IL96506A - Transdermal system for administering pharmacological compounds under HP controlled conditions - Google Patents

Transdermal system for administering pharmacological compounds under HP controlled conditions

Info

Publication number: IL96506A
Authority: IL; Israel
Prior art keywords: skin; active substance; delivery system; additive; plaster
Prior art date: 1989-12-01

Application number

IL9650690A

Other languages

English (en)

Hebrew (he)

Other versions

IL96506A0 (en

Original Assignee

Boehringer Ingelheim Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-01

Filing date

1990-11-29

Publication date

1996-01-19

1990-11-29 Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg

1991-08-16 Publication of IL96506A0 publication Critical patent/IL96506A0/xx

1996-01-19 Publication of IL96506A publication Critical patent/IL96506A/en

Links

150000001875 compounds Chemical class 0.000 title abstract description 4
229940100640 transdermal system Drugs 0.000 title description 9
239000013543 active substance Substances 0.000 claims description 49
239000000654 additive Substances 0.000 claims description 25
239000011505 plaster Substances 0.000 claims description 25
230000000996 additive effect Effects 0.000 claims description 18
229920000642 polymer Polymers 0.000 claims description 18
STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical group CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 claims description 17
229960001117 clenbuterol Drugs 0.000 claims description 16
239000011159 matrix material Substances 0.000 claims description 16
239000000243 solution Substances 0.000 claims description 15
239000002253 acid Substances 0.000 claims description 11
230000004907 flux Effects 0.000 claims description 11
239000000203 mixture Substances 0.000 claims description 11
150000003839 salts Chemical class 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 8
238000000034 method Methods 0.000 claims description 7
238000002360 preparation method Methods 0.000 claims description 7
239000002904 solvent Substances 0.000 claims description 7
230000001225 therapeutic effect Effects 0.000 claims description 7
239000007853 buffer solution Substances 0.000 claims description 4
229920000058 polyacrylate Polymers 0.000 claims description 4
239000003960 organic solvent Substances 0.000 claims description 2
239000004480 active ingredient Substances 0.000 claims 1
238000001704 evaporation Methods 0.000 claims 1
229920006254 polymer film Polymers 0.000 claims 1
210000003491 skin Anatomy 0.000 description 46
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 18
239000010410 layer Substances 0.000 description 12
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
229920001577 copolymer Polymers 0.000 description 8
239000002245 particle Substances 0.000 description 8
238000009792 diffusion process Methods 0.000 description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
238000003756 stirring Methods 0.000 description 6
239000000872 buffer Substances 0.000 description 5
239000004908 Emulsion polymer Substances 0.000 description 4
229920003163 Eudragit® NE 30 D Polymers 0.000 description 4
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
229940079593 drug Drugs 0.000 description 4
239000003814 drug Substances 0.000 description 4
239000012528 membrane Substances 0.000 description 4
229910000029 sodium carbonate Inorganic materials 0.000 description 4
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
230000008901 benefit Effects 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
GLVVKKSPKXTQRB-UHFFFAOYSA-N ethenyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC=C GLVVKKSPKXTQRB-UHFFFAOYSA-N 0.000 description 3
230000009477 glass transition Effects 0.000 description 3
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 3
239000011976 maleic acid Substances 0.000 description 3
229920000193 polymethacrylate Polymers 0.000 description 3
239000000725 suspension Substances 0.000 description 3
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
102000002723 Atrial Natriuretic Factor Human genes 0.000 description 2
101800001288 Atrial natriuretic factor Proteins 0.000 description 2
101800001890 Atrial natriuretic peptide Proteins 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
229920003134 Eudragit® polymer Polymers 0.000 description 2
241000282412 Homo Species 0.000 description 2
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
239000000853 adhesive Substances 0.000 description 2
230000001070 adhesive effect Effects 0.000 description 2
239000012790 adhesive layer Substances 0.000 description 2
230000036765 blood level Effects 0.000 description 2
238000009835 boiling Methods 0.000 description 2
NSQLIUXCMFBZME-MPVJKSABSA-N carperitide Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)=O)[C@@H](C)CC)C1=CC=CC=C1 NSQLIUXCMFBZME-MPVJKSABSA-N 0.000 description 2
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 2
239000000499 gel Substances 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
239000000463 material Substances 0.000 description 2
