IL96734A - Spray pharmaceuticals containing autoantigens - Google Patents

Spray pharmaceuticals containing autoantigens

Info

Publication number: IL96734A
Authority: IL; Israel
Prior art keywords: mbp; aerosol; disease; autoimmune; administration
Prior art date: 1989-12-20

Application number

IL9673490A

Other languages

English (en)

Hebrew (he)

Other versions

IL96734A0 (en

Original Assignee

Brigham & Womens Hospital

Autoimmune Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-20

Filing date

1990-12-20

Publication date

1996-11-14

1990-12-20 Application filed by Brigham & Womens Hospital, Autoimmune Inc filed Critical Brigham & Womens Hospital

1991-09-16 Publication of IL96734A0 publication Critical patent/IL96734A0/xx

1996-11-14 Publication of IL96734A publication Critical patent/IL96734A/en

Links

239000000203 mixture Substances 0.000 title claims description 10
238000009472 formulation Methods 0.000 title claims description 8
239000008249 pharmaceutical aerosol Substances 0.000 title description 3
239000000443 aerosol Substances 0.000 claims abstract description 93
208000023275 Autoimmune disease Diseases 0.000 claims abstract description 56
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 46
239000012634 fragment Substances 0.000 claims abstract description 45
201000010099 disease Diseases 0.000 claims abstract description 44
241000124008 Mammalia Species 0.000 claims abstract description 34
239000003795 chemical substances by application Substances 0.000 claims abstract description 20
KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims description 40
102000047918 Myelin Basic Human genes 0.000 claims description 37
101710107068 Myelin basic protein Proteins 0.000 claims description 37
201000006417 multiple sclerosis Diseases 0.000 claims description 12
206010039073 rheumatoid arthritis Diseases 0.000 claims description 9
102000008186 Collagen Human genes 0.000 claims description 8
108010035532 Collagen Proteins 0.000 claims description 8
229920001436 collagen Polymers 0.000 claims description 8
239000008194 pharmaceutical composition Substances 0.000 claims description 8
230000006472 autoimmune response Effects 0.000 claims description 6
239000003085 diluting agent Substances 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 2
238000000034 method Methods 0.000 abstract description 21
241001465754 Metazoa Species 0.000 description 72
201000002491 encephalomyelitis Diseases 0.000 description 55
241000700159 Rattus Species 0.000 description 36
238000011282 treatment Methods 0.000 description 28
210000004027 cell Anatomy 0.000 description 25
230000000694 effects Effects 0.000 description 21
208000024891 symptom Diseases 0.000 description 19
230000004044 response Effects 0.000 description 17
239000002671 adjuvant Substances 0.000 description 16
230000001363 autoimmune Effects 0.000 description 16
230000001404 mediated effect Effects 0.000 description 16
230000001629 suppression Effects 0.000 description 16
102000006386 Myelin Proteins Human genes 0.000 description 15
108010083674 Myelin Proteins Proteins 0.000 description 15
210000005012 myelin Anatomy 0.000 description 14
241000283690 Bos taurus Species 0.000 description 12
210000001519 tissue Anatomy 0.000 description 12
125000000539 amino acid group Chemical group 0.000 description 10
239000000427 antigen Substances 0.000 description 10
102000036639 antigens Human genes 0.000 description 10
108091007433 antigens Proteins 0.000 description 10
206010003246 arthritis Diseases 0.000 description 10
239000000463 material Substances 0.000 description 10
238000002474 experimental method Methods 0.000 description 9
239000002953 phosphate buffered saline Substances 0.000 description 9
210000004989 spleen cell Anatomy 0.000 description 9
208000009386 Experimental Arthritis Diseases 0.000 description 8
238000012387 aerosolization Methods 0.000 description 8
230000006698 induction Effects 0.000 description 8
108090000765 processed proteins & peptides Proteins 0.000 description 8
235000018102 proteins Nutrition 0.000 description 7
102000004169 proteins and genes Human genes 0.000 description 7
108090000623 proteins and genes Proteins 0.000 description 7
239000000126 substance Substances 0.000 description 7
201000000596 systemic lupus erythematosus Diseases 0.000 description 7
101001018362 Bos taurus Myelin basic protein Proteins 0.000 description 6
125000003275 alpha amino acid group Chemical group 0.000 description 6
210000004556 brain Anatomy 0.000 description 6
206010012601 diabetes mellitus Diseases 0.000 description 6
229940079593 drug Drugs 0.000 description 6
239000003814 drug Substances 0.000 description 6
239000000284 extract Substances 0.000 description 6
210000000987 immune system Anatomy 0.000 description 6
230000003053 immunization Effects 0.000 description 6
238000002649 immunization Methods 0.000 description 6
238000011694 lewis rat Methods 0.000 description 6
239000006199 nebulizer Substances 0.000 description 6
239000002245 particle Substances 0.000 description 6
108091003079 Bovine Serum Albumin Proteins 0.000 description 5
108010041390 Collagen Type II Proteins 0.000 description 5
102000000503 Collagen Type II Human genes 0.000 description 5
