IL92098A - Glucan dietary additives - Google Patents

Glucan dietary additives

Info

Publication number: IL92098A
Authority: IL; Israel
Prior art keywords: glucan; whole; dietary supplement; fiber; glucans
Prior art date: 1988-10-28

Application number

IL9209889A

Other languages

English (en)

Other versions

IL92098A0 (en

Original Assignee

Alpha Beta Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-28

Filing date

1989-10-23

Publication date

1994-04-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23004531&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL92098(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-10-23 Application filed by Alpha Beta Technology filed Critical Alpha Beta Technology

1990-07-12 Publication of IL92098A0 publication Critical patent/IL92098A0/xx

1994-04-12 Publication of IL92098A publication Critical patent/IL92098A/en

Links

229920001503 Glucan Polymers 0.000 title claims description 170
239000002778 food additive Substances 0.000 title abstract description 10
239000000835 fiber Substances 0.000 claims abstract description 53
235000005911 diet Nutrition 0.000 claims abstract description 29
239000000203 mixture Substances 0.000 claims abstract description 21
241001465754 Metazoa Species 0.000 claims abstract description 15
235000021391 short chain fatty acids Nutrition 0.000 claims abstract description 13
150000004666 short chain fatty acids Chemical class 0.000 claims abstract description 13
239000004067 bulking agent Substances 0.000 claims abstract description 12
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 46
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 36
230000037213 diet Effects 0.000 claims description 27
102000004190 Enzymes Human genes 0.000 claims description 19
108090000790 Enzymes Proteins 0.000 claims description 19
235000015872 dietary supplement Nutrition 0.000 claims description 17
230000029087 digestion Effects 0.000 claims description 17
210000005253 yeast cell Anatomy 0.000 claims description 16
102000005575 Cellulases Human genes 0.000 claims description 14
108010084185 Cellulases Proteins 0.000 claims description 14
230000002550 fecal effect Effects 0.000 claims description 10
239000002253 acid Substances 0.000 claims description 5
230000002475 laxative effect Effects 0.000 claims description 3
230000004580 weight loss Effects 0.000 claims description 3
230000002708 enhancing effect Effects 0.000 claims description 2
239000008141 laxative Substances 0.000 claims description 2
239000012669 liquid formulation Substances 0.000 claims description 2
241000124008 Mammalia Species 0.000 claims 2
235000018823 dietary intake Nutrition 0.000 claims 2
244000025254 Cannabis sativa Species 0.000 claims 1
239000003292 glue Substances 0.000 claims 1
238000000034 method Methods 0.000 abstract description 24
229920002498 Beta-glucan Polymers 0.000 abstract description 3
230000000378 dietary effect Effects 0.000 abstract description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 46
235000013325 dietary fiber Nutrition 0.000 description 19
229940088598 enzyme Drugs 0.000 description 17
235000012000 cholesterol Nutrition 0.000 description 15
229940038580 oat bran Drugs 0.000 description 15
240000004808 Saccharomyces cerevisiae Species 0.000 description 13
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 13
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 12
210000004027 cell Anatomy 0.000 description 12
239000008103 glucose Substances 0.000 description 12
230000000694 effects Effects 0.000 description 11
102000004169 proteins and genes Human genes 0.000 description 11
108090000623 proteins and genes Proteins 0.000 description 11
229940088594 vitamin Drugs 0.000 description 11
229930003231 vitamin Natural products 0.000 description 11
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239000011782 vitamin Substances 0.000 description 11
241000699800 Cricetinae Species 0.000 description 10
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102000004895 Lipoproteins Human genes 0.000 description 9
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229920002101 Chitin Polymers 0.000 description 7
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 7
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CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
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229910052500 inorganic mineral Inorganic materials 0.000 description 6
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235000010755 mineral Nutrition 0.000 description 6
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238000008214 LDL Cholesterol Methods 0.000 description 5
108010007622 LDL Lipoproteins Proteins 0.000 description 5
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235000020940 control diet Nutrition 0.000 description 5
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150000003626 triacylglycerols Chemical class 0.000 description 5
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YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
241000894006 Bacteria Species 0.000 description 4
229920002261 Corn starch Polymers 0.000 description 4
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 4
206010012735 Diarrhoea Diseases 0.000 description 4
241000282412 Homo Species 0.000 description 4
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
241000699673 Mesocricetus auratus Species 0.000 description 4
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
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150000001720 carbohydrates Chemical class 0.000 description 4
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239000008120 corn starch Substances 0.000 description 4
RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 4
239000003925 fat Substances 0.000 description 4
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 4
238000009472 formulation Methods 0.000 description 4
150000004676 glycans Chemical class 0.000 description 4
235000009200 high fat diet Nutrition 0.000 description 4
230000003871 intestinal function Effects 0.000 description 4
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229920001282 polysaccharide Polymers 0.000 description 4
239000005017 polysaccharide Substances 0.000 description 4
229960002477 riboflavin Drugs 0.000 description 4
239000005720 sucrose Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
206010009944 Colon cancer Diseases 0.000 description 3
241000283984 Rodentia Species 0.000 description 3
-1 acetic acid Chemical class 0.000 description 3
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208000019902 chronic diarrheal disease Diseases 0.000 description 3
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239000002285 corn oil Substances 0.000 description 3
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238000006297 dehydration reaction Methods 0.000 description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
238000000605 extraction Methods 0.000 description 3
235000019197 fats Nutrition 0.000 description 3
238000000855 fermentation Methods 0.000 description 3
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239000012530 fluid Substances 0.000 description 3
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210000002429 large intestine Anatomy 0.000 description 3
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210000003205 muscle Anatomy 0.000 description 3
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230000002572 peristaltic effect Effects 0.000 description 3
SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 3
239000000843 powder Substances 0.000 description 3
239000002151 riboflavin Substances 0.000 description 3
235000019192 riboflavin Nutrition 0.000 description 3
238000012360 testing method Methods 0.000 description 3
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 2
239000002028 Biomass Substances 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
235000019743 Choline chloride Nutrition 0.000 description 2
102100030797 Conserved oligomeric Golgi complex subunit 2 Human genes 0.000 description 2
108010023302 HDL Cholesterol Proteins 0.000 description 2
108010010234 HDL Lipoproteins Proteins 0.000 description 2
102000015779 HDL Lipoproteins Human genes 0.000 description 2
101000920113 Homo sapiens Conserved oligomeric Golgi complex subunit 2 Proteins 0.000 description 2
208000035150 Hypercholesterolemia Diseases 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
208000005016 Intestinal Neoplasms Diseases 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 2
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
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235000001465 calcium Nutrition 0.000 description 2
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FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 2
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229960003178 choline chloride Drugs 0.000 description 2
SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 2
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ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 2
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125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
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150000002500 ions Chemical class 0.000 description 2
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
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229910001629 magnesium chloride Inorganic materials 0.000 description 2
235000011147 magnesium chloride Nutrition 0.000 description 2
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SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 2
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AOFUBOWZWQFQJU-SNOJBQEQSA-N (2r,3s,4s,5r)-2,5-bis(hydroxymethyl)oxolane-2,3,4-triol;(2s,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O AOFUBOWZWQFQJU-SNOJBQEQSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/24—Cellulose or derivatives thereof
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
- A23L29/271—Curdlan; beta-1-3 glucan; Polysaccharides produced by agrobacterium or alcaligenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Nutrition Science (AREA)
Dispersion Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Mycology (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Plant Substances (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Jellies, Jams, And Syrups (AREA)