238000010979 pH adjustment Methods 0.000 description 2
230000035699 permeability Effects 0.000 description 2
229920001289 polyvinyl ether Polymers 0.000 description 2
230000001681 protective effect Effects 0.000 description 2
239000011877 solvent mixture Substances 0.000 description 2
210000000434 stratum corneum Anatomy 0.000 description 2
238000012360 testing method Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
241000255925 Diptera Species 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
229920002292 Nylon 6 Polymers 0.000 description 1
PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 description 1
239000005062 Polybutadiene Substances 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 description 1
206010040880 Skin irritation Diseases 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
239000000150 Sympathomimetic Substances 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 description 1
108010004977 Vasopressins Proteins 0.000 description 1
102000002852 Vasopressins Human genes 0.000 description 1
239000011543 agarose gel Substances 0.000 description 1
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
-1 aliphatic alcohols Chemical class 0.000 description 1
125000005907 alkyl ester group Chemical group 0.000 description 1
KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
229910021538 borax Inorganic materials 0.000 description 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
239000004327 boric acid Substances 0.000 description 1
235000010338 boric acid Nutrition 0.000 description 1
229920005549 butyl rubber Polymers 0.000 description 1
YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
230000008859 change Effects 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
229960002896 clonidine Drugs 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
230000007423 decrease Effects 0.000 description 1
235000019797 dipotassium phosphate Nutrition 0.000 description 1
229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
229960002179 ephedrine Drugs 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
125000004494 ethyl ester group Chemical group 0.000 description 1
229960002428 fentanyl Drugs 0.000 description 1
IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
229960003711 glyceryl trinitrate Drugs 0.000 description 1
150000005826 halohydrocarbons Chemical class 0.000 description 1
OXLZNBCNGJWPRV-UHFFFAOYSA-N hexoprenaline Chemical compound C=1C=C(O)C(O)=CC=1C(O)CNCCCCCCNCC(O)C1=CC=C(O)C(O)=C1 OXLZNBCNGJWPRV-UHFFFAOYSA-N 0.000 description 1
229960000708 hexoprenaline Drugs 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
239000004816 latex Substances 0.000 description 1
229920000126 latex Polymers 0.000 description 1
229960003587 lisuride Drugs 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
235000019691 monocalcium phosphate Nutrition 0.000 description 1
239000000178 monomer Substances 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
229910000403 monosodium phosphate Inorganic materials 0.000 description 1
235000019799 monosodium phosphate Nutrition 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
235000005152 nicotinamide Nutrition 0.000 description 1
239000011570 nicotinamide Substances 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
229960001697 physostigmine Drugs 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
229920002239 polyacrylonitrile Polymers 0.000 description 1
229920002857 polybutadiene Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
229920001290 polyvinyl ester Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
239000001472 potassium tartrate Substances 0.000 description 1
229940111695 potassium tartrate Drugs 0.000 description 1
235000011005 potassium tartrates Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000011253 protective coating Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
229960002052 salbutamol Drugs 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000001433 sodium tartrate Substances 0.000 description 1
229960002167 sodium tartrate Drugs 0.000 description 1
235000011004 sodium tartrates Nutrition 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229960001367 tartaric acid Drugs 0.000 description 1
229960000195 terbutaline Drugs 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Medical Informatics (AREA)
Materials Engineering (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL9650690A 1989-12-01 1990-11-29 Transdermal system for administering pharmacological compounds under HP controlled conditions IL96506A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3939703A DE3939703C2 (de)	1989-12-01	1989-12-01	Verbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen

Publications (2)

Publication Number	Publication Date
IL96506A0 IL96506A0 (en)	1991-08-16
IL96506A true IL96506A (en)	1996-01-19

Family

ID=6394557

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9650690A IL96506A (en)	1989-12-01	1990-11-29	Transdermal system for administering pharmacological compounds under HP controlled conditions

Country Status (20)

