IL90146A - Glycosylation derivatives of tissue plasminogen activator - Google Patents

Glycosylation derivatives of tissue plasminogen activator

Info

Publication number: IL90146A
Authority: IL; Israel
Prior art keywords: des; variant; native; site; asparagine
Prior art date: 1988-05-20

Application number

IL9014689A

Other languages

English (en)

Hebrew (he)

Other versions

IL90146A0 (en

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-05-20

Filing date

1989-05-01

Publication date

1994-10-07

1989-05-01 Application filed by Genentech Inc filed Critical Genentech Inc

1989-12-15 Publication of IL90146A0 publication Critical patent/IL90146A0/xx

1994-10-07 Publication of IL90146A publication Critical patent/IL90146A/en

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL9014689A 1988-05-20 1989-05-01 Glycosylation derivatives of tissue plasminogen activator IL90146A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US19690988A	1988-05-20	1988-05-20

Publications (2)

Publication Number	Publication Date
IL90146A0 IL90146A0 (en)	1989-12-15
IL90146A true IL90146A (en)	1994-10-07

Family

ID=22727245

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9014689A IL90146A (en)	1988-05-20	1989-05-01	Glycosylation derivatives of tissue plasminogen activator

Country Status (11)

Country	Link
EP (1)	EP0424405B1 (de)
JP (1)	JP2928798B2 (de)
AT (1)	ATE111525T1 (de)
AU (1)	AU624158B2 (de)
CA (1)	CA1341432C (de)
DE (1)	DE68918279T2 (de)
DK (1)	DK175938B1 (de)
ES (1)	ES2013500A6 (de)
IL (1)	IL90146A (de)
NZ (1)	NZ229081A (de)
WO (1)	WO1989011531A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5098840A (en) *	1986-07-03	1992-03-24	The Green Cross Corporation	Human prourokinase mutants
US5218092A (en) *	1988-09-29	1993-06-08	Kyowa Hakko Kogyo Co., Ltd.	Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
NO894967L (no) *	1988-12-12	1990-06-13	Yamanouchi Pharma Co Ltd	Fremgangsmaate for fremstilling av nye thrombolytiske proteiner.
JPH0387180A (ja) *	1989-05-18	1991-04-11	Green Cross Corp:The	変異ヒトプロウロキナーゼ、その製法、ｄｎａ配列、プラスミド、宿主
DK0542869T3 (da) *	1990-07-31	1996-02-05	Genentech Inc	Vævsplasminogenaktivatorvarianter med nedsat udskillelse
US5246850A (en) *	1990-07-31	1993-09-21	Genentech, Inc.	DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
US5242688A (en) *	1990-12-24	1993-09-07	Eli Lilly And Company	Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5595736A (en) *	1991-04-22	1997-01-21	Eli Lilly And Company	Compounds and methods for treatment of thromboembolic disorders
US5223408A (en) *	1991-07-11	1993-06-29	Genentech, Inc.	Method for making variant secreted proteins with altered properties
ATE155816T1 (de)	1992-06-03	1997-08-15	Genentech Inc	Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US5945432A (en) *	1995-12-22	1999-08-31	The University Of Vermont And State Agricultural College	Thrombolytic agents and thienopyridine derivatives in acute stroke
US7553930B2 (en)	2003-01-06	2009-06-30	Xencor, Inc.	BAFF variants and methods thereof
MXPA06008126A (es) *	2004-01-14	2008-02-14	Univ Ohio	Metodos para la produccion de peptidos/proteinas en plantas y peptidos/proteinas producidos de este modo.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8528321D0 (en) *	1985-11-18	1985-12-24	Ciba Geigy Ag	Modified fibrinolytic agents
ES2031826T3 (es) *	1985-12-23	1993-01-01	Chiron Corporation	Procedimiento para producir nuevos peptidos activadores del plasminogeno.
DK43387A (da) *	1986-01-29	1987-07-30	Beecham Group Plc	Fibrinolytisk enzym
AU7090787A (en) *	1986-02-19	1987-10-08	Beecham Group Plc	Tissue plasminogen activator
IE81073B1 (en) *	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation

1989
- 1989-05-01 IL IL9014689A patent/IL90146A/en unknown
- 1989-05-04 WO PCT/US1989/001947 patent/WO1989011531A1/en not_active Ceased
- 1989-05-04 JP JP1506287A patent/JP2928798B2/ja not_active Expired - Lifetime
- 1989-05-04 AU AU37448/89A patent/AU624158B2/en not_active Expired
- 1989-05-04 EP EP89906612A patent/EP0424405B1/de not_active Expired - Lifetime
- 1989-05-04 DE DE68918279T patent/DE68918279T2/de not_active Expired - Lifetime
- 1989-05-04 AT AT89906612T patent/ATE111525T1/de not_active IP Right Cessation
- 1989-05-11 NZ NZ229081A patent/NZ229081A/en unknown
- 1989-05-19 ES ES8901686A patent/ES2013500A6/es not_active Expired - Lifetime
- 1989-05-19 CA CA000600277A patent/CA1341432C/en not_active Expired - Lifetime
1990
- 1990-11-19 DK DK199002749A patent/DK175938B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK274990A (da)	1991-01-18
HK1007333A1 (en)	1999-04-09
DE68918279T2 (de)	1995-03-23
CA1341432C (en)	2003-06-17
EP0424405B1 (de)	1994-09-14
JP2928798B2 (ja)	1999-08-03
JPH03504327A (ja)	1991-09-26
DK175938B1 (da)	2005-07-25
AU3744889A (en)	1989-12-12
ES2013500A6 (es)	1990-05-01
DE68918279D1 (de)	1994-10-20
AU624158B2 (en)	1992-06-04
WO1989011531A1 (en)	1989-11-30
EP0424405A1 (de)	1991-05-02
NZ229081A (en)	1991-03-26
IL90146A0 (en)	1989-12-15
DK274990D0 (da)	1990-11-19
ATE111525T1 (de)	1994-09-15

Legal Events

Date	Code	Title
1999-10-28	KB	Patent renewed
2003-07-06	KB	Patent renewed
2007-07-06	KB	Patent renewed

Publication	Publication Date	Title
US5147643A (en)	1992-09-15	DNA sequences encoding human t-PA substituted at position 275 or at positions 275 and 277 and pharmaceutical compositions
EP0093619B1 (de)	1989-09-13	Plasminogenaktivator für menschliches Gewebe, diesen Aktivator enthaltende pharmazeutische Zusammensetzungen, Verfahren zur Herstellung des Aktivators sowie DNA und transformierte Zellzwischenprodukte hierfür
AU626323B2 (en)	1992-07-30	Tissue plasminogen activator having zymogenic or fibrin specific properties
CA1341612C (en)	2011-04-12	Human tissue plasminogen activator variants and processes
US4935237A (en)	1990-06-19	Processes for the preparation of t-PA mutants
US4853330A (en)	1989-08-01	Human tissue plasminogen activator
US5270198A (en)	1993-12-14	DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5702938A (en)	1997-12-30	Human tissue plasminogen activator
EP0424405B1 (de)	1994-09-14	Plasminogenaktivator-varianten und verfahren zu ihrer herstellung
US5073494A (en)	1991-12-17	Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
EP0365597B2 (de)	2005-02-09	Verfahren zur behandlung von gefässkrankheiten
US5037646A (en)	1991-08-06	Processes for the treatment of vascular disease
US5346824A (en)	1994-09-13	DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
HK1007333B (en)	1999-04-09	Variants of plasminogen activators and processes for their production
AU2079588A (en)	1989-01-30	Improved processes for the treatment of vascular disease
HK1007334B (en)	1999-04-09	Tissue plasminogen activator having zymogenic or fibrin specific properties
HU210541A9 (hu)	1995-05-29	Zimogén- vagy fibrin-specifikus tulajdonságú, a 296-299 aminosav-tartományban helyettesített szöveti plazminogén aktivátor, ezt kódoló DNS-molekulák, vektorok és gazdasejtek