IL99725A0 - Saturated hydroxyalkylquinoline acids and pharmaceutical compositions containing them - Google Patents
Saturated hydroxyalkylquinoline acids and pharmaceutical compositions containing themInfo
- Publication number
- IL99725A0 IL99725A0 IL99725A IL9972591A IL99725A0 IL 99725 A0 IL99725 A0 IL 99725A0 IL 99725 A IL99725 A IL 99725A IL 9972591 A IL9972591 A IL 9972591A IL 99725 A0 IL99725 A0 IL 99725A0
- Authority
- IL
- Israel
- Prior art keywords
- saturated
- pharmaceutical compositions
- compositions containing
- hydroxyalkylquinoline
- acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59684490A | 1990-10-12 | 1990-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL99725A0 true IL99725A0 (en) | 1992-08-18 |
Family
ID=24388953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL99725A IL99725A0 (en) | 1990-10-12 | 1991-10-13 | Saturated hydroxyalkylquinoline acids and pharmaceutical compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5428033A (cs) |
| EP (1) | EP0480716A1 (cs) |
| JP (1) | JP2538155B2 (cs) |
| KR (1) | KR920008004A (cs) |
| CN (1) | CN1061408A (cs) |
| AU (1) | AU639611B2 (cs) |
| CA (1) | CA2053216C (cs) |
| CS (1) | CS309391A3 (cs) |
| FI (1) | FI914797A7 (cs) |
| HU (1) | HUT61980A (cs) |
| IE (1) | IE913611A1 (cs) |
| IL (1) | IL99725A0 (cs) |
| MX (1) | MX9101557A (cs) |
| NO (1) | NO914002L (cs) |
| PT (1) | PT99212B (cs) |
| ZA (1) | ZA918120B (cs) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856322A (en) * | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
| US5472964A (en) * | 1992-12-22 | 1995-12-05 | Merck Frosst Canada, Inc. | Diaryl 5,6-fused heterocyclic acids as leukotriene antagonists |
| CA2111372C (en) * | 1992-12-22 | 2007-01-16 | Robert N. Young | Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists |
| US5438141A (en) * | 1993-05-21 | 1995-08-01 | Merck Frosst Canada, Inc. | Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists |
| ES2080656B1 (es) * | 1993-07-19 | 1996-10-16 | Merck Frosst Canada Inc | Acidos de hidroxialquilquinolina fluorados como antagonistas del leucotrieno. |
| TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
| US5750539A (en) * | 1995-06-07 | 1998-05-12 | Merck Frosst Canada | Heteroaryl diol acids as leukotriene antagonists |
| US6696466B1 (en) | 2000-09-07 | 2004-02-24 | Leslie Joe Dunaway | Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines |
| ES2274005T3 (es) * | 2001-01-26 | 2007-05-16 | Chugai Seiyaku Kabushiki Kaisha | Inhibidores de malonyl-coa decarboxilasa usados como moduladores metabolicos. |
| KR100637564B1 (ko) * | 2001-01-26 | 2006-10-20 | 추가이 세이야쿠 가부시키가이샤 | 대사 조절자로서 유용한 말로닐-코에이 데카르복실라제억제제 |
| ES2284817T3 (es) | 2001-01-26 | 2007-11-16 | Chugai Seiyaku Kabushiki Kaisha | Procedimientos para el tratamiento de enfermedades con inhibidores de la malonil coa descarboxilasa. |
| NZ526883A (en) | 2001-02-20 | 2005-11-25 | Chugai Pharmaceutical Co Ltd | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
| US7709510B2 (en) * | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| EP2208495B1 (en) * | 2003-08-01 | 2011-12-14 | Chugai Seiyaku Kabushiki Kaisha | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors |
| WO2005011812A1 (en) * | 2003-08-01 | 2005-02-10 | Chugai Seiyaku Kabushiki Kaisha | Cyanoamide compounds useful as malonyl-coa decarboxylase inhibithors |
