IL89500A - Human tissue plasminogen activator variants methods for their production and pharmaceutical compositions and preparations containing them - Google Patents

Human tissue plasminogen activator variants methods for their production and pharmaceutical compositions and preparations containing them

Info

Publication number: IL89500A
Authority: IL; Israel
Prior art keywords: variant; des; native; site; amino acid
Prior art date: 1988-03-21

Application number

IL8950089A

Other languages

English (en)

Other versions

IL89500A0 (en

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-21

Filing date

1989-03-06

Publication date

1998-09-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22620139&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL89500(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-03-06 Application filed by Genentech Inc filed Critical Genentech Inc

1989-09-10 Publication of IL89500A0 publication Critical patent/IL89500A0/xx

1998-09-24 Publication of IL89500A publication Critical patent/IL89500A/en

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Diabetes (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Artificial Filaments (AREA)
Inorganic Fibers (AREA)

IL8950089A 1988-03-21 1989-03-06 Human tissue plasminogen activator variants methods for their production and pharmaceutical compositions and preparations containing them IL89500A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/170,510 US5094953A (en)	1988-03-21	1988-03-21	Human tissue plasminogen activator variants

Publications (2)

Publication Number	Publication Date
IL89500A0 IL89500A0 (en)	1989-09-10
IL89500A true IL89500A (en)	1998-09-24

Family

ID=22620139

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8950089A IL89500A (en)	1988-03-21	1989-03-06	Human tissue plasminogen activator variants methods for their production and pharmaceutical compositions and preparations containing them

Country Status (13)

Country	Link
US (4)	US5094953A (da)
EP (1)	EP0401303B2 (da)
JP (2)	JP2605155B2 (da)
AT (1)	ATE107960T1 (da)
AU (1)	AU635892B2 (da)
CA (1)	CA1341612C (da)
DE (1)	DE68916532T3 (da)
DK (1)	DK175776B1 (da)
ES (1)	ES2018367A6 (da)
GR (1)	GR1000387B (da)
IL (1)	IL89500A (da)
NZ (1)	NZ228401A (da)
WO (1)	WO1989009266A1 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU200615B (en) *	1982-05-05	1990-07-28	Genentech Inc	Methods of preparing tissue plasiminogen activator derivative composition
FI831484A7 (fi) *	1982-05-05	1983-11-06	Genentech Inc	Ihmiskudoksen plasminogeenien aktivaattori.
US5714372A (en) *	1985-04-22	1998-02-03	Genentech, Inc.	Tissue plasminogen activator variants
KR970005046B1 (ko) *	1987-10-29	1997-04-11	야마노우찌 세이야꾸 가부시끼가이샤	개량형 조직 플라스미노겐 활성화 인자
DE3923339A1 (de) *	1989-05-31	1990-12-06	Boehringer Mannheim Gmbh	Gewebs-plasminogen-aktivator-derivat
US5242688A (en) *	1990-12-24	1993-09-07	Eli Lilly And Company	Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5595736A (en) *	1991-04-22	1997-01-21	Eli Lilly And Company	Compounds and methods for treatment of thromboembolic disorders
US5468505A (en) *	1992-02-28	1995-11-21	Board Of Regents, The University Of Texas System	Local delivery of fibrinolysis enhancing agents
US5811252A (en) *	1994-07-07	1998-09-22	Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno	Modified proenzymes as substrates for proteolytic enzymes
US6136548A (en) *	1994-11-22	2000-10-24	Rutgers, The State University Of New Jersey	Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging
US6461640B1 (en)	1995-12-08	2002-10-08	Board Of Regents, The University Of Texas System	Local delivery of fibrinolysis enhancing agents
US20030113271A1 (en) *	1997-01-29	2003-06-19	University Technology Corporation	Formulations for pulmonary delivery
AU729489B2 (en) *	1997-07-23	2001-02-01	Roche Diagnostics Gmbh	Production of human mutated proteins in human cells by means of homologous recombination
US6136536A (en) *	1997-10-29	2000-10-24	Genetics Institute, Inc.	Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
US6283300B1 (en)	1998-08-21	2001-09-04	Joseph B. Bielagus	Feed distribution for low velocity air density separation
US6242473B1 (en)	1999-01-08	2001-06-05	Maxim Pharmaceuticals, Inc.	Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
JP3880036B2 (ja) *	2001-05-11	2007-02-14	全国酪農業協同組合連合会	タンパク質の濃縮方法
DE10153601A1 (de) *	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
EP1448127A1 (en) *	2001-11-06	2004-08-25	Maxim Pharmaceuticals, Inc.	Compositions for the treatment of infectious diseases
US20080057050A1 (en) *	2003-05-02	2008-03-06	Paion Deutschland Gmbh	Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke
DE10342518A1 (de) *	2003-09-12	2005-05-12	Paion Gmbh	Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität
AR068914A1 (es) *	2007-10-18	2009-12-16	Paion Deutschland Gmbh	Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
WO2015023830A1 (en)	2013-08-14	2015-02-19	Stc.Unm	Treatment and prevention of stroke and other neurological disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR861037B (en) *	1985-04-22	1986-07-16	Genentech Inc	Novel human tissue plasminogen activator mutants
ES2031826T3 (es) *	1985-12-23	1993-01-01	Chiron Corporation	Procedimiento para producir nuevos peptidos activadores del plasminogeno.
WO1987004722A1 (en) *	1986-01-31	1987-08-13	Genetics Institute, Inc.	Novel thrombolytic proteins
EP0234051B1 (en) *	1986-02-17	1991-12-11	Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis	Tissue-type plasminogen activator mutants; recombinant genetic information coding therefor and process for preparing said mutants; their use and pharmaceutical compositions
PT84588B (en) *	1986-04-02	1989-05-09	Beecham Group Plc	Process for preparing a fibrinolytic enzyme
SE8702562L (sv) *	1987-06-18	1988-12-19	Kabigen Ab	Nya fibrinolytiska enzymer
US4935237A (en) *	1988-03-21	1990-06-19	Genentech, Inc.	Processes for the preparation of t-PA mutants
IL87276A (en) *	1987-08-03	1995-07-31	Fujisawa Pharmaceutical Co	Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
EP0386240B1 (en) *	1987-10-29	1995-07-19	Yamanouchi Pharmaceutical Co. Ltd.	Novel polypeptide compounds
DE3937589C2 (de) *	1989-11-10	2001-12-13	Laing Oliver	Zirkulationsgerät mit Widerstandsheizung