108010062580 Concanavalin A Proteins 0.000 description 5
208000030836 Hashimoto thyroiditis Diseases 0.000 description 5
210000001744 T-lymphocyte Anatomy 0.000 description 5
229940098773 bovine serum albumin Drugs 0.000 description 5
239000002552 dosage form Substances 0.000 description 5
230000028993 immune response Effects 0.000 description 5
239000007788 liquid Substances 0.000 description 5
206010028417 myasthenia gravis Diseases 0.000 description 5
238000007911 parenteral administration Methods 0.000 description 5
230000004224 protection Effects 0.000 description 5
239000007787 solid Substances 0.000 description 5
241000700199 Cavia porcellus Species 0.000 description 4
108010033040 Histones Proteins 0.000 description 4
230000005875 antibody response Effects 0.000 description 4
238000000338 in vitro Methods 0.000 description 4
230000000670 limiting effect Effects 0.000 description 4
230000002516 postimmunization Effects 0.000 description 4
239000000243 solution Substances 0.000 description 4
239000007921 spray Substances 0.000 description 4
230000008961 swelling Effects 0.000 description 4
238000012546 transfer Methods 0.000 description 4
241000700198 Cavia Species 0.000 description 3
102100039869 Histone H2B type F-S Human genes 0.000 description 3
101001035372 Homo sapiens Histone H2B type F-S Proteins 0.000 description 3
206010020751 Hypersensitivity Diseases 0.000 description 3
206010062016 Immunosuppression Diseases 0.000 description 3
241000187479 Mycobacterium tuberculosis Species 0.000 description 3
101710137302 Surface antigen S Proteins 0.000 description 3
101001018322 Sus scrofa Myelin basic protein Proteins 0.000 description 3
208000026935 allergic disease Diseases 0.000 description 3
230000008901 benefit Effects 0.000 description 3
230000037396 body weight Effects 0.000 description 3
239000007975 buffered saline Substances 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
231100000673 dose–response relationship Toxicity 0.000 description 3
230000009610 hypersensitivity Effects 0.000 description 3
230000008629 immune suppression Effects 0.000 description 3
230000001506 immunosuppresive effect Effects 0.000 description 3
230000001965 increasing effect Effects 0.000 description 3
230000001939 inductive effect Effects 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
239000000843 powder Substances 0.000 description 3
102000004196 processed proteins & peptides Human genes 0.000 description 3
230000001681 protective effect Effects 0.000 description 3
241000894007 species Species 0.000 description 3
206010062269 Adrenalitis Diseases 0.000 description 2
208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 2
108010009685 Cholinergic Receptors Proteins 0.000 description 2
206010008909 Chronic Hepatitis Diseases 0.000 description 2
206010019755 Hepatitis chronic active Diseases 0.000 description 2
102000000588 Interleukin-2 Human genes 0.000 description 2
108010002350 Interleukin-2 Proteins 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
101001018324 Rattus norvegicus Myelin basic protein Proteins 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
238000000692 Student's t-test Methods 0.000 description 2
102000009843 Thyroglobulin Human genes 0.000 description 2
108010034949 Thyroglobulin Proteins 0.000 description 2
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
102000034337 acetylcholine receptors Human genes 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
230000004957 immunoregulator effect Effects 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
210000001165 lymph node Anatomy 0.000 description 2
210000004698 lymphocyte Anatomy 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
229940071648 metered dose inhaler Drugs 0.000 description 2
229910052760 oxygen Inorganic materials 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
230000001769 paralizing effect Effects 0.000 description 2
238000010647 peptide synthesis reaction Methods 0.000 description 2
229920001184 polypeptide Polymers 0.000 description 2
230000009696 proliferative response Effects 0.000 description 2
230000002035 prolonged effect Effects 0.000 description 2
230000002685 pulmonary effect Effects 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
239000007909 solid dosage form Substances 0.000 description 2
210000000952 spleen Anatomy 0.000 description 2
210000004988 splenocyte Anatomy 0.000 description 2
229960002175 thyroglobulin Drugs 0.000 description 2
239000002753 trypsin inhibitor Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
241000557626 Corvus corax Species 0.000 description 1
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
229930105110 Cyclosporin A Natural products 0.000 description 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
108010036949 Cyclosporine Proteins 0.000 description 1
108020004414 DNA Proteins 0.000 description 1
208000006313 Delayed Hypersensitivity Diseases 0.000 description 1
208000016192 Demyelinating disease Diseases 0.000 description 1
238000002965 ELISA Methods 0.000 description 1
208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
208000026350 Inborn Genetic disease Diseases 0.000 description 1
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