IL9209889A 1988-10-28 1989-10-23 Glucan dietary additives IL92098A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/264,091 US4962094A (en)	1988-10-28	1988-10-28	Glucan dietary additives

Publications (2)

Publication Number	Publication Date
IL92098A0 IL92098A0 (en)	1990-07-12
IL92098A true IL92098A (en)	1994-04-12

Family

ID=23004531

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9209889A IL92098A (en)	1988-10-28	1989-10-23	Glucan dietary additives

Country Status (13)

Country	Link
US (1)	US4962094A (de)
EP (1)	EP0440725B1 (de)
JP (1)	JPH04505997A (de)
AT (1)	ATE106193T1 (de)
AU (1)	AU643670B2 (de)
CA (1)	CA2001754C (de)
DE (1)	DE68915773T2 (de)
IE (1)	IE64707B1 (de)
IL (1)	IL92098A (de)
MX (1)	MX168000B (de)
NZ (1)	NZ231176A (de)
WO (1)	WO1990004334A1 (de)
ZA (1)	ZA898174B (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5370894A (en) *	1988-06-24	1994-12-06	The Nutrasweet Company	Carbohydrate cream substitute
US5153020A (en) *	1988-06-24	1992-10-06	The Nutrasweet Company	Carbohydrate cream substitute
US6020324A (en) *	1989-10-20	2000-02-01	The Collaborative Group, Ltd.	Glucan dietary additives
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1988
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1989
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- 1989-10-20 AT AT89912342T patent/ATE106193T1/de not_active IP Right Cessation
- 1989-10-20 AU AU44924/89A patent/AU643670B2/en not_active Expired
- 1989-10-20 EP EP89912342A patent/EP0440725B1/de not_active Expired - Lifetime
- 1989-10-20 DE DE68915773T patent/DE68915773T2/de not_active Expired - Lifetime
- 1989-10-20 WO PCT/US1989/004734 patent/WO1990004334A1/en not_active Ceased
- 1989-10-23 IE IE341389A patent/IE64707B1/en not_active IP Right Cessation
- 1989-10-23 IL IL9209889A patent/IL92098A/en unknown
- 1989-10-27 NZ NZ231176A patent/NZ231176A/en unknown
- 1989-10-27 MX MX018129A patent/MX168000B/es unknown
- 1989-10-27 ZA ZA898174A patent/ZA898174B/xx unknown
- 1989-10-30 CA CA002001754A patent/CA2001754C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL92098A0 (en)	1990-07-12
AU643670B2 (en)	1993-11-25
ATE106193T1 (de)	1994-06-15
US4962094A (en)	1990-10-09
WO1990004334A1 (en)	1990-05-03
IE893413L (en)	1990-04-28
AU4492489A (en)	1990-05-14
CA2001754A1 (en)	1990-04-28
CA2001754C (en)	2000-08-22
JPH04505997A (ja)	1992-10-22
EP0440725A1 (de)	1991-08-14
DE68915773T2 (de)	1994-11-03
DE68915773D1 (de)	1994-07-07
ZA898174B (en)	1991-10-30
NZ231176A (en)	1997-05-26
IE64707B1 (en)	1995-08-23
MX168000B (es)	1993-04-27
EP0440725B1 (de)	1994-06-01

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