IL94243A - Merged polypeptide and its preparation - Google Patents

Merged polypeptide and its preparation

Info

Publication number: IL94243A
Authority: IL; Israel
Prior art keywords: variant; hsa; terminal; fusion polypeptide; physiologically equivalent
Prior art date: 1989-04-29

Application number

IL9424390A

Other languages

English (en)

Hebrew (he)

Other versions

IL94243A0 (en

Original Assignee

Delta Biotechnology Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-29

Filing date

1990-04-29

Publication date

1995-10-31

1990-04-29 Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd

1991-01-31 Publication of IL94243A0 publication Critical patent/IL94243A0/xx

1995-10-31 Publication of IL94243A publication Critical patent/IL94243A/en

Links

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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

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Bioinformatics & Cheminformatics (AREA)
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General Engineering & Computer Science (AREA)
Biophysics (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
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Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL9424390A 1989-04-29 1990-04-29 Merged polypeptide and its preparation IL94243A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898909916A GB8909916D0 (en)	1989-04-29	1989-04-29	Polypeptides

Publications (2)

Publication Number	Publication Date
IL94243A0 IL94243A0 (en)	1991-01-31
IL94243A true IL94243A (en)	1995-10-31

Family

ID=10656000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9424390A IL94243A (en)	1989-04-29	1990-04-29	Merged polypeptide and its preparation

Country Status (12)

Country	Link
EP (1)	EP0470165A1 (de)
JP (1)	JP2781459B2 (de)
KR (1)	KR100227167B1 (de)
AU (1)	AU630450B2 (de)
CA (1)	CA2015687C (de)
FI (1)	FI104255B (de)
GB (2)	GB8909916D0 (de)
HU (1)	HUT61049A (de)
IE (1)	IE67651B1 (de)
IL (1)	IL94243A (de)
WO (1)	WO1990013653A1 (de)
ZA (1)	ZA903237B (de)

