IL98223A0 - Pharmaceutical compositions containing fluorene derivatives,some such novel compounds and their preparation - Google Patents

Pharmaceutical compositions containing fluorene derivatives,some such novel compounds and their preparation

Info

Publication number
IL98223A0
IL98223A0 IL98223A IL9822391A IL98223A0 IL 98223 A0 IL98223 A0 IL 98223A0 IL 98223 A IL98223 A IL 98223A IL 9822391 A IL9822391 A IL 9822391A IL 98223 A0 IL98223 A0 IL 98223A0
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
novel compounds
fluorene derivatives
Prior art date
Application number
IL98223A
Other languages
English (en)
Original Assignee
Novo Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Pharmaceutical Corp filed Critical Novo Pharmaceutical Corp
Publication of IL98223A0 publication Critical patent/IL98223A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL98223A 1990-05-29 1991-05-22 Pharmaceutical compositions containing fluorene derivatives,some such novel compounds and their preparation IL98223A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/529,356 US5079260A (en) 1989-06-22 1990-05-29 Method for treating inflammation and compounds and compositions suitable for use therein

Publications (1)

Publication Number Publication Date
IL98223A0 true IL98223A0 (en) 1992-06-21

Family

ID=24109577

Family Applications (1)

Application Number Title Priority Date Filing Date
IL98223A IL98223A0 (en) 1990-05-29 1991-05-22 Pharmaceutical compositions containing fluorene derivatives,some such novel compounds and their preparation

Country Status (11)

Country Link
US (1) US5079260A (fr)
EP (1) EP0531443A4 (fr)
JP (1) JPH05509299A (fr)
AU (1) AU7951591A (fr)
CA (1) CA2083134A1 (fr)
FI (1) FI925327A0 (fr)
IE (1) IE911823A1 (fr)
IL (1) IL98223A0 (fr)
NZ (1) NZ238272A (fr)
WO (1) WO1991018596A1 (fr)
ZA (1) ZA914102B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668230A (en) * 1991-07-23 1997-09-16 Phillips Petroleum Company Olefin polymerization
US5472973A (en) * 1991-12-12 1995-12-05 Scios Nova Inc. Fluorenyl derivatives as anti-inflammatory agents
IL104043A0 (en) * 1991-12-12 1993-05-13 Scios Nova Inc Fluorenyl derivatives and pharmaceutical compositions containing them
IT1270694B (it) * 1994-11-15 1997-05-07 Italfarmaco Spa Derivati fluorenil-idrossammici ad attivita' immunosoppressiva ed antiinfiammatoria
US5788982A (en) * 1995-06-16 1998-08-04 Nadoolman; Wolffe Method and composition for treating oral pain using capsaicin
AU2745700A (en) 1999-02-01 2000-08-18 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
WO2001009117A1 (fr) * 1999-07-29 2001-02-08 Allellix Neuroscience Inc. Composes tricycliques comme inhibiteurs de transport de glycine
US20040082623A1 (en) * 2000-06-29 2004-04-29 Stephane Rochhi Fmoc-l-leucine and derivatives thereof as ppar-gamma agonists
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
US20020035104A1 (en) * 2000-08-18 2002-03-21 Genentech, Inc. Integrin receptor inhibitors
GB0312426D0 (en) * 2003-05-30 2003-07-09 Albachem Ltd Purification means
CN100412060C (zh) * 2005-01-27 2008-08-20 中国科学院大连化学物理研究所 2-(n-咔唑基)-乙氧基碳酰肼的制备方法
DE102005062741A1 (de) * 2005-12-22 2007-06-28 Bayer Schering Pharma Ag Fluorene und Carbazole als Liganden des EP2 Rezeptors
CN101328136B (zh) * 2008-07-23 2011-02-09 中国科学院广州化学研究所 一种氨基酸酰胺类化合物及其制备方法
CN108774158A (zh) * 2018-06-20 2018-11-09 南京肽业生物科技有限公司 一种Fmoc和疏水性氨基酸的反应

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2877269A (en) * 1956-04-17 1959-03-10 Wm S Merrell Co Guanyl substituted triphenylethanes, triphenylethylenes and benzalfluorenes
US3845097A (en) * 1969-09-06 1974-10-29 Ajinomoto Kk N-substituted amino acids and novel ester
US3919291A (en) * 1969-09-06 1975-11-11 Ajinomoto Kk N-ethylcarbaminomethylisoleucine
NL7013043A (fr) * 1969-09-06 1971-03-09
US3835175A (en) * 1971-03-15 1974-09-10 Research Corp 9-fluorenylmethanol haloformates, carbonates and thiocarbonates
US3906031A (en) * 1971-03-15 1975-09-16 Research Corp Novel 9-fluorenylmethoxycarbonyl compounds
EP0129075A3 (fr) * 1983-05-20 1985-08-28 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Dérivés d'amino-acides protégés et leur préparation
EP0288965A2 (fr) * 1987-04-29 1988-11-02 Hoechst Aktiengesellschaft Peptides inhibant l'activité de phospholipase-A2
JPH04506350A (ja) * 1989-06-22 1992-11-05 ノバ　ファーマスーティカル　コーポレイション 炎症の処置用の医薬組成物及び炎症の処置方法

Also Published As

Publication number Publication date
EP0531443A4 (en) 1993-04-21
CA2083134A1 (fr) 1991-11-30
IE911823A1 (en) 1991-12-04
US5079260A (en) 1992-01-07
FI925327A7 (fi) 1992-11-24
FI925327A0 (fi) 1992-11-24
ZA914102B (en) 1993-02-24
NZ238272A (en) 1994-03-25
EP0531443A1 (fr) 1993-03-17
WO1991018596A1 (fr) 1991-12-12
JPH05509299A (ja) 1993-12-22
AU7951591A (en) 1991-12-31

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