108010028275 Leukocyte Elastase Proteins 0.000 description 1
102000016799 Leukocyte elastase Human genes 0.000 description 1
208000024556 Mendelian disease Diseases 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
206010033799 Paralysis Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
241000721454 Pemphigus Species 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
206010039710 Scleroderma Diseases 0.000 description 1
235000009233 Stachytarpheta cayennensis Nutrition 0.000 description 1
-1 Steroid compounds Chemical class 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
230000024932 T cell mediated immunity Effects 0.000 description 1
206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 1
LEBBDRXHHNYZIA-LDUWYPJVSA-N [(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] n-[(z)-1,3-dihydroxyoctadec-4-en-2-yl]carbamate Chemical compound CCCCCCCCCCCCC\C=C/C(O)C(CO)NC(=O)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O LEBBDRXHHNYZIA-LDUWYPJVSA-N 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
230000009471 action Effects 0.000 description 1
210000004100 adrenal gland Anatomy 0.000 description 1
VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
210000002821 alveolar epithelial cell Anatomy 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000010171 animal model Methods 0.000 description 1
208000037908 antibody-mediated disorder Diseases 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
230000000599 auto-anti-genic effect Effects 0.000 description 1
201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
229960002170 azathioprine Drugs 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
230000007248 cellular mechanism Effects 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
229960001265 ciclosporin Drugs 0.000 description 1
229960004397 cyclophosphamide Drugs 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
230000003413 degradative effect Effects 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
229940112141 dry powder inhaler Drugs 0.000 description 1
238000010410 dusting Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
230000001712 encephalitogenic effect Effects 0.000 description 1
230000003090 exacerbative effect Effects 0.000 description 1
230000006870 function Effects 0.000 description 1
210000004051 gastric juice Anatomy 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
210000003958 hematopoietic stem cell Anatomy 0.000 description 1
238000010231 histologic analysis Methods 0.000 description 1
238000010562 histological examination Methods 0.000 description 1
230000007124 immune defense Effects 0.000 description 1
230000036737 immune function Effects 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000017555 immunoglobulin mediated immune response Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
229940073062 imuran Drugs 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
210000004153 islets of langerhan Anatomy 0.000 description 1
208000027906 leg weakness Diseases 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
229940040511 liver extract Drugs 0.000 description 1
206010025135 lupus erythematosus Diseases 0.000 description 1
210000002751 lymph Anatomy 0.000 description 1
230000007257 malfunction Effects 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
244000000010 microbial pathogen Species 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
239000003595 mist Substances 0.000 description 1
238000010172 mouse model Methods 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
238000002663 nebulization Methods 0.000 description 1
239000013642 negative control Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
244000052769 pathogen Species 0.000 description 1
208000005987 polymyositis Diseases 0.000 description 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
229960004618 prednisone Drugs 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
238000010298 pulverizing process Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
208000004124 rheumatic heart disease Diseases 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000009288 screen filtration Methods 0.000 description 1
210000004927 skin cell Anatomy 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000002904 solvent Substances 0.000 description 1
210000000273 spinal nerve root Anatomy 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
108700022380 synthetic erythropoiesis Proteins 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000003582 thrombocytopenic effect Effects 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
230000005951 type IV hypersensitivity Effects 0.000 description 1
208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
210000001364 upper extremity Anatomy 0.000 description 1
210000004885 white matter Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Rheumatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Dispersion Chemistry (AREA)
Diabetes (AREA)
Hematology (AREA)
Rehabilitation Therapy (AREA)
Toxicology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Marine Sciences & Fisheries (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Microbiology (AREA)
Mycology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