1988
- 1988-03-21 US US07/170,510 patent/US5094953A/en not_active Expired - Lifetime
1989
- 1989-03-06 WO PCT/US1989/000896 patent/WO1989009266A1/en not_active Ceased
- 1989-03-06 DE DE68916532T patent/DE68916532T3/de not_active Expired - Lifetime
- 1989-03-06 AT AT89904712T patent/ATE107960T1/de not_active IP Right Cessation
- 1989-03-06 IL IL8950089A patent/IL89500A/en active IP Right Grant
- 1989-03-06 JP JP1504276A patent/JP2605155B2/ja not_active Expired - Lifetime
- 1989-03-06 AU AU34148/89A patent/AU635892B2/en not_active Expired
- 1989-03-06 EP EP89904712A patent/EP0401303B2/en not_active Expired - Lifetime
- 1989-03-17 GR GR890100164A patent/GR1000387B/el not_active IP Right Cessation
- 1989-03-20 NZ NZ228401A patent/NZ228401A/xx unknown
- 1989-03-21 ES ES8901017A patent/ES2018367A6/es not_active Expired - Lifetime
- 1989-03-21 CA CA594301A patent/CA1341612C/en not_active Expired - Fee Related
1990
- 1990-09-20 DK DK199002273A patent/DK175776B1/da not_active IP Right Cessation
1992
- 1992-02-19 US US07/846,245 patent/US5314818A/en not_active Expired - Lifetime
1993
- 1993-02-11 US US08/016,815 patent/US5366886A/en not_active Expired - Lifetime
1994
- 1994-07-18 US US08/276,862 patent/US5770425A/en not_active Expired - Fee Related
1996
- 1996-08-30 JP JP8229871A patent/JPH09168387A/ja active Pending

Also Published As

Publication number	Publication date
NZ228401A (en)	1991-09-25
GR1000387B (el)	1992-06-30
AU635892B2 (en)	1993-04-08
US5770425A (en)	1998-06-23
AU3414889A (en)	1989-10-16
DK227390A (da)	1990-09-20
IL89500A0 (en)	1989-09-10
EP0401303B2 (en)	1999-11-03
DE68916532T3 (de)	2000-02-03
EP0401303A1 (en)	1990-12-12
JPH09168387A (ja)	1997-06-30
US5094953A (en)	1992-03-10
JPH03503363A (ja)	1991-08-01
DE68916532T2 (de)	1995-01-12
ES2018367A6 (es)	1991-04-01
DK227390D0 (da)	1990-09-20
DK175776B1 (da)	2005-02-14
JP2605155B2 (ja)	1997-04-30
DE68916532D1 (de)	1994-08-04
EP0401303B1 (en)	1994-06-29
WO1989009266A1 (en)	1989-10-05
US5366886A (en)	1994-11-22
CA1341612C (en)	2011-04-12
US5314818A (en)	1994-05-24
ATE107960T1 (de)	1994-07-15
GR890100164A (en)	1990-01-19

Legal Events

Date	Code	Title
1999-01-26	FF	Patent granted
1999-08-17	KB	Patent renewed
2003-07-06	KB	Patent renewed
2007-07-06	KB	Patent renewed

Publication	Publication Date	Title
CA1341612C (en)	2011-04-12	Human tissue plasminogen activator variants and processes
US5147643A (en)	1992-09-15	DNA sequences encoding human t-PA substituted at position 275 or at positions 275 and 277 and pharmaceutical compositions
EP0457758B1 (en)	1995-06-28	Tissue plasminogen activator having zymogenic or fibrin specific properties
US4935237A (en)	1990-06-19	Processes for the preparation of t-PA mutants
US5770426A (en)	1998-06-23	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5073494A (en)	1991-12-17	Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
EP0424405B1 (en)	1994-09-14	Variants of plasminogen activators and processes for their production
US5338546A (en)	1994-08-16	Tissue plasminogen activator variants with decreased clearance
US5714372A (en)	1998-02-03	Tissue plasminogen activator variants
EP0365597B1 (en)	1993-12-29	Improved processes for the treatment of vascular disease
US5258180A (en)	1993-11-02	Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5037646A (en)	1991-08-06	Processes for the treatment of vascular disease
EP0517756B1 (en)	1994-11-09	Tissue plaminogen activator having fibrin specific properties
EP0542869B1 (en)	1995-09-13	Tissue plasminogen activator variants with decreased clearance
US5756093A (en)	1998-05-26	Tissue plasminogen activator variants
AU2079588A (en)	1989-01-30	Improved processes for the treatment of vascular disease
HK1007333B (en)	1999-04-09	Variants of plasminogen activators and processes for their production
HK1007334B (en)	1999-04-09	Tissue plasminogen activator having zymogenic or fibrin specific properties