IL80108A - Process for preparing 1,4-diisopropyl-2,5-diketopiperazines - Google Patents
Process for preparing 1,4-diisopropyl-2,5-diketopiperazinesInfo
- Publication number
- IL80108A IL80108A IL80108A IL8010886A IL80108A IL 80108 A IL80108 A IL 80108A IL 80108 A IL80108 A IL 80108A IL 8010886 A IL8010886 A IL 8010886A IL 80108 A IL80108 A IL 80108A
- Authority
- IL
- Israel
- Prior art keywords
- diketopiperazines
- diisopropyl
- preparing
- unsubstituted
- substituted
- Prior art date
Links
- LCTYQXDHTHVMLH-UHFFFAOYSA-N 1,4-di(propan-2-yl)piperazine-2,5-dione Chemical class CC(C)N1CC(=O)N(C(C)C)CC1=O LCTYQXDHTHVMLH-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical class NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 haloacetyl halide Chemical class 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical class O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/778,817 US4694081A (en) | 1985-09-23 | 1985-09-23 | Process to prepare 2,5-diketopiperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL80108A0 IL80108A0 (en) | 1986-12-31 |
| IL80108A true IL80108A (en) | 1991-07-18 |
Family
ID=25114475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL80108A IL80108A (en) | 1985-09-23 | 1986-09-22 | Process for preparing 1,4-diisopropyl-2,5-diketopiperazines |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4694081A (de) |
| EP (1) | EP0216746B1 (de) |
| JP (1) | JPS6272676A (de) |
| AT (1) | ATE57694T1 (de) |
| AU (1) | AU588626B2 (de) |
| CA (1) | CA1257266A (de) |
| DE (1) | DE3675134D1 (de) |
| HU (1) | HU196382B (de) |
| IL (1) | IL80108A (de) |
| ZA (1) | ZA867212B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806538A (en) * | 1984-11-02 | 1989-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compound as PAF-antagonist |
| US4992552A (en) * | 1988-08-31 | 1991-02-12 | Eastman Kodak Company | Process for preparation of amino acids |
| JPH04234374A (ja) * | 1990-12-27 | 1992-08-24 | Ajinomoto Co Inc | ジケトピペラジン誘導体の製造方法 |
| US5208375A (en) * | 1991-07-02 | 1993-05-04 | Mallinckrodt Medical, Inc. | Compositions for magnetic resonance imaging |
| US5874589A (en) * | 1997-07-18 | 1999-02-23 | Glaxo Wellcome, Inc. | Methods for synthesizing diverse collections of tetramic acids and derivatives thereof |
| US6967202B2 (en) * | 2000-08-04 | 2005-11-22 | Dmi Biosciences, Inc. | Method of synthesizing diketopiperazines |
| JP5048201B2 (ja) | 2000-08-04 | 2012-10-17 | ディーエムアイ バイオサイエンシズ インコーポレイテッド | ジケトピペラジン類の使用方法とジケトピペラジン類を含む組成物 |
| KR100542820B1 (ko) * | 2002-09-17 | 2006-01-20 | 이재호 | 옥사릴 클로라이드를 이용한 1-에틸-2,3-디옥소피페라진의제조방법 |
| DK1571970T3 (da) * | 2002-10-02 | 2011-11-28 | Dmi Biosciences Inc | Diagnose og monitorering af sygdomme |
| CN102210852B (zh) | 2003-05-15 | 2016-10-19 | 安皮奥制药股份有限公司 | T-细胞介导的疾病的治疗 |
| JP5856843B2 (ja) * | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| US8116047B2 (en) * | 2008-12-18 | 2012-02-14 | Sandisk Technologies Inc. | Electrostatic discharge protective circuit having rise time detector and discharge sustaining circuitry |
| KR101278140B1 (ko) * | 2010-07-15 | 2013-06-27 | 공주대학교 산학협력단 | 2,5-다이케토피페라진 유도체를 활성성분으로 포함하는 농업용 약제 |
| EP2613786A4 (de) | 2010-09-07 | 2013-10-23 | Dmi Acquisition Corp | Behandlung von erkrankungen |
