IL95385A0 - Macrocyclic compounds,their production and pharmaceutical compositions containing them - Google Patents

Macrocyclic compounds,their production and pharmaceutical compositions containing them

Info

Publication number
IL95385A0
IL95385A0 IL95385A IL9538590A IL95385A0 IL 95385 A0 IL95385 A0 IL 95385A0 IL 95385 A IL95385 A IL 95385A IL 9538590 A IL9538590 A IL 9538590A IL 95385 A0 IL95385 A0 IL 95385A0
Authority
IL
Israel
Prior art keywords
production
pharmaceutical compositions
compositions containing
macrocyclic compounds
macrocyclic
Prior art date
Application number
IL95385A
Other languages
English (en)
Original Assignee
Fisons Plc
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898918927A external-priority patent/GB8918927D0/en
Priority claimed from GB898922653A external-priority patent/GB8922653D0/en
Priority claimed from GB909012426A external-priority patent/GB9012426D0/en
Application filed by Fisons Plc, Fujisawa Pharmaceutical Co filed Critical Fisons Plc
Publication of IL95385A0 publication Critical patent/IL95385A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL95385A 1989-08-18 1990-08-15 Macrocyclic compounds,their production and pharmaceutical compositions containing them IL95385A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898918927A GB8918927D0 (en) 1989-08-18 1989-08-18 Compounds
GB898922653A GB8922653D0 (en) 1989-10-09 1989-10-09 Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
GB909012426A GB9012426D0 (en) 1990-06-04 1990-06-04 Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same

Publications (1)

Publication Number Publication Date
IL95385A0 true IL95385A0 (en) 1991-06-30

Family

ID=27264646

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95385A IL95385A0 (en) 1989-08-18 1990-08-15 Macrocyclic compounds,their production and pharmaceutical compositions containing them

Country Status (9)

Country Link
EP (1) EP0487593A1 (fr)
JP (1) JPH05504944A (fr)
CN (1) CN1049503A (fr)
AU (1) AU6286690A (fr)
GR (1) GR900100614A (fr)
IE (1) IE902995A1 (fr)
IL (1) IL95385A0 (fr)
PT (1) PT95039A (fr)
WO (1) WO1991002736A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920700212A (ko) * 1989-06-14 1992-02-19 쟝 크라머·한스 루돌프 하우스 헤테로원자-함유 트리사이클릭 화합물
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
WO1992018506A1 (fr) * 1991-04-11 1992-10-29 Pfizer, Inc. Nouvel agent immunosuppresseur prepare a partir de streptomyces braegensis
NO921449L (no) * 1991-04-17 1992-10-19 American Home Prod Karbamater av rapamycin
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
ES2179823T3 (es) * 1991-09-05 2003-02-01 Abbott Lab Inmunosupresor macrolido.
US5534632A (en) * 1991-09-05 1996-07-09 Abbott Laboratories Macrocyclic carbamate immunomodulators
US5708002A (en) * 1991-09-05 1998-01-13 Abbott Laboratories Macrocyclic immunomodulators
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
GB9125660D0 (en) * 1991-12-03 1992-01-29 Smithkline Beecham Plc Novel compound
WO1993018042A1 (fr) * 1992-03-02 1993-09-16 Pfizer Inc. Derives de desosamino de macrolides utiles comme immunosuppresseurs et antifongiques
WO1993018049A1 (fr) * 1992-03-02 1993-09-16 Pfizer Inc. Derives du fluorosucre de macrolides
ES2102642T3 (es) * 1992-03-02 1997-08-01 Pfizer Derivados azucares de macrolidos.
CA2131373C (fr) * 1992-03-02 1999-01-26 Kevin Koch 2-aminoglycomacrolides
CA2091194A1 (fr) * 1992-04-08 1993-10-09 Richard D. Connell Derives 2-oxoethyliques utilises comme immunosuppresseurs
US5284877A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkyl and alkenyl macrolides having immunosuppressive activity
US5284840A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkylidene macrolides having immunosuppressive activity
CA2106034A1 (fr) * 1992-09-24 1994-03-25 Ralph J. Russo La 21-norrapamycine
US5258389A (en) * 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
US5310901A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US7186518B2 (en) * 2003-11-21 2007-03-06 Dade Behring Inc. Method and composition useful for determining FK 506
WO2006115509A2 (fr) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
KR102109168B1 (ko) * 2018-12-11 2020-05-12 인트론바이오테크놀로지 신규 화합물 및 이를 포함하는 진균감염 치료용 약학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
WO1989005304A1 (fr) * 1987-12-09 1989-06-15 Fisons Plc Composes macrocycliques
US4981792A (en) * 1988-06-29 1991-01-01 Merck & Co., Inc. Immunosuppressant compound
DE68921934T2 (de) * 1988-06-29 1995-10-19 Merck & Co Inc Immunsuppressives Agens.
ATE131536T1 (de) * 1988-08-01 1995-12-15 Fujisawa Pharmaceutical Co Fr-901154- und fr-901155-derivate, verfahren zu ihrer herstellung
EP0356399A3 (fr) * 1988-08-26 1991-03-20 Sandoz Ag Dérivés substitués du 4-azatricyclo (22.3.1.04.9) octacos-18-ène, leur préparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
GR900100614A (el) 1991-12-30
AU6286690A (en) 1991-04-03
JPH05504944A (ja) 1993-07-29
EP0487593A1 (fr) 1992-06-03
CN1049503A (zh) 1991-02-27
PT95039A (pt) 1991-04-18
IE902995A1 (en) 1991-02-27
WO1991002736A1 (fr) 1991-03-07

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