IL9673490A 1989-12-20 1990-12-20 Spray pharmaceuticals containing autoantigens IL96734A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US45480689A	1989-12-20	1989-12-20

Publications (2)

Publication Number	Publication Date
IL96734A0 IL96734A0 (en)	1991-09-16
IL96734A true IL96734A (en)	1996-11-14

Family

ID=23806184

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL9673490A IL96734A (en)	1989-12-20	1990-12-20	Spray pharmaceuticals containing autoantigens

Country Status (14)

Country	Link
EP (1)	EP0506785B1 (de)
JP (1)	JP2625253B2 (de)
KR (1)	KR0185747B1 (de)
AT (1)	ATE190496T1 (de)
AU (1)	AU642693B2 (de)
BR (1)	BR9007950A (de)
CA (1)	CA2070281C (de)
DE (1)	DE69033487T2 (de)
DK (1)	DK0506785T3 (de)
ES (1)	ES2144398T3 (de)
GR (1)	GR3033634T3 (de)
HU (2)	HUT61487A (de)
IL (1)	IL96734A (de)
WO (1)	WO1991008760A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5843445A (en) *	1987-06-24	1998-12-01	Autoimmune, Inc.	Method of treating rheumatoid arthritis with type II collagen
US6645504B1 (en)	1987-06-24	2003-11-11	Autoimmune Inc.	Bystander suppression of type I diabetes by oral administration of glucagon
US5869054A (en) *	1987-06-24	1999-02-09	Autoimmune Inc.	Treatment of multiple sclerosis by oral administration of autoantigens
US5849298A (en) *	1987-06-24	1998-12-15	Autoimmune Inc.	Treatment of multiple sclerosis by oral administration of bovine myelin
FI920139A0 (fi) *	1989-07-14	1992-01-13	Autoimmune Inc	Foerfaranden foer behandling och foerfindrande av autoimmun uveoretinitis hos daeggdjur.
IL99699A (en) *	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
CA2092905C (en) *	1990-10-15	2002-01-08	Howard L. Weiner	Treatment of autoimmune diseases by oral administration of autoantigens
BR9306042A (pt) *	1992-02-28	1997-11-18	Autoimmune Inc	Método para tratar uma doença auto-immune em um mamifero e formas de dosagens farmacêuticas oral e inalável
EP0662838A4 (de) *	1992-09-25	1996-07-24	Autoimmune Inc	Verfahren zur behandlung rheumatoider arthritis mittels typ-ii-kollagen.
AU674584B2 (en) *	1993-06-02	1997-01-02	Tvw Telethon Institute For Child Health Research	Cryptic peptides for use in inducing immunologic tolerance
CZ122697A3 (en) *	1994-10-25	1997-09-17	Immulogic Pharma Corp	Preparations and methods of treating disseminated sclerosis
US6488933B2 (en)	1995-07-05	2002-12-03	Yeda Research And Development Co. Ltd.	Preparations for the treatment of T cell mediated diseases
US5856446A (en) *	1995-07-07	1999-01-05	Autoimmune Inc.	Method of treating rheumatoid arthritis with low dose type II collagen
CA2238439C (en) *	1996-01-05	2004-11-30	Autoimmune, Inc.	Method for preparation of type ii collagen
AUPO269996A0 (en) *	1996-10-01	1996-10-24	Walter And Eliza Hall Institute Of Medical Research, The	A method of prophylaxis and treatment
NZ336381A (en)	1996-12-30	2000-11-24	Battelle Memorial Institute	Formulation and method for treating neoplasms by inhalation
US7097845B2 (en)	1997-04-23	2006-08-29	Jacob Sten Petersen	Combinations of antigen and mucosal binding component for inducing specific immunological tolerance
US6905686B1 (en)	1997-12-02	2005-06-14	Neuralab Limited	Active immunization for treatment of alzheimer's disease
US6761888B1 (en)	2000-05-26	2004-07-13	Neuralab Limited	Passive immunization treatment of Alzheimer's disease
US6750324B1 (en)	1997-12-02	2004-06-15	Neuralab Limited	Humanized and chimeric N-terminal amyloid beta-antibodies
US6913745B1 (en)	1997-12-02	2005-07-05	Neuralab Limited	Passive immunization of Alzheimer's disease
US6923964B1 (en)	1997-12-02	2005-08-02	Neuralab Limited	Active immunization of AScr for prion disorders
