IL98546A - Ace inhibitor ester derivatives their preparation and pharmaceutical compositions containing them - Google Patents
Ace inhibitor ester derivatives their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL98546A IL98546A IL9854691A IL9854691A IL98546A IL 98546 A IL98546 A IL 98546A IL 9854691 A IL9854691 A IL 9854691A IL 9854691 A IL9854691 A IL 9854691A IL 98546 A IL98546 A IL 98546A
- Authority
- IL
- Israel
- Prior art keywords
- oxopropoxy
- methyl
- mercapto
- acid
- propanoic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909013994A GB9013994D0 (en) | 1990-06-22 | 1990-06-22 | Compounds |
| GB909021411A GB9021411D0 (en) | 1990-10-02 | 1990-10-02 | Compounds |
| GB919107237A GB9107237D0 (en) | 1991-04-06 | 1991-04-06 | Compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL98546A0 IL98546A0 (en) | 1992-07-15 |
| IL98546A true IL98546A (en) | 1996-05-14 |
Family
ID=27265153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9854691A IL98546A (en) | 1990-06-22 | 1991-06-18 | Ace inhibitor ester derivatives their preparation and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5348978A (de) |
| EP (1) | EP0535042B1 (de) |
| JP (1) | JPH05507919A (de) |
| AT (1) | ATE120453T1 (de) |
| CA (1) | CA2085993A1 (de) |
| DE (1) | DE69108553T2 (de) |
| DK (1) | DK0535042T3 (de) |
| ES (1) | ES2070500T3 (de) |
| FI (1) | FI925799A0 (de) |
| IE (1) | IE65893B1 (de) |
| IL (1) | IL98546A (de) |
| NO (1) | NO179902C (de) |
| NZ (1) | NZ238644A (de) |
| PT (1) | PT98057B (de) |
| WO (1) | WO1992000276A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0009289A (pt) * | 1999-03-29 | 2002-01-22 | Bristol Myers Squibb Co | Uso de inibidores da vasopeptidase para tratar angina pectoris |
| PL2191001T4 (pl) | 2007-04-09 | 2017-01-31 | University Of Florida Research Foundation, Inc. | Kompozycje wektora RAAV mające białka kapsydu zmodyfikowane tyrozyną i sposoby ich zastosowania |
| HK1251920A1 (zh) * | 2015-07-02 | 2019-05-03 | Novus International Inc. | 阴离子表面活性剂 |
| US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
| JP7169584B2 (ja) * | 2018-01-30 | 2022-11-11 | 公立大学法人横浜市立大学 | オーキシン生合成阻害活性を有する新規化合物、その製造方法及びその用途 |
| GB202403369D0 (en) * | 2024-03-08 | 2024-04-24 | Astrazeneca Ab | Process and intermediates for the production of a jak1 inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4611002A (en) * | 1977-07-14 | 1986-09-09 | E. R. Squibb And Sons, Inc. | Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors |
| CA1090354A (en) * | 1977-07-14 | 1980-11-25 | Miguel A. Ondetti | Carboxymethyl esters of mercaptopropanoic acids |
| US4242265A (en) * | 1979-01-10 | 1980-12-30 | E. R. Squibb & Sons, Inc. | Indolylalkyl esters of mercaptoalkanoic acids |
-
1991
- 1991-06-18 IL IL9854691A patent/IL98546A/en not_active IP Right Cessation
- 1991-06-18 EP EP91910962A patent/EP0535042B1/de not_active Expired - Lifetime
- 1991-06-18 JP JP91510751A patent/JPH05507919A/ja active Pending
- 1991-06-18 ES ES91910962T patent/ES2070500T3/es not_active Expired - Lifetime
- 1991-06-18 US US07/956,877 patent/US5348978A/en not_active Expired - Fee Related
- 1991-06-18 CA CA002085993A patent/CA2085993A1/en not_active Abandoned
- 1991-06-18 DK DK91910962.9T patent/DK0535042T3/da active
- 1991-06-18 AT AT91910962T patent/ATE120453T1/de not_active IP Right Cessation
- 1991-06-18 IE IE208891A patent/IE65893B1/en not_active IP Right Cessation
- 1991-06-18 DE DE69108553T patent/DE69108553T2/de not_active Expired - Fee Related
- 1991-06-18 WO PCT/GB1991/000980 patent/WO1992000276A2/en not_active Ceased
- 1991-06-20 PT PT98057A patent/PT98057B/pt not_active IP Right Cessation
- 1991-06-21 NZ NZ238644A patent/NZ238644A/xx unknown
-
1992
- 1992-12-21 NO NO924953A patent/NO179902C/no unknown
- 1992-12-21 FI FI925799A patent/FI925799A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ238644A (en) | 1993-05-26 |
| NO924953D0 (no) | 1992-12-21 |
| IE912088A1 (en) | 1992-01-01 |
| IL98546A0 (en) | 1992-07-15 |
| EP0535042A1 (de) | 1993-04-07 |
| US5348978A (en) | 1994-09-20 |
| NO179902B (no) | 1996-09-30 |
| PT98057B (pt) | 1998-11-30 |
| DE69108553T2 (de) | 1995-08-03 |
| IE65893B1 (en) | 1995-11-29 |
| FI925799A7 (fi) | 1992-12-21 |
| ATE120453T1 (de) | 1995-04-15 |
| FI925799A0 (fi) | 1992-12-21 |
| WO1992000276A3 (en) | 1992-02-20 |
| JPH05507919A (ja) | 1993-11-11 |
| AU8067791A (en) | 1992-01-23 |
| PT98057A (pt) | 1992-05-29 |
| ES2070500T3 (es) | 1995-06-01 |
| AU638588B2 (en) | 1993-07-01 |
| EP0535042B1 (de) | 1995-03-29 |
| DE69108553D1 (de) | 1995-05-04 |
| NO924953L (no) | 1993-02-12 |
| CA2085993A1 (en) | 1991-12-23 |
| DK0535042T3 (da) | 1995-07-24 |
| NO179902C (no) | 1997-01-08 |
| WO1992000276A2 (en) | 1992-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| RH | Patent void |