IL94243A - Merged polypeptide and its preparation - Google Patents

Merged polypeptide and its preparation

Info

Publication number: IL94243A
Authority: IL; Israel
Prior art keywords: variant; hsa; terminal; fusion polypeptide; physiologically equivalent
Prior art date: 1989-04-29

Application number

IL9424390A

Other languages

English (en)

Hebrew (he)

Other versions

IL94243A0 (en

Original Assignee

Delta Biotechnology Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-29

Filing date

1990-04-29

Publication date

1995-10-31

1990-04-29 Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd

1991-01-31 Publication of IL94243A0 publication Critical patent/IL94243A0/xx

1995-10-31 Publication of IL94243A publication Critical patent/IL94243A/en

Links

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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

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Organic Chemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL9424390A 1989-04-29 1990-04-29 Merged polypeptide and its preparation IL94243A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898909916A GB8909916D0 (en)	1989-04-29	1989-04-29	Polypeptides

Publications (2)

Publication Number	Publication Date
IL94243A0 IL94243A0 (en)	1991-01-31
IL94243A true IL94243A (en)	1995-10-31

Family

ID=10656000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9424390A IL94243A (en)	1989-04-29	1990-04-29	Merged polypeptide and its preparation

Country Status (12)

Country	Link
EP (1)	EP0470165A1 (de)
JP (1)	JP2781459B2 (de)
KR (1)	KR100227167B1 (de)
AU (1)	AU630450B2 (de)
CA (1)	CA2015687C (de)
FI (1)	FI104255B (de)
GB (2)	GB8909916D0 (de)
HU (1)	HUT61049A (de)
IE (1)	IE67651B1 (de)
IL (1)	IL94243A (de)
WO (1)	WO1990013653A1 (de)
ZA (1)	ZA903237B (de)

