IL95244A - Pharmaceutical compositions containing derivatives of 2,3,4,5-tetrahydro-2-(1h-imidazol-4-ylmethyl)-[4,3-b]- indol-1-one and the corresponding azepine homolog for the treatment of conditions involving excessive eating - Google Patents

Pharmaceutical compositions containing derivatives of 2,3,4,5-tetrahydro-2-(1h-imidazol-4-ylmethyl)-[4,3-b]- indol-1-one and the corresponding azepine homolog for the treatment of conditions involving excessive eating

Info

Publication number: IL95244A
Authority: IL; Israel
Prior art keywords: group; hydrogen atom; pharmaceutical composition; methyl; phenyl
Prior art date: 1989-08-01

Application number

IL9524490A

Other languages

English (en)

Other versions

IL95244A0 (en

Original Assignee

Glayo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-01

Filing date

1990-07-31

Publication date

1994-07-31

1990-07-31 Application filed by Glayo Group Limited filed Critical Glayo Group Limited

1991-06-10 Publication of IL95244A0 publication Critical patent/IL95244A0/xx

1994-07-31 Publication of IL95244A publication Critical patent/IL95244A/en

Links

238000011282 treatment Methods 0.000 title claims abstract description 16
206010020710 Hyperphagia Diseases 0.000 title claims abstract description 11
239000008194 pharmaceutical composition Substances 0.000 title claims description 16
XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 40
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 26
-1 phenylC1-3alkyl Chemical group 0.000 claims abstract description 21
150000003839 salts Chemical class 0.000 claims abstract description 19
239000012453 solvate Substances 0.000 claims abstract description 15
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 12
208000032841 Bulimia Diseases 0.000 claims abstract description 8
206010006550 Bulimia nervosa Diseases 0.000 claims abstract description 8
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract description 7
125000005843 halogen group Chemical group 0.000 claims abstract description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 3
125000002883 imidazolyl group Chemical group 0.000 claims abstract description 3
HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims abstract description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
239000004480 active ingredient Substances 0.000 claims description 12
125000000217 alkyl group Chemical group 0.000 claims description 7
QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical class N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 2
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125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
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QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
239000003826 tablet Substances 0.000 description 11
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
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UBHDUFNPQJWPRQ-UHFFFAOYSA-N (5-methyl-1h-imidazol-3-ium-4-yl)methanol;chloride Chemical compound Cl.CC=1NC=NC=1CO UBHDUFNPQJWPRQ-UHFFFAOYSA-N 0.000 description 2
FEROPKNOYKURCJ-UHFFFAOYSA-N 4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-methoxybenzamide Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)NC1C(CC2)CCN2C1 FEROPKNOYKURCJ-UHFFFAOYSA-N 0.000 description 2
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DKXNBNKWCZZMJT-JVCRWLNRSA-N (2r,3r,4r,5r)-2,3,5,6-tetrahydroxy-4-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanal Chemical compound O=C[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O DKXNBNKWCZZMJT-JVCRWLNRSA-N 0.000 description 1
PCOCCSRRHOKKPJ-UHFFFAOYSA-N 1-azabicyclo[2.2.2]octane;benzamide Chemical class C1CC2CCN1CC2.NC(=O)C1=CC=CC=C1 PCOCCSRRHOKKPJ-UHFFFAOYSA-N 0.000 description 1
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
ZBFZXENHYIJZGA-UHFFFAOYSA-N 2,3,4,4a-tetrahydrocarbazol-1-one Chemical class C1=CC=C2C3CCCC(=O)C3=NC2=C1 ZBFZXENHYIJZGA-UHFFFAOYSA-N 0.000 description 1
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JGDYBCWUMHYESH-UHFFFAOYSA-N 5-ethyl-2-[(5-methyl-1h-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one Chemical compound O=C1C=2C3=CC=CC=C3N(CC)C=2CCN1CC=1N=CNC=1C JGDYBCWUMHYESH-UHFFFAOYSA-N 0.000 description 1
102000040125 5-hydroxytryptamine receptor family Human genes 0.000 description 1
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QHXIDADTZDZQAE-UHFFFAOYSA-N 5-methyl-2-[(5-methylimidazol-1-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one;hydrochloride Chemical compound Cl.CC1=CN=CN1CN1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 QHXIDADTZDZQAE-UHFFFAOYSA-N 0.000 description 1
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AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Child & Adolescent Psychology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IL9524490A 1989-08-01 1990-07-31 Pharmaceutical compositions containing derivatives of 2,3,4,5-tetrahydro-2-(1h-imidazol-4-ylmethyl)-[4,3-b]- indol-1-one and the corresponding azepine homolog for the treatment of conditions involving excessive eating IL95244A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898917557A GB8917557D0 (en)	1989-08-01	1989-08-01	Medicaments