| JP2014530063A (ja) | 2011-10-10 | 2014-11-17 | アンピオ ファーマシューティカルズ，インコーポレイテッド | 免疫寛容が高められた埋込み型医療用デバイス、ならびに製造方法および埋込み方法 |
| PH12014500685B1 (en) | 2011-10-10 | 2018-10-03 | Ampio Pharmaceuticals Inc | Treatment of degenerative joint disease |
| HK1198812A1 (en) | 2011-10-28 | 2015-06-12 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| CA2906864A1 (en) | 2013-03-15 | 2014-09-18 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| EP4066836A1 (de) | 2014-08-18 | 2022-10-05 | Ampio Pharmaceuticals, Inc. | Behandlung von gelenkerkrankungen |
| EP3310375A4 (de) | 2015-06-22 | 2019-02-20 | Ampio Pharmaceuticals, Inc. | Verwendung von niedermolekularen fraktionen von humanem serumalbumin bei der behandlung von erkrankungen |
| US11129878B1 (en) | 2020-03-24 | 2021-09-28 | Ampio Pharmaceuticals, Inc. | Methods for treating diseases associated with respiratory viruses |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2913496A (en) * | 1957-06-07 | 1959-11-17 | Du Pont | N-(2-hydroxyethyl)-n'-pentenyl-ethylenediamine |
| DE1189553B (de) * | 1962-08-09 | 1965-03-25 | Degussa | Verfahren zur Herstellung von racemischen und optisch aktiven Piperazinderivaten |
| US4140791A (en) * | 1978-05-30 | 1979-02-20 | Chevron Research Company | 1,4-Di-(2,6-dimethylphenyl)-2,5-piperazinedione and its fungicidal use |
| JPS5618969A (en) * | 1979-07-24 | 1981-02-23 | Toyama Chem Co Ltd | Novel 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative, its acid addition salt, and their preparation |
| US4400330A (en) * | 1982-07-29 | 1983-08-23 | Stauffer Chemical Company | Method for preparation of N-phosphonomethylglycine |
| GB8427735D0 (en) * | 1984-11-02 | 1984-12-12 | Fujisawa Pharmaceutical Co | Piperazine compound |
| US4694082A (en) * | 1985-09-23 | 1987-09-15 | Monsanto Company | Compound 1,4-diisopropyl-2,5-diketopiperazine |
| US4804499A (en) * | 1985-09-23 | 1989-02-14 | Monsanto Company | Process for the preparation of N-substituted aminomethylphosphonic acids |
-
1985
- 1985-09-23 US US06/778,817 patent/US4694081A/en not_active Expired - Fee Related
-
1986
- 1986-09-22 CA CA000518770A patent/CA1257266A/en not_active Expired
- 1986-09-22 HU HU864016A patent/HU196382B/hu not_active IP Right Cessation
- 1986-09-22 AU AU63034/86A patent/AU588626B2/en not_active Ceased
- 1986-09-22 EP EP86870133A patent/EP0216746B1/de not_active Expired - Lifetime
- 1986-09-22 JP JP61222275A patent/JPS6272676A/ja active Pending
- 1986-09-22 AT AT86870133T patent/ATE57694T1/de active
- 1986-09-22 DE DE8686870133T patent/DE3675134D1/de not_active Expired - Lifetime
- 1986-09-22 IL IL80108A patent/IL80108A/xx unknown
- 1986-09-22 ZA ZA867212A patent/ZA867212B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6272676A (ja) | 1987-04-03 |
| EP0216746B1 (de) | 1990-10-24 |
| HUT41748A (en) | 1987-05-28 |
| HU196382B (en) | 1988-11-28 |
| AU6303486A (en) | 1987-03-26 |
| DE3675134D1 (de) | 1990-11-29 |
| AU588626B2 (en) | 1989-09-21 |
| IL80108A0 (en) | 1986-12-31 |
| US4694081A (en) | 1987-09-15 |
| EP0216746A2 (de) | 1987-04-01 |
| EP0216746A3 (en) | 1987-09-09 |
| ZA867212B (en) | 1987-08-26 |
| CA1257266A (en) | 1989-07-11 |
| ATE57694T1 (de) | 1990-11-15 |
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