Country	Link
EP (1)	EP0456792B1 (da)
JP (1)	JPH04506811A (da)
KR (1)	KR0143549B1 (da)
AT (1)	ATE185492T1 (da)
AU (1)	AU637861B2 (da)
CA (1)	CA2046337C (da)
DE (2)	DE3939703C2 (da)
DK (1)	DK0456792T3 (da)
ES (1)	ES2139570T3 (da)
FI (1)	FI107707B (da)
GR (1)	GR3032175T3 (da)
HU (1)	HU206993B (da)
IE (1)	IE904322A1 (da)
IL (1)	IL96506A (da)
NO (1)	NO302156B1 (da)
NZ (1)	NZ236280A (da)
PT (1)	PT96045B (da)
RU (1)	RU1834665C (da)
WO (1)	WO1991007998A1 (da)
ZA (1)	ZA909624B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6057133A (en) *	1992-11-24	2000-05-02	G. D. Searle	Multivariant human IL-3 fusion proteins and their recombinant production
JP3526887B2 (ja) *	1993-04-23	2004-05-17	帝國製薬株式会社	消炎鎮痛外用貼付剤
US6395292B2 (en)	1996-02-02	2002-05-28	Alza Corporation	Sustained delivery of an active agent using an implantable system
DE60207606T2 (de)	2001-12-21	2006-07-27	Coloplast A/S	Artikel zur wundbehandlung
US11253484B2 (en) *	2018-01-30	2022-02-22	Nitto Denko Corporation	Transdermal absorption preparation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3598122A (en) *	1969-04-01	1971-08-10	Alza Corp	Bandage for administering drugs
US4756710A (en) *	1985-04-05	1988-07-12	Merck & Co., Inc.	pH-Mediated drug delivery system
US4645502A (en) *	1985-05-03	1987-02-24	Alza Corporation	Transdermal delivery of highly ionized fat insoluble drugs
US4690683A (en) *	1985-07-02	1987-09-01	Rutgers, The State University Of New Jersey	Transdermal varapamil delivery device
US4830856A (en) *	1987-01-27	1989-05-16	Peppers James M	Chelation product
DE58906975D1 (de) *	1988-08-02	1994-03-24	Ciba Geigy	Mehrschichtiges Pflaster.
IL92496A0 (en) *	1988-12-01	1990-08-31	Schering Corp	Compositions for transdermal delivery of estradiol
DE3843557A1 (de) *	1988-12-23	1990-06-28	Beiersdorf Ag	Transdermales therapeutisches system zur verabreichung von clenbuterol

1989
- 1989-12-01 DE DE3939703A patent/DE3939703C2/de not_active Expired - Fee Related
1990
- 1990-11-29 AU AU68757/91A patent/AU637861B2/en not_active Expired
- 1990-11-29 CA CA002046337A patent/CA2046337C/en not_active Expired - Lifetime
- 1990-11-29 IL IL9650690A patent/IL96506A/en not_active IP Right Cessation
- 1990-11-29 ES ES90917612T patent/ES2139570T3/es not_active Expired - Lifetime
- 1990-11-29 EP EP90917612A patent/EP0456792B1/de not_active Expired - Lifetime
- 1990-11-29 DK DK90917612T patent/DK0456792T3/da active
- 1990-11-29 KR KR1019910700815A patent/KR0143549B1/ko not_active Expired - Lifetime
- 1990-11-29 WO PCT/EP1990/002052 patent/WO1991007998A1/de not_active Ceased
- 1990-11-29 JP JP3500118A patent/JPH04506811A/ja active Pending
- 1990-11-29 DE DE59010885T patent/DE59010885D1/de not_active Expired - Lifetime
- 1990-11-29 NZ NZ236280A patent/NZ236280A/en unknown
- 1990-11-29 HU HU912638A patent/HU206993B/hu unknown
- 1990-11-29 AT AT90917612T patent/ATE185492T1/de not_active IP Right Cessation
- 1990-11-30 ZA ZA909624A patent/ZA909624B/xx unknown
- 1990-11-30 PT PT96045A patent/PT96045B/pt not_active IP Right Cessation
- 1990-11-30 IE IE432290A patent/IE904322A1/en not_active IP Right Cessation
1991
- 1991-07-30 RU SU915001146A patent/RU1834665C/ru active
- 1991-07-31 FI FI913645A patent/FI107707B/fi active
- 1991-07-31 NO NO912985A patent/NO302156B1/no not_active IP Right Cessation
1999
- 1999-12-17 GR GR990403261T patent/GR3032175T3/el unknown

