IL85587A - Magainin polypeptides active against gram-positive and gram-negative bacteria,fungi,viruses and protozoa and a pharmaceutical composition containing the same - Google Patents

Magainin polypeptides active against gram-positive and gram-negative bacteria,fungi,viruses and protozoa and a pharmaceutical composition containing the same

Info

Publication number
IL85587A
IL85587A IL85587A IL8558788A IL85587A IL 85587 A IL85587 A IL 85587A IL 85587 A IL85587 A IL 85587A IL 8558788 A IL8558788 A IL 8558788A IL 85587 A IL85587 A IL 85587A
Authority
IL
Israel
Prior art keywords
gram
magainin
protozoa
fungi
viruses
Prior art date
Application number
IL85587A
Other languages
English (en)
Other versions
IL85587A0 (en
Original Assignee
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/021,493 external-priority patent/US4810777A/en
Application filed by Us Health filed Critical Us Health
Publication of IL85587A0 publication Critical patent/IL85587A0/xx
Publication of IL85587A publication Critical patent/IL85587A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL85587A 1987-03-04 1988-02-29 Magainin polypeptides active against gram-positive and gram-negative bacteria,fungi,viruses and protozoa and a pharmaceutical composition containing the same IL85587A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/021,493 US4810777A (en) 1987-03-04 1987-03-04 Antimicrobial compounds
US7673487A 1987-07-23 1987-07-23
US8179387A 1987-08-05 1987-08-05

Publications (2)

Publication Number Publication Date
IL85587A0 IL85587A0 (en) 1988-08-31
IL85587A true IL85587A (en) 1992-09-06

Family

ID=27361650

Family Applications (1)

Application Number Title Priority Date Filing Date
IL85587A IL85587A (en) 1987-03-04 1988-02-29 Magainin polypeptides active against gram-positive and gram-negative bacteria,fungi,viruses and protozoa and a pharmaceutical composition containing the same

Country Status (9)

Country Link
US (1) US5567681A (de)
EP (1) EP0362209B1 (de)
JP (1) JP2555174B2 (de)
AT (1) ATE106896T1 (de)
AU (1) AU609118B2 (de)
CA (1) CA1339387C (de)
DE (1) DE3850107T2 (de)
IL (1) IL85587A (de)
WO (1) WO1988006597A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266562A (en) * 1987-11-19 1993-11-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Anti-inflammatory agents
ATE115146T1 (de) * 1988-05-27 1994-12-15 Philadelphia Children Hospital Amphiphile peptide und deren verwendung.
WO1990004408A1 (en) * 1988-10-21 1990-05-03 Magainin Sciences, Inc. Composition and treatment with biologically active peptides and certain anions
CA2007913A1 (en) * 1989-01-30 1990-07-30 Michael Zasloff Composition and treatment with peptide combinations
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
GR1000913B (el) * 1989-05-18 1993-03-16 Magainin Sciences Inc Συνθεση & θεραπεια με βιολογικως δραστικα πεπτιδια & ορισμενα ανιοντα
ES2095255T3 (es) * 1989-07-07 1997-02-16 Scripps Research Inst Analogos de sustitucion de peptidos magainina.
US5912231A (en) * 1989-07-07 1999-06-15 Scripps Clinic And Research Foundation Substitution analogues of magainin peptides
EP0528861A4 (en) * 1990-04-23 1993-07-28 Magainin Sciences, Inc. Composition and treatment with biologically active peptides and toxic cations
JPH05507273A (ja) * 1990-05-14 1993-10-21 マゲイニン　サイエンセズ　インコーポレーテッド Ｄアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法
WO1992000090A1 (en) * 1990-06-27 1992-01-09 Magainin Pharmaceuticals Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit dna gyrase
JPH07242696A (ja) * 1990-08-10 1995-09-19 Enichem Partecipazioni Spa 植物病原体に対して活性な抗菌性ペプチド、その使用法およびこれに関連するスクリーニング法
AU648140B2 (en) * 1991-02-01 1994-04-14 Virtual Drug Development, Inc. Reverse antimicrobial peptides and antimicrobial compositions
US5424290A (en) * 1992-10-26 1995-06-13 Magainin Pharmaceuticals Inc. Biologically active peptides and uses therefor
AU3512595A (en) * 1994-09-13 1996-03-29 Magainin Pharmaceuticals, Inc. Method for inhibiting sexually transmitted diseases using magaining antimicrobials or squalamine compounds
CN114432428B (zh) * 2022-02-24 2024-07-23 西北农林科技大学 PGLa提高细菌对抗生素的敏感性和延缓细菌耐药性产生的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4936815A (de) * 1972-08-18 1974-04-05
US3928306A (en) * 1973-10-23 1975-12-23 Eisai Co Ltd Peptides having xenopsin-like pharmacological activity

Also Published As

Publication number Publication date
DE3850107T2 (de) 1995-02-23
IL85587A0 (en) 1988-08-31
JP2555174B2 (ja) 1996-11-20
US5567681A (en) 1996-10-22
DE3850107D1 (de) 1994-07-14
AU609118B2 (en) 1991-04-26
CA1339387C (en) 1997-08-26
ATE106896T1 (de) 1994-06-15
EP0362209A4 (de) 1990-07-03
JPH02503083A (ja) 1990-09-27
EP0362209A1 (de) 1990-04-11
WO1988006597A1 (en) 1988-09-07
AU1495588A (en) 1988-09-26
EP0362209B1 (de) 1994-06-08

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