IL91423A - Preparation for the treatment of blood clots - Google Patents

Preparation for the treatment of blood clots

Info

Publication number: IL91423A
Authority: IL; Israel
Prior art keywords: leu; ala; gin; ser; pro
Prior art date: 1988-08-24

Application number

IL9142389A

Other languages

English (en)

Hebrew (he)

Other versions

IL91423A0 (en

Original Assignee

Chugai Seiyaku Kabishiki Kaish

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-24

Filing date

1989-08-24

Publication date

1995-06-29

1989-08-24 Application filed by Chugai Seiyaku Kabishiki Kaish filed Critical Chugai Seiyaku Kabishiki Kaish

1990-04-29 Publication of IL91423A0 publication Critical patent/IL91423A0/xx

1995-06-29 Publication of IL91423A publication Critical patent/IL91423A/en

Links

208000007536 Thrombosis Diseases 0.000 title claims abstract description 32
239000000203 mixture Substances 0.000 title claims description 15
101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 claims abstract description 91
239000004480 active ingredient Substances 0.000 claims abstract description 6
239000003937 drug carrier Substances 0.000 claims abstract description 5
108010001014 Plasminogen Activators Proteins 0.000 claims description 37
102000001938 Plasminogen Activators Human genes 0.000 claims description 37
229940127126 plasminogen activator Drugs 0.000 claims description 37
210000004027 cell Anatomy 0.000 claims description 25
230000000694 effects Effects 0.000 claims description 21
230000003480 fibrinolytic effect Effects 0.000 claims description 18
210000003556 vascular endothelial cell Anatomy 0.000 claims description 15
229940012957 plasmin Drugs 0.000 claims description 10
210000002889 endothelial cell Anatomy 0.000 claims description 8
150000001413 amino acids Chemical group 0.000 claims description 7
230000028327 secretion Effects 0.000 claims description 7
UPLYXVPQLJVWMM-KKUMJFAQSA-N Ser-Phe-Leu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O UPLYXVPQLJVWMM-KKUMJFAQSA-N 0.000 claims description 6
238000010521 absorption reaction Methods 0.000 claims description 6
229920001184 polypeptide Polymers 0.000 claims description 6
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MKZCBYZBCINNJN-DLOVCJGASA-N Ala-Asp-Phe Chemical compound C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MKZCBYZBCINNJN-DLOVCJGASA-N 0.000 claims description 3
CCDFBRZVTDDJNM-GUBZILKMSA-N Ala-Leu-Glu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O CCDFBRZVTDDJNM-GUBZILKMSA-N 0.000 claims description 3
108010011667 Ala-Phe-Ala Proteins 0.000 claims description 3
IPZQNYYAYVRKKK-FXQIFTODSA-N Ala-Pro-Ala Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O IPZQNYYAYVRKKK-FXQIFTODSA-N 0.000 claims description 3
KUFVXLQLDHJVOG-SHGPDSBTSA-N Ala-Thr-Thr Chemical compound C[C@H]([C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)[C@H](C)N)O KUFVXLQLDHJVOG-SHGPDSBTSA-N 0.000 claims description 3
KWKQGHSSNHPGOW-BQBZGAKWSA-N Arg-Ala-Gly Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)NCC(O)=O KWKQGHSSNHPGOW-BQBZGAKWSA-N 0.000 claims description 3
SRIRHERUAMYIOQ-CIUDSAMLSA-N Cys-Leu-Ser Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O SRIRHERUAMYIOQ-CIUDSAMLSA-N 0.000 claims description 3
PYTZFYUXZZHOAD-WHFBIAKZSA-N Gly-Ala-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CN PYTZFYUXZZHOAD-WHFBIAKZSA-N 0.000 claims description 3
UHPAZODVFFYEEL-QWRGUYRKSA-N Gly-Leu-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)CN UHPAZODVFFYEEL-QWRGUYRKSA-N 0.000 claims description 3
TVUWMSBGMVAHSJ-KBPBESRZSA-N Gly-Leu-Phe Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 TVUWMSBGMVAHSJ-KBPBESRZSA-N 0.000 claims description 3
BAYQNCWLXIDLHX-ONGXEEELSA-N Gly-Val-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)CN BAYQNCWLXIDLHX-ONGXEEELSA-N 0.000 claims description 3
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PZAJPILZRFPYJJ-SRVKXCTJSA-N His-Ser-Leu Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O PZAJPILZRFPYJJ-SRVKXCTJSA-N 0.000 claims description 3
LHSGPCFBGJHPCY-UHFFFAOYSA-N L-leucine-L-tyrosine Natural products CC(C)CC(N)C(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 LHSGPCFBGJHPCY-UHFFFAOYSA-N 0.000 claims description 3
WNGVUZWBXZKQES-YUMQZZPRSA-N Leu-Ala-Gly Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O WNGVUZWBXZKQES-YUMQZZPRSA-N 0.000 claims description 3