Also Published As

Publication number	Publication date
KR0143549B1 (ko)	1998-07-01
HUT59615A (en)	1992-06-29
NO912985L (no)	1991-07-31
HU206993B (en)	1993-03-01
HU912638D0 (en)	1992-01-28
NO302156B1 (no)	1998-02-02
PT96045A (pt)	1991-09-13
IL96506A0 (en)	1991-08-16
DE3939703C2 (de)	1998-07-02
DE59010885D1 (de)	1999-11-18
KR920700704A (ko)	1992-08-10
EP0456792B1 (de)	1999-10-13
JPH04506811A (ja)	1992-11-26
PT96045B (pt)	1998-01-30
CA2046337A1 (en)	1991-06-02
ATE185492T1 (de)	1999-10-15
DE3939703A1 (de)	1991-06-06
GR3032175T3 (en)	2000-04-27
ZA909624B (en)	1992-08-26
IE904322A1 (en)	1991-06-05
FI107707B (fi)	2001-09-28
ES2139570T3 (es)	2000-02-16
NZ236280A (en)	1994-06-27
CA2046337C (en)	2004-05-25
DK0456792T3 (da)	2000-04-03
AU637861B2 (en)	1993-06-10
EP0456792A1 (de)	1991-11-21
RU1834665C (ru)	1993-08-15
FI913645A0 (fi)	1991-07-31
AU6875791A (en)	1991-06-26
WO1991007998A1 (de)	1991-06-13
NO912985D0 (no)	1991-07-31

Legal Events

Date	Code	Title
1996-06-18	FF	Patent granted
1997-02-18	KB	Patent renewed
2001-04-30	KB	Patent renewed
2005-02-20	KB	Patent renewed
2009-06-15	KB	Patent renewed
2011-07-31	EXP	Patent expired

Publication	Publication Date	Title
US5462744A (en)	1995-10-31	Transdermal system for the administration of pharmacological compounds under pH-controlled conditions
CA1272954A (en)	1990-08-21	Ph-mediated drug delivery system
CA1336071C (en)	1995-06-27	Pharmaceutical composition for systemic transdermal administration
FI82602B (fi)	1990-12-31	Foerfarande foer framstaellning av verksamma plaoster.
KR100300477B1 (ko)	2001-10-22	활성성분으로서 갈란타민을 포함하는 경피치료시스템
US5252588A (en)	1993-10-12	Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation
US20090285877A1 (en)	2009-11-19	Percutaneous absorption preparation containing palonosetron
US20040071764A1 (en)	2004-04-15	Transdermal therapeutic system for administering non-steroidal antiphlogistic agents containing carboxyl groups, and a method for the production of the same
US7951395B2 (en)	2011-05-31	Dermal application system for aminolaevulinic acid
EP0435199B2 (en)	2000-01-19	Acrylic gel material and acrylic gel preparation
CA2487123C (en)	2011-10-18	Patch containing fentanyl
JP2000044476A (ja)	2000-02-15	フェンタニル含有経皮吸収投与マトリックス型貼付剤
CA2041330C (en)	1996-05-28	Percutaneously absorbable eperisone or tolperisone preparation
CA2046337C (en)	2004-05-25	Improved transdermal system for the administration of pharmacological compounds under ph-controlled conditions
KR100549846B1 (ko)	2006-02-06	활성물질 스코폴라민 염기를 함유하는 경피 치료 시스템
US5385736A (en)	1995-01-31	Transdermal melatonin delivery system
KR20130049353A (ko)	2013-05-14	펜타닐을 함유하는 경피투여용 패취시스템
KR102710072B1 (ko)	2024-09-24	장기 투여용 리바스티그민 패취
JPH0556325B2 (da)	1993-08-19
KR100439658B1 (ko)	2004-07-12	이소소르비드 디니트레이트를 활성성분으로 하는경피흡수제제 및 그 제조방법
KR20050019084A (ko)	2005-02-28	펜타닐을 함유하는 패치
JPH02243626A (ja)	1990-09-27	医療用貼付剤