IL98920A - 1-(substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediates for their preparation and their use as medicaments - Google Patents

1-(substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediates for their preparation and their use as medicaments

Info

Publication number
IL98920A
IL98920A IL9892091A IL9892091A IL98920A IL 98920 A IL98920 A IL 98920A IL 9892091 A IL9892091 A IL 9892091A IL 9892091 A IL9892091 A IL 9892091A IL 98920 A IL98920 A IL 98920A
Authority
IL
Israel
Prior art keywords
compound
hydrogen
formula
loweralkyi
indol
Prior art date
Application number
IL9892091A
Other languages
English (en)
Inventor
Richard Charles Effland
Larry Davis
Gordon Edward Olsen
Joseph Thomas Klein
David Gordon Wettlaufer
Peter Allen Nemoto
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of IL98920A publication Critical patent/IL98920A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9892091A 1990-07-23 1991-07-22 1-(substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediates for their preparation and their use as medicaments IL98920A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/555,890 US5102891A (en) 1990-07-23 1990-07-23 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates

Publications (1)

Publication Number Publication Date
IL98920A true IL98920A (en) 1995-08-31

Family

ID=24218998

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9892091A IL98920A (en) 1990-07-23 1991-07-22 1-(substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediates for their preparation and their use as medicaments

Country Status (23)

Country Link
US (1) US5102891A (de)
EP (1) EP0468401B1 (de)
JP (1) JP2564714B2 (de)
KR (1) KR100201515B1 (de)
AT (1) ATE171176T1 (de)
AU (1) AU639581B2 (de)
BR (1) BR1100534A (de)
CA (1) CA2047531C (de)
CZ (1) CZ283253B6 (de)
DE (1) DE69130196T2 (de)
DK (1) DK0468401T3 (de)
ES (1) ES2121761T3 (de)
FI (1) FI102067B (de)
HU (1) HUT58317A (de)
IE (1) IE912567A1 (de)
IL (1) IL98920A (de)
MX (1) MX9100342A (de)
NO (1) NO300132B1 (de)
NZ (1) NZ239038A (de)
PL (1) PL291185A1 (de)
PT (1) PT98413B (de)
SG (1) SG48059A1 (de)
ZA (1) ZA915723B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
CZ284437B6 (cs) * 1991-04-17 1998-11-11 Hoechst Marion Roussel, Inc. Substituované (pyridinylamino)-benzisoxazoly a -benzo[b]thiofeny, způsob jejich přípravy farmaceutický prostředek obsahující tyto sloučeniny a použití těchto sloučenin
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
JP4256937B2 (ja) * 1996-12-27 2009-04-22 アベンティス・ファーマスーティカルズ・インコーポレイテッド Ｎ−（ピリジニルアミノ）イソインドリン類および関連化合物
US6004977A (en) * 1996-12-27 1999-12-21 Hoechst Marion Roussel, Inc. N-(pyridinylamino) isoindolines and related compounds
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
EP2533645B1 (de) * 2010-02-09 2016-07-27 The Johns Hopkins University Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP2968220B1 (de) 2013-03-15 2021-05-05 Agenebio, Inc. Verfahren und zusammensetzungen zur verbesserung von kognitiven funktionen
EP2968237A4 (de) 2013-03-15 2016-08-31 Univ Johns Hopkins Verfahren und zusammensetzungen zur verbesserung der kognitiven funktion
MX384391B (es) 2015-05-22 2025-03-14 Agenebio Inc Composiciones farmacéuticas de levetiracetam de liberación extendida.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
ATE115143T1 (de) * 1987-04-24 1994-12-15 Hoechst Roussel Pharma N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel.
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4992448A (en) * 1989-10-24 1991-02-12 Hoechst-Roussel Pharmaceuticals Inc. Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders

Also Published As

Publication number Publication date
FI102067B1 (fi) 1998-10-15
IE912567A1 (en) 1992-01-29
NZ239038A (en) 1994-04-27
FI913502A0 (fi) 1991-07-19
NO912866L (no) 1992-01-24
EP0468401B1 (de) 1998-09-16
MX9100342A (es) 1992-02-28
ZA915723B (en) 1992-04-29
CA2047531C (en) 2003-01-07
DK0468401T3 (da) 1999-06-14
AU639581B2 (en) 1993-07-29
PL291185A1 (en) 1993-04-05
PT98413B (pt) 1999-01-29
DE69130196D1 (de) 1998-10-22
ES2121761T3 (es) 1998-12-16
HU912450D0 (en) 1991-12-30
JPH04243878A (ja) 1992-08-31
JP2564714B2 (ja) 1996-12-18
BR1100534A (pt) 2000-03-14
FI102067B (fi) 1998-10-15
CA2047531A1 (en) 1992-01-24
US5102891A (en) 1992-04-07
FI913502A7 (fi) 1992-01-24
CS228191A3 (en) 1992-02-19
EP0468401A3 (en) 1992-07-29
ATE171176T1 (de) 1998-10-15
SG48059A1 (en) 1998-04-17
EP0468401A2 (de) 1992-01-29
HUT58317A (en) 1992-02-28
DE69130196T2 (de) 1999-04-01
NO300132B1 (no) 1997-04-14
AU8121691A (en) 1992-01-30
PT98413A (pt) 1992-05-29
KR920002585A (ko) 1992-02-28
NO912866D0 (no) 1991-07-22
KR100201515B1 (ko) 1999-06-15
CZ283253B6 (cs) 1998-02-18

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Legal Events

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KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees