IL81790A0 - Hydroxylamine derivatives,their manufacture and pharmaceutical compositions containing them - Google Patents

Hydroxylamine derivatives,their manufacture and pharmaceutical compositions containing them

Info

Publication number
IL81790A0
IL81790A0 IL81790A IL8179087A IL81790A0 IL 81790 A0 IL81790 A0 IL 81790A0 IL 81790 A IL81790 A IL 81790A IL 8179087 A IL8179087 A IL 8179087A IL 81790 A0 IL81790 A0 IL 81790A0
Authority
IL
Israel
Prior art keywords
manufacture
pharmaceutical compositions
compositions containing
hydroxylamine derivatives
hydroxylamine
Prior art date
Application number
IL81790A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868605977A external-priority patent/GB8605977D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL81790A0 publication Critical patent/IL81790A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
IL81790A 1986-03-11 1987-03-05 Hydroxylamine derivatives,their manufacture and pharmaceutical compositions containing them IL81790A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868605977A GB8605977D0 (en) 1986-03-11 1986-03-11 Hydroxylamine derivatives
GB868629712A GB8629712D0 (en) 1986-03-11 1986-12-12 Hydroxylamine derivatives

Publications (1)

Publication Number Publication Date
IL81790A0 true IL81790A0 (en) 1987-10-20

Family

ID=26290467

Family Applications (1)

Application Number Title Priority Date Filing Date
IL81790A IL81790A0 (en) 1986-03-11 1987-03-05 Hydroxylamine derivatives,their manufacture and pharmaceutical compositions containing them

Country Status (11)

Country Link
US (1) US4996358A (da)
EP (1) EP0236872B1 (da)
JP (1) JPH0629228B2 (da)
AU (1) AU588437B2 (da)
CA (1) CA1314655C (da)
DE (1) DE3782751D1 (da)
DK (1) DK77487A (da)
IE (1) IE60128B1 (da)
IL (1) IL81790A0 (da)
NZ (1) NZ219494A (da)
PH (1) PH26637A (da)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686422A (en) * 1987-03-17 1997-11-11 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase
WO1990005141A1 (en) * 1988-11-10 1990-05-17 Australian Commercial Research & Development Limited Amino acid and peptide inhibitors of human leukocytic elastase and collagenase
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
DE3915755A1 (de) * 1989-05-13 1990-11-29 Bayer Ag Fungizide mittel sowie substituierte aminosaeureamid-derivate und deren herstellung
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
EP0455818A4 (en) * 1989-11-24 1993-05-12 Banyu Pharmaceutical Co., Ltd. Physiologically active substance be-16627
US5892112A (en) * 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
DE4102042A1 (de) * 1991-01-24 1992-07-30 Bayer Ag Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) * 1991-02-07 1991-03-27 British Bio Technology Compounds
WO1992022523A2 (en) * 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
EP0520573A1 (en) * 1991-06-27 1992-12-30 Glaxo Inc. Cyclic imide derivatives
US5530161A (en) * 1991-07-08 1996-06-25 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
US5525629A (en) * 1992-04-07 1996-06-11 British Bio-Technology Limited Inhibition of cytokine production
EP0639982A1 (en) * 1992-05-01 1995-03-01 British Biotech Pharmaceuticals Limited Use of mmp inhibitors
GB9211706D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
GB9211707D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
AU666727B2 (en) * 1992-06-25 1996-02-22 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives
US5326760A (en) * 1992-06-29 1994-07-05 Glaxo, Inc. Aminobutanoic acid compounds having metalloprotease inhibiting properties
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
GB9220845D0 (en) * 1992-10-03 1992-11-18 British Bio Technology Vasoactive peptide inhibition
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
US5506242A (en) * 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
AU671724B2 (en) * 1993-03-16 1996-09-05 British Biotech Pharmaceuticals Limited Hydroxamic acid derivatives as metalloproteinase inhibitors
US5594006A (en) * 1993-03-18 1997-01-14 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives as matrix metalloproteinases inhibitors
GB9320660D0 (en) * 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
JP3297053B2 (ja) * 1994-01-20 2002-07-02 ブリテッシュ バイオテック ファーマシューティカルズ リミテッド 金属タンパク質分解酵素阻害剤
GB9401034D0 (en) * 1994-01-20 1994-03-16 British Bio Technology Metalloproteinase inhibitors
GB9401129D0 (en) * 1994-01-21 1994-03-16 British Bio Technology Hydroxamic acid derivatives as metalloproteinase inhibitors
GB2299335B (en) * 1994-01-21 1997-12-17 British Biotech Pharm Hydroxamic acid derivatives as metalloproteinase inhibitors
AU678884B2 (en) * 1994-01-22 1997-06-12 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5665753A (en) * 1994-03-03 1997-09-09 Smithkline Beecham Corporation Cytokine inhibiting imidazole substituted hydroxamic acid derivatives
GB9404046D0 (en) * 1994-03-03 1994-04-20 Smithkline Beecham Corp Novel compounds
AU690703B2 (en) * 1994-06-22 1998-04-30 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
GB2308844B (en) * 1994-11-26 1998-09-02 British Biotech Pharm Derivatives of Hydroxamic and Carboxylic Acids, and their use as Matrix Metalloproteinase
GB9423914D0 (en) * 1994-11-26 1995-01-11 British Biotech Pharm Polyether derivatives as metalloproteinase inhibitors
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5919940A (en) * 1995-01-20 1999-07-06 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5672598A (en) * 1995-03-21 1997-09-30 The Procter & Gamble Company Lactam-containing hydroxamic acids
US6124333A (en) * 1995-06-22 2000-09-26 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
US5917090A (en) * 1995-06-30 1999-06-29 British Biotech Pharmaceuticals Ltd. Matrix metalloproteinase inhibitors
GB9514867D0 (en) * 1995-07-20 1995-09-20 British Biotech Pharm Metalloproteinase inhibitors
US6548084B2 (en) * 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
GB2318353B (en) * 1995-07-20 1999-10-06 British Biotech Pharm Metalloproteinase inhibitors
NZ322553A (en) 1995-11-23 1998-12-23 British Biotech Pharm Metalloproteinase inhibitors
US6777550B1 (en) 1996-04-12 2004-08-17 Bristol-Myers Squibb Company N-formyl hydroxylamine containing compounds useful as ACE inhibitors and/or NEP inhibitors
WO1997038705A1 (en) * 1996-04-12 1997-10-23 Bristol-Myers Squibb Company N-formyl hydroxylamine containing compounds useful as ace inhibitors and/or nep inhibitors
WO1997042168A1 (en) * 1996-05-06 1997-11-13 Zeneca Limited Thio derivatives of hydroxamic acids
US5932579A (en) 1996-06-18 1999-08-03 Affymax Technologies N.V. Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use
GB9613547D0 (en) * 1996-06-27 1996-08-28 Pharmacia Spa Matrix metalloproteinase inhibitors
ATE226573T1 (de) * 1996-08-28 2002-11-15 Procter & Gamble Heterozyklische metalloproteaseinhibitoren
HUP0000505A3 (en) * 1996-08-28 2001-12-28 Procter & Gamble Saturated 7-9 membered heterocyclic n-hydroxycarboxamide derivatives and pharmaceutical compositions containing them
HUP9903916A3 (en) * 1996-08-28 2001-06-28 Procter And Gamble Co Cincinna Phosphinic acid amides and pharmaceutical compositions containing the same
TR199900429T2 (xx) * 1996-08-28 1999-05-21 The Procter & Gamble Company Spirosiklik metaloproteaz inhibit�rleri.
CN1228771A (zh) * 1996-08-28 1999-09-15 普罗克特和甘保尔公司 1,3－二杂环金属蛋白酶抑制剂
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
ES2178759T3 (es) * 1996-10-02 2003-01-01 Novartis Ag Derivados de acido hidroxamico.
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
CN1265647A (zh) 1997-07-31 2000-09-06 普罗克特和甘保尔公司 无环金属蛋白酶抑制剂
PL194240B1 (pl) * 1998-02-07 2007-05-31 British Biotech Pharm Zastosowanie pochodnych N-formylohydroksyloaminy i amidowa pochodna N-formylohydroksyloaminy
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6172064B1 (en) 1998-08-26 2001-01-09 Glaxo Wellcome Inc. Formamides as therapeutic agents
US6329400B1 (en) 1998-08-26 2001-12-11 Glaxo Wellcome Inc. Formamide compounds as therapeutic agents
EP1121118A4 (en) * 1998-08-26 2002-09-11 Glaxo Group Ltd FORMAMIDE-BASED THERAPEUTIC AGENTS
GB9818605D0 (en) 1998-08-26 1998-10-21 Glaxo Group Ltd Formamide compounds as therepeutic agents
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
KR20010102486A (ko) 1999-03-03 2001-11-15 데이비드 엠 모이어 알케닐- 및 알키닐-함유 메탈로프로테아제 저해제
US6716878B1 (en) * 1999-04-09 2004-04-06 Vernalis (Oxford) Limited Antimicrobial agents
JP2001055327A (ja) * 1999-06-11 2001-02-27 Fuji Chemical Industries Ltd 新規なヒドロキサム酸誘導体を含む医薬
ES2242411T3 (es) * 1999-08-10 2005-11-01 Vernalis (Oxford) Ltd Agentes antibacterianos.
US6696456B1 (en) * 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US6509330B2 (en) 2000-02-17 2003-01-21 Bristol-Myers Squibb Company Hydroxamic acid containing compounds useful as ACE inhibitors and/or NEP inhibotors
WO2001070682A2 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
RU2245876C2 (ru) * 2000-03-21 2005-02-10 Дзе Проктер Энд Гэмбл Компани Производные сульфонамидов и фармацевтическая композиция на их основе
CA2401728A1 (en) * 2000-03-21 2001-09-27 The Procter & Gamble Company Difluorobutyric acid metalloprotease inhibitors
UY27192A1 (es) * 2001-03-01 2002-09-30 Smithkline Beecham Corp Inhibidores de peptido-deformilasa
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
DK1406893T3 (da) 2001-06-15 2007-08-06 Vicuron Pharm Inc Bicykliske pyrrolidinforbindelser
AU2003300379A1 (en) * 2002-12-27 2004-07-29 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collagen and MMPI

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA706911A (en) * 1965-03-30 Gaeumann Ernst Process for the manufacture of long-chain trihydroxamic acids
GB999582A (en) * 1959-09-25 1965-07-28 Ciba Ltd Trihydroxamic acids
DE1133360B (de) * 1961-02-18 1962-07-19 Basf Ag Verfahren zur Herstellung von Harnstoffderivaten
DE1135890B (de) * 1961-03-16 1962-09-06 Basf Ag Verfahren zur Herstellung von N-Hydroxyharnstoffen
US4028401A (en) * 1976-07-01 1977-06-07 Morton-Norwich Products, Inc. (Substituted)ureidoacetohydroxamic acids
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
NZ201998A (en) * 1981-09-25 1985-11-08 Wellcome Found Amides and pharmaceutical compositions
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
US4684482A (en) * 1984-01-26 1987-08-04 Oral-D (L.P.) Orally effective ion chelators
US4671901A (en) * 1984-01-26 1987-06-09 Oral-D Orally effective ion chelators
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
US4599361A (en) * 1985-09-10 1986-07-08 G. D. Searle & Co. Hydroxamic acid based collagenase inhibitors
WO1987004440A1 (en) * 1986-01-23 1987-07-30 Pfizer Inc. Heptanoyl-glu-asp-ala-amino acid immunostimulants

Also Published As

Publication number Publication date
IE60128B1 (en) 1994-06-01
JPH0629228B2 (ja) 1994-04-20
NZ219494A (en) 1990-09-26
US4996358A (en) 1991-02-26
EP0236872A3 (en) 1989-09-13
DK77487A (da) 1987-09-12
AU588437B2 (en) 1989-09-14
AU6990287A (en) 1987-09-17
DK77487D0 (da) 1987-02-16
EP0236872B1 (de) 1992-11-25
EP0236872A2 (de) 1987-09-16
IE870610L (en) 1987-09-11
DE3782751D1 (de) 1993-01-07
JPS62230757A (ja) 1987-10-09
PH26637A (en) 1992-09-04
CA1314655C (en) 1993-03-16

Similar Documents

Publication Publication Date Title
IL82448A0 (en) Tetrahydronaphthalene derivatives,their manufacture and pharmaceutical compositions containing them
IL77004A0 (en) 5-amino-4-hydroxyvaleryl derivatives,their manufacture and pharmaceutical compositions containing them
IL78970A (en) 3-(heteroaralkylamino-alkyl)-3-benzazepin-2-one derivatives,their preparation and pharmaceutical compositions containing them
IL81322A0 (en) Thieno-1,4-diazepines,their preparation and pharmaceutical compositions containing them
IL84302A0 (en) Substituted alpha-aminoacids,their preparation and pharmaceutical compositions containing them
IL84060A0 (en) Imidazobenzoxazinones,their preparation and pharmaceutical compositions containing them
IL83432A (en) N-phenylcarboxamide derivatives,their preparation and pharmaceutical compositions containing them
IL84765A0 (en) Pyridazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
IL87644A0 (en) Oxadiazolyl-azabicycloheptanes,their preparation and pharmaceutical compositions containing them
IL84128A0 (en) 3-propenylcephem derivatives,their preparation and pharmaceutical compositions containing them
IL88446A0 (en) Substituted hydroxylamines,their preparation and pharmaceutical compositions containing them
IL83049A (en) 4-quinolinone-3-carboxylic acid derivatives,their manufacture and pharmaceutical compositions containing them
IL87563A (en) Isoxazole-b-carboline derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
IL85722A0 (en) Propiolophenone derivatives,their manufacture and pharmaceutical compositions containing them
IL83753A (en) Sulphonamidoethyl derivatives,their preparation and pharmaceutical compositions containing them
EP0159652A3 (en) 4-phenylphthalazine derivatives, their preparation and pharmaceutical compositions containing them
IL81355A0 (en) 8alpha-acylaminoergolines,their production and pharmaceutical compositions containing them
IL76312A (en) Xenocoumacins and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL86478A (en) Substituted vinylcephalosporins, their preparation and pharmaceutical compositions containing them
DE3561808D1 (en) Phenylnonatetraenic-acid derivatives, their preparation and pharmaceutical compositions containing them
IL86926A0 (en) 1h-pyrazole-1-alkanamides,their preparation and pharmaceutical compositions containing them
GB2179347B (en) Methylenedioxyphenanthrene and -stilbene derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL90958A0 (en) Cycloalkylthiazole derivatives,their manufacture and pharmaceutical compositions containing them
IL83778A0 (en) Isoprene derivatives,their manufacture and pharmaceutical compositions containing them
IL84366A0 (en) 2,6-diamino-3-halogenbenzylpyridines,their manufacture and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
RH Patent void