US6787523B1 (en)	1997-12-02	2004-09-07	Neuralab Limited	Prevention and treatment of amyloidogenic disease
US6710226B1 (en)	1997-12-02	2004-03-23	Neuralab Limited	Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
US7179892B2 (en)	2000-12-06	2007-02-20	Neuralab Limited	Humanized antibodies that recognize beta amyloid peptide
US20080050367A1 (en)	1998-04-07	2008-02-28	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
US7588766B1 (en)	2000-05-26	2009-09-15	Elan Pharma International Limited	Treatment of amyloidogenic disease
US7790856B2 (en)	1998-04-07	2010-09-07	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en)	1997-12-02	2005-09-21	Elan Pharm Inc	N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US20030147882A1 (en)	1998-05-21	2003-08-07	Alan Solomon	Methods for amyloid removal using anti-amyloid antibodies
US6787637B1 (en)	1999-05-28	2004-09-07	Neuralab Limited	N-Terminal amyloid-β antibodies
UA81216C2 (en)	1999-06-01	2007-12-25		Prevention and treatment of amyloid disease
SE9902155L (sv) *	1999-06-09	2000-12-10	Bjoern Rydevik	Serum antibodies
WO2001089557A2 (en)	2000-05-24	2001-11-29	The United States Of America, As Represented By Secretary Of The Department Of Health & Human Services	Methods for preventing strokes by inducing tolerance to e-selectin
US7897575B2 (en)	2000-05-24	2011-03-01	The United States Of America As Represented By The Department Of Health And Human Services	Treatment and prevention of vascular dementia
US7700751B2 (en)	2000-12-06	2010-04-20	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize β-amyloid peptide
PE20020574A1 (es)	2000-12-06	2002-07-02	Wyeth Corp	Anticuerpos humanizados que reconocen el peptido amiloideo beta
MY139983A (en)	2002-03-12	2009-11-30	Janssen Alzheimer Immunotherap	Humanized antibodies that recognize beta amyloid peptide
DE10230381A1 (de)	2002-07-05	2004-01-22	Institut für Medizintechnologie Magdeburg GmbH, IMTM	Verwendung von Inhibitoren der Alanyl-Aminopeptidasen und diese umfassende pharmazeutischen Zubereitungen
WO2004024906A1 (en)	2002-09-13	2004-03-25	UNIVERSITé LAVAL	Nucleoside triphosphate diphosphohydrolase (ntpdase 8) and uses thereof
TWI306458B (en)	2003-05-30	2009-02-21	Elan Pharma Int Ltd	Humanized antibodies that recognize beta amyloid peptide
ES2396555T3 (es)	2004-12-15	2013-02-22	Janssen Alzheimer Immunotherapy	Anticuerpos que reconocen péptido beta amiloide
EP1838348B1 (de)	2004-12-15	2013-06-26	Janssen Alzheimer Immunotherapy	Humanisierte amyloid-beta-antikörper zur verbesserung der kognition
EP2305701A1 (de)	2005-07-01	2011-04-06	Forsyth Dental Infirmary for Children	Assays zur Detektion von Tuberkuloseantigenen und Impfstoffe
US8784810B2 (en)	2006-04-18	2014-07-22	Janssen Alzheimer Immunotherapy	Treatment of amyloidogenic diseases
US8003097B2 (en)	2007-04-18	2011-08-23	Janssen Alzheimer Immunotherapy	Treatment of cerebral amyloid angiopathy
ES2498040T3 (es)	2007-07-27	2014-09-24	Janssen Alzheimer Immunotherapy	Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
JO3076B1 (ar)	2007-10-17	2017-03-15	Janssen Alzheimer Immunotherap	نظم العلاج المناعي المعتمد على حالة apoe
US9067981B1 (en)	2008-10-30	2015-06-30	Janssen Sciences Ireland Uc	Hybrid amyloid-beta antibodies
US20130236484A1 (en)	2012-03-08	2013-09-12	Detectogen Inc.	Leishmaniasis antigen detection assays and vaccines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US379778A (en) *		1888-03-20		Machine for mitering printers rules
US65734A (en) *		1867-06-11		Joseph fantou
JP2512796B2 (ja) *	1987-06-24	1996-07-03	オートイミュン・インコーポレイテッド	自己抗原の経口投与による自己免疫疾患の治療法
KR900700617A (ko) *	1988-04-08	1990-08-16	브루스 엠. 에이센	뼈 및 연골 유도 조성물

