IL92856A - Process for the in vivo recombination of partially homologous dna sequences having up to 30% of mismatches - Google Patents

Process for the in vivo recombination of partially homologous dna sequences having up to 30% of mismatches

Info

Publication number
IL92856A
IL92856A IL9285689A IL9285689A IL92856A IL 92856 A IL92856 A IL 92856A IL 9285689 A IL9285689 A IL 9285689A IL 9285689 A IL9285689 A IL 9285689A IL 92856 A IL92856 A IL 92856A
Authority
IL
Israel
Prior art keywords
mismatch repair
strain
mismatches
defective
recombination
Prior art date
Application number
IL9285689A
Other languages
English (en)
Other versions
IL92856A0 (en
Original Assignee
Setratech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Setratech filed Critical Setratech
Publication of IL92856A0 publication Critical patent/IL92856A0/xx
Publication of IL92856A publication Critical patent/IL92856A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL9285689A 1988-12-26 1989-12-22 Process for the in vivo recombination of partially homologous dna sequences having up to 30% of mismatches IL92856A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8817185A FR2641793B1 (fr) 1988-12-26 1988-12-26 Procede de recombinaison in vivo de sequences d'adn presentant des mesappariements de bases

Publications (2)

Publication Number Publication Date
IL92856A0 IL92856A0 (en) 1990-09-17
IL92856A true IL92856A (en) 2001-04-30

Family

ID=9373422

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9285689A IL92856A (en) 1988-12-26 1989-12-22 Process for the in vivo recombination of partially homologous dna sequences having up to 30% of mismatches

Country Status (13)

Country Link
US (2) US5912119A (de)
EP (1) EP0449923B1 (de)
JP (1) JP3056524B2 (de)
AT (1) ATE127519T1 (de)
AU (1) AU4834390A (de)
CA (1) CA2006549C (de)
DE (1) DE68924174T2 (de)
ES (1) ES2077058T3 (de)
FR (1) FR2641793B1 (de)
IE (1) IE72469B1 (de)
IL (1) IL92856A (de)
WO (1) WO1990007576A1 (de)
ZA (1) ZA899902B (de)