FJUKMPUELVROGK-IHRRRGAJSA-N Leu-Arg-His Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)N FJUKMPUELVROGK-IHRRRGAJSA-N 0.000 claims description 3
QCSFMCFHVGTLFF-NHCYSSNCSA-N Leu-Asp-Val Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O QCSFMCFHVGTLFF-NHCYSSNCSA-N 0.000 claims description 3
QPXBPQUGXHURGP-UWVGGRQHSA-N Leu-Gly-Met Chemical compound CC(C)C[C@@H](C(=O)NCC(=O)N[C@@H](CCSC)C(=O)O)N QPXBPQUGXHURGP-UWVGGRQHSA-N 0.000 claims description 3
YFBBUHJJUXXZOF-UWVGGRQHSA-N Leu-Gly-Pro Chemical compound CC(C)C[C@H](N)C(=O)NCC(=O)N1CCC[C@H]1C(O)=O YFBBUHJJUXXZOF-UWVGGRQHSA-N 0.000 claims description 3
OYQUOLRTJHWVSQ-SRVKXCTJSA-N Leu-His-Ser Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(O)=O OYQUOLRTJHWVSQ-SRVKXCTJSA-N 0.000 claims description 3
YOKVEHGYYQEQOP-QWRGUYRKSA-N Leu-Leu-Gly Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O YOKVEHGYYQEQOP-QWRGUYRKSA-N 0.000 claims description 3
DCGXHWINSHEPIR-SRVKXCTJSA-N Leu-Lys-Cys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O)N DCGXHWINSHEPIR-SRVKXCTJSA-N 0.000 claims description 3
GPAHWYRSHCKICP-GUBZILKMSA-N Met-Glu-Glu Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O GPAHWYRSHCKICP-GUBZILKMSA-N 0.000 claims description 3
YBAFDPFAUTYYRW-UHFFFAOYSA-N N-L-alpha-glutamyl-L-leucine Natural products CC(C)CC(C(O)=O)NC(=O)C(N)CCC(O)=O YBAFDPFAUTYYRW-UHFFFAOYSA-N 0.000 claims description 3
FKYKZHOKDOPHSA-DCAQKATOSA-N Pro-Leu-Ser Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O FKYKZHOKDOPHSA-DCAQKATOSA-N 0.000 claims description 3
NBDHWLZEMKSVHH-UVBJJODRSA-N Pro-Trp-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@@H]3CCCN3 NBDHWLZEMKSVHH-UVBJJODRSA-N 0.000 claims description 3
RFBKULCUBJAQFT-BIIVOSGPSA-N Ser-Cys-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CS)NC(=O)[C@H](CO)N)C(=O)O RFBKULCUBJAQFT-BIIVOSGPSA-N 0.000 claims description 3
BSXKBOUZDAZXHE-CIUDSAMLSA-N Ser-Pro-Glu Chemical compound [H]N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O BSXKBOUZDAZXHE-CIUDSAMLSA-N 0.000 claims description 3
RRRRCRYTLZVCEN-HJGDQZAQSA-N Thr-Leu-Asp Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O RRRRCRYTLZVCEN-HJGDQZAQSA-N 0.000 claims description 3
QYSBJAUCUKHSLU-JYJNAYRXSA-N Tyr-Arg-Val Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(O)=O QYSBJAUCUKHSLU-JYJNAYRXSA-N 0.000 claims description 3
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108010076324 alanyl-glycyl-glycine Proteins 0.000 claims description 3
108010087924 alanylproline Proteins 0.000 claims description 3
108010072405 glycyl-aspartyl-glycine Proteins 0.000 claims description 3
108010066198 glycyl-leucyl-phenylalanine Proteins 0.000 claims description 3
108010050848 glycylleucine Proteins 0.000 claims description 3
108010025306 histidylleucine Proteins 0.000 claims description 3
108010083708 leucyl-aspartyl-valine Proteins 0.000 claims description 3
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DCVYRWFAMZFSDA-ZLUOBGJFSA-N Ala-Ser-Ala Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O DCVYRWFAMZFSDA-ZLUOBGJFSA-N 0.000 claims description 2
CREYEAPXISDKSB-FQPOAREZSA-N Ala-Thr-Tyr Chemical compound [H]N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O CREYEAPXISDKSB-FQPOAREZSA-N 0.000 claims description 2
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PHONXOACARQMPM-BQBZGAKWSA-N Gly-Ala-Met Chemical compound [H]NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(O)=O PHONXOACARQMPM-BQBZGAKWSA-N 0.000 claims description 2
GGLIDLCEPDHEJO-BQBZGAKWSA-N Gly-Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)CN GGLIDLCEPDHEJO-BQBZGAKWSA-N 0.000 claims description 2
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KVLPXRKIIFWZLM-DPZBCOQUSA-N tert-butyl n-[(2s)-1-[[(2s)-1-[[(2s)-6-amino-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate Chemical compound CC1=CC(=O)OC2=CC(NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)CC(C)C)=CC=C21 KVLPXRKIIFWZLM-DPZBCOQUSA-N 0.000 description 1
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Toxicology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Surgical Instruments (AREA)
Materials For Medical Uses (AREA)
Networks Using Active Elements (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL9142389A 1988-08-24 1989-08-24 Preparation for the treatment of blood clots IL91423A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP21037688		1988-08-24

