-06-05 |
| EP0193405A1 (de) | 1986-09-03 |
| HUT42055A (en) | 1987-06-29 |
| US4777291A (en) | 1988-10-11 |
| HU196586B (en) | 1988-12-28 |
| EP0193405B1 (de) | 1989-03-08 |
| KR860006433A (ko) | 1986-09-11 |
| ATE41144T1 (de) | 1989-03-15 |
| JPS61210059A (ja) | 1986-09-18 |
| KR870002180B1 (ko) | 1987-12-28 |
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