Publications (2)

Publication Number	Publication Date
IL95244A0 IL95244A0 (en)	1991-06-10
IL95244A true IL95244A (en)	1994-07-31

Family

ID=10660973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9524490A IL95244A (en)	1989-08-01	1990-07-31	Pharmaceutical compositions containing derivatives of 2,3,4,5-tetrahydro-2-(1h-imidazol-4-ylmethyl)-[4,3-b]- indol-1-one and the corresponding azepine homolog for the treatment of conditions involving excessive eating

Country Status (7)

Country	Link
EP (1)	EP0411901A3 (fr)
JP (1)	JPH03223286A (fr)
KR (1)	KR910004195A (fr)
GB (1)	GB8917557D0 (fr)
IE (1)	IE902768A1 (fr)
IL (1)	IL95244A (fr)
ZA (1)	ZA905998B (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE460359B (sv) *	1984-01-25	1989-10-02	Glaxo Group Ltd	3-imidazolylmetyltetrahydrokarbazoloner, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
HU895334D0 (en) *	1986-07-30	1990-01-28	Sandoz Ag	Process for the preparation of nasal pharmaceutical compositions
EP0306323B1 (fr) *	1987-09-03	1994-09-21	Glaxo Group Limited	Dérivés de lactames

1989
- 1989-08-01 GB GB898917557A patent/GB8917557D0/en active Pending
1990
- 1990-07-31 ZA ZA905998A patent/ZA905998B/xx unknown
- 1990-07-31 IL IL9524490A patent/IL95244A/en not_active IP Right Cessation
- 1990-07-31 EP EP19900308413 patent/EP0411901A3/en not_active Withdrawn
- 1990-07-31 IE IE276890A patent/IE902768A1/en not_active Application Discontinuation
- 1990-07-31 KR KR1019900011700A patent/KR910004195A/ko not_active Withdrawn
- 1990-07-31 JP JP2203756A patent/JPH03223286A/ja active Pending

Also Published As

Publication number	Publication date
KR910004195A (ko)	1991-03-28
GB8917557D0 (en)	1989-09-13
JPH03223286A (ja)	1991-10-02
IL95244A0 (en)	1991-06-10
IE902768A1 (en)	1991-02-27
ZA905998B (en)	1991-06-26
EP0411901A3 (en)	1992-09-02
EP0411901A2 (fr)	1991-02-06

Legal Events

Date	Code	Title	Description
1997-04-15	RH	Patent void

Publication	Publication Date	Title
IE873230L (en)	1988-05-28	5ht3-antagonists plus ranitidine compositions
IL87658A (en)	1994-06-24	Tetrahydro-2- (1h-imidazolylmethyl) pyrido- (and azepino)[4,3-(b)] indol-1-ones, their preparation and pharmaceutical compositions containing them
US20100204267A1 (en)	2010-08-12	Preventive and therapeutic medicament for gastroesophageal reflux disease
EP0276559B1 (fr)	1992-08-05	Emploi de dérivés de cétone pour le traitement de la dépression
EP0275668B1 (fr)	1992-09-30	Emploi de dérivés de cétone pour le traitement de troubles de la démence
EP0696194B1 (fr)	2002-08-21	Utilisation de derives d'indoles comme antagonistes de 5ht1
AU627769B2 (en)	1992-09-03	The use of lactam derivatives in the treatment of cognitive disorders
IL95244A (en)	1994-07-31	Pharmaceutical compositions containing derivatives of 2,3,4,5-tetrahydro-2-(1h-imidazol-4-ylmethyl)-[4,3-b]- indol-1-one and the corresponding azepine homolog for the treatment of conditions involving excessive eating
CA2022379A1 (fr)	1991-02-02	Medicaments
US5276050A (en)	1994-01-04	Medicaments
CA1330535C (fr)	1994-07-05	Medicament pour le traitement de la depression
US5229407A (en)	1993-07-20	Medicaments
EP0523013B1 (fr)	1994-12-21	Utilisation des dérivés de l'acide benzimidazoline-2-oxo-1-carboxylique dans le traitement des maladies mentales organiques
CA2022380A1 (fr)	1991-02-02	Medicaments
EP0269452A2 (fr)	1988-06-01	Application de dérivés de cétone pour la fabrication de médicaments
US5221687A (en)	1993-06-22	Medicaments
AU627768B2 (en)	1992-09-03	The use of lactam derivatives in the treatment of addiction
JPH01250319A (ja)	1989-10-05	医薬