1990
- 1990-12-17 DK DK91901622T patent/DK0506785T3/da active
- 1990-12-17 WO PCT/US1990/007455 patent/WO1991008760A1/en not_active Ceased
- 1990-12-17 EP EP91901622A patent/EP0506785B1/de not_active Expired - Lifetime
- 1990-12-17 CA CA002070281A patent/CA2070281C/en not_active Expired - Lifetime
- 1990-12-17 KR KR1019920701486A patent/KR0185747B1/ko not_active Expired - Lifetime
- 1990-12-17 BR BR909007950A patent/BR9007950A/pt not_active Application Discontinuation
- 1990-12-17 HU HU922072A patent/HUT61487A/hu unknown
- 1990-12-17 AT AT91901622T patent/ATE190496T1/de not_active IP Right Cessation
- 1990-12-17 AU AU69791/91A patent/AU642693B2/en not_active Expired
- 1990-12-17 DE DE69033487T patent/DE69033487T2/de not_active Expired - Lifetime
- 1990-12-17 JP JP3501992A patent/JP2625253B2/ja not_active Expired - Fee Related
- 1990-12-17 ES ES91901622T patent/ES2144398T3/es not_active Expired - Lifetime
- 1990-12-20 IL IL9673490A patent/IL96734A/en not_active IP Right Cessation
1995
- 1995-02-15 HU HU95P/P00074P patent/HU210715A9/hu unknown
2000
- 2000-06-08 GR GR20000401321T patent/GR3033634T3/el unknown