| CA2533749C (en) * | 2003-08-01 | 2012-07-10 | Chugai Seiyaku Kabushiki Kaisha | Piperidine compounds useful as malonyl-coa decarboxylase inhibitors |
| JP4727578B2 (ja) * | 2003-08-01 | 2011-07-20 | 中外製薬株式会社 | マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用な複素環式化合物 |
| US7553853B2 (en) * | 2003-10-10 | 2009-06-30 | Synthon Bv | Solid-state montelukast |
| WO2005075427A2 (en) * | 2004-01-30 | 2005-08-18 | Teva Pharmaceutical Industries Ltd. | Montelukast sodium polymorphs |
| KR20060117356A (ko) * | 2004-01-30 | 2006-11-16 | 테바 파마슈티컬 인더스트리즈 리미티드 | 몬테루카스트 유리산 다형체 |
| US7547787B2 (en) * | 2004-04-21 | 2009-06-16 | Teva Pharmaceutical Industries Ltd. | Processes for preparing montelukast sodium |
| EP1904448B1 (en) * | 2005-07-05 | 2011-02-02 | Teva Pharmaceutical Industries, Ltd. | Purification of montelukast |
| AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
| WO2009001374A2 (en) * | 2007-06-25 | 2008-12-31 | Aptuit Laurus Pvt Ltd | Preparation of ethyl-3'-[((7-chloro-2-quinolinyl)ethenyl)phenyl]-3-oxopropanoate, a key intermediate for montelukast sodium |
| EP2276739A1 (en) * | 2008-04-25 | 2011-01-26 | Synthon B.V. | Process for making montelukast intermediates |
| KR20140108627A (ko) * | 2011-07-26 | 2014-09-12 | 썬 파마 어드밴스트 리서치 컴패니 리미티드 | 퀴놀린-, 퀸옥살린 또는 벤조티아졸계 시스테이닐 류코트리엔 길항물질 (ltc4) |
| MA54707A (fr) * | 2019-01-10 | 2021-11-17 | Jiangyin Mucocare Pharmaceutical Co Ltd | Nouvelles formulations contenant des antagonistes des récepteurs des leucotriènes |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1144905A (en) | 1965-03-25 | 1969-03-12 | Fisons Pharmaceuticals Ltd | Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3630200A (en) | 1969-06-09 | 1971-12-28 | Alza Corp | Ocular insert |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4325961A (en) | 1977-06-01 | 1982-04-20 | Merck & Co., Inc. | Fluorinated amino acids |
| PT68303A (en) | 1977-07-26 | 1978-08-01 | Merck & Co Inc | Process for the preparation of dibenzo/b,f/thiepin |
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| PH16099A (en) | 1979-03-06 | 1983-06-24 | Yamanouchi Pharma Co Ltd | Guanidinothiazole compounds,process for preparing them and medical composition containing them |
| JPS6056143B2 (ja) | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
| GB2058785B (en) | 1979-09-05 | 1983-05-25 | Glaxo Group Ltd | Phenol derivatives |
| US4237160A (en) | 1979-11-27 | 1980-12-02 | Merck Sharp & Dohme (I.A.) Corp. | 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists |
| DE3175201D1 (en) | 1980-04-30 | 1986-10-02 | Merck & Co Inc | Aminothiadiazoles as gastric secretion inhibitors |
| US4394508A (en) | 1980-06-07 | 1983-07-19 | Bristol-Myers Company | Chemical compounds |
| EP0056172B1 (en) | 1981-01-09 | 1985-04-03 | FISONS plc | Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them |
| EP0061800B1 (en) | 1981-03-24 | 1985-08-28 | FISONS plc | Anti srs-a carboxylic acid derivatives, processes for their production and pharmaceutical formulations containing them |
| IL69691A (en) | 1982-09-23 | 1988-01-31 | Merck Frosst Canada Inc | Leukotriene antagonists,their preparation and pharmaceutical compositions containing them |
| ATE22072T1 (de) | 1982-09-30 | 1986-09-15 | Merck Frosst Canada Inc | Leukotrienantagonisten, deren herstellung und diese enthaltende zusammensetzungen. |
| NZ206795A (en) | 1983-01-21 | 1987-08-31 | Merck Frosst Canada Inc | Phenothiazines, analogues and pharmaceutical compositions |