Publications (2)

Publication Number	Publication Date
IL91423A0 IL91423A0 (en)	1990-04-29
IL91423A true IL91423A (en)	1995-06-29

Family

ID=16588321

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9142389A IL91423A (en)	1988-08-24	1989-08-24	Preparation for the treatment of blood clots

Country Status (8)

Country	Link
US (1)	US5202117A (de)
EP (1)	EP0355811B1 (de)
KR (1)	KR950003492B1 (de)
AT (1)	ATE97813T1 (de)
CA (1)	CA1339071C (de)
DE (1)	DE68911061T2 (de)
IL (1)	IL91423A (de)
ZA (1)	ZA896463B (de)

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* Cited by examiner, † Cited by third party
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GB9120304D0 (en) *	1991-09-24	1991-11-06	Erba Carlo Spa	Stable pharmaceutical compositions containing a granulocyte macrophage colony stimulating factor
FR2693907B1 (fr) *	1992-07-23	1994-09-02	Rhone Poulenc Rorer Sa	Procédé d'administration de solutions de facteur de stimulation des colonies granulocytaires.
US5879794A (en) *	1994-08-25	1999-03-09	W. L. Gore & Associates, Inc.	Adhesive-filler film composite
DE19539574A1 (de) *	1995-10-25	1997-04-30	Boehringer Mannheim Gmbh	Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
WO1998020528A1 (en)	1996-11-08	1998-05-14	W.L. Gore & Associates, Inc.	METHOD FOR IMPROVING RELIABILITY OF THIN CIRCUIT SUBSTRATES BY INCREASING THE Tg OF THE SUBSTRATE
WO1999044630A1 (en) *	1998-03-06	1999-09-10	Chugai Seiyaku Kabushiki Kaisha	Protein-free preparations
US8435939B2 (en)	2000-09-05	2013-05-07	Biokine Therapeutics Ltd.	Polypeptide anti-HIV agent containing the same
US20020198150A1 (en) *	2001-06-07	2002-12-26	Ayelet Chajut	Methods of using colony stimulating factors in the treatment of tissue damage and ischemia
AU2003261723A1 (en)	2002-08-27	2004-03-19	Takeda Chemical Industries, Ltd.	Cxcr4 antagonist and use thereof
US20090226397A1 (en) *	2003-10-24	2009-09-10	Nora Therapeutics, Inc.	Compositions and methods for reducing the likelihood of implantation failure or miscarriage in recipients of artificial insemination
KR100812274B1 (ko) *	2006-10-30	2008-03-13	한양대학교 산학협력단	Ｇ-ｃｓｆ를 유효성분으로 하는 당뇨성 말초신경병 예방 및치료제
WO2008075371A2 (en)	2006-12-21	2008-06-26	Biokine Therapeutics Ltd.	T-140 peptide analogs having cxcr4 super-agonist activity for immunomodulation
MX344166B (es)	2008-02-08	2016-12-07	Ambrx Inc	Leptina-polipeptidos modificados y sus usos.
CN102159230A (zh)	2008-07-23	2011-08-17	Ambrx公司	经修饰的牛g-csf多肽和其用途
US9155780B2 (en)	2009-02-11	2015-10-13	Yeda Research And Development Co. Ltd.	Short beta-defensin-derived peptides
BRPI1009663A2 (pt)	2009-06-14	2016-10-11	Biokine Therapeutics Ltd	"método para elevação dos níveis plaquetários em um indivíduo com essa necessidade, método de inibição de hemorragia em um indivíduo que a necessite e composição farmacêutica"
TWI480288B (zh)	2010-09-23	2015-04-11	Lilly Co Eli	牛顆粒細胞群落刺激因子及其變體之調配物
EP2841084B1 (de)	2012-04-24	2018-05-30	Biokine Therapeutics Ltd.	Cxcr4 antagonist peptid zur verwendung in der behandlung von lungenkrebs
US10786547B2 (en)	2015-07-16	2020-09-29	Biokine Therapeutics Ltd.	Compositions, articles of manufacture and methods for treating cancer
KR102033920B1 (ko)	2016-02-23	2019-10-18	바이오라인알엑스 리미티드	급성 골수성 백혈병을 치료하는 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4766075A (en) *	1982-07-14	1988-08-23	Genentech, Inc.	Human tissue plasminogen activator
JPS61227526A (ja) *	1984-07-25	1986-10-09	Chugai Pharmaceut Co Ltd	新規なコロニー刺激因子
US5120534A (en) *	1988-07-29	1992-06-09	Otsuka Pharmaceutical Co., Ltd.	IL-1α derivatives and medicament for treating thrombocytopenia
JP2805224B2 (ja) *	1989-01-13	1998-09-30	味の素株式会社	血小板減少症治療剤