Also Published As

Publication number	Publication date
JP2625253B2 (ja)	1997-07-02
KR0185747B1 (ko)	1999-05-01
HU210715A9 (en)	1995-06-28
ATE190496T1 (de)	2000-04-15
IL96734A0 (en)	1991-09-16
ES2144398T3 (es)	2000-06-16
WO1991008760A1 (en)	1991-06-27
DE69033487D1 (de)	2000-04-20
EP0506785B1 (de)	2000-03-15
CA2070281C (en)	2005-08-23
DK0506785T3 (da)	2000-07-24
EP0506785A1 (de)	1992-10-07
GR3033634T3 (en)	2000-10-31
AU642693B2 (en)	1993-10-28
AU6979191A (en)	1991-07-18
EP0506785A4 (en)	1993-09-08
KR920703081A (ko)	1992-12-17
DE69033487T2 (de)	2000-06-29
HUT61487A (en)	1993-01-28
BR9007950A (pt)	1992-10-27
HU9202072D0 (en)	1992-09-28
CA2070281A1 (en)	1991-06-21
JPH05504341A (ja)	1993-07-08

Legal Events

Date	Code	Title
1997-04-15	FF	Patent granted
1997-11-20	KB	Patent renewed
2001-04-30	KB	Patent renewed
2005-02-20	KB	Patent renewed
2009-07-20	KB	Patent renewed
2011-07-31	EXP	Patent expired

Publication	Publication Date	Title
EP0506785B1 (de)	2000-03-15	Behandlung von autoimmunkrankheiten durch verabreichung von autoantigenen in form von aerosol
US5645820A (en)	1997-07-08	Treatment of autoimmune diseases by aerosol administration of autoantigens
US5571499A (en)	1996-11-05	Treatment of autoimmune diseases by aerosol administration of autoantigens
US5571500A (en)	1996-11-05	Treatment of autoimmune diseases through administration by inhalation of autoantigens
US5641474A (en)	1997-06-24	Prevention of autoimmune diseases by aerosol administration of autoantigens
JP3712260B2 (ja)	2005-11-02	自己免疫疾患のバイスタンダー抑制
EP1033998B1 (de)	2005-10-19	Unterdrückung von veränderungen in zusammenhang mit beta-amyloid bei alzheimer
US5783188A (en)	1998-07-21	Method of treating rheumatoid arthritis with type collagen peptide fragments containing repeating sequences
US6645504B1 (en)	2003-11-11	Bystander suppression of type I diabetes by oral administration of glucagon
WO1994007520A9 (en)	1994-07-07	Method of treating rheumatoid arthritis with type ii collagen
WO1994007520A1 (en)	1994-04-14	Method of treating rheumatoid arthritis with type ii collagen
IL97446A (en)	1996-03-31	Medicinal product for the improvement of down-regulation of autoimmune diseases
US5935577A (en)	1999-08-10	Treatment of autoimmune disease using tolerization in combination with methotrexate
KR20000070460A (ko)	2000-11-25	메토트렉세이트와 공동으로 내성화를 사용한 자기면역질병의 치료
WO1998032451A9 (en)	1998-12-30	Treatment of autoimmune disease using tolerization in combination with methotrexate
Al-Sabbagh et al.	1996	Antigen-driven peripheral immune tolerance: suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen
CA2320044A1 (en)	1999-08-19	Treatment of multiple sclerosis using cop-1 and th2-enhancing cytokines
US20070253975A1 (en)	2007-11-01	Methods for preventing strokes by inducing tolerance to E-selectin
AU2001264813A1 (en)	2002-02-21	Methods for preventing strokes by inducing tolerance to E-selectin
WO1999037315A1 (en)	1999-07-29	Chemical derivatives of autoantigens and autoimmune-suppressive peptides and pharmaceutical composition containing the same
EP1842551A1 (de)	2007-10-10	E-selectin zur behandlung oder vorbeugung von schlaganfall
US20040115217A1 (en)	2004-06-17	Bystander suppression of autoimmune diseases
EP0662838A1 (de)	1995-07-19	Verfahren zur behandlung rheumatoider arthritis mittels typ-ii-kollagen
AU2005235514A1 (en)	2005-12-08	Pharmaceutical formulations and methods for preventing or treating damage to brain tissue