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FR2686899B1 (fr) *	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2686900B1 (fr) *	1992-01-31	1995-07-21	Rhone Poulenc Rorer Sa	Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
WO1994016085A2 (en) *	1992-12-30	1994-07-21	Zymogenetics, Inc.	Hybrid proteins having cross-linking and tissue-binding activities
GB9408466D0 (en) *	1994-04-27	1994-06-22	Univ Nottingham	Cloning and functional expression of neurotoxins
US5543308A (en) *	1994-10-18	1996-08-06	New England Biolabs, Inc.	Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same
US7112320B1 (en)	1995-06-07	2006-09-26	Andre Beaulieu	Solid wound healing formulations containing fibronectin
US5877149A (en)	1995-06-07	1999-03-02	Beaulieu; Andre	Deepithelialized skin diffusion cell system
US5641483A (en) *	1995-06-07	1997-06-24	Beaulieu; Andre	Wound healing formulations containing human plasma fibronectin
GB9526733D0 (en)	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
US6423512B1 (en)	1996-07-26	2002-07-23	Novartis Ag	Fusion polypeptides
AR008077A1 (es) *	1996-07-26	1999-12-09	Talarico Salinas Laura Beatriz	Un polipeptido de fusion o una sal del mismo, su uso, un proceso para prepararlos, una composicion farmaceutica que los comprende, y un vector.
US5932693A (en) *	1996-12-10	1999-08-03	Washington University	Antithrombotic peptides
AU2149899A (en)	1998-01-23	1999-08-09	Novo Nordisk A/S	Process for making desired polypeptides in yeast
DE69933216T2 (de)	1998-06-15	2007-09-20	GTC Biotherapeutics, Inc., Framingham	Erythropoietin-analog-menschliches serum-albumin fusionsprotein
EP2213743A1 (de) *	2000-04-12	2010-08-04	Human Genome Sciences, Inc.	Albuminfusionsproteine
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
KR100888915B1 (ko)	2001-08-15	2009-03-16	다카라 바이오 가부시키가이샤	항원특이적 세포상해성 ｔ 세포 확대배양방법
WO2005003296A2 (en)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Albumin fusion proteins
AU2002364586A1 (en)	2001-12-21	2003-07-30	Delta Biotechnology Limited	Albumin fusion proteins
JP4406566B2 (ja)	2002-03-25	2010-01-27	タカラバイオ株式会社	細胞傷害性リンパ球の製造方法
KR101331746B1 (ko) *	2003-08-22	2013-11-20	다카라 바이오 가부시키가이샤	세포 상해성 림프구의 제조 방법
US7850970B2 (en)	2003-08-26	2010-12-14	The Regents Of The University Of Colorado	Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
GB0329681D0 (en)	2003-12-23	2004-01-28	Delta Biotechnology Ltd	Gene expression technique
US9057061B2 (en)	2003-12-23	2015-06-16	Novozymes Biopharma Dk A/S	Gene expression technique
WO2006067511A1 (en)	2004-12-23	2006-06-29	Novozymes Delta Limited	Gene expression technique
GB0329722D0 (en)	2003-12-23	2004-01-28	Delta Biotechnology Ltd	Modified plasmid and use thereof
EP1816201A1 (de)	2006-02-06	2007-08-08	CSL Behring GmbH	Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät
WO2007146038A2 (en)	2006-06-07	2007-12-21	Human Genome Sciences, Inc.	Albumin fusion proteins
EP2049560B1 (de)	2006-07-13	2013-05-15	Novozymes Biopharma DK A/S	Verfahren zur herstellung von partikeln aus proteinhaltigem material
KR101722961B1 (ko)	2009-02-11	2017-04-04	알부메딕스 에이/에스	알부민 변이체 및 접합체
EP2493921B1 (de)	2009-10-30	2018-09-26	Albumedix Ltd	Albuminvarianten
EP2556087A1 (de)	2010-04-09	2013-02-13	Novozymes Biopharma DK A/S	Albuminderivate und varianten
WO2012178102A2 (en) *	2011-06-24	2012-12-27	The Regents Of The Unversity Of Colorado, A Body Corporate	Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
EP2780364A2 (de)	2011-11-18	2014-09-24	Eleven Biotherapeutics, Inc.	Proteine mit verbesserter halbwertzeit und anderen eigenschaften
DK2825556T3 (en)	2012-03-16	2018-04-16	Albumedix As	albumin Variants
MX2015005363A (es)	2012-11-08	2015-11-06	Novozymes Biopharma Dk As	Variantes de albumina.
EP2968587A2 (de)	2013-03-13	2016-01-20	Bristol-Myers Squibb Company	Serumalbumingebundene fibronectin-gerüstdomänen oder daran bindendes element
JP7007261B2 (ja)	2015-08-20	2022-01-24	アルブミディクスリミティド	アルブミン変異体及びコンジュゲート
WO2018089702A1 (en) *	2016-11-10	2018-05-17	Keros Therapeutics, Inc.	Gdnf fusion polypeptides and methods of use thereof
CA3117961A1 (en) *	2018-10-29	2020-05-07	Spin Therapeutics, Llc	Compositions and methods for alpha-1-antitrypsin disorders
EP3711772A1 (de)	2019-03-20	2020-09-23	Oslo Universitetssykehus HF	Rekombinante proteine und fusionsproteine

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SE459586B (sv) *	1987-09-14	1989-07-17	Mta Szegedi Biolog Koezponti	Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
GB8725529D0 (en) *	1987-10-30	1987-12-02	Delta Biotechnology Ltd	Polypeptides

1989
- 1989-04-29 GB GB898909916A patent/GB8909916D0/en active Pending
1990
- 1990-04-26 HU HU904413A patent/HUT61049A/hu unknown
- 1990-04-26 WO PCT/GB1990/000650 patent/WO1990013653A1/en not_active Ceased
- 1990-04-26 EP EP90907285A patent/EP0470165A1/de active Pending
- 1990-04-26 AU AU55646/90A patent/AU630450B2/en not_active Expired
- 1990-04-26 JP JP2506978A patent/JP2781459B2/ja not_active Expired - Lifetime
- 1990-04-27 IE IE155490A patent/IE67651B1/en not_active IP Right Cessation
- 1990-04-27 ZA ZA903237A patent/ZA903237B/xx unknown
- 1990-04-27 CA CA002015687A patent/CA2015687C/en not_active Expired - Lifetime
- 1990-04-29 IL IL9424390A patent/IL94243A/en not_active IP Right Cessation
1991
- 1991-09-06 GB GB9119043A patent/GB2246783B/en not_active Expired - Lifetime
- 1991-10-14 KR KR1019910701334A patent/KR100227167B1/ko not_active Expired - Fee Related
- 1991-10-28 FI FI915073A patent/FI104255B/fi active