1989
- 1989-08-22 US US07/396,949 patent/US5202117A/en not_active Expired - Lifetime
- 1989-08-22 CA CA000608935A patent/CA1339071C/en not_active Expired - Fee Related
- 1989-08-23 DE DE89115562T patent/DE68911061T2/de not_active Expired - Fee Related
- 1989-08-23 AT AT89115562T patent/ATE97813T1/de not_active IP Right Cessation
- 1989-08-23 EP EP89115562A patent/EP0355811B1/de not_active Expired - Lifetime
- 1989-08-24 ZA ZA896463A patent/ZA896463B/xx unknown
- 1989-08-24 IL IL9142389A patent/IL91423A/en not_active IP Right Cessation
- 1989-08-24 KR KR1019890012089A patent/KR950003492B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR950003492B1 (ko)	1995-04-13
AU625914B2 (en)	1992-07-16
ATE97813T1 (de)	1993-12-15
US5202117A (en)	1993-04-13
EP0355811B1 (de)	1993-12-01
DE68911061D1 (de)	1994-01-13
KR900002800A (ko)	1990-03-23
DE68911061T2 (de)	1994-03-24
EP0355811A3 (de)	1991-03-20
CA1339071C (en)	1997-07-29
IL91423A0 (en)	1990-04-29
ZA896463B (en)	1990-05-30
EP0355811A2 (de)	1990-02-28
AU4014789A (en)	1990-03-01

Legal Events

Date	Code	Title
2000-01-31	KB	Patent renewed
2003-10-31	KB	Patent renewed
2008-06-05	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
CA1339071C (en)	1997-07-29	Thrombus control agent
EP0506757B2 (de)	2005-10-26	Rekombinanter abkömmling des menschlichen faktors iii
EP0123304B1 (de)	1991-01-16	Verfahren zur Stabilisierung eines Gewebeplasminogenaktivators und diesen enthaltende stabile wässrige Lösung oder Pulver
US5112609A (en)	1992-05-12	Acidic formulations of t-PA
US4968617A (en)	1990-11-06	Solid hydrochloride salt of t-PA
JPS6391325A (ja)	1988-04-22	顆粒球コロニ−刺激因子を含有する徐放性製剤
CA1338698C (en)	1996-11-12	Process for the preparation of a solution of high concentration of a protein having tissue plasminogen activator (t-pa) activity, a solution containing protein having t-pa activity and the use of the solution in human and veterinary medicine
CN118834284A (zh)	2024-10-25	一种重组iii型人源胶原蛋白及其制备方法和用途
CA1308377C (en)	1992-10-06	Complex of polyethyleneglycol and tissue plasminogen activator
JP2907447B2 (ja)	1999-06-21	抗血栓剤
EP0151996B1 (de)	1991-04-03	Verfahren zur Herstellung eines doppelkettigen Plasminogenaktivators
JP2589094B2 (ja)	1997-03-12	抗悪性腫瘍剤
US20020151481A1 (en)	2002-10-17	MMP-2 propeptide for use as antiangiogenic or antitumor agent
JP2697725B2 (ja)	1998-01-14	悪性腫瘍治療用キット
JPH0369332B2 (de)	1991-10-31
NZ229611A (en)	1991-12-23	A bolus formulation containing at least 12.5 mu of t-pa
HK1050537A (en)	2003-06-27	A recombinant human factor viii derivative
HK1009290B (en)	2000-07-14	A recombinant human factor viii derivative
HK1019449B (en)	2003-05-09	A recombinant human factor viii derivative