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US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
WO1997005268A1 (en) * 1995-07-26 1997-02-13 Setratech Homologous recombination in mismatch repair inactivated eukaryotic cells
US20020028443A1 (en) * 1999-09-27 2002-03-07 Jay M. Short Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
US6489145B1 (en) 1996-07-09 2002-12-03 Diversa Corporation Method of DNA shuffling
DK0873398T3 (da) * 1996-01-10 2005-08-15 Novozymes As Fremgangsmåde til in vivo produktion af et mutantbibliotek i celler
US6165718A (en) * 1996-01-10 2000-12-26 Novo Nordisk A/S Novo Alle Method for in vivo production of a mutant library in cells
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US7115413B2 (en) 1996-04-01 2006-10-03 Mixis France S.A. Meiotic recombination in vivo of partially homologous DNA sequences
US6242211B1 (en) 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
EP0948615B1 (de) * 1996-12-20 2004-12-15 Novozymes A/S In vivo rekombination
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AU743305C (en) 1997-01-17 2006-03-30 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AU6029998A (en) 1997-01-17 1998-08-07 Regents Of The University Of Minnesota Dna molecules and protein displaying improved triazine compound degrading ability
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
AUPO974597A0 (en) * 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
AU746786B2 (en) * 1997-12-08 2002-05-02 California Institute Of Technology Method for creating polynucleotide and polypeptide sequences
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US6846655B1 (en) * 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
US6438561B1 (en) * 1998-11-19 2002-08-20 Navigation Technologies Corp. Method and system for using real-time traffic broadcasts with navigation systems
WO2000042560A2 (en) 1999-01-19 2000-07-20 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides
US6376246B1 (en) * 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US20030054390A1 (en) * 1999-01-19 2003-03-20 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
WO2000042559A1 (en) * 1999-01-18 2000-07-20 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6917882B2 (en) * 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7024312B1 (en) * 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US20070065838A1 (en) * 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
EP1157095A1 (de) * 1999-02-24 2001-11-28 Novozymes A/S Pilzzellen mit inaktiviertem dna-mismatch reparatursystem
US6518042B1 (en) 1999-02-24 2003-02-11 Novozymes A/S Process for making DNA libraries in filamentous fungal cells using a novel cloned gene involved in the mismatch repair system of filamentous fungal cells
US7430477B2 (en) * 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
AU2001291057A1 (en) * 2000-09-18 2002-04-02 Pioneer Hi-Bred International, Inc. Rice MLH1 ortholog and uses thereof
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
ATE548461T1 (de) * 2002-01-18 2012-03-15 Morphotek Inc Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse
ATE319845T1 (de) * 2002-01-31 2006-03-15 Mixis France Sa Methode zur reversiblen funktionellen inaktivierung des mismatch reparatursystems
WO2003093426A2 (en) * 2002-05-02 2003-11-13 University Of North Carolina At Chapel Hill In vitro mutagenesis, phenotyping, and gene mapping
KR20070029240A (ko) * 2004-07-06 2007-03-13 믹시스 프랑스 에스. 에이. 박테리오파지에서 재조합 유전자의 생산법
EP1734125A1 (de) * 2005-06-16 2006-12-20 Institut National De La Recherche Agronomique Homeologische Rekombination in MSH2 inaktivierten Pflanzen oder deren Zellen
US20080124355A1 (en) * 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
WO2010111691A2 (en) 2009-03-27 2010-09-30 Life Technologies Corp Conjugates of biomolecules to nanoparticles
DK2478100T3 (da) 2010-04-09 2014-02-17 Eviagenics S A Fremgangsmåde til frembringelse af genmosaikker
EP2677881B1 (de) 2011-02-24 2020-04-01 Erber Aktiengesellschaft Enzyme zur futtermittel behandlung
CN103764828A (zh) 2011-06-21 2014-04-30 艾威艾基克斯有限公司 代谢进化方法
EP2766488A1 (de) 2011-10-12 2014-08-20 Eviagenics S.A. Verfahren zur erzeugung von genmosaiken in eukaryotischen zellen
US10519472B2 (en) 2012-12-27 2019-12-31 Rhodia Operations Recombinant host cell for biosynthetic production
EP2749644B2 (de) 2012-12-27 2024-12-25 Specialty Operations France Rekombinante Wirtszelle zur biosynthetischen Herstellung von Vanillin
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
KR102127358B1 (ko) 2013-03-13 2020-06-29 지니위브 바이오사이언시스, 인코포레이티드 비-복제 형질도입 입자 및 형질도입 입자-기반 리포터 시스템
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria

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US4863727A (en) * 1986-04-09 1989-09-05 Cetus Corporation Combination therapy using interleukin-2 and tumor necrosis factor
DE3724625A1 (de) * 1987-07-24 1989-02-02 Boehringer Mannheim Gmbh Enzymatisch inaktive, immunologisch aktive ss-galactosidase-muteine

Also Published As

Publication number Publication date
WO1990007576A1 (fr) 1990-07-12
CA2006549C (fr) 2000-09-05
IE72469B1 (en) 1997-04-09
DE68924174D1 (de) 1995-10-12
EP0449923B1 (de) 1995-09-06
JP3056524B2 (ja) 2000-06-26
CA2006549A1 (fr) 1990-06-26
FR2641793A1 (fr) 1990-07-20
IE894182L (en) 1990-06-26
DE68924174T2 (de) 1996-03-14
ES2077058T3 (es) 1995-11-16
EP0449923A1 (de) 1991-10-09
ATE127519T1 (de) 1995-09-15
IL92856A0 (en) 1990-09-17
AU4834390A (en) 1990-08-01
US5912119A (en) 1999-06-15
ZA899902B (en) 1990-09-26
JPH04503601A (ja) 1992-07-02
FR2641793B1 (fr) 1993-10-01
US5965415A (en) 1999-10-12

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