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US5629287A (en) *	1991-01-18	1997-05-13	University College London	Depot formulations
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2686900B1 (fr) *	1992-01-31	1995-07-21	Rhone Poulenc Rorer Sa	Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
WO1994016085A2 (en) *	1992-12-30	1994-07-21	Zymogenetics, Inc.	Hybrid proteins having cross-linking and tissue-binding activities
GB9408466D0 (en) *	1994-04-27	1994-06-22	Univ Nottingham	Cloning and functional expression of neurotoxins
US5543308A (en) *	1994-10-18	1996-08-06	New England Biolabs, Inc.	Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same
US5641483A (en) *	1995-06-07	1997-06-24	Beaulieu; Andre	Wound healing formulations containing human plasma fibronectin
US7112320B1 (en)	1995-06-07	2006-09-26	Andre Beaulieu	Solid wound healing formulations containing fibronectin
US5877149A (en)	1995-06-07	1999-03-02	Beaulieu; Andre	Deepithelialized skin diffusion cell system
GB9526733D0 (en)	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
US6423512B1 (en)	1996-07-26	2002-07-23	Novartis Ag	Fusion polypeptides
AR008077A1 (es) *	1996-07-26	1999-12-09	Talarico Salinas Laura Beatriz	Un polipeptido de fusion o una sal del mismo, su uso, un proceso para prepararlos, una composicion farmaceutica que los comprende, y un vector.
US5932693A (en) *	1996-12-10	1999-08-03	Washington University	Antithrombotic peptides
WO1999037793A1 (en)	1998-01-23	1999-07-29	Novo Nordisk A/S	Process for making desired polypeptides in yeast
JP4087563B2 (ja)	1998-06-15	2008-05-21	ジーティーシーバイオセラピューティックスインコーポレイテッド	エリスロポエチン類似体−ヒト血清アルブミン融合物
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
EP1803730A1 (de) *	2000-04-12	2007-07-04	Human Genome Sciences, Inc.	Albuminfusionsproteine
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
JP4949607B2 (ja)	2001-08-15	2012-06-13	タカラバイオ株式会社	抗原特異的細胞傷害性ｔ細胞拡大培養方法
EP1997829A1 (de)	2001-12-21	2008-12-03	Human Genome Sciences, Inc.	Albumin Fusionsproteine
ES2397319T3 (es)	2002-03-25	2013-03-06	Takara Bio Inc.	Proceso para producir linfocitos citotóxicos
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
KR20060039940A (ko)	2003-08-22	2006-05-09	다카라 바이오 가부시키가이샤	세포 상해성 림프구의 제조 방법
CA2536918A1 (en)	2003-08-26	2005-03-03	Leland Shapiro	Compositions of, and methods for, alpha-1 antitrypsin fc fusion molecules
GB0329681D0 (en)	2003-12-23	2004-01-28	Delta Biotechnology Ltd	Gene expression technique
GB0329722D0 (en)	2003-12-23	2004-01-28	Delta Biotechnology Ltd	Modified plasmid and use thereof
AU2005317828A1 (en)	2004-12-23	2006-06-29	Novozymes Delta Limited	Gene expression technique
EP1816201A1 (de)	2006-02-06	2007-08-08	CSL Behring GmbH	Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät
EP2474318A1 (de)	2006-06-07	2012-07-11	Human Genome Sciences, Inc.	Albumin-Fusionsproteine
AU2007274035A1 (en)	2006-07-13	2008-01-17	Novozymes Biopharma Dk A/S	Process for preparing particles of proteinaceous material
JP5936112B2 (ja)	2009-02-11	2016-06-15	アルブミディクスアクティーゼルスカブ	アルブミン変異体及び複合体
BR112012009450A2 (pt)	2009-10-30	2017-05-23	Novozymes Biopharma Dk As	variantes de albumina
US10233228B2 (en)	2010-04-09	2019-03-19	Albumedix Ltd	Albumin derivatives and variants
KR102103476B1 (ko)	2011-06-24	2020-04-23	더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트	알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
HK1200842A1 (en)	2011-11-18	2015-08-14	Albumedix Ltd	Proteins with improved half-life and other properties
CN104736559B (zh)	2012-03-16	2022-04-08	阿尔布梅迪克斯医疗有限公司	白蛋白变体
CN105452290A (zh)	2012-11-08	2016-03-30	诺维信生物制药丹麦公司	白蛋白变体
WO2014165093A2 (en)	2013-03-13	2014-10-09	Bristol-Myers Squibb Company	Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto
MX2018001825A (es)	2015-08-20	2018-05-07	Albumedix As	Variantes y conjugados de albumina.
US11912750B2 (en)	2016-11-10	2024-02-27	Keros Therapeutics, Inc.	GDNF fusion polypeptides and methods of use thereof
US12497441B2 (en) *	2018-10-29	2025-12-16	Spin Therapeutics, Llc	Compositions and methods for alpha-1-antitrypsin disorders

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SE459586B (sv) *	1987-09-14	1989-07-17	Mta Szegedi Biolog Koezponti	Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
GB8725529D0 (en) *	1987-10-30	1987-12-02	Delta Biotechnology Ltd	Polypeptides

1989
- 1989-04-29 GB GB898909916A patent/GB8909916D0/en active Pending
1990
- 1990-04-26 AU AU55646/90A patent/AU630450B2/en not_active Expired
- 1990-04-26 JP JP2506978A patent/JP2781459B2/ja not_active Expired - Lifetime
- 1990-04-26 EP EP90907285A patent/EP0470165A1/de active Pending
- 1990-04-26 HU HU904413A patent/HUT61049A/hu unknown
- 1990-04-26 WO PCT/GB1990/000650 patent/WO1990013653A1/en not_active Ceased
- 1990-04-27 CA CA002015687A patent/CA2015687C/en not_active Expired - Lifetime
- 1990-04-27 ZA ZA903237A patent/ZA903237B/xx unknown
- 1990-04-27 IE IE155490A patent/IE67651B1/en not_active IP Right Cessation
- 1990-04-29 IL IL9424390A patent/IL94243A/en not_active IP Right Cessation
1991
- 1991-09-06 GB GB9119043A patent/GB2246783B/en not_active Expired - Lifetime
- 1991-10-14 KR KR1019910701334A patent/KR100227167B1/ko not_active Expired - Fee Related
- 1991-10-28 FI FI915073A patent/FI104255B/fi active