Also Published As

Publication number	Publication date
GB8909916D0 (en)	1989-06-14
HU904413D0 (en)	1992-01-28
FI915073A0 (fi)	1991-10-28
HUT61049A (en)	1992-11-30
WO1990013653A1 (en)	1990-11-15
KR920701451A (ko)	1992-08-11
EP0470165A1 (de)	1992-02-12
GB2246783B (en)	1992-10-14
IE901554L (en)	1990-10-29
AU5564690A (en)	1990-11-29
IL94243A0 (en)	1991-01-31
FI104255B1 (fi)	1999-12-15
GB2246783A (en)	1992-02-12
JPH04506598A (ja)	1992-11-19
JP2781459B2 (ja)	1998-07-30
ZA903237B (en)	1991-03-27
AU630450B2 (en)	1992-10-29
CA2015687C (en)	2000-08-29
KR100227167B1 (ko)	1999-10-15
GB9119043D0 (en)	1991-12-04
FI104255B (fi)	1999-12-15
IE67651B1 (en)	1996-04-17
CA2015687A1 (en)	1990-10-29

Legal Events

Date	Code	Title
1996-03-31	FF	Patent granted
1996-07-23	KB	Patent renewed
2000-08-31	KB	Patent renewed
2004-06-20	KB	Patent renewed
2008-06-05	KB	Patent renewed
2011-04-28	EXP	Patent expired

Publication	Publication Date	Title
CA2015687C (en)	2000-08-29	Human serum albomin fusion polypeptide
EP0399666B1 (de)	1993-07-28	N-terminale Fragmente von menschliches Serumalbumin enthaltenden Fusionsproteinen
US5766883A (en)	1998-06-16	Polypeptides
US4766073A (en)	1988-08-23	Expression of biologically active PDGF analogs in eucaryotic cells
US5187263A (en)	1993-02-16	Expression of biologically active PDGE analogs in eucaryotic cells
AU619768B2 (en)	1992-02-06	Polypeptides
JP2708518B2 (ja)	1998-02-04	合成酵母リーダーペプチド
CZ290069B6 (cs)	2002-05-15	DNA expresní kazeta, kvasinkový expresní vektor,buňka kvasinky a způsob výroby heterologního polypeptidu v kvasinkách
IE892361L (en)	1990-01-23	Peptide and dna sequences
JPS61135591A (ja)	1986-06-23	組み換え融合タン白質
US5705484A (en)	1998-01-06	Biologically active polypeptide fusion dimers
JPS63251095A (ja)	1988-10-18	新規融合蛋白質およびその精製方法
PT99848A (pt)	1993-06-30	Processo para a preparacao de sequencias lider sinteticas
JPH02167095A (ja)	1990-06-27	異種蛋白質の製造方法、組換えｄｎａ、形質転換体
EP0338634B1 (de)	1994-04-06	Polypeptide aus Vipergift und deren Genexpression
JPH01240191A (ja)	1989-09-25	酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
AU665034B2 (en)	1995-12-14	Production of human parathyroid hormone from microorganisms
EP0129073B1 (de)	1991-03-06	Hybride DNS-Synthese von reifem wachstumshormonauslösendem Faktor
US5420242A (en)	1995-05-30	Production of human parathyroid hormone from microorganisms
IL88925A (en)	1995-11-27	Hirudin derivative and pharmaceutical composition containing same
Can et al.	1989	High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28] echistatin
Barklis et al.	1985	Structure of the Dictyostelium discoideum prestalk D11 gene and protein
JP4180112B2 (ja)	2008-11-12	酵母細胞におけるｎ末端を伸長されたタンパクの発現のためのベクター
IE890559L (en)	1989-08-23	A hirudin derivative
WO1997003089A2 (en)	1997-01-30	Method for the preparation of insulin by cleavage of a fusion protein and fusion proteins containing insulin a and b chains