| EP0136893B1 (en) | 1983-10-05 | 1989-08-16 | Merck Frosst Canada Inc. | Benzo[a]phenothiazines and hydro-derivatives and pharmaceutical compositions containing them |
| DE3484745D1 (de) | 1983-10-05 | 1991-08-01 | Merck Frosst Canada Inc | Inhibitoren fuer die leukotrien-biosynthese. |
| ES8602818A1 (es) | 1983-10-31 | 1985-12-01 | Merck Frosst Canada Inc | Una composicion farmaceutica |
| IE861607L (en) * | 1985-06-18 | 1986-12-18 | Bunce Roger A | 2-substituted quinolines |
| US4851409A (en) | 1986-02-14 | 1989-07-25 | Merck Frosst Canada Inc. | 2-substituted quinoline dioic acids and pharmaceutical compositions |
| IE59889B1 (en) * | 1986-02-14 | 1994-04-20 | Merck Frosst Canada Inc | 2-substituted quinoline dioic acids |
| EP0271287A3 (en) | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Quinoline dioic acids and amides |
| DE3700732A1 (de) * | 1987-01-13 | 1988-07-21 | Boehringer Mannheim Gmbh | Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
| US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US5104882A (en) * | 1987-11-25 | 1992-04-14 | Merck Frosst Canada, Inc. | Diarylstrylquinoline diacids and pharmaceutical compositions thereof |
| EP0318093A3 (en) | 1987-11-25 | 1990-12-05 | Merck Frosst Canada Inc. | Diarylquinoline diacids and their use as medicaments |
| NZ233752A (en) * | 1989-05-24 | 1993-05-26 | Merck Frosst Canada Inc | Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof |
-
1991
- 1991-10-10 EP EP91309305A patent/EP0480716A1/en not_active Withdrawn
- 1991-10-10 CA CA002053216A patent/CA2053216C/en not_active Expired - Fee Related
- 1991-10-10 US US07/774,396 patent/US5428033A/en not_active Expired - Fee Related
- 1991-10-10 HU HU913216A patent/HUT61980A/hu unknown
- 1991-10-11 CN CN91110823A patent/CN1061408A/zh active Pending
- 1991-10-11 MX MX9101557A patent/MX9101557A/es unknown
- 1991-10-11 ZA ZA918120A patent/ZA918120B/xx unknown
- 1991-10-11 AU AU85796/91A patent/AU639611B2/en not_active Ceased
- 1991-10-11 CS CS913093A patent/CS309391A3/cs unknown
- 1991-10-11 PT PT99212A patent/PT99212B/pt not_active IP Right Cessation
- 1991-10-11 FI FI914797A patent/FI914797A7/fi not_active Application Discontinuation
- 1991-10-11 NO NO91914002A patent/NO914002L/no unknown
- 1991-10-12 KR KR1019910017951A patent/KR920008004A/ko not_active Withdrawn
- 1991-10-13 IL IL99725A patent/IL99725A0/xx unknown
- 1991-10-14 JP JP3331111A patent/JP2538155B2/ja not_active Expired - Lifetime
- 1991-10-16 IE IE361191A patent/IE913611A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0480716A1 (en) | 1992-04-15 |
| AU8579691A (en) | 1992-04-16 |
| JP2538155B2 (ja) | 1996-09-25 |
| HUT61980A (en) | 1993-03-29 |
| MX9101557A (es) | 1994-05-31 |
| AU639611B2 (en) | 1993-07-29 |
| PT99212A (pt) | 1992-09-30 |
| HU913216D0 (en) | 1992-01-28 |
| NO914002D0 (no) | 1991-10-11 |
| ZA918120B (en) | 1992-06-24 |
| FI914797L (fi) | 1992-04-13 |
| CS309391A3 (en) | 1992-05-13 |
| PT99212B (pt) | 1999-04-30 |
| CN1061408A (zh) | 1992-05-27 |
| JPH06206868A (ja) | 1994-07-26 |
| FI914797A0 (fi) | 1991-10-11 |
| CA2053216C (en) | 2003-04-08 |
| NO914002L (no) | 1992-04-13 |
| CA2053216A1 (en) | 1992-04-13 |
| FI914797A7 (fi) | 1992-04-13 |
| IE913611A1 (en) | 1992-04-22 |
| KR920008004A (ko) | 1992-05-27 |
| US5428033A (en) | 1995-06-27 |
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