Also Published As

Publication number	Publication date
WO1990013653A1 (en)	1990-11-15
FI915073A0 (fi)	1991-10-28
IE901554L (en)	1990-10-29
FI104255B1 (fi)	1999-12-15
GB2246783A (en)	1992-02-12
AU630450B2 (en)	1992-10-29
IL94243A0 (en)	1991-01-31
FI104255B (fi)	1999-12-15
JPH04506598A (ja)	1992-11-19
HU904413D0 (en)	1992-01-28
CA2015687A1 (en)	1990-10-29
KR100227167B1 (ko)	1999-10-15
JP2781459B2 (ja)	1998-07-30
AU5564690A (en)	1990-11-29
GB9119043D0 (en)	1991-12-04
HUT61049A (en)	1992-11-30
ZA903237B (en)	1991-03-27
GB2246783B (en)	1992-10-14
CA2015687C (en)	2000-08-29
IE67651B1 (en)	1996-04-17
KR920701451A (ko)	1992-08-11
GB8909916D0 (en)	1989-06-14
EP0470165A1 (de)	1992-02-12

Legal Events

Date	Code	Title
1996-03-31	FF	Patent granted
1996-07-23	KB	Patent renewed
2000-08-31	KB	Patent renewed
2004-06-20	KB	Patent renewed
2008-06-05	KB	Patent renewed
2011-04-28	EXP	Patent expired

Publication	Publication Date	Title
CA2015687C (en)	2000-08-29	Human serum albomin fusion polypeptide
EP0399666B1 (de)	1993-07-28	N-terminale Fragmente von menschliches Serumalbumin enthaltenden Fusionsproteinen
US5766883A (en)	1998-06-16	Polypeptides
US4766073A (en)	1988-08-23	Expression of biologically active PDGF analogs in eucaryotic cells
US5187263A (en)	1993-02-16	Expression of biologically active PDGE analogs in eucaryotic cells
AU619768B2 (en)	1992-02-06	Polypeptides
JP2708518B2 (ja)	1998-02-04	合成酵母リーダーペプチド
CZ290069B6 (cs)	2002-05-15	DNA expresní kazeta, kvasinkový expresní vektor,buňka kvasinky a způsob výroby heterologního polypeptidu v kvasinkách
IE892361L (en)	1990-01-23	Peptide and dna sequences
JPS61135591A (ja)	1986-06-23	組み換え融合タン白質
US5705484A (en)	1998-01-06	Biologically active polypeptide fusion dimers
JPS63251095A (ja)	1988-10-18	新規融合蛋白質およびその精製方法
PT99848A (pt)	1993-06-30	Processo para a preparacao de sequencias lider sinteticas
JPH02167095A (ja)	1990-06-27	異種蛋白質の製造方法、組換えｄｎａ、形質転換体
EP0338634B1 (de)	1994-04-06	Polypeptide aus Vipergift und deren Genexpression
JPH01240191A (ja)	1989-09-25	酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
AU665034B2 (en)	1995-12-14	Production of human parathyroid hormone from microorganisms
EP0129073B1 (de)	1991-03-06	Hybride DNS-Synthese von reifem wachstumshormonauslösendem Faktor
US5420242A (en)	1995-05-30	Production of human parathyroid hormone from microorganisms
IL88925A (en)	1995-11-27	Hirudin derivative and pharmaceutical composition containing same
Can et al.	1989	High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28] echistatin
Barklis et al.	1985	Structure of the Dictyostelium discoideum prestalk D11 gene and protein
JP4180112B2 (ja)	2008-11-12	酵母細胞におけるｎ末端を伸長されたタンパクの発現のためのベクター
IE890559L (en)	1989-08-23	A hirudin derivative
WO1997003089A2 (en)	1997-01-30	Method for the preparation of insulin by cleavage of a fusion protein and fusion proteins containing insulin a and b chains