IL84009A - 1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them - Google Patents

1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL84009A
Authority: IL; Israel
Prior art keywords: lower alkyl; carbamoyl; indolo; pyrazino; tetrahydro
Prior art date: 1986-10-01

Application number

IL84009A

Other languages

English (en)

Other versions

IL84009A0 (en

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-01

Filing date

1987-09-28

Publication date

1992-01-15

1987-09-28 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1988-02-29 Publication of IL84009A0 publication Critical patent/IL84009A0/xx

1992-01-15 Publication of IL84009A publication Critical patent/IL84009A/xx

Links

229940049706 benzodiazepine Drugs 0.000 title 1
150000001557 benzodiazepines Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
NDXBXFJJXPKPGD-UHFFFAOYSA-N 1,3,4,16b-tetrahydro-2h,10h-indolo[2,1-c]pyrazino[1,2-a][1,4]benzodiazepine Chemical class C1C2=CC=CC=C2N2CCNCC2C2=CC3=CC=CC=C3N21 NDXBXFJJXPKPGD-UHFFFAOYSA-N 0.000 abstract 1
102000056834 5-HT2 Serotonin Receptors Human genes 0.000 abstract 1
108091005479 5-HT2 receptors Proteins 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 hydroxy, amino Chemical group 0.000 abstract 1
239000002464 receptor antagonist Substances 0.000 abstract 1
229940044551 receptor antagonist Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IL84009A 1986-10-01 1987-09-28 1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them IL84009A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/914,028 US4737496A (en)	1986-10-01	1986-10-01	1,3,4,16b-tetrahydro-2H,10H-indolo[2,1-c]pyrazino-[1,2-a][1,4]benzodiazepines useful as serotonin-2 receptor antagonists

Publications (2)

Publication Number	Publication Date
IL84009A0 IL84009A0 (en)	1988-02-29
IL84009A true IL84009A (en)	1992-01-15

Family

ID=25433828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL84009A IL84009A (en)	1986-10-01	1987-09-28	1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them

Country Status (19)

Country	Link
US (1)	US4737496A (pt)
EP (1)	EP0266308B1 (pt)
JP (1)	JPS6396187A (pt)
KR (1)	KR880005134A (pt)
AT (1)	ATE65503T1 (pt)
AU (1)	AU605507B2 (pt)
DD (1)	DD275050A5 (pt)
DE (1)	DE3771652D1 (pt)
DK (1)	DK513087A (pt)
ES (1)	ES2044971T3 (pt)
FI (1)	FI874245A7 (pt)
GR (1)	GR3002362T3 (pt)
HU (1)	HU198937B (pt)
IL (1)	IL84009A (pt)
NO (1)	NO166186C (pt)
NZ (1)	NZ221975A (pt)
PH (1)	PH24754A (pt)
PT (1)	PT85822B (pt)
ZA (1)	ZA877360B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3803620A1 (de) *	1988-02-06	1989-08-17	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
US4897392A (en) *	1989-07-03	1990-01-30	Hoechst-Roussel Pharmaceuticals, Inc.	4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines
WO2009082268A2 (ru)	2007-12-21	2009-07-02	Alla Chem, Llc	ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
CN103288831A (zh) *	2012-02-24	2013-09-11	中国科学院大连化学物理研究所	一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓-6-酮的方法
CN103288830A (zh) *	2012-02-24	2013-09-11	中国科学院大连化学物理研究所	一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓的方法
CN103288828A (zh) *	2012-02-24	2013-09-11	中国科学院大连化学物理研究所	一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法
CN110437236B (zh) *	2019-08-28	2020-08-18	青岛农业大学	一种吲哚-1,2-并1,4-苯并二氮杂卓类化合物及其合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4316900A (en) *	1977-10-05	1982-02-23	Ciba-Geigy Corporation	Piperazinopyrrolobenzodiazepines
ZA784475B (en) *	1977-10-05	1979-07-25	Ciba Geigy Ag	Piperazinopyrrolobenzodiazepines
US4192803A (en) *	1978-09-15	1980-03-11	American Cyanamid Company	5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives
US4362666A (en) *	1979-08-22	1982-12-07	Ciba-Geigy Corporation	Diazepinopyrrolobenzodiazepines
US4424221A (en) *	1982-09-28	1984-01-03	Ciba-Geigy Corporation	Method of treating anxiety
US4529724A (en) *	1983-10-11	1985-07-16	Mcneilab, Inc.	6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives
US4587244A (en) *	1984-04-11	1986-05-06	Mcneilab, Inc.	Amidine benzodiazepines, methods for their use and intermediates
US4547497A (en) *	1984-04-11	1985-10-15	Mcneilab, Inc.	Amidine benzodiazepines, methods for their use and intermediates
US4596799A (en) *	1985-01-29	1986-06-24	Ciba-Geigy Corporation	9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines

1986
- 1986-10-01 US US06/914,028 patent/US4737496A/en not_active Expired - Fee Related
1987
- 1987-09-03 PH PH35768A patent/PH24754A/en unknown
- 1987-09-25 DE DE8787810557T patent/DE3771652D1/de not_active Expired - Lifetime
- 1987-09-25 EP EP87810557A patent/EP0266308B1/de not_active Expired - Lifetime
- 1987-09-25 ES ES87810557T patent/ES2044971T3/es not_active Expired - Lifetime
- 1987-09-25 AT AT87810557T patent/ATE65503T1/de not_active IP Right Cessation
- 1987-09-28 FI FI874245A patent/FI874245A7/fi not_active Application Discontinuation
- 1987-09-28 IL IL84009A patent/IL84009A/xx not_active IP Right Cessation
- 1987-09-29 NZ NZ221975A patent/NZ221975A/xx unknown
- 1987-09-29 PT PT85822A patent/PT85822B/pt not_active IP Right Cessation
- 1987-09-29 DK DK513087A patent/DK513087A/da not_active Application Discontinuation
- 1987-09-29 DD DD87307377A patent/DD275050A5/de not_active IP Right Cessation
- 1987-09-30 KR KR870010880A patent/KR880005134A/ko not_active Withdrawn
- 1987-09-30 JP JP62244425A patent/JPS6396187A/ja active Pending
- 1987-09-30 NO NO874111A patent/NO166186C/no unknown
- 1987-09-30 ZA ZA877360A patent/ZA877360B/xx unknown
- 1987-09-30 AU AU79094/87A patent/AU605507B2/en not_active Ceased
- 1987-09-30 HU HU874415A patent/HU198937B/hu not_active IP Right Cessation
1991
- 1991-07-25 GR GR91400909T patent/GR3002362T3/el unknown

Also Published As

Publication number	Publication date
US4737496A (en)	1988-04-12
ES2044971T3 (es)	1994-01-16
JPS6396187A (ja)	1988-04-27
AU605507B2 (en)	1991-01-17
IL84009A0 (en)	1988-02-29
NO166186C (no)	1991-06-12
GR3002362T3 (en)	1992-12-30
DK513087D0 (da)	1987-09-29
PH24754A (en)	1990-10-01
AU7909487A (en)	1988-04-14
EP0266308A1 (de)	1988-05-04
FI874245A0 (fi)	1987-09-28
ATE65503T1 (de)	1991-08-15
NO874111D0 (no)	1987-09-30
DK513087A (da)	1988-04-02
EP0266308B1 (de)	1991-07-24
HUT47284A (en)	1989-02-28
NO166186B (no)	1991-03-04
DE3771652D1 (de)	1991-08-29
DD275050A5 (de)	1990-01-10
FI874245A7 (fi)	1988-04-02
ZA877360B (en)	1989-06-28
KR880005134A (ko)	1988-06-28
HU198937B (en)	1989-12-28
PT85822B (pt)	1990-07-31
PT85822A (pt)	1987-10-01
NZ221975A (en)	1990-02-26
NO874111L (no)	1988-04-05

Legal Events

Date	Code	Title	Description
2005-07-25	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
TW221434B (pt)	1994-03-01
DE69428476D1 (de)	2001-11-08	Heterocyclische Verbindungen als Bradykinin Antagonisten
IL73258A (en)	1987-11-30	6-(ar)alkyl-7-aminoazolo(1,5-a)pyrimidines,their preparation and their use as fungicides
CA2296665A1 (en)	1999-02-04	Triazolo[4,5-d]pyrimidine derivatives as anti-thromobotic agents
CA2132297A1 (en)	1993-09-30	Pyrido[2,3-d]pyrimidine derivatives as phosphodiesterase inhibitors
AU533295B2 (en)	1983-11-17	Triazolo (4,3-a)pyridines
AU553112B2 (en)	1986-07-03	Imidazo(1,2-alpha) pyridine derivatives
DE69401716D1 (de)	1997-03-20	Imidazo [1,2-a] pyrasin-4-on-derivate welche als ampa und nmda receptor antagonisten dienen
IL84009A (en)	1992-01-15	1,3,4,16b-tetrahydro-2h,10h-indolo(2,1-c)-pyrazino(1,2-a)(1,4)benzodiazepines,their preparation and pharmaceutical compositions containing them
IL103019A0 (en)	1993-02-21	Dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
AU4596089A (en)	1990-06-14	11-amino-1,2,3,4-tetrahydro-6H-quinindolin-1-one and its pre paration and use
DE69124335D1 (de)	1997-03-06	Pyrrolo[2,3-d]Pyrimidine mit kardiovasculärer Aktivität, Verfahren zur Herstellung und diese enthaltende Zusammensetzungen
IL97913A0 (en)	1992-06-21	Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
AU6781387A (en)	1987-07-23	Pyrrolo (1,2-a)(4,1) benzoxazepine derivatives
IL87780A (en)	1992-02-16	3-substituted 4-alkyl-4,5-dihydro-5-oxo-imidazo(1,5-a)thieno(2,3-d)-and(3,2-e)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IT1250646B (it)	1995-04-21	Derivati di pirazolo (4,3-e)pirrolo(1,2-a)(1,4)diazepina ad attivita` antitumorale.
IL101032A0 (en)	1992-11-15	1,2,4-triazolo(1,5-a)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
IT1233837B (it)	1992-04-21	Derivati diidropiridinici, loro preparazione e impieghi farmaceutici.